DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cirl and mthl4

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	NP_788394.1	Gene:	mthl4 / 36960	FlyBaseID:	FBgn0034219	Length:	517	Species:	Drosophila melanogaster

Alignment Length:	557	Identity:	107/557 - (19%)
Similarity:	192/557 - (34%)	Gaps:	195/557 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   571 LLSVRVLETKTIQSSVVFPDSDQWPLSSDRIELPRAALIDNS----EGGLV--------RIVFAA 623
            :|.:.||.....:|:...|..|.:    |.:::.:|....|.    ||.|:        .....|
  Fly     3 ILLIAVLFLLMPKSNAEIPGCDFF----DTVDISKAPRFSNGSYLYEGLLIPAHLTAEYDYKLLA 63

  Fly   624 FDRLESILK-----------------PSYDHFDLKSSRSYVRNTAILSNDSDVNAGEIQQRLRIL 671
            .|..|.:..                 |.|.  .::.|:.|          .|::..|:.:
  Fly    64 DDSKEKVASHVRGCACHLRPCIRFCCPQYQ--KMQKSKCY----------GDMSEDELNK----- 111

  Fly   672 NSKVISASLGKGRHIQLSQPITLTLKHLKTE-----NVTNPTCVFWNYIDHAWSANGCSL----- 726
            :...::.:|..|         ::..:|.|.:     ::..|.|....:::|....|..:|
  Fly   112 HDPFVNVTLSDG---------SVVRRHFKEDLIVQSDLAKPGCPRMYFLNHELPGNEFTLFENGS 167

  Fly   727 --------ESTNRTHSVCSCNHLT----------NFAILMDVVDEHQHSLFTMFDGNMRIFIYIS 773
                    |.:.|.:.|   .||:          :|..|.   .||..:..|       :.|.||
  Fly   168 LLRHWDKVELSKREYCV---QHLSFKDDSIRIAPHFCPLS---SEHSRTWKT-------VAIVIS 219

  Fly   774 IGICVVFIVIALLTLKLFNGVFVKSARTSIYTSIYLCLLA---IELLFLLGIEQTETSIFC---G 832
            : ||::      ||:.::  ::|:..| :::...::|.||   :...||:......:|.||   |
  Fly   220 L-ICII------LTISVY--LYVEKLR-NLHGKCFICYLASLFLGYFFLVLNVWKYSSGFCVTAG 274

  Fly   833 FITIFLHCAILSGTAWFCYEAFH---SYSTLTSDELLLEVDQTPKVNCYYLLSYGLSLSVVAISL 894
            |:..|   ::::...|......|   .:| |.|:.|...:.:.| ...|.|.::|:.|.:.||:.
  Fly   275 FLGYF---SVMAAFFWLSVIGIHLRIKFS-LASNCLHRLLPENP-FRAYNLYAWGIPLIMTAITY 334

  Fly   895 VIDPST-----------------YTQNDYCVLMEANALFYATFVI----PVLVFFVAAIGYTFLS 938
            ..|...                 || .|..|::    .||...::    .:::|.::||
  Fly   335 TADQVVKNEKLRPRVGVGKNCWIYT-GDMTVMI----YFYGPMLLLIAFNIIMFVLSAI------ 388

  Fly   939 WIIMCRKSRTGLKTKEHT--------------RL-----ASVRFDIRCSFVFLLLLSAVWCSAYF 984
            :|...:|:..||..|:.|              ||     .|..|:|   ..|||.....|..|..
  Fly   389 YIYNIKKNVKGLVHKQQTNQQINDQQMFAIFLRLFILMGLSWSFEI---LSFLLTKQQAWARALM 450

  Fly   985 YLRGAKMDDDTADVYGYCFICFNTLLGLYIFVFHCIQ 1021
                      .||.       ||...|..|||...::
  Fly   451 ----------VADY-------FNWSQGTIIFVLFILK 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328
		GAIN	453..680	CDD:293098	21/137 (15%)
		GPS	705..752	CDD:197639	12/69 (17%)
		7tm_4	763..1014	CDD:304433	64/299 (21%)
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:284145	30/210 (14%)
mthl4	NP_788394.1	7tm_4	213..>385	CDD:304433	42/198 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900