DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cirl and Adgrl1

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	XP_030099484.1	Gene:	Adgrl1 / 330814	MGIID:	1929461	Length:	1543	Species:	Mus musculus

Alignment Length:	1249	Identity:	313/1249 - (25%)
Similarity:	486/1249 - (38%)	Gaps:	305/1249 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 PPQHTAVTHSTPSSSTTAVGGGRLKGGATSTTTTKHPAGRHDGLPPPPQLHHHHNHHGEDTASPT 245
            ||..:|...::|..||              |||.:          |.|.         ..||||.
Mouse   470 PPDPSAGPATSPPLST--------------TTTAR----------PTPL---------TSTASPA 501

  Fly   246 KPSSKLPAGGNATSPSNTRILT--GVGGSGTDDGTLLTTKSSPNRPPGTAASGSVVPGNGSVVRT 308
                       ||:|.....||  .||.         ..:..|:.||.||.:.|        .|.
Mouse   502 -----------ATTPLRRAPLTTHPVGA---------INQLGPDLPPATAPAPS--------TRR 538

  Fly   309 INNINLNAAGMSGGDDESKLFCGPTHARNLYWNMTRVGDVNVQPCPGGAAGIAKWRCVLMKRIPD 373
            ....||:.:        .:|||.|...|.:.|..|:.|.:..:|||.|..|||.::|:
Mouse   539 PPAPNLHVS--------PELFCEPREVRRVQWPATQQGMLVERPCPKGTRGIASFQCL------- 588

  Fly   374 SGYDEYDDDISSTTPAPSGGDCLHNSSSCEPPVSMAHKVNQRLRNFEPTWHPATPDLTQCRSLWL 438
                            |:.|                            .|:|..|||:.|.|.|:
Mouse   589 ----------------PALG----------------------------LWNPRGPDLSNCTSPWV 609

  Fly   439 NNLEMRVNQRDSSLISIANDMSEVTSSKTLYGGDMLVTTKIIQTVSEKMMHDKETF-PDQRQ--- 499
            |.:..::...::: .:||::::..|.. ::|.||:..:.|:::.:.:.:....:.. |.:|:
Mouse   610 NQVAQKIKSGENA-ANIASELARHTRG-SIYAGDVSSSVKLMEQLLDILDAQLQALRPIERESAG 672

  Fly   500 --------REAMIMELLHCVVKTGSNLLDESQLSSWLDLNPEDQMRVATSLLTGLEYNAFLLADT 556
                    ||....:.:..||:|..|||....|.||.|:|..:|:..||.||..||..||||||.
Mouse   673 KNYNKMHKRERTCKDYIKAVVETVDNLLRPEALESWKDMNATEQVHTATMLLDVLEEGAFLLADN 737

  Fly   557 IIRERSVVQKVKNILLSVRVLETKTIQSSVVFPDSDQWPLSSDRIELPRAALIDNSEGGLVRIVF 621
            :......:...:|::|.|.||.|:.....:|||  .::| |.:.|:|....:..||..|:|::||
Mouse   738 VREPARFLAAKQNVVLEVTVLNTEGQVQELVFP--QEYP-SENSIQLSANTIKQNSRNGVVKVVF 799

  Fly   622 AAFDRLESILKPSYDHFDLKSSRSYVRNTAILSNDSDVNAGEIQQRLRILNSKVISASLGK-GRH 685
            ..::.|...|.               ...|.:....:...|.......::||:||:||:.| ...
Mouse   800 ILYNNLGLFLS---------------TENATVKLAGEAGTGGPGGASLVVNSQVIAASINKESSR 849

  Fly   686 IQLSQPITLTLKHLKTENVTNPTCVFWNYIDHA----WSANGCSLESTNRTHSVCSCNHLTNFAI 746
            :.|..|:..|:.||:.:|..|..|.||||.:.:    ||..||.|..:|:||:.|:|:||||||:
Mouse   850 VFLMDPVIFTVAHLEAKNHFNANCSFWNYSERSMLGYWSTQGCRLVESNKTHTTCACSHLTNFAV 914

  Fly   747 LMDVVDEHQHSLFTMFDGNMRIFIYISIGICVVFIVIALLTLKLFNGVFVKSARTSIYTSIYLCL 811
            ||...:.:|..:..:.   :.:..::.|.|.:|.:.|.:.|.....|  :::.|.:|:.::.:.|
Mouse   915 LMAHREIYQGRINELL---LSVITWVGIVISLVCLAICISTFCFLRG--LQTDRNTIHKNLCINL 974

  Fly   812 LAIELLFLLGIEQTETSIFCGFITIFLHCAILSGTAWFCYEAFHSYSTLTSDELLLEV--DQTPK 874
            ...|||||:||::|:..:.|......||...|:..:|.|.|..|.|.      ||:||  .:..:
Mouse   975 FLAELLFLVGIDKTQYEVACPIFAGLLHYFFLAAFSWLCLEGVHLYL------LLVEVFESEYSR 1033

