DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cirl and adgrl1a

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	XP_021330394.1	Gene:	adgrl1a / 562531	ZFINID:	ZDB-GENE-131127-267	Length:	1524	Species:	Danio rerio

Alignment Length:	1864	Identity:	405/1864 - (21%)
Similarity:	651/1864 - (34%)	Gaps:	581/1864 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PTILSISYEHISLDLSKYQTAYACEGKKLTIECDPGDVINLIRANYGRFSITICN-DHGNVEWSV 66
            |:..::|...:...|.:.:  .||||..:.:.|...|||.:..|||||....||: |...:| :|
Zfish    20 PSAQALSRSAMPFGLMRRE--LACEGYPIELRCPGSDVIMIETANYGRTDDKICDADPFQME-NV 81

  Fly    67 NCMFPKSLSVLNSRCAHKQSCGVLAATSMFGDPCPGTHKYLEAHYQCI----------------- 114
            .|..|.:..:::.||.::..|.|:|.:.:|.||||||:||||..|:|:
Zfish    82 QCYLPDAFKIMSQRCNNRTQCVVVAGSDVFPDPCPGTYKYLEIQYECVPYKVDQKVFVCPGTLLR 146

  Fly   115 -------------SAA------------------------------------QTSTTT----NRP 126
                         |.|                                    ..:|||    ||.
Zfish   147 VQAASLLQEAEHQSGAWCKDPLQSGDRLYVMPWTPYRTDMLYEYASWEDFKQNRATTTYKLPNRV 211

  Fly   127 SPPPWVLSNGPPIFG-----------------NGSGLIHPPGVGAGAP-------------PPPR 161
            ....:|:.:|...:.                 :|..:::.......:|             ....
Zfish   212 DGTGFVVYDGAVFYNKERTRNIVKYDLRTRIKSGEAIVNNANYHDTSPYRWGGKSDIDLAVDENG 276

  Fly   162 LPTLPGVVGISGNPGLFNVPPQ--------HTAVTHSTPSSSTTAVG----------------GG 202
            |..:......:|...:..|.|.        .|:......|::..|.|                ||
Zfish   277 LWVIYATEANNGRLVVSQVNPYTLRFEGTWETSFDKRLASNAFMACGVLYAVRSVYQDDDSEAGG 341

  Fly   203 RLKGGATSTTTTK-HPAGRHDGLPPPPQLHHHHNHHGEDTA----------------SPTKPSSK 250
            .|...|.:|...: .|.  |...|.|.|.....:::..|..                .|..|::.
Zfish   342 DLVLYAYNTNRAREEPV--HIPFPNPYQYVSSVDYNPRDNQLYVWNNYNVLRYPLEFGPPDPTAG 404

  Fly   251 LPAGGNATSPSNTRILTGVGGSGTDDGTLLTTKSSPNR----PPGTAASGSV------VPGNGSV 305
            .|            :.|.:..|.|.....:|:.|.|:.    ||.....|::      .|...:|
Zfish   405 PP------------VTTQMSSSTTTAARPITSTSLPSTIRPLPPTAHPIGAINKAPDLRPITATV 457

  Fly   306 VRTINNINLNAAGMSGGDDESKLFCGPTHARNLYWNMTRVGDVNVQPCPGGAAGIAKWRCVLMKR 370
            ..|...:.:...|......||::      ||.:.|..|:.|:...:|||.|:.|||.::|
Zfish   458 PVTRRPLRVPPQGPEIEVCESRV------ARGVQWPATQKGETVDRPCPKGSLGIASFQC----- 511

  Fly   371 IPDSGYDEYDDDISSTTPAPSGGDCLHNSSSCEPPVSMAHKVNQRLRNFEPTWHPATPDLTQCRS 435
                        :||                   ||               .|:|..|||:.|.|
Zfish   512 ------------LSS-------------------PV---------------LWNPRGPDLSNCTS 530

  Fly   436 LWLNNLEMRVNQRDSSLISIANDMSEVTSSKTLYGGDMLVTTKIIQTVSEKM--------MHDKE 492
            .|:|.:..::...::: .:||.::...|..: ::.||:..:.::|:.:.:.:        ..:||
Zfish   531 PWVNQVAQKIKSGENA-ANIAAELVNHTQGR-IHAGDVSSSVRLIEQLLDILDAQLQALRPGNKE 593

