Protein Alignment Cirl and Adgre5

DIOPT Version :10

• Sequence 1: NP_001260807.1
• Gene: Cirl / 35846
• FlyBaseID: FBgn0033313
• Length: 1711
• Species: Drosophila melanogaster
• Sequence 2: XP_063134184.1
• Gene: Adgre5 / 361383
• RGDID: 1305595
• Length: 965
• Species: Rattus norvegicus
• Alignment Length: 1157
• Identity: 234/1157 - (20%)
• Similarity: 379/1157 - (32%)
• Gaps: 366/1157 - (31%)

  Fly    96 FGDPCPGTHKYLEAHYQCISAAQTSTTTNRPSPPPWVLSNGPPIFGNGSGLIHPPGVGAGAPPPP 160
            || |||                  |:..:|.|.|           ...||:...||.||...
  Rat     3 FG-PCP------------------SSRGDRVSGP-----------RAQSGVAFVPGAGARRA--- 34

  Fly   161 RLPTLPGVVGISGNPGLFNVPPQHTAVTHSTPSSSTTAVGGGRLKGGATSTTTTKHPAGRHDGLP 225
                          .|||   |:|..||...         ||:.:||.......|.||      .
  Rat    35 --------------LGLF---PRHFPVTFQR---------GGQFRGGPCPRPLHKGPA------Q 67

  Fly   226 PP------------------------------PQLHHHHNHHGEDTASPTKPSS--------KLP 252
            ||                              |.|...........|....|:|        |..
  Rat    68 PPATALCQPRRCPFRATMRGVSCHLLLVLCFVPNLSGVGTQKASGCARWCPPNSECESNRSCKCK 132

  Fly   253 AGGNATSPSNTRILTGVGGSGTD-----------------------------------DGTLLTT 282
            .|.|::||..  ::|....|..|                                   .|....|
  Rat   133 PGFNSSSPDG--LITNPAQSCEDINECIQTDNLCGPYAMCMNSEGSYYCVCNLGYKLLSGAESFT 195

  Fly   283 KSSPNRPPGTAASGSV-VPGNGSVVRTINNI-----------NLNAAGMSGGDDESKLFCG---- 331
            ..|.|....:..:|.: ||.:...|.|...:           .|..:|.....|.::...|
  Rat   196 NKSENTCQASVDTGMIPVPSSIHTVPTARKLPEQPTTVHPRTQLGDSGERTPKDVNECTSGQNQC 260

  Fly   332 --PTHARNLYWNMTRVGDVNVQPCPGGAAGIAKWRCVLMKRIPDSGYDEYDDDISSTTPAPSGGD 394
              .||..|.....:.:.....:|.||...|.....|               :|:...:   ||..
  Rat   261 HQSTHCINKMGGYSCICRRGWKPAPGSPNGPVNTVC---------------EDVDECS---SGQH 307

  Fly   395 CLHNSSSCE----------PPVSMA---HKVNQRL---RNFEPTWHPATPDLTQCRSLWLNNLEM 443
            ..|:|:.|:          ||..:|   .|.|..:   .:| |||    ..|....|..|.:..:
  Rat   308 QCHSSAICKNIPGSYKCRCPPGWIAIPRDKPNNTVCQEPHF-PTW----TLLPTAHSQALLSFSV 367

  Fly   444 RVNQRDSSLISIANDMSEVTSSKTLYGGDMLVTTKIIQTVSEKMMHDKETFPDQRQREAMIMELL 508
            .|.       ::..|.:..|.:.|:        .|:|:.|      ||            ::|:.
  Rat   368 EVQ-------NLLRDFNPATVNYTI--------QKLIEAV------DK------------LLEMP 399

  Fly   509 HCVVKTGSNLLDESQLSSWLDLNPEDQMRVATSLLTGLEYNAFLLADTIIRERSVVQKVKNILLS 573
                               :|:..:.| :|||.||:.||.:...||..:.:.....:...|..|:
  Rat   400 -------------------MDIGTQTQ-QVATQLLSNLEQSLRTLAQFLPKGPFTYKSPSNTELA 444

  Fly   574 VRVLE-----TKTIQSSVVFPDSDQWPLSSDRIELPRAALIDNSEGGLVRIVFAAFDRLESILKP 633
            :.|.|     ..|:..|..:...| |.::         |...:||.|.......:...::.:|..
  Rat   445 LMVKEQDNKDVTTVHHSQAWMQLD-WAVT---------AGAKSSENGYSVAGILSSPNIQKLLAN 499

