DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cirl and adgrg11

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	XP_017208200.1	Gene:	adgrg11 / 563883	ZFINID:	ZDB-GENE-041210-320	Length:	793	Species:	Danio rerio

Alignment Length:	811	Identity:	165/811 - (20%)
Similarity:	288/811 - (35%)	Gaps:	248/811 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   369 KRIPDS------GYDEYDDDISSTT-------PAPSGGDCLHN--SSSCEP----PVSMAHKVNQ 414
            |..||.      |.|.:...:.|.|       |:|....|..:  |.:|..    |||::....|
Zfish    40 KNSPDMMDFFIFGADGFVGYMKSGTCKNGAWDPSPGSSQCNLSDWSGTCRKDVWNPVSLSELCRQ 104

  Fly   415 ------------RLRNFE-----PTWHPATPDLTQCRSLWLNNLEMRVNQRDSSLISIANDMSEV 462
                        ::.:.:     .||.| :|..::|      ||..: ::::||:.....|.|..
Zfish   105 NGDAALTVLTYLQMNSLQGTCKNGTWVP-SPSSSRC------NLTGQ-SEKNSSICVFPIDGSST 161

  Fly   463 TSSKTLYGGDMLVTTKIIQTVSEKMMHDKET-FPDQRQR--EAMIMELLHCVVK----------- 513
            :.:.|::..|:.|:           ...|:| :.||.|.  ...::..:.|::.
Zfish   162 SENATIFRSDLGVS-----------FPRKDTAYTDQYQLNISRSVLPTIVCLIGKDCRNVTWANW 215

  Fly   514 -TGSN-------------------LLDESQLSSWLDLNP---EDQMRVATSLLTGLEYNA----- 550
             ||:|                   .|:..:.......||   :|.....::.:...|.|.
Zfish   216 ITGNNCSWTKQTTTSFNNNTCNVTCLNTKKACETASYNPSCSDDNSNNVSNKMNTFEINGGSAAC 280

  Fly   551 ------FLLADTIIRERSVVQK-----------------------------------------VK 568
                  |..|.||.....:.:|                                         ||
Zfish   281 IKCGNPFQPAQTITLPAEITEKFNQNDTKTVIDAGAAASAMKDLSSMLSYMGNLTVASVSMGSVK 345

  Fly   569 NILLSVR----VLETKTIQSSVVFPDSDQWPLSSDRIELPRAALIDNSEGGLVRIVFAAFDRLES 629
            .||..::    |.||..|.|          |.:..|: :....::.|....|:....||...|.
Zfish   346 GILKKIQSESEVTETAFIYS----------PATGVRL-IDDPTVLKNYPNALIVPKEAAQQALN- 398

  Fly   630 ILKPSYDHFDLKSSRSYV-----RNTAILSNDSDVNAGEIQQRLRILNSKVISASLGKGRHIQLS 689
                       :||.:::     .|.:..:|:|||           ||::|.:..:|. :...||
Zfish   399 -----------QSSNAFLGVFRFPNMSKDANNSDV-----------LNNEVYAIEMGT-KIKNLS 440

  Fly   690 QPITLTLKHLKTENVTNPTCVFW--NYIDHAWSANGCSLESTNRTHSVCSCNHLTNFAILMDVVD 752
            ..|.|:....::.:.| |||..|  |.....|:..||. ...|.:...|.|.|||.||:||...|
Zfish   441 NTINLSFNMSQSTSGT-PTCYSWDGNGSKPDWTTEGCR-TVVNGSGITCKCEHLTFFAVLMAPPD 503

  Fly   753 EHQHSLFTMFDGNMRIFIYIS---IGICVVFIVIALLTLKLFNGVFVKSARTS----IYTSIYLC 810
                  .|:.:.::....||:   .|:.:.|:.:.     ||....::.|:.:    :..:::|.
Zfish   504 ------ITLRESDLTALTYITYIGCGLSMFFLGVG-----LFMHFLMRKAKATNSVHVLINLFLA 557

  Fly   811 LLAIELLFLLG--IEQTETSIFCGFITIFLHCAILSGTAWFCYEAFHSYSTLTSDELLLEVDQTP 873
            |..:.:.||..  :.|.:.||.|..:..|||..:||...||..||.|         |.|::.:|.
Zfish   558 LFMLNVAFLTNEYVVQAQNSILCRVMAAFLHYCLLSSFTWFAVEALH---------LCLQMTKTA 613

  Fly   874 KVNCYYLLSY---GLSLSVVAISLVIDPSTYTQNDYCVLMEANALFYATFVIPVLVFFVAAIGY- 934
            .:. :|||..   |.:.....:|::.....|.:::   :|..:......:::...|.:|..|||
Zfish   614 TLK-HYLLKITVAGWAPPAFVVSVIFSLGKYGEDN---IMTESRNVTMCWIVDSTVHYVVNIGYY 674

  Fly   935 ---------TFL---SWIIMCRKSRTGLKTKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLR 987
                     ||:   .|:.|.|.|:.. |..:..|..:...||........||...|..::|...
Zfish   675 CFVFTFTLGTFIVVVRWLSMLRMSKWS-KDGKVKRSGTATSDISTMLGLCCLLGLTWGISFFSYG 738

  Fly   988 GAKMDDDTADVYGYCFICFNTLLGLYIFVFH 1018
            ..:|..     | |.|...|:|.|.::||::
Zfish   739 ALRMPS-----Y-YIFTILNSLQGFFLFVYY 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328
		GAIN	453..680	CDD:293098	51/324 (16%)
		GPS	705..752	CDD:197639	19/48 (40%)
		7tm_4	763..1014	CDD:304433	61/275 (22%)
adgrg11	XP_017208200.1	GPS	457..498	CDD:280071	16/41 (39%)
adgrg11	XP_017208200.1	7tm_4	511..759	CDD:304433	61/272 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900