Protein Alignment Cirl and adgrg6

DIOPT Version :10

• Sequence 1: NP_001260807.1
• Gene: Cirl / 35846
• FlyBaseID: FBgn0033313
• Length: 1711
• Species: Drosophila melanogaster
• Sequence 2: XP_073788884.1
• Gene: adgrg6 / 561970
• ZFINID: ZDB-GENE-041014-357
• Length: 2223
• Species: Danio rerio
• Alignment Length: 1214
• Identity: 258/1214 - (21%)
• Similarity: 430/1214 - (35%)
• Gaps: 369/1214 - (30%)

  Fly    16 DLSKYQTAYACEGKKLTIECDPGDVINLIRANYGRFSITICNDHGNVEWSVNCMFPKSLSVLNSR 80
            :.|.|:|.:..:.:.:       |:.|.|             :.|||       ||       ||
Zfish  1106 EASPYETKFRYQSETI-------DISNFI-------------EPGNV-------FP-------SR 1136

  Fly    81 CAHKQSCGVLAATSMFGDPCPGTHKYLEAHYQCISAAQTSTTTNRPSPPPWVLS---NGPPI--- 139
            ...|........:|.:......||||:||                 :|..|.|.   |.|.:
Zfish  1137 SKEKVYHDRFIISSAYTRISSTTHKYIEA-----------------TPTTWPLKTTLNIPDVSKS 1184

  Fly   140 ---------------FGNGSGLIHP----PGV-------GAGAPPPPRLPTLPGVVGISGNPGLF 178
                           |......|.|    |.:       ...:..||..|.......||..|.:.
Zfish  1185 FKKKQISNTIQDYELFKINMHTIEPFHTQPHLQITMTYADLSSHTPPNTPLHQFHTSISSMPSVL 1249

  Fly   179 NVPPQHTA-VTHSTPSSSTTAVGG---GRLKGGATSTTTTKHPAGRHDGLPPPPQLHHHHNHHGE 239
                :.|| ::...||.|.....|   ..|......::|||.|....:
Zfish  1250 ----EWTASISVFQPSKSIHISSGYSEDLLDAKHVHSSTTKWPFWAKN----------------- 1293

  Fly   240 DTASPTKPSSKLPAGGNATSPSNTRILTGVGGSGTDDGTLLTTKSSPNRPPGTAASGSVVPGNGS 304
            ::|:|:..|..:.....||:.:.|.....:     ||...:.|.       ||||:    |.||
Zfish  1294 ESANPSSHSHNVLVVQPATTDTKTHPTPAI-----DDQPFVPTN-------GTAAT----PANG- 1341

  Fly   305 VVRTINNINLNAAGMSGGDDESKLFC---GPTHA----------RNLYWNMTRVGDVNVQPCPGG 356
            |:.:..:::..|...:..|......|   .|.|.          :::::..|.|......|....
Zfish  1342 VIPSFGSVHAGATNGTTTDPHELAPCPCKAPFHITCLCGLSAGNKDIFYRSTLVVTDEQTPDRDA 1406

  Fly   357 AAGIAKWRCVLMKRIPDSGYDEYDDDISSTT-------------------------------PAP 390
            .|.|::|   |.:...:..|..|.|.|..||                               ||.
Zfish  1407 TAIISQW---LNQTFQNWMYRVYVDGIRITTTRQIYLALLVYKNTTDVNLAEVEIESMLRSAPAI 1468

  Fly   391 SGG--------DCLHNSSSCEPPV-------------------------SMAHKVNQRLRNFEPT 422
            ..|        :.:.|..:.|.||                         |....:|:  .|:...
Zfish  1469 GNGLTLDSVTVNLMENCQADEFPVHYRWPESRPTVTQYVPCFPYKDRNASRTCMINR--DNYTSF 1531

  Fly   423 WHPATPDLTQCRSLWLNNLEMRVNQRDSSLISIANDMSEVTSSKTLYGGDMLVTTKIIQTVSEKM 487
            |  |.||...|    .|...:.|:|.::  :.:|..:::::::.........|.||:::.|:...
Zfish  1532 W--ALPDRGNC----TNITSITVSQENA--MDVAVQLADISNNGLSKEELTQVVTKVMELVNIAK 1588

  Fly   488 MHDKETFPDQRQREAMIMELLHCVVKTGSNLLDESQLSSWLDLNPEDQMRVATSLLTGLEYNAFL 552
            ::               ..|...||...||::..|: .:..|.: |..::....|:..:|::.
Zfish  1589 IN---------------ATLASTVVTIISNVMVSSE-DAQKDAS-ETALKAVDELVQKIEFDG-- 1634

