DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cirl and Adgre1

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	NP_001007558.1	Gene:	Adgre1 / 316137	RGDID:	1359214	Length:	932	Species:	Rattus norvegicus

Alignment Length:	1116	Identity:	245/1116 - (21%)
Similarity:	392/1116 - (35%)	Gaps:	302/1116 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 GNVEWSVNCMFPKSLSVLNSRCAHKQSCGVLAATSMFGDPCPGTHKYLEAHYQCISAAQTSTTTN 124
            |...|.:.     :|::|..|......|.....       ||       |:..|....::...|.
  Rat    14 GTHRWGMT-----TLAILGQRLNGVNECQDTTT-------CP-------AYATCTDTTESYYCTC 59

  Fly   125 RPSPPPWVLSNGPPIFGNGSGL-----------IHPPG---VGAGAPPPPRLPTLPGVVG----- 170
            :....|   |||...| .|.|:           ..|.|   |....|...|...|.|...
  Rat    60 KQGFLP---SNGQTNF-QGPGVECQDVNECLRSDSPCGSNSVCTNIPGRARCSCLSGFSSSAGGS 120

  Fly   171 -ISGNPGLF-----------NVPPQHTAVTHSTPSSSTTAVGGGRLKGGAT----STTTTKHPAG 219
             |.|:||.|           .:.|:::..::|..|.|.|. ..|.:..|:|    ....|::...
  Rat   121 WILGSPGHFLCTDVDECLTIGICPKNSNCSNSVGSYSCTC-QSGFVSNGSTCEDEDECVTRNACP 184

  Fly   220 RHDGLPPPPQLHHHHNHHG----------------------EDTASPTKPSSKLPAGGNAT--SP 260
            .|...         ||..|                      |::.......|:     |:|  .|
  Rat   185 EHATC---------HNTLGSYYCTCNEGLEFSGGGPMFQGLEESCEDVDECSR-----NSTLCGP 235

  Fly   261 SNTRILT-GVGGSGTDDGTLLTTKSSPNRPPGTAASGS---------VVPGNGSVVRTINNINLN 315
            |...|.| |........|..|:|...|..|    |.|:         :.|.|.|...|:.:....
  Rat   236 SFICINTLGSYSCSCPAGFSLSTFQIPGHP----ADGNCTDIDECDDICPSNSSCTNTLGSYFCT 296

  Fly   316 AAGMSGGDDESKLFCGPTHA-RNLYWNMT--RVGDVNVQPCPGGAAGIAKWRCVLMKRIPDSGYD 377
                          |.|..| .|...|.|  .|...::..|...     .:||         |.:
  Rat   297 --------------CHPGFASSNGQLNFTDQEVTCEDIDECTQD-----PFRC---------GRN 333

  Fly   378 EYDDDISSTTPAPSGGDCLHNSSSCEPPVSMAHKVNQRLRNF---------EPTWHPATPDLTQC 433
                  ||.|..|...:|     ||.|...|....:|...||         :....|.:..:.||
  Rat   334 ------SSCTNVPGSYNC-----SCLPDFRMDPGGSQAHGNFTCKRIPFKCKEDLIPKSEQIEQC 387

  Fly   434 RSLWLNNLEMRVNQRDSSLISIANDMSEVTSSKTLYGGDMLVTTKIIQTVSEKMMHDKETFPDQR 498
            ::....||:.      :|..:..|                 .|..|:....|     .::.|...
  Rat   388 QAGQGRNLDY------TSFCTFVN-----------------ATFTILDNTCE-----NKSAPVSL 424

  Fly   499 QREAMIMELLHCVVKTGSNLLDESQLSSWLDLNPEDQMRVATSLLTGLEYNAFLLADTIIRERSV 563
            |..|           |..:|:.| |.|:|.:.:.|:...:.|.||..:|  :.:||..:....:.
  Rat   425 QSAA-----------TSVSLMLE-QASTWFEFSREETSTLGTILLETVE--STMLAALLTPSGNA 475

