DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cirl and Adgrf2

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	XP_017173054.1	Gene:	Adgrf2 / 435529	MGIID:	2182728	Length:	673	Species:	Mus musculus

Alignment Length:	749	Identity:	155/749 - (20%)
Similarity:	267/749 - (35%)	Gaps:	165/749 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 AKWRCVLMKRIP-------DSGYDEYDDDISSTTPAPSGGDCLHNSSSCE---PPVSMAHKVNQR 415
            |.|...||..:|       .....:..:.::|.......|.|.:|.:.|.   ||.|   :.|.:
Mouse     4 AHWLYCLMLLLPIESCRILCQASSKSKEKVTSRPHDVCDGVCNNNGTPCFQSCPPDS---EGNMK 65

  Fly   416 LRNFEPTWHPATPDLTQCRSLWLNNLEMRVNQRDSSLISIANDMSEVTSSKTLYGGDMLVTTKII 480
            .......||..|   ..|.:|..::    :.:.|..|.|:.:  |:.|....::..::   ..|:
Mouse    66 FACKAKKWHKVT---ETCHTLNTHS----IFEEDKELYSVQS--SDSTIRTHMFHREL---KTIM 118

  Fly   481 QTVSEKMMHDK-------ETFPDQRQREAMIMELLHCVVKT----------------GSNLLDES 522
            .|:.||...|.       |..|......|::::|||.:..|                .:::|:..
Mouse   119 DTLMEKCPKDLSCVIKGIERSPRMPGNIAVVVQLLHNISTTLTKDVNEEKMQSYSAMANHILNSK 183

  Fly   523 QLSSWLDLNPEDQMRVATSLLTGLEYNAFL-------------LADTIIRERSVVQKVKNILLSV 574
            .:|:|..:...:...|....:.......|:             ...|::...|:   .||...|:
Mouse   184 SISNWTFIQDRNSSCVLLQSIHSFASKLFMKEHLINISHVFIHTLGTVVSRGSL---GKNFTFSM 245

  Fly   575 RVLET--KTIQSSVVFPDSDQWPLSSDRIELPRAALIDNSEGGLVRIVFAAFDRLESILKPSYDH 637
            |:.||  |.....::.|:..|        ::|.|          .:::..||..|.:||:.|
Mouse   246 RINETSDKVTGRLLLSPEELQ--------KVPSA----------FQVISIAFPTLGAILEAS--- 289

  Fly   638 FDLKSSRSYVRNTAILSNDSDVNAGEIQQRLRILNSKVISASLGKGRHIQLSQPITLTLKHLKTE 702
                          :|.|.:             :|..|:|..|.:    :|.. |:|..:.::..
Mouse   290 --------------LLENVT-------------VNGLVLSVILPE----ELKN-ISLIFEKIRKS 322

  Fly   703 NVTNPTCVFWNYIDHAWSANGCSLESTNRTHSVCSC--NHL-TNFAILMDVVDEHQHSLFTMFDG 764
            ......||.|:.::..|....|.....|...:||.|  |.| |:|:|||        |..|:...
Mouse   323 GERKSQCVGWHSLESRWDWRACKTIQENSRQAVCRCRPNKLYTSFSILM--------SPNTLESP 379

  Fly   765 NMRIFIYISIGICVVFIVIALLTLKLFNGVFVKSARTSIYTSIYLCLLAIELLFLLGIEQTETSI 829
            .:....||.:||.:..::|.|....|   |:.:..:|.|....:||:..|....|:.......:.
Mouse   380 VLTYITYIGLGISICSLIICLAIEVL---VWSQVTKTEISYLRHLCIANIAATLLMADAWFIVAS 441

  Fly   830 F----------CGFITIFLHCAILSGTAWFCYEAFHSYSTLTSDELLLEVDQTPK---VNCYYLL 881
            |          |...|.|:|...||...|...:|.     |....:|:.....||   |...:.:
Mouse   442 FLSGPVLHHNGCVAATFFVHFFYLSVFFWMLAKAL-----LILYGILIVFHTLPKSCLVASLFSV 501

  Fly   882 SYGLSLSVVAISL-VIDPST-YTQNDYCVLMEANALFYATFVIPVLVFFVAAIGYTFLSWIIMCR 944
            .||..|.:..|:| |.:|.. |.:.:.|.|..........||:|.|...|..: .|....||..:
Mouse   502 GYGCPLVIAIITLAVTEPGKGYLRPEACWLNWDMTKALLAFVVPALAIVVVNL-ITVTMVIIKTQ 565

  Fly   945 KSRTGLKTKEHTRLASVRFDIRCSFVFLL--LLSAVWCSAYFYLRGAKMDDDTADVYGYCFICFN 1007
            ::..|....:..| |.||.   |..:.:|  ||...|....     |.:.:..:..:...|...|
Mouse   566 RAAIGSSMFQEVR-AIVRI---CKNIAILTPLLGLTWGFGI-----ATVINGHSLAFHIIFSLLN 621

  Fly  1008 TLLGLYIFVFHCIQNEKIRREYRKYVRQHAWLPK 1041
            .|.|.:|.:|..|.:.|||...:..:....|:.:
Mouse   622 ALQGFFILLFGTILDPKIREALKSRITSAKWISR 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328
		GAIN	453..680	CDD:293098	44/264 (17%)
		GPS	705..752	CDD:197639	16/49 (33%)
		7tm_4	763..1014	CDD:304433	61/267 (23%)
Adgrf2	XP_017173054.1	GPS	326..373	CDD:383024	16/54 (30%)
		7tmB2_GPR111_115	378..644	CDD:320660	67/283 (24%)
		TM helix 1	381..405	CDD:320660	6/23 (26%)
		TM helix 2	420..441	CDD:320660	4/20 (20%)
		TM helix 3	454..476	CDD:320660	6/21 (29%)
		TM helix 4	497..513	CDD:320660	3/15 (20%)
		TM helix 5	535..558	CDD:320660	6/23 (26%)
		TM helix 6	581..606	CDD:320660	8/32 (25%)
		TM helix 7	611..636	CDD:320660	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810