DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cirl and Adgrg5

DIOPT Version :9

Sequence 1:NP_001260807.1 Gene:Cirl / 35846 FlyBaseID:FBgn0033313 Length:1711 Species:Drosophila melanogaster
Sequence 2:NP_001139444.1 Gene:Adgrg5 / 382045 MGIID:2685955 Length:524 Species:Mus musculus


Alignment Length:525 Identity:128/525 - (24%)
Similarity:195/525 - (37%) Gaps:138/525 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   562 SVVQKVKNILLSVR--VLETKTIQSSVVFPDSDQWP---LSSDRI----------------ELPR 605
            |:.||:.|......  .|:|.:|| |:||..|..:|   |||..:                ||.:
Mouse    51 SLEQKLLNASFGGHNLTLQTNSIQ-SLVFKLSCDFPGLSLSSTTLTNVSQVRAPHAMQFPAELTK 114

  Fly   606 AALIDNSEGGLVRIVFAAFDRLESILKPSYDHFDLKSSRSYVRNTAILSNDSDVNAGEIQQRLRI 670
            .|.:.:....|..|....|                         ||.|..| |.|:.       :
Mouse   115 GACVTSRPAELRLICIYFF-------------------------TAHLFQD-DRNSS-------L 146

  Fly   671 LNSKVISASLGKGRHIQLSQPITLTLKHLKTENVTNPTCVFWNYIDH-----AWSANGCSLESTN 730
            ||:.|:.|.|.......|.:|:.::..|.::......:||||.....     |||..||..|..:
Mouse   147 LNNYVLGAQLDHRPVNNLQKPVNISFWHNRSLEGYTVSCVFWKEGASKSSWGAWSPEGCYTEQPS 211

  Fly   731 RTHSVCSCNHLTNFAILMD-----VVDEHQHSLFTMFDGNMRIFIYISIGICVVFIVIALLTLKL 790
            .|..:|.|||||.||:||.     |..|.|..|           .|||...|.:.||.:|||:.|
Mouse   212 ATQVLCHCNHLTYFAVLMQLSGDPVPAELQVPL-----------EYISFVGCSISIVASLLTILL 265

  Fly   791 FNGVFVKS-ARTSIYTSIYLCLLAIELLFLLGIEQTETSI---FCGFITIFLHCAILSGTAWFCY 851
            :.....:| :.|.|:.::...:|.:.:.|||..:.|..::   .|..:...||.|:||...|...
Mouse   266 YAQSRKQSDSTTRIHMNLNGSVLLLNVTFLLSSQMTLPTMPRPVCKVLAAVLHYALLSSLTWMAI 330

  Fly   852 EAFHSYSTLTSDELLLEVDQTPKVNCYYL----LSYGLSLSVVAISLVIDPSTYTQNDYCVLMEA 912
            |.|:.|       |.|.......:..|.|    |.:|....:|.:.|:|..|.|..   ||...:
Mouse   331 EGFNLY-------LFLGRVYNAYIRRYLLKLCMLGWGFPALLVLLLLMIKSSVYGP---CVTSLS 385

  Fly   913 NALFYAT--------FVIPVLVFFVAAIGY---------TFLSWI--IMCRKSRTGLKTKEHTRL 958
            .:....|        ::...:|..:..:||         ..|:|.  |:||     |:.:|....
Mouse   386 KSQENGTGFQNVSMCWIRSPMVHSILVMGYGGFTSLFNLVVLAWALWILCR-----LRAREKALS 445

  Fly   959 ASVRFDIRCSFVFLLLLSAVWCSAYFYLRGAKMDDDTADVYG-------YCFICFNTLLGLYIFV 1016
            .....|........:||...|..|:|             .:|       :.|..||:|.|.::|:
Mouse   446 PWAYRDTAMVLGLTVLLGTTWTLAFF-------------SFGVFLLPQLFLFTIFNSLYGFFLFL 497

  Fly  1017 FHCIQ 1021
            :.|.|
Mouse   498 WFCSQ 502

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CirlNP_001260807.1 Gal_Lectin 33..113 CDD:280328
GAIN 453..680 CDD:293098 32/138 (23%)
GPS 705..752 CDD:197639 22/56 (39%)
7tm_4 763..1014 CDD:304433 64/284 (23%)
Adgrg5NP_001139444.1 GPS 184..228 CDD:366827 19/43 (44%)
7tm_GPCRs 242..514 CDD:391938 68/300 (23%)
TM helix 1 244..268 CDD:341315 11/34 (32%)
TM helix 2 277..298 CDD:341315 6/20 (30%)
TM helix 3 311..333 CDD:341315 7/21 (33%)
TM helix 4 353..369 CDD:341315 3/15 (20%)
TM helix 5 405..428 CDD:341315 3/22 (14%)
TM helix 6 449..474 CDD:341315 6/37 (16%)
TM helix 7 478..503 CDD:341315 8/25 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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