DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cirl and adgrb3

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	XP_003199786.1	Gene:	adgrb3 / 566117	ZFINID:	ZDB-GENE-070424-99	Length:	1528	Species:	Danio rerio

Alignment Length:	1603	Identity:	309/1603 - (19%)
Similarity:	523/1603 - (32%)	Gaps:	494/1603 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 DVINLIRANYGRFSI-TICNDHGNVEWSVNCM---FPKSLSVLNSRCAHKQSCG------VLAAT 93
            :.:.|.:|:..:|.. .:|.      |..||:   ..:|..::.::|...|..|      ||..:
Zfish   156 EFVVLNKASPSQFGCQVLCT------WLENCLKAEKAESCGIVYAKCTCPQHLGDGESESVLMLS 214

  Fly    94 SMFGDPCPGTHKYLEAHYQCISAAQTSTTTNRPSPPPWVLSNGPPIFGNGSGLIHPPGVGAGAPP 158
            ::.....|.|...|....:.......|....|||...:             |:|     |.....
Zfish   215 NVVLPLNPQTEGCLTPQVRTAQVCNLSAEVRRPSKEEY-------------GMI-----GEHTVK 261

  Fly   159 PPRLPTLPGVVGI------------SGNPGLFNVPPQHTAVTHSTPSSSTTAVGGGRLKGGATST 211
            ..|..::....|:            :|:||         |...|..||.:...|    :|....|
Zfish   262 SQRPRSVHDTKGLQERDESAKFMAQTGDPG---------AEEWSQWSSCSVTCG----QGSQVRT 313

  Fly   212 TTTKHPAGRHDGLP-------------------------------------------PPPQLHHH 233
            .|...|.|.|...|                                           .|||
Zfish   314 RTCVSPYGSHCSGPLRESRVCNNTAPCPVHGSWEEWSPWSLCSFTCGRGHRTRTRICTPPQ---- 374

  Fly   234 HNHHGEDTASPTKPSSKL------PAGG----------------NATSPSNTRILTGVGGSGTDD 276
               ||.......:..|||      |..|                |.|.....:......|.....
Zfish   375 ---HGGRACDGPETQSKLCNIALCPVDGQWQEWSPWSDCSVTCANGTQQRKRQCSAAAHGGSECR 436

  Fly   277 GTLLTTKSSPNRPPGTAASGSVVP-------------GNGSVVRTINNINLNAAGMSGGDDESKL 328
            |....::...|  |...|:|...|             |....||....:.:......|..:|.:.
Zfish   437 GHWAESRECSN--PECTANGQWNPWAAWSGCSKSCDGGWQRRVRVCQGLAVTGQPCEGSGEEVRR 499

  Fly   329 -----------FCGPTHARNLYWNMTRVGDVNVQPCPGGAAGIAKWRCVLMKRIPDSGYDEYDDD 382
                       .|...:|.::.|..|..|::....||..|.|....||.|..|    |...::.
Zfish   500 CSEQRCPAPYEICPEDYAVSMLWRRTPSGELAFNRCPPNATGTTSRRCSLDHR----GVAYWEQ- 559

  Fly   383 ISSTTPAPSGGDCLHNSSSCEPPVSMAHKV-NQRLRNFEPTWHPATPDLTQCRSLWLNNLEMRVN 446
                   ||...|:.|...........|.. .||                              |
Zfish   560 -------PSYARCIANEYRYLQQSVQGHLAKGQR------------------------------N 587

  Fly   447 QRDSSLISIANDMSEVTSSKTLYGGDMLVTTKIIQTVSEKMMH-DKETFPDQRQREAMIMELLHC 510
            .....:..:...:.::|..:..|.||:|.:.:|::.|::.... ..|...|..|....|:
Zfish   588 LAGDGMSQVTKVLLDLTQRRNFYAGDLLSSVEILRNVTDTFKRASYEPSSDDVQNFFQII----- 647

