Protein Alignment Cirl and adgrl3.1

DIOPT Version :10

• Sequence 1: NP_001260807.1
• Gene: Cirl / 35846
• FlyBaseID: FBgn0033313
• Length: 1711
• Species: Drosophila melanogaster
• Sequence 2: XP_005170997.2
• Gene: adgrl3.1 / 560631
• ZFINID: ZDB-GENE-030131-7856
• Length: 1540
• Species: Danio rerio
• Alignment Length: 1672
• Identity: 366/1672 - (21%)
• Similarity: 596/1672 - (35%)
• Gaps: 470/1672 - (28%)

  Fly     3 PTILSISYEHISLDLSKYQTAYACEGKKLTIECDPGDVINLIRANYGRFSITIC-NDHGNVEWSV 66
            |..|.:|...:.:.:.:.:  .:|||..:.:.|...|||.:..|||||....|| :|...:| :.
Zfish    38 PVTLVLSRAPVPMAVVRRE--LSCEGYPIELRCPGTDVIMIESANYGRTDDKICDSDPAQME-NT 99

  Fly    67 NCMFPKSLSVLNSRCAHKQSCGVLAATSMFGDPCPGTHKYLEAHYQCI----------------- 114
            .|..|.:..::..||.::..|.|:|...:|.||||||:||||..|:|:
Zfish   100 RCYLPDAYKIMGFRCNNRTQCAVVAGPDVFPDPCPGTYKYLEVQYECVPYKVEQKVFLCPGVLRG 164

  Fly   115 ---------SAAQTST-------TTNRPSPPPWVLSNGPPI--FGNGSGLIHPPGVGAGAPP--- 158
                     |..|..:       ::|:....||.......:  :.:....|      ||.|.
Zfish   165 VYQSEHLFESDHQAGSWCKDPLQSSNKIYYMPWTPYRTDTLTEYSSKEDFI------AGRPTTTY 223

  Fly   159 --PPRLPTLPGVV----------------------------GISGNPGLFNVPPQHTA------- 186
              |.|:.....||                            .|..|....:..|....
Zfish   224 KLPHRVDGTGFVVYDGALFFNKERTRNIVKFDLRTRIKSGEAIIANANYHDTSPYRWGGKSDIDL 288

  Fly   187 --------VTHSTPSSSTTAVGGGRL-----------KGGATSTTTTKHPAGR------------ 220
                    |.::|..::      ||:           ..|:..|:..|..|..
Zfish   289 AVDENGLWVIYATEQNN------GRIVVSQLNPYTLRVEGSWDTSYDKRSASNAFMICGILYVVK 347

  Fly   221 ---------------------------HDGLPPP------------PQ---LHHHHNHH------ 237
                                       |..:|.|            |:   |:..:|:|
Zfish   348 SVYEDDDNEALGNKIDYMYNTEKSRETHLSIPFPNSYQYIAAVDYNPRDNLLYVWNNYHVVIYSL 412

  Fly   238 ---------GEDTASPTKPSSKLPAGGNATSPSNTRILTGVGGSGTDDGTLLTTKSSPNRPPGTA 293
                     |.|..|.......||...::|:|....       :||...:|.||.::...||
Zfish   413 DFGNNDNRLGFDPPSSVLLPDPLPPVRSSTTPPRPY-------TGTLRPSLTTTTTTTMVPP--- 467

  Fly   294 ASGSVVPGNGSVVRTINNINLNAAGMSGGDDESKL---FCGPTHARNLYWNMTRVGDVNVQPCPG 355
                         |..||:...|...:....::.:   :|.|.....:.|..|..|.|..||||.
Zfish   468 -------------RRHNNVLPEALTRAPPSPQTPVTVDYCAPRLTAEISWPRTHQGQVAKQPCPP 519

  Fly   356 GAAGIAKWRCVLMKRIPDSGYDEYDDDISSTTPAPSGGDCLHNSSSCEPPVSMAHKVNQRLRNFE 420
            |..|:|.:.|:|       ||
Zfish   520 GTIGVATFNCLL-------GY-------------------------------------------- 533

