DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cirl and Adgrg3

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	NP_766624.3	Gene:	Adgrg3 / 54672	MGIID:	1859670	Length:	542	Species:	Mus musculus

Alignment Length:	545	Identity:	122/545 - (22%)
Similarity:	204/545 - (37%)	Gaps:	109/545 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   533 EDQMRVATSLLTGLEYNAFLLADTI-------IRERSVVQKVKNILLSVRVLETKTIQSSVVFPD 590
            |:...|...|..|.||:.|.|.||.       ..|.|... |.|:.......|:..:::|:
Mouse    23 EEPRNVCRRLQEGHEYDTFDLNDTAQCFTKCGQSEHSPCD-VGNLQRYWLNYESYLLENSM---- 82

  Fly   591 SDQWPLSSDRIELPRA-ALIDN-----SEGGLVRIVFAAFDR---------LESILKPSYDHFDL 640
                    :.:::|.. |||.|     ||..|..::.:...|         .:.:..|......|
Mouse    83 --------ETVDMPFVKALIQNISTDVSEDLLYSLMLSQIPRQVMQGEDEPADGVRLPKSLFGAL 139

  Fly   641 KSSRSYVRNTAILSNDSDVNAGEI--------QQRLRILNSKVISASLGKGRHIQLSQPITLTLK 697
            ..:||.||   :.....|:.||.:        .:...:||::::..|:|:.....||:|:.:|..
Mouse   140 PGNRSAVR---LAITVLDIGAGNVFKGPKLLEDKGSSVLNNRMVGLSVGQMHATGLSEPVEITFS 201

  Fly   698 HLKTENVTNPTCVFWNYIDHAWSANGCS-LESTNRTHSVCSCNHLTNFAILM-DVVDEHQHSLFT 760
            |.:.......|||||:.....|.::||| :....||  ||.|:|||.||:|: .::|.......|
Mouse   202 HERQPPNVILTCVFWDMAKGDWDSHGCSTVPGDGRT--VCRCDHLTFFALLLRPILDLATAQTLT 264

  Fly   761 MFD--GNMRIFIYISIGICVVFIVIALLTLKLFNGVFVKSARTSIYTSIYLCLLAIELLFLLGIE 823
            ...  |:....|:::      |.::..:..:.....|.......|:.::.:.|..:.|.||:.:.
Mouse   265 RISQAGSAVSMIFLA------FTMVLYVAFRFSLQRFKSEDAPKIHMALSISLFLLNLTFLINVG 323

  Fly   824 QTETS--IFCGFITIFLHCAILSGTAWFCYEAFHSYSTLTSDELLLEVDQTPKVNCYY------- 879
            .:...  ..|.......|..:|....|...||||.|.      |.:.|     .|.|:
Mouse   324 SSSQGPPASCWVRAAIFHYFLLCVFTWMGLEAFHLYL------LAIRV-----FNTYFGHYFLKL 377

  Fly   880 -LLSYGLSLSVV---------AISLVIDPSTYTQNDYCVLMEANALFYATFVIPVLVFFVAAIGY 934
             ||::||.:.||         .:..:.|....|..:.|...:..||:.......::.|...|:..
Mouse   378 SLLAWGLPVLVVIGAGSSNSYGVYTIRDQENRTSLELCWFQKEPALYATVHGYFLVTFLFGAVVL 442

  Fly   935 TFLSWIIMCRKSRTGLKTKEHTRLASVRFDIRCSFVFLLLLSAV----WCSAYFYLRGAKMDDDT 995
            ..::|.|....|.|..|.:..|..         |.:.:|.||::    |..|.....|....
Mouse   443 ALVAWKIFTLPSVTAGKGQGPTWK---------SVLTVLGLSSLVGMTWGLAVLTPLGLSTI--- 495

  Fly   996 ADVYGYCFICFNTLLGLYIFVFHCI 1020
                 |.|...|:|.||:||.:..|
Mouse   496 -----YVFTLLNSLQGLFIFCWFII 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328
		GAIN	453..680	CDD:293098	36/176 (20%)
		GPS	705..752	CDD:197639	20/48 (42%)
		7tm_4	763..1014	CDD:304433	54/275 (20%)
Adgrg3	NP_766624.3	GPS	211..250	CDD:280071	19/40 (48%)
Adgrg3	NP_766624.3	7tm_4	262..509	CDD:304433	55/280 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900