DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cirl and mthl9

DIOPT Version :10

Sequence 1:NP_001260807.1 Gene:Cirl / 35846 FlyBaseID:FBgn0033313 Length:1711 Species:Drosophila melanogaster
Sequence 2:NP_612029.1 Gene:mthl9 / 38056 FlyBaseID:FBgn0035131 Length:513 Species:Drosophila melanogaster


Alignment Length:435 Identity:90/435 - (20%)
Similarity:159/435 - (36%) Gaps:118/435 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   661 AGEIQQRLRILNSKVISASLG-KGRHIQLSQPITLTLKHLKTENVTNPTCVFWNYIDHAWS--AN 722
            |.....::||.:..|:...|| :.:.:.        .||   :|       ||.     |.  .|
  Fly   124 ANRTVDQVRIRDRFVVRTELGCRNKFVD--------KKH---DN-------FWQ-----WDLFEN 165

  Fly   723 GCSLESTNR---THSVCSCNHLTNFAILMDVVDEHQHSLFTM-------FDGNMRIFIYISIGIC 777
            | :|...||   |...|       |:.|     ||....:.:       |....|::||   .||
  Fly   166 G-TLRRDNRLWSTDEYC-------FSPL-----EHNPEQWELTPLNCERFQTGYRVWIY---AIC 214

  Fly   778 -VVFIVIALLTLKLFNGVFVKSARTSIYTSI---YL--CLLAIELLFLLGIEQTE--TSIFC--- 831
             ::.|:|.:..|.|...  |:.||.|.|..:   ||  .::...||..|.::...  :.:.|   
  Fly   215 SIIAIIINIFILSLLGS--VRDARKSHYGQLIIYYLLSMIVGYSLLVYLALKNPMKLSHVACRNI 277

  Fly   832 GFITIFLHCAILSGTAWFCYEAFHSYSTLTSDELLLEVDQTPKVNCYYLLSYGLSLSVVA----- 891
            ||:            |:||......:..:.|.:.||:..|....:....||  |:|:|:|     
  Fly   278 GFL------------AYFCIMLSFVFLAICSLDFLLKFKQKAVRSSVRRLS--LALAVLAVIGLR 328

  Fly   892 --ISLVID---PSTYTQ---NDYCVLMEANALFYATFVIPVLVFFVAAIGYTFLSWIIMCRKSRT 948
              :||..|   |..:..   .|||        ::......:|:::...|....:..|:.|.|:..
  Fly   329 FLVSLAQDSKLPKHFKPGMGEDYC--------WFDVRTWGILIYYYGPIALLLIFSIVCCLKAYF 385

  Fly   949 GLKTKE-------HTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLRGAKMDDDTADVYGYCFICF 1006
            .:....       .|:|..|:........:::.:.|||.........|::.:....:..:..|| 
  Fly   386 SIYELPPDTQYILGTQLKIVKTHFYAFSAYIVGVFAVWIREIVVYIMARVREHFFIIDFWSGIC- 449

  Fly  1007 NTLLGLYIFVFHCIQNEKIRREYRKYVRQHAWLPKCLRCSKTSIS 1051
              :|||.|..|..:..:.:      :|:  :|....:..|:|.:|
  Fly   450 --ILGLAIAGFILLLGKNL------HVK--SWWAINVESSQTDLS 484

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CirlNP_001260807.1 Gal_Rha_Lectin_dCirl 22..113 CDD:438687
GAIN 451..682 CDD:465137 6/21 (29%)
GPS 705..752 CDD:197639 12/51 (24%)
7tmB2_CELSR_Adhesion_IV 763..1035 CDD:320557 62/302 (21%)
TM helix 1 765..790 CDD:320557 8/25 (32%)
TM helix 2 801..823 CDD:320557 7/26 (27%)
TM helix 3 832..859 CDD:320557 5/26 (19%)
TM helix 4 875..895 CDD:320557 7/26 (27%)
TM helix 5 913..942 CDD:320557 3/28 (11%)
TM helix 6 960..987 CDD:320557 4/26 (15%)
TM helix 7 997..1022 CDD:320557 7/24 (29%)
Herpes_TAF50 <1219..1365 CDD:308764
mthl9NP_612029.1 Methuselah_N 29..199 CDD:429053 23/110 (21%)
7tmB3_Methuselah-like 232..473 CDD:410632 54/273 (20%)
TM helix 2 241..263 CDD:410632 5/21 (24%)
TM helix 3 275..302 CDD:410632 7/38 (18%)
TM helix 4 314..334 CDD:410632 7/21 (33%)
TM helix 5 358..387 CDD:410632 5/28 (18%)
TM helix 6 404..431 CDD:410632 4/26 (15%)
TM helix 7 440..465 CDD:410632 7/27 (26%)
Blue background indicates that the domain is not in the aligned region.

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