DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cirl and Adgrl3

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	XP_011247763.1	Gene:	Adgrl3 / 319387	MGIID:	2441950	Length:	1586	Species:	Mus musculus

Alignment Length:	1696	Identity:	381/1696 - (22%)
Similarity:	627/1696 - (36%)	Gaps:	460/1696 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ILSISYEHISLDLSKYQTAYACEGKKLTIECDPGDVINLIRANYGRFSITIC-NDHGNVEWSVNC 68
            |.:.::....:.::..:...:||...:.:.|...|||.:..|||||....|| :|...:| ::.|
Mouse    83 IAAQAFSRAPIPMAVVRRELSCESYPIELRCPGTDVIMIESANYGRTDDKICDSDPAQME-NIRC 146

  Fly    69 MFPKSLSVLNSRCAHKQSCGVLAATSMFGDPCPGTHKYLEAHYQCI------------------- 114
            ..|.:..:::.||.::..|.|:|...:|.||||||:||||..|:|:
Mouse   147 YLPDAYKIMSQRCNNRTQCAVVAGPDVFPDPCPGTYKYLEVQYECVPYKVEQKVFLCPGLLKGVY 211

  Fly   115 -----------SAA--------------------QTSTTTNRPSPPPWV---------------- 132
                       |.|                    :|.|.|...|...::
Mouse   212 QSEHLFESDHQSGAWCKDPLQASDKIYYMPWTPYRTDTLTEYSSKDDFIAGRPTTTYKLPHRVDG 276

  Fly   133 ----------------------------LSNGPPIFG------------------------NGSG 145
                                        :.:|..|..                        ||..
Mouse   277 TGFVVYDGALFFNKERTRNIVKFDLRTRIKSGEAIIANANYHDTSPYRWGGKSDIDLAVDENGLW 341

  Fly   146 LIHPPGVGAG----APPPPRLPTLPG----------------VVGI---------------SGN- 174
            :|:......|    :...|....:.|                :.||               :||
Mouse   342 VIYATEQNNGKIVISQLNPYTLRIEGTWDTAYDKRSASNAFMICGILYVVKSVYEDDDNEATGNK 406

  Fly   175 -----------PGLFNVP-P---QHTAVTHSTPSSSTTAVGGGRLKGGATSTTTTKHPA--GRHD 222
                       ..|.:|| |   |:.|.....|..:...|.        .:....|:..  |..|
Mouse   407 IDYIYNTDQSKDSLVDVPFPNSYQYIAAVDYNPRDNLLYVW--------NNYHVVKYSLDFGPLD 463

  Fly   223 GLPPPPQLHHHHNHHGEDT--ASPTKPSSKL---PAGGNATSPSNTRILTGVGGSGTDDGTLLTT 282
            ....|.       |||:.:  :.|....|:|   |..|.:|:.|     .|: ||.|...||.||
Mouse   464 SRSGPV-------HHGQVSYISPPIHLDSELERPPVRGISTTGS-----LGM-GSTTTSTTLRTT 515

  Fly   283 -----KSSPNRPPGTAASGSVVPGNGSVVRTINNINL---NAAGMSGGDDESKLFCGPTHARNLY 339
                 :|:....||.....:..|  ...|..::::..   :||......:||   |....||.:.
Mouse   516 TWNIGRSTTASLPGRRNRSTSTP--SPAVEVLDDVTTHLPSAASQIPAMEES---CEAVEAREIM 575

  Fly   340 WNMTRVGDVNVQPCPGGAAGIAKWRCVLMKRIPDSGYDEYDDDISSTTPAPSGGDCLHNSSSCEP 404
            |..||.|.|..||||.|..|::.:.|:                      ||.|
Mouse   576 WFKTRQGQVAKQPCPAGTIGVSTYLCL----------------------APDG------------ 606

  Fly   405 PVSMAHKVNQRLRNFEPTWHPATPDLTQCRSLWLNNLEMRVNQRDSSLISIANDMSEVTSSKTLY 469
                             .|.|..|||:.|.|.|:|::..::...::: .:||.:::|.|.:. |.
Mouse   607 -----------------IWDPQGPDLSNCSSPWVNHITQKLKSGETA-ANIARELAEQTRNH-LN 652

