DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cirl and adgrv1

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	XP_009300028.1	Gene:	adgrv1 / 415105	ZFINID:	ZDB-GENE-040624-6	Length:	6208	Species:	Danio rerio

Alignment Length:	776	Identity:	158/776 - (20%)
Similarity:	283/776 - (36%)	Gaps:	205/776 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   431 TQCRSLW--LNNLEMRVNQR--DSSLISIANDMS-EVTSSKTLYGGDMLVTTKIIQTVSEKMMHD 490
            |:.:::|  |:.|...:.:.  :..|.::.|.:| ::|..:.:          .:...|.|::.:
Zfish  5524 TETQAVWALLDQLHQPLEETIINRVLHALINKVSRDITPEQLM----------AVLDASSKILSN 5578

  Fly   491 KETFPDQRQREAMIMELLHCVVKTGSNLLDE---SQLSSWLDLNPEDQMRVATSLLTGLEYNAFL 552
            .|..|.:.....:..||| |.: ...|..|.   ||||       |...|.|.||||.::..|
Zfish  5579 AEQTPLKDSSRGLTYELL-CAM-ANPNRTDTQGVSQLS-------EVAERFAYSLLTDIKCGA-- 5632

  Fly   553 LADTIIRERSVVQKVKNILLSVRVLET---KTIQSSVVFP-----------DSDQWPLSSDRIEL 603
                         :.|.   .:.:|:.   .||.:...:|           ::|.:.|....:|:
Zfish  5633 -------------EGKR---GITILDNCPYFTIAAHHWYPMQINGHTFIGKNTDTFTLPETLLEV 5681

  Fly   604 PRAALIDNSEGGLVRIVFAAFDRLESILKPSYDHFDLKSSRSYVRNTAILSNDSDVNAGEIQQRL 668
            ........:.....::.|..:         |.:|:.|.:.:.
Zfish  5682 LALPADSTAPSACYKVHFTEY---------STEHWFLTNKKP----------------------- 5714

  Fly   669 RILNSKVISASL-GKG-RHIQLSQPITLTLKHLKTENVTNPT---CVFWNYIDHAWSANG--CSL 726
            ..||.||.|.|| |:| :.:...|.:...:..........|:   |:.||....:|.::|  |.|
Zfish  5715 SALNGKVFSVSLYGRGSKPLSEGQEVVYRIHTPDRRGKPKPSQSLCLLWNQAAESWLSDGQFCRL 5779

  Fly   727 ESTNRTHSVCSCNHLTNFAILMDVVDEHQHSLFTMFDGNMRIFIYISIGICVVFIVIALLTLKLF 791
            ....:.:..|:|:||:.:....::     .||.:..:.     .|.:..||:....:|::: .|.
Zfish  5780 VDDTQNYVECACSHLSIYTAYAEI-----ESLASFNEA-----FYAAGFICISGFALAMVS-HLM 5833

  Fly   792 NGVFVKSARTSIYTSIYLCLLAIELLFLL----GIEQTETSIFCGFITIFLHCAILSGTAWFCYE 852
            ...|:..| ..:.|.:.:..|..::.||:    |...:|.|  |..:.:|.|...||..:|...:
Zfish  5834 CARFLMFA-AKLLTHMMVACLGTQICFLVSAFRGRMFSEDS--CAALGLFFHYFHLSQFSWMLVQ 5895

  Fly   853 AFHSYSTLTSDELLLEVDQTPKVNCYYLLSYGLSLSVVAISLVI--------DPSTY--TQNDYC 907
            |.:.:..|..::...|    .:...|:|||:||...|:.:.:|:        ..|.|  .|.|.|
Zfish  5896 AINFWQILVMNDEHTE----RRYLLYFLLSWGLPALVIIVLVVVLLGGFGWSIHSVYGLVQGDLC 5956

  Fly   908 VLMEANALFYATFVIP------VLVFFVAAIGYTFLSWIIMCRKSRTGLKTKEHTRLASVRFDIR 966
            .:....|......::|      |||.|:.|...| ..|     |:...: .:..|..:.|...:
Zfish  5957 FIPNVYAALCTAALVPLICLVGVLVIFIHAYQVT-QQW-----KAYDDI-YRGRTNSSEVPMML- 6013

  Fly   967 CSFVF-LLLLSAVWCSAYFYLRGAKMDDDTADVYGYCF-----ICFNTLLGLYIFVFHCIQNEKI 1025
              ::| |:.|..||...:.             .|.|.:     :.||..||||:|..:.:.:.::
Zfish  6014 --YLFALVTLVCVWAGLHM-------------AYRYIWMLILLVIFNIFLGLYVFSVYFVMHNQL 6063

  Fly  1026 ----RREYRKYVRQHAWLPKCLRCSKTSI--SSGIVT-GNGPTAGTLCSVSTSKKPKLPLGVSEE 1083
                :..|...:..|:        |..||  |:|..| |.|         ..||..:..:...||
Zfish  6064 FWPGKATYTVEMNGHS--------SPDSIYQSTGAATVGGG---------EISKSTQNLISAMEE 6111

  Fly  1084 AHDD-------PQQQQQT---PVP-----ITEDAIMGATSDCELNEAQQRRTLKSGLMTGT 1129
            ...|       |..|..:   |.|     |||...:. ||..:..|:|:...|...|.||:
Zfish  6112 ISADWERASLRPSSQPSSIFKPSPQDEAYITEGGFIN-TSLVQDEESQEFDDLIFALKTGS 6171

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328
		GAIN	453..680	CDD:293098	42/244 (17%)
		GPS	705..752	CDD:197639	12/51 (24%)
		7tm_4	763..1014	CDD:304433	60/276 (22%)
adgrv1	XP_009300028.1	Calx-beta	138..230	CDD:295344
		Calx-beta	256..355	CDD:295344
		Calx-beta	766..853	CDD:295344
		Calx-beta	880..971	CDD:295344
		Calx-beta	996..1082	CDD:295344
		Laminin_G_3	1343..1484	CDD:290121
		Calx-beta	1576..1654	CDD:295344
		Calx-beta	1712..1794	CDD:295344
		Calx-beta	1849..1939	CDD:295344
		Calx-beta	1975..2065	CDD:295344
		Calx-beta	2105..2193	CDD:295344
		Calx-beta	2220..2310	CDD:295344
		Calx-beta	2590..2656	CDD:295344
		Calx-beta	2951..3039	CDD:295344
		Calx-beta	<3574..3614	CDD:295344
		Calx-beta	3641..3729	CDD:295344
		Calx-beta	<3788..3864	CDD:295344
		Calx-beta	4021..4112	CDD:295344
		Calx-beta	4257..4345	CDD:295344
		Calx-beta	4390..4480	CDD:295344
		Calx-beta	5003..5085	CDD:295344
		7tm_4	<5871..>5926	CDD:304433	17/60 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900