DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cirl and Adgre4

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	NP_631877.2	Gene:	Adgre4 / 52614	MGIID:	1196464	Length:	689	Species:	Mus musculus

Alignment Length:	744	Identity:	166/744 - (22%)
Similarity:	302/744 - (40%)	Gaps:	140/744 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   382 DISSTTPAPSGGDCLHNSSSCEPPVSMAHKV--------NQRLRNFEPTWHPATPDLTQCRSLWL 438
            :||::.|     .|..| :||   .:..|.|        ::..|..||  |....|:.:|   .|
Mouse    33 NISASCP-----QCNEN-ASC---FNSTHCVCKEGFWTGSENRRIIEP--HEKCQDINEC---LL 83

  Fly   439 NNLEMRVNQRDSSLISIANDMSEVTSSKTLYGGDMLVTTKIIQTVSEKMMHDKETFPDQRQREAM 503
            ..|             :..|:|...:....|....:|...:...|                  |.
Mouse    84 KEL-------------VCKDVSYCRNKIGTYICSCVVKYPLFNWV------------------AG 117

  Fly   504 IMELLH--CVV----KTGSNLLDESQLSSWLDLNPEDQMRVATSLLTGLEYNAFLLADTIIRERS 562
            |:.:.|  |.|    .|||.......||.:  .:.|:..:.||.||..:|::       |:.|.|
Mouse   118 IINIDHPDCYVNKSKNTGSKTHTLGVLSEF--KSKEEVAKGATKLLRKVEHH-------ILNENS 173

  Fly   563 -VVQKVKNILLSVRVLETKTIQSSVVFPDSDQWPLSSDRIELPRAALIDNSEGGLVRIVFAAFDR 626
             :.:|.:|.||.: |.|||..::..:....:    ::.:::. .:...:::.||...:.|.|:..
Mouse   174 DIPKKDENPLLDI-VYETKRCKTMTLLEAGN----NTMKVDC-TSGFKEHNSGGETAVAFIAYKS 232

  Fly   627 LESILKPSYDHFDLKSSRSYVRNTAILSNDSDVNAGEIQQRLRILNSKVISASLGKGRHIQLSQP 691
            |.::|                 |.:..||:....  |:     .|||.::|.::.......||:|
Mouse   233 LGNLL-----------------NGSFFSNEEGFQ--EV-----TLNSHIVSGAIRSEVKPVLSEP 273

  Fly   692 ITLTLKHLK-TENVTNPTCVFWNYIDH--AWSANGCSLESTNRTHSVCSCNHLTNFAILMDVVDE 753
            :.|||:::: .::.....||.|...:.  :||..|||...||.::::|.|.||::||:||.:..|
Mouse   274 VLLTLQNIQPIDSRAEHLCVHWEGSEEGGSWSTKGCSHVYTNNSYTICKCFHLSSFAVLMALPHE 338

  Fly   754 HQHSLFTMFDGNMRIFIYISIGICVVFIVIALLTLKLFNGVFVKSARTSIYTSIYLCLLAIELLF 818
            ....|     ..:.:..|:.:.:.::.:.:|.:|..|...  :::..|:::..:.:||...:|||
Mouse   339 EDGVL-----SALSVITYVGLSLSLLCLFLAAITFLLCRP--IQNTSTTLHLQLSICLFLADLLF 396

  Fly   819 LLGIEQTETSIFCGFITIFLHCAILSGTAWFCYEAFHSYSTLTSDELLLEVDQTP-----KVNCY 878
            |.||.:|:..:.|..|...||...|:...|...|..|.:.|:::    |:|....     |....
Mouse   397 LTGINRTKPKVLCSIIAGMLHYLYLASFMWMFLEGLHLFLTVSN----LKVANYSNSGRFKKRFM 457

  Fly   879 YLLSYGLSLSVVAISLVIDPSTYTQNDYCVLMEANALFYATFVIPVLVFFVAAIGYTFLSWIIMC 943
            |.:.|||...:||:|.:.....|..:::|.|.......::.......:..:..:.|..:.||:
Mouse   458 YPVGYGLPAFIVAVSAIAGHKNYGTHNHCWLSLHRGFIWSFLGPAAAIILINLVFYFLIIWIL-- 520

  Fly   944 RKSRTGLKTKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLRGAKMDDDTADVYGYCFICFNT 1008
             :|:.....||.:.|...:.....:.|.|.:|...|....|..  .::......:..|.|...|.
Mouse   521 -RSKLSSLNKEVSTLQDTKVMTFKAIVQLFVLGCSWGIGLFIF--IEVGKTVRLIVAYLFTIINV 582

  Fly  1009 LLGLYIFVFHCIQNEKIRREYRKYVRQHAWLPKCLRCSKTSISSGIVTGNGPTAGTLCSVSTSKK 1073
            |.|:.||:.||:.|.::|.||:|:..:   |.|.:....|.:|..       |..|...:|.:.:
Mouse   583 LQGVLIFMVHCLLNRQVRMEYKKWFHR---LRKEVESESTEVSHS-------TTHTKMGLSLNLE 637

  Fly  1074 PKLPLGVSEEAHDDPQQQQQTPVPITEDA 1102
            ...|.|   ..||    ...:.:|.||.|
Mouse   638 NFCPTG---NLHD----PSDSILPSTEVA 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328
		GAIN	453..680	CDD:293098	46/233 (20%)
		GPS	705..752	CDD:197639	18/48 (38%)
		7tm_4	763..1014	CDD:304433	53/255 (21%)
Adgre4	NP_631877.2	EGF_CA	77..>105	CDD:214542	7/43 (16%)
		GAIN	<214..262	CDD:293098	14/71 (20%)
		GPS	290..332	CDD:280071	16/41 (39%)
		7tm_4	343..588	CDD:304433	54/260 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12011
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.000