  Fly   493 T----FPDQRQREAMIMELLHCVVKTGSNLLDESQLSSWLDLNPEDQMRVATSLLTGLEYNAFLL 553
            :    :...::||......:..||:|..|||....|.||.|:|..:|...||.||..:|..||||
Zfish   594 SAARNYNKWQKRERTCRAYVQAVVQTVDNLLRAEALESWQDMNSTEQAHTATMLLDVMEKGAFLL 658

  Fly   554 ADTIIRERSVVQKVKNILLSVRVLETKTIQSSVVFPDSDQWPLSSDRIELPRAALIDNSEGGLVR 618
            |:.:.... ......|:.|.||||.|:|....:.||.|..   |...|:|..:.....|..|.|:
Zfish   659 ANNMYNNH-FSDHAANVDLEVRVLNTETDSQDLSFPQSGP---SDSSIQLSASTFKQYSRNGQVK 719

  Fly   619 IVFAAFDRLESILKPSYDHFDLKSSRSYVRNTAILSNDSDVNAGEIQQRLRILNSKVISASLGK- 682
            :||..:..|.|.|.              ..|..:   ..::.|| |..|...:||.||:||:.|
Zfish   720 VVFVLYKNLGSFLS--------------TENATV---KMEMEAG-IGGRGLAVNSHVIAASINKE 766

  Fly   683 GRHIQLSQPITLTLKHLKTENVTNPTCVFWNYIDHA----WSANGCSLESTNRTHSVCSCNHLTN 743
            ...:.|::|:..||:||:.||..:|.|.||||.:.:    ||:.||.|..||.||:.|||:||||
Zfish   767 SSRVFLTEPVVFTLRHLQLENHFSPNCSFWNYSERSMTGQWSSQGCRLIETNSTHTTCSCSHLTN 831

  Fly   744 FAILMDVVDEHQHSLFTMFDGNMR-----IFIYISIGICVVFIVIALLTLKLFNGVFVKSARTSI 803
            ||:||   ..|:..    :.|.|.     :..::.|.|.:|.:.|.:.|.....|  :::.|.:|
Zfish   832 FAVLM---VHHEPD----YPGRMHELILFVITWVGIVISLVCLAICISTFCFLRG--LQTDRNTI 887

  Fly   804 YTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSGTAWFCYEAFHSYSTLTSDELLLE 868
            :.::.:.|...|||||:||::|:..|.|......||...|:..:|.|.|....|.      :|:|
Zfish   888 HKNLCINLFIAELLFLIGIDKTQYHIACPIFAGLLHFFFLAAFSWMCLEGIQLYL------MLVE 946

  Fly   869 V--DQTPKVNCYYLLSYGLSLSVVAISLVIDPSTYTQNDYCVLMEANALFYATFVIPVLVFFVAA 931
            |  .:..:...|||..|.....||.||..||..:|.....|.|...| .|..:|:.|  |.|:..
Zfish   947 VFESEYSRKKYYYLCGYCFPALVVGISAAIDYRSYGTKKACWLRVDN-YFIWSFIGP--VSFIIM 1008

  Fly   932 IGYTFLSWII--MCRKSRTGLKTKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLRGAKMDDD 994
            :...||...:  |.|.| :.|| .:.:||.:::.....:...|.||...|.....::      ::
Zfish  1009 LNLVFLMITLHKMIRNS-SALK-PDSSRLDNIKSWALGAIALLFLLGLTWAFGLLFI------NE 1065

  Fly   995 TADVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYRKYVRQHAWLPKCLRCSKTSISSGIVTGNG 1059
            ...:..|.|..||...|::||:|||...:|:.:||.|.:| |::   |  ||:||.:|
Zfish  1066 NTVIMAYLFTTFNAFQGMFIFIFHCALQKKVHKEYSKCLR-HSY---C--CSRTSTTS------- 1117

  Fly  1060 PTAGTLCSVSTSKKPKLPLGVSEEAHDDPQQQQQTPVPITEDAIMGATSDCELNEAQQRRTLKSG 1124
             :.|:|.:.:.....:...| |:..|....:|.:.. .:..|.:              |:..:|.
Zfish  1118 -SHGSLKNSALRTNNRYYTG-SQTRHAAVHRQSRIR-RMWNDTV--------------RKQTESS 1165

  Fly  1125 LMTGTLQAPPQ----TLGGHVVLERGSTLRSTGHASPTSSAGSTHLIFAHKQQQQQQQQGPLGES 1185
            .|.|.:.:.|.    |:|.|::  ....|::...:||.::.                    |.|:
Zfish  1166 FMAGDINSTPTLNRGTMGNHLL--TNPVLQTRTGSSPYNTL--------------------LAET 1208