  Fly   634 SYDHFDLKSSRSYVRNTAILSNDSDVNAGEIQQRLRILNSKVISASLGKGRHIQLSQPITL---- 694
            :..:.:.|      |:|.     .|:....:|.......|.:.:..|......:|:..:|.
  Rat   500 TSLNLEQK------RDTL-----EDLYGSPVQSVTLTFLSNINAIFLTNTDTEKLASDVTFKFNL 553

  Fly   695 -TLKHLKTENVTNPTCVFWNYIDH---AWSANGCSLESTNRTHSVCSCNHLTNFAILMDVVDEHQ 755
             ::|.||...  ...|.:|...|:   :|:.:|||:..|    ..|.|||||:||:||
  Rat   554 TSVKSLKARE--ELMCAYWKSHDNGSGSWATDGCSMNDT----GFCHCNHLTSFAVLM------- 605

  Fly   756 HSLFTMFDGNMRIFIYISIGICVVFIVIALLTLKLFNGVFVKSARTSIYTSIYLCLLAIELLFLL 820
             :.:.:.|..:.:...:.:.:.:|.:::.:||..|...  ::|:||.::..:.:||....::||:
  Rat   606 -AQYHVQDPRLELITKVGLLLSLVCLLLCILTFLLVKP--IQSSRTMVHLHLCICLFLGSVIFLV 667

  Fly   821 GIEQT--ETSIFCGFITIFLHCAILSGTAWFCYEAFHSYSTLTSDELLLEVDQTPKVNCYY--LL 881
            |:|..  |..:.|..:.:.||...|:...|...|....|.      |::.|.|...::.::  |:
  Rat   668 GVENEGGEVGLRCRLVAMLLHFCFLAAFCWMALEGVELYF------LVVRVFQGQGLSTWHRCLV 726

  Fly   882 SYGLSLSVVAISLVIDPSTYTQNDYCVLMEANALFYATFVIPV--LVFFVAAIGYTFLSWIIMCR 944
            .||:.|.:||||.......|....||.|......|..:|..||  ::|..||| :....|.:..:
  Rat   727 GYGVPLLIVAISAAARMDGYGHATYCWLDFRKQGFLWSFSGPVAFIIFCNAAI-FVITVWKLTKK 790

  Fly   945 KSRTGLKTKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLRGAKMDDDTADVYGYCFICFNTL 1009
            .|......|   :|...|.....:...||:|...|....|      :.:..:....|.|...|.|
  Rat   791 FSEINPNMK---KLRKARVLTITAIAQLLVLGCTWGFGLF------LFNPHSTWLSYIFTLLNCL 846

  Fly  1010 LGLYIFVFHCIQNEKIRREYRKY-----------------------VRQHAW----LPKCLRCSK 1047
            .||:::|..|:.|:|:|.||.|:                       .|...|    |..|...|.
  Rat   847 QGLFLYVTLCLLNKKVREEYWKWACMVTGNKYTEFTSSTTGTGTSQTRVRGWPAVGLGGCAWLSS 911

  Fly  1048 TSISSGIVTGNGP-----------------TAGTLCSVSTSKKPKLPLGVSE 1082
            ||.:|.:...:||                 .|..|.||..:..|..||.:.|
  Rat   912 TSRASFLCRPSGPQNRGCEGKFHVGQQHIFKAAILPSVPATLPPLAPLQIKE 963

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Rha_Lectin_dCirl	22..113	CDD:438687	5/16 (31%)
		GAIN	451..682	CDD:465137	40/235 (17%)
		GPS	705..752	CDD:197639	18/49 (37%)
		7tmB2_CELSR_Adhesion_IV	763..1035	CDD:320557	69/300 (23%)
		TM helix 1	765..790	CDD:320557	3/24 (13%)
		TM helix 2	801..823	CDD:320557	6/21 (29%)
		TM helix 3	832..859	CDD:320557	6/26 (23%)
		TM helix 4	875..895	CDD:320557	8/21 (38%)
		TM helix 5	913..942	CDD:320557	9/30 (30%)
		TM helix 6	960..987	CDD:320557	6/26 (23%)
		TM helix 7	997..1022	CDD:320557	8/24 (33%)
		Herpes_TAF50	<1219..1365	CDD:308764
Adgre5	XP_063134184.1	None