Protein Alignment Cirl and mthl14

DIOPT Version :9

• Sequence 1: NP_001260807.1
• Gene: Cirl / 35846
• FlyBaseID: FBgn0033313
• Length: 1711
• Species: Drosophila melanogaster
• Sequence 2: NP_728509.1
• Gene: mthl14 / 318046
• FlyBaseID: FBgn0052476
• Length: 533
• Species: Drosophila melanogaster
• Alignment Length: 545
• Identity: 86/545 - (15%)
• Similarity: 173/545 - (31%)
• Gaps: 195/545 - (35%)

  Fly   638 FDLKSSRSYVRNTAILSNDS-------------DVNAGEIQQRLRILNSKVISASLGKGRHIQLS 689
            |:..:..|.|.|::..||:|             ||....|...|.:..:....|:...|.....|
  Fly    19 FNASAQISTVNNSSKGSNNSNIFHEDTFNSTSIDVLDASIHSTLVVPQTYSTEAATISGARFATS 83

  Fly   690 QPITLTL------------KHLKTENVTNPTCVFWNYIDHAWSANGCSLESTNRTHSVCSCNHLT 742
            .|:...:            :..:.:.|..|:........|..:.|   :...|::.|:|. |.|.
  Fly    84 VPVQSPVDNPLDPADCSQREKYRKQPVATPSSRLRKCCPHGENLN---IYRENQSDSMCD-NGLL 144

  Fly   743 NF------AILMD------------------------VVDEHQHSLFTMFDGNMRIF-------- 769
            :|      |:|.|                        :.|:.....|.:.||::.|.
  Fly   145 SFEPTIISAVLFDNCIEDLEVETTLDYDIGNPCNSSLLYDDKDDVFFVLQDGSLLIIDKFGNESY 209

  Fly   770 ----------------------------------IYISIGI-----CVVFIVIALLTLKLFNGVF 795
                                              :::::.:     |::.:....:||:|...:.
  Fly   210 TVKEHYCLDIDKSGHLFAFTCVTQVEEQIAFAKVVFVAVLMLISMPCLLLVSYLHMTLRLLRNLH 274

  Fly   796 VKSARTSIYTSIYLCL----LAIELLFLLGIEQTETSIFCGFITIFLHCAILSGTAWF------- 849
            ..|     .:.:.|||    ....::.:.||...      |||...:...|||...|:
  Fly   275 GLS-----LSLMSLCLASGYFVHSVVHIYGIPNQ------GFIGYVIQFCILSYFFWYLCICFNV 328

  Fly   850 ----------CYEAFHSYSTLTSDELLLEVDQTPKVNCYYLLSYGLSLSVVAIS----LVIDPST 900
                      |.:...|::|.             ...||.:.::....::||::    |...||.
  Fly   329 LLNVWYKLPCCIQCSKSWATF-------------NFACYAVFAFSGPATIVALTVQKGLPGMPSY 380

  Fly   901 YTQNDYCVLMEA------------NALFYATFVIPVLVFFVAAIGYTFLSWIIMCRKSRTGLKTK 953
            :.|.    |.|:            :.:.:.:|::.::.||    |:..:|......|:....|..
  Fly   381 FLQG----LTESIRDSQRYFIPPVSTILFLSFLLNIISFF----GFQRISGYAKAEKNIQERKCL 437

  Fly   954 -EHTRLASVRFDIRCSFVFLLLLSAVWCSAY--FYLRGAKMDDDTADVYGYCFIC--FNTLLGLY 1013
             :..:...|:.|.:|..:..:::...|....  || .|:..:        |..:|  .|.|.|::
  Fly   438 FDQQKYEDVKKDAKCVSLLGIIMVVSWLLEIITFY-SGSNSN--------YLILCDMVNGLQGVW 493

  Fly  1014 IFVFHCIQNEKIRREYRKYVRQHAW 1038
            :.:...:    :||  |:.:....|
  Fly   494 VLLIFLV----VRR--RRTIILRWW 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328
		GAIN	453..680	CDD:293098	12/54 (22%)
		GPS	705..752	CDD:197639	12/76 (16%)
		7tm_4	763..1014	CDD:304433	52/339 (15%)
mthl14	NP_728509.1	7tmB3_Methuselah-like	239..512	CDD:320167	52/319 (16%)
		TM helix 1	241..266	CDD:320167	1/24 (4%)
		TM helix 2	275..297	CDD:320167	4/26 (15%)
		TM helix 3	306..331	CDD:320167	5/24 (21%)
		TM helix 4	349..369	CDD:320167	4/32 (13%)
		TM helix 5	389..418	CDD:320167	3/32 (9%)
		TM helix 6	445..472	CDD:320167	4/26 (15%)
		TM helix 7	477..502	CDD:320167	5/36 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462167
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930