  Fly  1186 YYHQPDYYSWKQPSTG----TGGLKTPREYYNNAGAAASSPQQAHEVFYWTQKPNSGHNGKKKRG 1246
            :         ..||.|    ||..:.|:.                     |...|..|.|.:...
Zfish  1209 F---------TPPSPGVFNSTGTFRDPKS---------------------TLSKNRDHGGMETLP 1243

  Fly  1247 AGGVPASPSGSLHSRTAAASQVLFYPSYKKTKPGQPTGYPQYAEALDPPLATGNAAAYYQQQQQL 1311
            ..|   :.:.|...|:...|             |.|.|...:       |..|..
Zfish  1244 LNG---NFNNSYSLRSVGGS-------------GAPGGSCDF-------LGGGGG---------- 1275

  Fly  1312 RRQQLHQQQQQQQQQQLSSDEEQAEQHAHLLHLQRRAGSQQQLPAPPPHMAQYQQEFMQRQYRNK 1376
                                                       .:|||.:.....|.:....||
Zfish  1276 -------------------------------------------DSPPPLLNPRGSETLGGIRRN- 1296

  Fly  1377 HSNCDLGMGDAYYNQGSVGGADGGPVYEEILSNRNSDVQHYEVGDFDVDEVYNNSV--GTGVFNN 1439
                   :.||             ..:|:::                :.|:.:|::  |.||...
Zfish  1297 -------LSDA-------------AAFEKMI----------------ISELVHNNLRGGGGVGGG 1325

  Fly  1440 MR--AAVAAGGSRYGGGSLSGG-----------SVSSRSQQQQLKKQ--------------QQQQ 1477
            .|  .::|.|....|.|...||           ...||..:|:..:.              |:.|
Zfish  1326 DRTCGSLARGHGHLGMGRAGGGVEPVIGMEDDEDFRSREARQRTPQDVELLYKALEEPLLLQRAQ 1390

  Fly  1478 SLAQQRSARRCTADDDDDEDEEEDEEATAAEQLHDSVCDEDEEEDESDLEDDAHGLPPQS---DE 1539
            |:..|           .|.||.|...|...|.|..|      ...........|..||.|   |.
Zfish  1391 SVLYQ-----------SDPDESESYTADLTESLGHS------GHSAQSAAGQGHSGPPDSPARDS 1438

  Fly  1540 RMRRLMAMQDEDFKRRFQRQLRKHGAPLDYGALPPGAGPQPEHNGAVFGVSGGVGEGSLRGAFRQ 1604
            ....:..::|..:         ...:|.....:|..|.|..|    ::..||....|| |||..|
Zfish  1439 LYTSITNLRDSPY---------PDSSPEPLEVVPRSAQPPEE----LYYSSGRPAIGS-RGAPMQ 1489

  Fly  1605 QQQQALNAKSPGGRLAVNELFGHGNSGPPLPPANQTPAQKRQQL 1648
            ...||     |..|.:..   .|     |.|.|..:....:.||
Zfish  1490 TFYQA-----PPRRPSTE---AH-----PAPEAPHSEGDGQMQL 1520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328	33/80 (41%)
		GAIN	453..680	CDD:293098	64/238 (27%)
		GPS	705..752	CDD:197639	26/50 (52%)
		7tm_4	763..1014	CDD:304433	68/259 (26%)
adgrl1a	XP_021330394.1	Gal_Lectin	48..128	CDD:307994	33/80 (41%)
		OLF	142..398	CDD:321983	30/257 (12%)
		HormR	474..535	CDD:214468	27/117 (23%)
		GAIN	545..765	CDD:318649	65/243 (27%)
		GPS	789..836	CDD:197639	24/46 (52%)
		7tmB2_Latrophilin-1	849..1106	CDD:320673	76/276 (28%)
		TM helix 1	851..876	CDD:320673	5/24 (21%)
		TM helix 2	885..907	CDD:320673	8/21 (38%)
		TM helix 3	916..943	CDD:320673	7/32 (22%)
		TM helix 4	955..975	CDD:320673	8/19 (42%)
		TM helix 5	992..1021	CDD:320673	8/31 (26%)
		TM helix 6	1037..1064	CDD:320673	4/32 (13%)
		TM helix 7	1068..1093	CDD:320673	10/24 (42%)
		Latrophilin	1105..1524	CDD:308136	112/655 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I8871
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	369	1.000	Inparanoid score	I2092
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000766
OrthoInspector	1	1.000	-	-		otm24884
orthoMCL	1	0.900	-	-		OOG6_102405
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X858
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.820