  Fly   470 GGDMLVTTKII-QTVSEKMMHDKETFPDQR-----------QREAMIMELLHCVVKTGSNLLDES 522
            .||:..:.:.: |.|....:..:...|..:           :||......:..:|:|.:|||...
Mouse   653 AGDITYSVRAMDQLVGLLDVQLRNLTPGGKDSAARSLNKLQKRERSCRAYVQAMVETVNNLLQPQ 717

  Fly   523 QLSSWLDLNPEDQMRVATSLLTGLEYNAFLLADTIIRERSVVQKVKNILLSVRVLETKTIQSSVV 587
            .|::|.||...||:|.||.||..:|.:||:|||.:::...|.:...||.|.|..|.|:.....:.
Mouse   718 ALNAWRDLTTSDQLRAATMLLDTVEESAFVLADNLLKTDIVRENTDNIQLEVARLSTEGNLEDLK 782

  Fly   588 FPDSDQWPLSSDRIELPRAALIDNSEGGLVRIVFAAFDRLESILKPSYDHFDLKSSRSYVRNTAI 652
            ||::..   ....|:|....|..|...|.:|:.|..::.|...|  |.::..:|      ..|..
Mouse   783 FPENMG---HGSTIQLSANTLKQNGRNGEIRVAFVLYNNLGPYL--STENASMK------LGTEA 836

  Fly   653 LSNDSDVNAGEIQQRLRILNSKVISASLGK--GRHIQLSQPITLTLKHLK-TENVTNPTCVFWNY 714
            :|.:..|          |:||.||:|::.|  ...:.|:.|:..|:||:| :|...||.|.||:|
Mouse   837 MSTNHSV----------IVNSPVITAAINKEFSNKVYLADPVVFTVKHIKQSEENFNPNCSFWSY 891

  Fly   715 IDHA----WSANGCSLESTNRTHSVCSCNHLTNFAILMDVVDEHQHSLFTMFDGNMRIFIYISIG 775
            ....    ||..||.|.:||:||:.||||||||||:||..| |.:|| ..:.|..:.:..::.|.
Mouse   892 SKRTMTGYWSTQGCRLLTTNKTHTTCSCNHLTNFAVLMAHV-EVKHS-DAVHDLLLDVITWVGIL 954

  Fly   776 ICVVFIVIALLTLKLFNGVFVKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHC 840
            :.:|.::|.:.|...|.|  ::|.|.:|:.::.:.|...|||||:||.:|:..|.|......||.
Mouse   955 LSLVCLLICIFTFCFFRG--LQSDRNTIHKNLCISLFVAELLFLIGINRTDQPIACAVFAALLHF 1017

  Fly   841 AILSGTAWFCYEAFHSYSTLTSDELLLEV--DQTPKVNCYYLLSYGLSLSVVAISLVIDPSTYTQ 903
            ..|:...|...|....|.      :|:||  .:..:...:||:.||:...:||:|..:|..:|..
Mouse  1018 FFLAAFTWMFLEGVQLYI------MLVEVFESEHSRRKYFYLVGYGMPALIVAVSAAVDYRSYGT 1076

  Fly   904 NDYCVLMEANALFYATFVIPVLVFFVAAIGYTFLSWIIMCRKSRTGLKTKEHTRLASVRFDIRCS 968
            :..|.| ..:..|..:|:.|..:  :..:...||...:......|.:...|...|.::.::....
Mouse  1077 DKVCWL-RLDTYFIWSFIGPATL--IIMLNVIFLGIALYKMFHHTAILKPESGCLDNINYEDNRP 1138

  Fly   969 FV---------FLLLLSAVWCSAYFYLRGAKMDDDTADVYGYCFICFNTLLGLYIFVFHCIQNEK 1024
            |:         .|.||...|.....|:      :::..:..|.|..||:|.|::||:|||:..:|
Mouse  1139 FIKSWVIGAIALLCLLGLTWAFGLMYI------NESTVIMAYLFTIFNSLQGMFIFIFHCVLQKK 1197

  Fly  1025 IRREYRKYVRQHAWLPKCLRCSKTSISSGIVTGNGPTAG--TLCSVSTSKKPKLPLGVSEEAHDD 1087
            :|:||.|.:|.|.       ||..|..|.|  |:|.|:|  |....||..:.::     ....:|
Mouse  1198 VRKEYGKCLRTHC-------CSGKSTESSI--GSGKTSGSRTPGRYSTGSQSRI-----RRMWND 1248

