DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cirl and CG11318

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	NP_651842.3	Gene:	CG11318 / 43678	FlyBaseID:	FBgn0039818	Length:	802	Species:	Drosophila melanogaster

Alignment Length:	855	Identity:	175/855 - (20%)
Similarity:	284/855 - (33%)	Gaps:	302/855 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   326 SKLFCGPTHARNLY-------------WNMTRVGDVNVQPCPGGAAGIAKWRCVLMKRIPDSGYD 377
            :.:||.|...::.|             |...|:|:                |..|
  Fly    59 TSMFCEPEEFQHDYITRNHDQTPHQNKWKRARIGE----------------RATL---------- 97

  Fly   378 EYDDDISSTTPAPSGGDCLHNSSSCEPPVSMAHKVNQRLRNFEPT--W-----------HPATPD 429
               .|:           ||..:..   ||:...:|.....|:|.|  |           |..:.|
  Fly    98 ---HDV-----------CLLRNGM---PVTRECRVKDNRANWESTEHWDPVVCLRRFREHTISGD 145

  Fly   430 LTQCRSLWLNNLEMRVNQRDS----SLISIANDM----------SEVTSSKTLYGG------DML 474
            |   .||..:.||.|....|:    .:..|..:|          ::|..:..::|.      |..
  Fly   146 L---NSLHDDVLEGRRRTNDTQGRREMTGIMRNMFRQRGGNLLPADVHMTGQMFGALMQQDKDAT 207

  Fly   475 VTTKIIQTVSEKMMHDKETFPDQRQREAMIMELLHCVVKTGSNLLDESQLSSWLDLNPE------ 533
            |:..::....|.|..|.:......|..|           |.|.|   ||..|::|..||
  Fly   208 VSVDLVSVCKEIMSCDSKVLRLSAQLNA-----------TNSLL---SQFESYMDALPEQLVPKD 258

  Fly   534 -----------DQMRVATSLLTGLE-YNAFLLADTIIRERSVVQKVKNILLSVRVLETKTIQSSV 586
                       |:...||   ||:| ||   .:|                :.|:.|.|..|  ||
  Fly   259 RCGKVVAKPTSDEAETAT---TGVETYN---FSD----------------IGVQALITGNI--SV 299

  Fly   587 VFPDSDQWPLSSDRIELPRAALIDNSEGGLVRIVFAA---------------FDRLESILKPSYD 636
            .|.:.:     .|||.            ||.  :|:|               |.|....|....:
  Fly   300 FFANPE-----CDRIT------------GLA--IFSAPGDQRKTSASGFWYRFIRFSEDLAKVKE 345

  Fly   637 HFDLKSSRSYVRNT--------------AILSNDSDVNAGEIQQRLRILNSKVISASLGKGRHIQ 687
            ..:|:::.....|.              .:.::|: :......||.|...|||||.|:...|...
  Fly   346 ESNLETAAFLPENLWRQVKSRGATYLIFKVYAHDA-LFVETSLQRTRKPRSKVISISIPGLRSNY 409

  Fly   688 LSQPITLTLKHLKTENVTNPT---------CVFWNYIDHAWSANGCSLESTNRTHS----VCSCN 739
            ||.|:...|::   ||:.||.         |.:|||  ..||..|.|.||::....    .|..|
  Fly   410 LSLPLPFLLRN---ENLRNPDSKAFSIGSGCGYWNY--ETWSTEGVSTESSSDLLKDAIIECHTN 469

  Fly   740 HLTNFAILMD----VVDEHQHSLFTMFDGNMRIFIYISI--------GICVVFIVIALLTLKLFN 792
            |||.||.|:.    ..|..:..|.|..  |.::...|||        ||..:|:..||.
  Fly   470 HLTQFAFLVGGSYRANDLGEEILITPI--NEKVLDIISIVGCSLSLLGILGIFLTAALF------ 526

  Fly   793 GVFVKSARTSIYTSI--YLCL-LAIELLFLLGIEQTETS---------IFCGFITIFLHCAILSG 845
                ||.|:...|.:  :||| :.::::..:.:...:.|         :.|..:...:..:||..
  Fly   527 ----KSWRSQASTKVLLHLCLAMCLQMMLFVFLNTDDVSEALVVNGNTVRCVALGAAMQYSILVL 587

  Fly   846 TAWFCYEAFHSYSTLTSDELLLEVDQTPKVNCYYLL-----SYGLSLSVVAISLVIDPSTY---- 901
            .:|....||..:....:   ::.:::.|:    |:|     ::.|.|....:..:|||.:|
  Fly   588 FSWMLIIAFLQFQRYVT---VIGIERPPR----YILKAAIVAWLLPLVPTLLVALIDPDSYVPSA 645

  Fly   902 ----TQNDYC----------VLMEANALFYATFVIPVLVFFVAAIGYTFLSWIIMCRKSRTGLKT 952
                |....|          |::....:.....||.|.||:  :|.::....|   .|:...:..
  Fly   646 AQLSTDTGICYPSGYGLIFGVVLPVTLITVCNLVIFVYVFY--SISHSLSQSI---HKNEKKMVV 705

  Fly   953 KEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLRGAKMDDDTADVYGYCFICFNTLLGLYIFVF 1017
            |:          ||.|.:...||...|....|....|.:      .:.|.|....|:.|..:|::
  Fly   706 KQ----------IRLSIMLFFLLGLTWIFGIFAFMQAGV------AFSYLFCITATMQGFVMFIY 754

  Fly  1018 HCIQNEKIRR 1027
            ..:.:...||
  Fly   755 FVLLDSTNRR 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328
		GAIN	453..680	CDD:293098	57/289 (20%)
		GPS	705..752	CDD:197639	20/63 (32%)
		7tm_4	763..1014	CDD:304433	56/293 (19%)
CG11318	NP_651842.3	GPS	437..475	CDD:280071	15/39 (38%)
CG11318	NP_651842.3	7tm_4	500..750	CDD:304433	55/287 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462144
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840