DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cirl and adgrg1

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	NP_001018317.1	Gene:	adgrg1 / 324948	ZFINID:	ZDB-GENE-030131-3671	Length:	648	Species:	Danio rerio

Alignment Length:	724	Identity:	138/724 - (19%)
Similarity:	255/724 - (35%)	Gaps:	217/724 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   395 CLHNSSSCEPPVSMAHKVNQRLRNFEPTWHPATPDLTQCRSLWLNNLEMRVNQRDSSLI------ 453
            |..:||     :.:....:|...:|...|.|.           |:.|.:.||.::.:|.
Zfish    76 CTQSSS-----IQLDSNPHQNQSHFCVFWEPL-----------LDLLIVEVNGKNHTLCKPNGLQ 124

  Fly   454 -SIANDMSE-VTSSKTLYG-------GDMLVTTKIIQTVSEKMMHD------KETFPDQRQREAM 503
             :...|:|: |..:..:||       ||:     |...:....:.|      ||.|.|:.:
Zfish   125 GTCCTDLSQGVQDNAHMYGIVNGSVKGDI-----ITGDLKGNYIFDGAHINCKEKFCDEAR---- 180

  Fly   504 IMELLHCVVKTGSNLLDESQLSSWLDLNPEDQMRVATSLLTGLEYNAFLLADTIIRERSVVQKVK 568
                   :...|:|:::|                      ..:.:||....|....:.:|::..:
Zfish   181 -------LKPRGANMIEE----------------------VVMRFNAKGRVDLPCAQGTVIEMDE 216

  Fly   569 NI------LLSVRVLETKTIQSSVVFPDSDQWPLSSDRIELPRAALIDNSEGGLVRIVFAAFDRL 627
            ..      :.:.|.::..|| .||..|.|                                   |
Zfish   217 EFTGHNFTVPAPRFVDANTI-PSVYIPSS-----------------------------------L 245

  Fly   628 ESILKPSYDHFDLKSSR---SYVRNTAILSNDSDVNAGEIQQRLRILNSKVISASLGKGRHIQLS 689
            .|:.:        :.|:   :|.:|..:.......:|         |...::..|:.......|.
Zfish   246 RSVSR--------RKSKVVCTYYKNKTLFERGPSKSA---------LLDDIVGLSVENETIRNLI 293

  Fly   690 QPITLTLKHLKTENVTNPTCVFW-----NYIDHAWSANGCSLESTNRTHSVCSCNHLTNFAILMD 749
            :|:.:...|......::..||.|     |.::  |..:||.....|...:.|.|||||.||||:.
Zfish   294 EPVKIRFHHRPFAPDSSGRCVSWDTKQDNEVN--WKDDGCDTVKINEEQTECHCNHLTYFAILVQ 356

  Fly   750 VVDEHQHSLFTMFDGNMRIFIYISIGICVVFIVIALLTL----KLFNGVFVKSARTSIYTSIYLC 810
            |  |.:.::     .:::...:|:...|.|.:|..|:..    |...|  .|:..:.::..:.:.
Zfish   357 V--EQKSTV-----RHLKALTFITAVGCAVSLVSCLVLFYWLCKRRRG--KKNQISLVHRGLVVA 412

  Fly   811 LLAIELLFLL-GI-EQTETSIFCGFITIFLHCAILSGTAWFCYEAFHSYSTLTSDELLLEVDQTP 873
            :..:.|.|:| || ........|......||..:||...|...|.||::.      |:.:|..:|
Zfish   413 IFLLCLFFILTGILANVANETVCQLTGSLLHYGLLSTLCWMAMEVFHTFL------LVRKVFNSP 471

  Fly   874 -KVNCYYLLSYGLSLSVVAISL---------VIDPSTYTQNDY--CVLMEANALFYATFVIPV-L 925
             .:..:||:.:|....:|:|.|         .|.||....|.|  |.:.|.:....|.::|.: |
Zfish   472 LPIWIFYLMGFGFPFLLVSILLSVGDIYGERKIKPSDDVNNPYRMCWMTEGDKSQLAHYIINIGL 536

  Fly   926 VFFVAAIGYTFLSWIIMCRKSRTGLKTKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLRGAK 990
            :..|.:.|...|..::...::|...| |.|....|: :.:.|      |....|  |..:|....
Zfish   537 LAVVVSSGLVMLFLVVREIRNRPDWK-KIHVAFLSI-WGLTC------LYGTTW--ALGFLDFGP 591

  Fly   991 MDDDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYRKYVRQHAWLPKCLRCSKTSISSGIV 1055
            ..:.|  ::.:|.|  |:|.|.::.:             |.|..:        |..|..:||
Zfish   592 FSEVT--LFLFCII--NSLQGFFLML-------------RYYALE--------RMKKKDVSS--- 628

  Fly  1056 TGNGPTAGT 1064
             .:|.::|:
Zfish   629 -SDGSSSGS 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328
		GAIN	453..680	CDD:293098	34/256 (13%)
		GPS	705..752	CDD:197639	19/51 (37%)
		7tm_4	763..1014	CDD:304433	60/269 (22%)
adgrg1	NP_001018317.1	GPS	312..354	CDD:280071	16/43 (37%)
adgrg1	NP_001018317.1	7tm_4	369..611	CDD:304433	60/263 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900