  Fly   511 VVKTGSNLLDESQLSSWLDL-----NPEDQMRVATSLL----TGLE--YNAFLLADTIIRERSVV 564
                 ||||:|.....|.|.     ...:.|:|....:    .|::  ::|:|:..
Zfish   648 -----SNLLEEENREKWEDAQQIYPGSVELMQVTEEFIHIVGLGMKDFHSAYLMTG--------- 698

  Fly   565 QKVKNILLSVRVLETKTIQSSVVFPDSDQ-----WPLSS-DRIELPRAALIDNS---EGGLVRIV 620
                |::.|::.|...::.:.:.||...:     |..:| |::.:|:...:..:   :|..|.|:
Zfish   699 ----NLVTSIQRLPAVSVMTDINFPMKGRKGMVDWARNSEDKVVIPKGLFVPQAADMDGSPVFIL 759

  Fly   621 FAAFDRLESILKPSYDHFDLKSSRSYVRNTAILSNDSDVNAGEIQQRLRILNSKVISASLGKGRH 685
            .....:...::.|:..:           |||:                   |||||:.::.....
Zfish   760 GMVLYKTLGLMLPAPRN-----------NTAV-------------------NSKVIAVTVRPEPK 794

  Fly   686 IQLSQPITLTLKHLKTENVTNPTCVFW-----NYIDHAWSANGCSLESTNRTHSVCSCNHLTNFA 745
            :..:| :.:.|.|| .....||.|..|     |....:||:.||....|:.:|:.|.|:.::.||
Zfish   795 VTEAQ-LEIELAHL-ANGTMNPFCALWDSSVMNDSWGSWSSKGCRTVLTDASHTKCLCDRVSTFA 857

  Fly   746 ILMDVVDEHQHSLFTMFDGNMRIFIYISIGI-CVVFIVIALLTLKLFNGVFVKSARTSIYTSIYL 809
            ||.    :....:...:.|...:.:.:..|: |:..|.:|::...|:.  :::|.|:.|..:..|
Zfish   858 ILA----QQPREIAMEYSGVPSVTLIVGCGLSCLALITLAVVYAVLWR--YIRSERSIILINFCL 916

  Fly   810 CLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSGTAWFCYEAFHSYSTLTSDELLLEVDQTPK 874
            .::...:|.|:|..||..:..|...|.|||...|:...|...||:.||..:|.           |
Zfish   917 SIICSNILILVGQTQTHNAGICTMTTAFLHFFFLASFCWVLTEAWQSYMAVTG-----------K 970

  Fly   875 VNC------YYLLSYGLSLSVVAISLVIDPST-YTQNDYCVLMEANALFYA-----------TFV 921
            |..      :..|.:||...|||||:....:. |....||.|.....|.||           ..|
Zfish   971 VRTRLIRKRFLCLGWGLPALVVAISMGFTKAKGYGTPQYCWLSLEGGLLYAFVGPAAAVVLVNMV 1035

  Fly   922 IPVLVF--FVAAIGYTFLSWIIMCR--KSRTGLKTKEHTRLASVRFDIRC--------------- 967
            |.:|||  .|:..|       |:.:  |.|.|..::.||.|.     ::|
Zfish  1036 IGILVFNKLVSRDG-------ILDKKLKHRAGQMSEPHTGLT-----LKCAKCGVVSTTALSATT 1088

  Fly   968 ----------SFVFLLLLSAVWCSAYFYLRGAKMDDDTADVYGYCFICFNTLLGLYIFVFHCIQN 1022
                      |.|.|.||:..|.||..     .|.|..:.::...|..|::|.|..|.:.|||
Zfish  1089 ASNAMASLWSSCVVLPLLALTWMSAVL-----AMTDKRSILFQILFAVFDSLQGFVIVMVHCI-- 1146

  Fly  1023 EKIRREYRKYVRQHAWLPKC-LRCSKTSISSGIVTGNGPTAGTLCSVSTSKKPKLPLGVSEEAHD 1086
              :|||.:...|       | ||..:..|:|. .||..|...  ..:.|..:..:.:......|.
Zfish  1147 --LRREVQDAFR-------CRLRNCQDPINSD-ATGTFPNGH--AQIMTDFEKDVDIACRSALHK 1199