  Fly   421 PTWHPATPDLTQCRSLWLNNLEMRVNQRDSSLISIANDMSEVTSSKTLYGGDMLVTTK----IIQ 481
              |.|..|||:.|.|.|.|::..|:...:::.| :|.:::|.|..: |..||:..|.|    :::
Zfish   534 --WDPKGPDLSNCTSPWTNHITQRMRSGETAAI-VARELAEQTKGE-LRPGDVPSTVKAMAQLVE 594

  Fly   482 TVSEKMMH----DKET----FPDQRQREAMIMELLHCVVKTGSNLLDESQLSSWLDLNPEDQMRV 538
            .:..::.:    .|:|    ....::||......:..:|:|.:|||.....::|.:|:..:|:|.
Zfish   595 LLDVQLRNLTPGGKDTAARSLNKLQKRERSCRFFIQAMVETVNNLLQVRSQAAWRELSVAEQLRC 659

  Fly   539 ATSLLTGLEYNAFLLADTIIRERSVVQKVKNILLSVRVLETKTIQSSVVFPDSDQWPLSSDRIEL 603
            ||.||..:|..||:|||.:::..::.:...||.|.|..|.|....:.:.||.|.   |:.:.|.|
Zfish   660 ATMLLDTVETGAFMLADNLLKTDTIQESTDNIQLEVARLSTDVNLADLSFPQSG---LTGNSIHL 721

  Fly   604 PRAALIDNSEGGLVRIVFAAFDRLESILKPSYDHFDLKSSRSYVRNTAILSNDSDVNAGEIQQRL 668
            ....|......|.:|:....:..|...|........|.|..:|...:.
Zfish   722 SANTLKQQGRNGEIRMALVLYKNLGQYLSTENASVRLGSEAAYPNYSL----------------- 769

  Fly   669 RILNSKVISASLGK-GRHIQLSQPITLTLKHL-KTENVTNPTCVFWNYIDHA----WSANGCSLE 727
             |:||.||:|::.| ...:.||:|:..|:||: ::|...||.|.||:|....    ||...|.|.
Zfish   770 -IVNSPVITAAINKDSNKVYLSEPVVFTVKHIQQSEENFNPNCSFWSYSKRTMTGFWSTQDCRLL 833

  Fly   728 STNRTHSVCSCNHLTNFAILMDVVD----EHQHSLFTMFDGNMRIFIYISIGICVVFIVIALLTL 788
            .|||||:.|||.||||||:||..|:    :..|.|.      :.:..::.|.:.:|.::|.:.|.
Zfish   834 GTNRTHTSCSCTHLTNFAVLMAHVEVKKADQVHELL------LDVITWVGILLSLVCLLICIFTF 892

  Fly   789 KLFNGVFVKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSGTAWFCYEA 853
            ..|.|  ::|.|.:|:.::.:.|...|.|||.||.:.:..|.|......||...|:...|...|.
Zfish   893 CFFRG--LQSDRNTIHKNLCISLFIAETLFLTGINRADQPIVCAVFAALLHFFFLAAFTWMFLEG 955

  Fly   854 FHSYSTLTSDELLLEV--DQTPKVNCYYLLSYGLSLSVVAISLVIDPSTYTQNDYCVLMEANALF 916
            ...|.      :|:||  .:..:...:||..||:...:||:|..:|..:|.....|.| ..:..|
Zfish   956 VQLYI------MLVEVFESEYSRTKYFYLTGYGVPAVIVAVSAAVDYRSYGTERVCWL-RLDTYF 1013

  Fly   917 YATFVIPVLVFFVAAIGYTFLSWIIMCRKSRTGLKTKEHTRLASVRFDIRCSFVFLLLLSAVWCS 981
            ..:|:.|..:  :..:...||...:......|.:...:...|.:::..:..:...|.||...|..
Zfish  1014 IWSFIGPATL--IIMLNVIFLGIALYKMFHHTAILKPDSGCLDNIKSWVIGAIALLCLLGLTWAF 1076

  Fly   982 AYFYLRGAKMDDDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYRKYVRQHAWLPKCLRCS 1046
            ...|:      :::..:..|.|..||:|.|::||:||||..:|:|:||.:.:|.|.       ||
Zfish  1077 GLMYI------NESTVIMAYLFTIFNSLQGMFIFIFHCILQKKVRKEYGRCLRTHC-------CS 1128

  Fly  1047 KTSISSGIVTG-NGPTAGTLCSVSTSKKPKLPLGVSEEAHDDPQQQQQTPVPITEDAIMGATSDC 1110
            ..|:.|.|.|. ...||.|....||:.:.::     ....:|..::|.....||.|....||
Zfish  1129 GKSVESTISTSTKTSTARTPGRYSTNSQSRI-----RRMWNDTVRKQSESSFITADMNSSAT--- 1185

  Fly  1111 ELNEAQQRRTLKSGLMTGTLQAPPQT------LGGHVVLERGSTLRSTGHASPTSSAGSTHLIFA 1169
             ||    |.|:.:.|::..|..|..|      ||...|....:.......||...|.|    |..
Zfish  1186 -LN----RGTMANHLISNALLRPHGTNPYNTLLGESAVYNNPTANMFNTQASYRDSKG----ILN 1241

  Fly  1170 HKQQQQQQQQGPL----GESY-YHQPDYYSW----KQPSTGTGGLKTPRE--------YYN---- 1213
            :.:........||    |.|| ....||.::    .:|.| |...|..:|        |.|
Zfish  1242 NARDSSVMDTLPLNGNHGNSYGVAAGDYLTYSSRGSEPPT-TLEKKILKELTANYAPSYLNTQER 1305

  Fly  1214 ------------------NAGAAASSPQQAHEVFYWTQKPNSGHNGKKKRGAGGV---------- 1250
                              |.|.|.||.....:|.. ...|.:.|   :....||:
Zfish  1306 QGKAHQGTLTNKLNNHLANGGVAGSSSIPKDDVMV-LDNPGAFH---RHDDGGGLSLELIREESQ 1366

  Fly  1251 -------PASPSG-------SLHSRTAAASQVLFYP--------SYKKT------KPGQPTGYPQ 1287
                   |..|..       :.|.|....:...|:|        |:..|      .|.:.:.|..
Zfish  1367 APLLPPRPPPPENHAPLHTFTAHRRLPQENSESFFPLLPNDTHSSHTHTPRAHTHSPLRDSLYTS 1431

  Fly  1288 YAEALDPPLATGNAAAYYQQQQQLRRQQLHQQQQQQQQQQLSSDEEQAEQHAHLLHLQRRAGSQQ 1352
            .....|.|..|.:..           ..||..:.:::::  ..:||:..:    |||....|
Zfish  1432 MPTLTDLPHGTDDLI-----------NGLHDDEDEEEEE--DGEEEEGSE----LHLANGKG--- 1476

  Fly  1353 QLPAPPPHMAQYQQEFMQRQYRNKHSNCDLGMGDAYYNQGSVGGADG 1399
                    :.....:...:...|..|...:...::||..|. ||:||
Zfish  1477 --------VIMESDDVYYKSMPNLGSRNHIQELESYYQMGR-GGSDG 1514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Rha_Lectin_dCirl	22..113	CDD:438687	35/91 (38%)
		GAIN	451..682	CDD:465137	58/242 (24%)
		GPS	705..752	CDD:197639	26/50 (52%)
		7tmB2_CELSR_Adhesion_IV	763..1035	CDD:320557	66/273 (24%)
		TM helix 1	765..790	CDD:320557	4/24 (17%)
		TM helix 2	801..823	CDD:320557	7/21 (33%)
		TM helix 3	832..859	CDD:320557	6/26 (23%)
		TM helix 4	875..895	CDD:320557	7/19 (37%)
		TM helix 5	913..942	CDD:320557	5/28 (18%)
		TM helix 6	960..987	CDD:320557	5/26 (19%)
		TM helix 7	997..1022	CDD:320557	12/24 (50%)
		Herpes_TAF50	<1219..1365	CDD:308764	28/183 (15%)
adgrl3.1	XP_005170997.2	None