  Fly   553 LADTIIRERSVVQKVKNILLSVRVLET-----KTIQSSVVFPDSD-QWPLSSDR------IELPR 605
                    .|:....||:::.|..|:|     .|:.:.:....:| |....|:.      :.||
Zfish  1635 --------PSLTISSKNLVVGVSALDTTNFNGSTLSAFIATNTTDPQIDFDSEAHNALAVVTLP- 1690

  Fly   606 AALIDNSEGGLV----RIVFAAFDRLESILKPSYDHFDLKSSRSYVRNTAILSNDSDVNAGEIQQ 666
            ..|:.|.....:    ||.|..|.|     ...:.||.           :::.:         |.
Zfish  1691 PTLLQNLSLSQIEKVSRINFMFFGR-----TGLFQHFG-----------SLMDH---------QN 1730

  Fly   667 RLRILNSKVISASLGKGRHIQLSQPITLTLKHLKTENVTNPTCVFWNY----IDHAWSANGCSLE 727
            ....|||.|:::|:|......|..|:.:.:.||:.:...||.||||::    ....|:::||.:.
Zfish  1731 NGLTLNSYVVASSVGNFTIKNLQDPVRIEIAHLEYQKDPNPQCVFWDFNLQNYSGGWNSDGCKVG 1795

  Fly   728 S-TNRTHSVCSCNHLTNFAILMDV------VDEHQHSLFTMFDGNMRIFI-YISIGICVVFIVIA 784
            | :|...:||.|||||:|.|||||      :||..:.:.|        || ||..||..:|....
Zfish  1796 SDSNSNRTVCLCNHLTHFGILMDVSRAAELIDEKNNRVLT--------FITYIGCGISAIFSAAT 1852

  Fly   785 LLTLKLFNGVFVKSAR---TSIYTSIYLCLLAIELLFLLG--IEQTETSIFCGFITIFLHCAILS 844
            |||...|.    |..|   :.|..::...||.:.::|||.  :...|....|..:.:|||..:|:
Zfish  1853 LLTYIAFE----KLRRDYPSKILMNLSTSLLFLNMVFLLDGWLASYEIKELCVTVAVFLHFFLLT 1913

  Fly   845 GTAWFCYEAFHSYSTLTSDELLLEVDQTPKV-NCY---YLLSY-----GLSLSVVAISLVIDPST 900
            ...|...|:.|.|..|.            || |.|   |:|.:     |:..::|||.|.:...:
Zfish  1914 SFTWMGLESIHMYIALV------------KVFNTYIRRYILKFCIVGWGVPATIVAIVLAVSKDS 1966

  Fly   901 YTQN------------DYCVLMEANALFYATFVIPVLVFFVAAIGYTFLSWIIMC-RKSRTGLKT 952
            |.:|            ::|.::.. .:||.|.|....:.|:..:....:..|.:| |..:...:|
Zfish  1967 YGKNYYGKGKDGQGTSEFCWILNP-VVFYVTCVAYFSIIFLMNVAMFIVVMIQICGRNGKRSNRT 2030

  Fly   953 KEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLRGAKMDDDTADVYGYCFICFNTLLGLYIFVF 1017
            .....|.::|..:..:|    ||...|..|:|......:      .:.|.|..||:|.||:||||
Zfish  2031 LREDILRNLRSVVSLTF----LLGMTWGFAFFAWGPVSL------AFMYLFTIFNSLQGLFIFVF 2085

  Fly  1018 HCIQNEKIRREYRKYVRQHAWLPKC---LRCSKTSISSGIVTGN 1058
            ||...|.:::::|:|:        |   ||.:..|..|...|.|
Zfish  2086 HCALKENVQKQWRRYL--------CCGKLRLADNSDWSKTATNN 2121

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Rha_Lectin_dCirl	22..113	CDD:438687	19/90 (21%)
		GAIN	451..682	CDD:465137	42/246 (17%)
		GPS	705..752	CDD:197639	24/57 (42%)
		7tmB2_CELSR_Adhesion_IV	763..1035	CDD:320557	77/299 (26%)
		TM helix 1	765..790	CDD:320557	10/25 (40%)
		TM helix 2	801..823	CDD:320557	6/23 (26%)
		TM helix 3	832..859	CDD:320557	8/26 (31%)
		TM helix 4	875..895	CDD:320557	9/28 (32%)
		TM helix 5	913..942	CDD:320557	6/28 (21%)
		TM helix 6	960..987	CDD:320557	7/26 (27%)
		TM helix 7	997..1022	CDD:320557	13/24 (54%)
		Herpes_TAF50	<1219..1365	CDD:308764
adgrg6	XP_073788884.1	None