  Fly  1087 DPQQQQQTPVPITEDAIMGATSDCELNEAQQRRTLKSGLMTGTLQAPPQTLGGHVVLERGSTLRS 1151
            |....:..       .|.||.|...||:.::.:. ..||...||   |..:...|::::.|.|..
Zfish  1200 DMGSCRAA-------TITGALSRISLNDEEEEKG-PEGLNYSTL---PGNIMSKVIIQQPSGLHM 1253

  Fly  1152 T------GHASPTSSAGSTHLIFAHKQQQQQQQQGPLGESYYHQPDYYSWKQPSTGTGGLKT--- 1207
            :      |.....|:|.....::.......:|.:..|...     |.....||    |.::|
Zfish  1254 SMGVGDLGEQCLDSTADMRRTVYLCTDDTTRQSEQELSAH-----DLSGHPQP----GQMETDYI 1309

  Fly  1208 --PREYYNNA---GAAASS-PQQAHEVFYWTQKPNSGHNG--KKKRGAGGVPASPSGSLHSRTAA 1264
              ||.  :.|   ||.:|| |....|....:...:..|:.  ..|.|| .....|||..|.
Zfish  1310 VLPRS--SGAVVSGAGSSSVPTLLKEESKMSMMDSLSHDRLMHYKMGA-EFNLGPSGMEHM---- 1367

  Fly  1265 ASQVLFYPSYKKTKPGQPTGYPQYAEAL-----DPPLATGNAAAYYQQQQQLRRQQLHQ------ 1318
                           |....||..||.:     :|..|..|..|..::...|.|.:...
Zfish  1368 ---------------GMEHQYPVQAEHMQNLPFEPRTAVKNFLAEMEESGGLSRSETGSTISMSS 1417

  Fly  1319 -QQQQQQQQQLSSDEEQAEQHAHLLHLQRRAGSQQQLPAPPPHMAQYQQEFMQRQYRNKHSNCDL 1382
             ::::.:.|.|..::        ::|.::|            ||..:|:  :.::::..
Zfish  1418 LERRKSRYQDLDFEK--------VMHTRKR------------HMELFQE--LNQKFQTL------ 1454

  Fly  1383 GMGDAYYNQGSVGGADGGPVYEEILSNRN--------SDVQHY 1417
               |.:.:..::|      :.::.:.|:|        |:.|:|
Zfish  1455 ---DRFRDIPNMG------IMDKAMPNKNPWESFNPASEYQNY 1488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328	16/83 (19%)
		GAIN	453..680	CDD:293098	44/247 (18%)
		GPS	705..752	CDD:197639	17/51 (33%)
		7tm_4	763..1014	CDD:304433	73/298 (24%)
adgrb3	XP_003199786.1	TSP1	294..341	CDD:214559	11/50 (22%)
		TSP1	346..396	CDD:214559	8/56 (14%)
		TSP1	401..450	CDD:214559	6/50 (12%)
		TSP1	456..506	CDD:214559	6/49 (12%)
		HormR	508..574	CDD:214468	18/77 (23%)
		GAIN	592..791	CDD:318649	44/251 (18%)
		GPS	813..864	CDD:197639	17/54 (31%)
		7tmB2_BAI3	869..1161	CDD:320655	83/332 (25%)
		TM helix 1	873..898	CDD:320655	4/24 (17%)
		TM helix 2	908..930	CDD:320655	5/21 (24%)
		TM helix 3	939..967	CDD:320655	10/27 (37%)
		TM helix 4	977..997	CDD:320655	8/19 (42%)
		TM helix 5	1015..1044	CDD:320655	8/28 (29%)
		TM helix 6	1091..1118	CDD:320655	8/31 (26%)
		TM helix 7	1123..1148	CDD:320655	8/28 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910