  Fly  1088 PQQQQQTPVPITEDAIMGATSDCELNEAQQRRTLKSGLMTGTLQAPPQTLGGHVVLERGSTLRST 1152
            ..::|.....||.|    ..|...||..                    .:..|::  ..:.||..
Mouse  1249 TVRKQSESSFITGD----INSSASLNRG--------------------AMANHLI--SNALLRPH 1287

  Fly  1153 GHASPTSSAGSTHLIFAHKQQQQQQQQGPLGE-SYYHQP--DYYSWKQPSTGTGGLKTPREYYNN 1214
            |..:|.::.                    ||| :..:.|  ..|:.::|...|.||      .||
Mouse  1288 GTNNPYNTL--------------------LGEPAVCNNPSISMYNTQEPYRETKGL------LNN 1326

  Fly  1215 AGAAASSPQQAHEVFYWTQKPNSGHNGKKKRGAGG------VPASPSGSLHSRTAAASQVL---- 1269
                      |.:.......|.:|::|.....|||      |.....|..|:.||...::|
Mouse  1327 ----------ARDTSVMDTLPLNGNHGNSYSIAGGEYLSNCVQIIDRGYNHNETALEKKILKELT 1381

  Fly  1270 --FYPSYKKTKPGQPTGYPQYAEALDPPLATGNA--------AAYYQQQQQLRRQQLHQQQQQQ- 1323
              :.|||.................|...|.:|:.        ||.:..::.|..:.:|::....
Mouse  1382 SNYIPSYLNNHERSSEQNRNMMNKLVNNLGSGSEDDAIVLDDAASFNHEESLGLELIHEESDAPL 1446

  Fly  1324 -QQQQLSSDEEQAEQHAHLLHLQRRAGSQQQLPAPPPHMAQYQQEFMQRQYRNKHSNCDLGMGDA 1387
             ..:..|:|..|..      |..||...|....:..|.:.....|.:|..:|           |:
Mouse  1447 LPPRVYSTDNHQPH------HYSRRRFPQDHSESFFPLLTDEHTEDLQSPHR-----------DS 1494

  Fly  1388 YYNQGSVGGADGGPVYEEILSNRNSDVQHYEVGDFDVDEVYNNSVGTGVFNNMRAAVAAGGSRYG 1452
            .|.  |:....|.|..:.:.::..::....:.||.: |..|.:....|..|::....|.  .:.|
Mouse  1495 LYT--SMPALAGVPAADSVTTSTQTEAAAAKGGDAE-DVYYKSMPNLGSRNHVHPLHAY--YQLG 1554

  Fly  1453 GGSLSG 1458
            .||..|
Mouse  1555 RGSSDG 1560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328	32/80 (40%)
		GAIN	453..680	CDD:293098	63/238 (26%)
		GPS	705..752	CDD:197639	27/50 (54%)
		7tm_4	763..1014	CDD:304433	61/261 (23%)
Adgrl3	XP_011247763.1	Gal_Lectin	111..191	CDD:366935	32/80 (40%)
		OLF	205..461	CDD:128580	27/263 (10%)
		HormR	563..627	CDD:214468	29/117 (25%)
		GAIN	636..856	CDD:374574	63/242 (26%)
		GPS	882..934	CDD:197639	28/52 (54%)
		7tmB2_Latrophilin-3	942..1208	CDD:320671	71/282 (25%)
		TM helix 1	945..969	CDD:320671	4/23 (17%)
		TM helix 2	978..999	CDD:320671	7/20 (35%)
		TM helix 3	1009..1031	CDD:320671	5/21 (24%)
		TM helix 4	1050..1066	CDD:320671	6/15 (40%)
		TM helix 5	1085..1108	CDD:320671	4/24 (17%)
		TM helix 6	1141..1166	CDD:320671	5/30 (17%)
		TM helix 7	1170..1195	CDD:320671	11/24 (46%)
		Latrophilin	1208..1586	CDD:367050	87/451 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	79	1.000	Domainoid score	I8635
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	357	1.000	Inparanoid score	I2216
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000766
OrthoInspector	1	1.000	-	-		otm43069
orthoMCL	1	0.900	-	-		OOG6_102405
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X858
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.820