  Fly   875 VNCYYLLSYGLSLSVVAISLVIDPSTYTQNDYCVLMEANALFYATFVIPVLVFFVAAIGYTFLSW 939
            ...|||..|.....||.|:..||..:|.....|.|...| .|..:|:.|  |.||..:...||..
Mouse  1034 TKYYYLGGYCFPALVVGIAAAIDYRSYGTEKACWLRVDN-YFIWSFIGP--VSFVIVVNLVFLMV 1095

  Fly   940 II--MCRKSRTGLKTKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLRGAKMDDDTADVYGYC 1002
            .:  |.|.|.. || .:.:||.:::.....:...|.||...|.....::....:      |..|.
Mouse  1096 TLHKMIRSSSV-LK-PDSSRLDNIKSWALGAIALLFLLGLTWAFGLLFINKESV------VMAYL 1152

  Fly  1003 FICFNTLLGLYIFVFHCIQNEKIRREYRKYVRQHAWLPKCLRCSKTSISSGIVTGNGPTAGTLCS 1067
            |..||...|::||||||...:|:.:||          .||||.|...|.|       |..||..|
Mouse  1153 FTTFNAFQGVFIFVFHCALQKKVHKEY----------SKCLRHSYCCIRS-------PPGGTHGS 1200

  Fly  1068 VSTS---KKPKLPLGVSEEAHDDPQQQQQTPVPITEDAIMGATSDCELNEAQQRRTLKSGLMTGT 1129
            :.||   ...:...|                   |:..|....:|      ..|:..:|..|.|.
Mouse  1201 LKTSAMRSNTRYYTG-------------------TQSRIRRMWND------TVRKQTESSFMAGD 1240

  Fly  1130 LQAPPQ----TLGGHVVLERGSTLRSTGHASP-----TSSAG---STHLIFAHKQQQQQQQQGPL 1182
            :.:.|.    |:|.|::  ....|:..|..||     ..|.|   |:..:| :.....::.:.||
Mouse  1241 INSTPTLNRGTMGNHLL--TNPVLQPRGGTSPYNTLIAESVGFNPSSPPVF-NSPGSYREPKHPL 1302

  Fly  1183 G-----------------ESY-YHQPDYYSWKQPSTGTGGLKTPREYYNNAGAAASSPQQAHEVF 1229
            |                 .|| ....|:      ..|.||.:.||. .|.|.|||.......|:.
Mouse  1303 GGREACGMDTLPLNGNFNNSYSLRSGDF------PPGDGGPEPPRG-RNLADAAAFEKMIISELV 1360

  Fly  1230 YWTQKPNSGHNGKKKRGAGGVPASPSGSLHSRTAAASQVLFYPSYKKTKPGQPTGYPQYAE---- 1290
            :...:..||       ||.|.|..|            .|...|...:.:.|.| |....||
Mouse  1361 HNNLRGASG-------GAKGPPPEP------------PVPPVPGVSEDEAGGP-GSADRAEIELL 1405

  Fly  1291 --ALDPPLATGNAAAYYQQQQQLRRQQLHQQQQQQQQQQLSSDEEQAEQHAHLLHLQ-------- 1345
              ||:.||....|.:.. .|..|...:....:.....:.|||...:...:|...:|:
Mouse  1406 YKALEEPLLLPRAQSVL-YQSDLDESESCTAEDGATSRPLSSPPGRDSLYASGANLRDSPSYPDS 1469

  Fly  1346 RRAGSQQQLPAPPP 1359
            ...|..:.||.|||
Mouse  1470 SPEGPNEALPPPPP 1483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328
		GAIN	453..680	CDD:293098	63/238 (26%)
		GPS	705..752	CDD:197639	24/50 (48%)
		7tm_4	763..1014	CDD:304433	68/254 (27%)
Adgrl1	XP_030099484.1	OLF	214..470	CDD:383019	313/1249 (25%)
		PLN02550	491..>573	CDD:178165	30/126 (24%)
		HormR	548..611	CDD:214468	26/113 (23%)
		GAIN	621..845	CDD:374574	64/243 (26%)
		GPS	869..921	CDD:197639	24/51 (47%)
		7tmB2_Latrophilin-1	928..1185	CDD:320673	80/288 (28%)
		TM helix 1	931..955	CDD:320673	5/23 (22%)
		TM helix 2	964..985	CDD:320673	7/20 (35%)
		TM helix 3	995..1017	CDD:320673	6/21 (29%)
		TM helix 4	1036..1052	CDD:320673	6/15 (40%)
		TM helix 5	1071..1094	CDD:320673	8/25 (32%)
		TM helix 6	1118..1143	CDD:320673	4/24 (17%)
		TM helix 7	1147..1172	CDD:320673	12/30 (40%)
		Latrophilin	1185..1543	CDD:367050	78/362 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	79	1.000	Domainoid score	I8635
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	357	1.000	Inparanoid score	I2216
Isobase	1	0.950	-	0.918296	Normalized mean entropy	S7056
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000766
OrthoInspector	1	1.000	-	-		otm43069
orthoMCL	1	0.900	-	-		OOG6_102405
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3208
SonicParanoid	1	1.000	-	-		X858
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.800