  Fly   564 VQKVKNILLSVRVLETKTIQSSVVFPDSDQWPLS------SDRIELPRAALIDNSEGGLVRIVFA 622
            .|.::.        |...|:|.|:..:.::..:|      .|::::....:.::...|...:.|.
  Rat   476 SQTIRT--------EYLEIESKVINEECNEENVSINLKARGDKMDVGCFIIKESESTGTPGVAFV 532

  Fly   623 AFDRLESILKPSYDHFDLKSSRSYVRNTAILSNDSDVNAGEIQQRLRILNSKVISASLGKGRHIQ 687
            :|..::|:|...:                       ...|:...:|| :||.|:..::...|...
  Rat   533 SFAHMDSVLDERF-----------------------FEDGQASWKLR-MNSHVVGGTVTGERKED 573

  Fly   688 LSQPITLTLKHLKTENVTNPT-CVFWN--YIDHAWSANGCSLESTNRTHSVCSCNHLTNFAILMD 749
            .|:||..||:|::.:..:..: ||.||  ..|..|:.:||.....:.||:|||||.:||.||:|
  Rat   574 FSKPIVYTLQHIQPKQKSERSICVSWNTDVEDGRWTPSGCETVEASETHTVCSCNRMTNLAIIM- 637

  Fly   750 VVDEHQHSLFTMFDGNMRIFIYISIGICVVFIVIALLTLKLFNGVFVKSARTSIYTSIYLCLLAI 814
                 .....|| :.::.|..|:...|.:|.:.:|:.|..||..  |::..|.::..:.:||...
  Rat   638 -----ASGELTM-EFSLYIISYVGTVISLVCLALAIATFLLFRA--VQNHNTYLHLHLCVCLFLA 694

  Fly   815 ELLFLLGIEQTETSIFCGFITIFLHCAILSGTAWFCYEAFHSYSTLTSDELLLEVDQTPKVNCYY 879
            ::|||.||::|:....|..|..|||...|:...|...||.         .|.|.|.....|| |:
  Rat   695 KILFLTGIDKTDNQTACAIIAGFLHYLFLACFFWMLVEAV---------MLFLMVRNLKVVN-YF 749

  Fly   880 -----------LLSYGLSLSVVAISLVIDPSTYTQNDYCVLMEANALFYATFVIPVLVFFVAAIG 933
                       ...|||.:.||.||..:.|..|..::.|.| .....|..:|:.||.:  :..|.
  Rat   750 SSRNIKMLHLCAFGYGLPVVVVIISATVHPWGYGMHNRCWL-NTETGFIWSFLGPVCM--IITIN 811

  Fly   934 YTFLSWIIMCRKSRTGLKTKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLRGAKMDDDTADV 998
            ...|:|.:...:.:......|.::|...|.....:...:.:|...|....|.:      ...|.:
  Rat   812 SALLAWTLWVLRQKLCSVNSEVSKLKDTRLLTFKAIAQIFILGCSWVLGIFQI------GPLASI 870

  Fly   999 YGYCFICFNTLLGLYIFVFHCIQNEKIRREYRKYVRQHAWLPKCLRCSKTSISSGIVTGNGPTAG 1063
            ..|.|...|:|.|.:||:.||:.|.::|.||||           |...||.:||     :..|:|
  Rat   871 MAYLFTTINSLQGAFIFLIHCLLNRQVRDEYRK-----------LLTRKTDLSS-----HSQTSG 919

  Fly  1064 TLCS--VSTSK 1072
            .|.|  .||||
  Rat   920 ILLSSMPSTSK 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328	9/52 (17%)
		GAIN	453..680	CDD:293098	38/232 (16%)
		GPS	705..752	CDD:197639	20/49 (41%)
		7tm_4	763..1014	CDD:304433	63/261 (24%)
Adgre1	NP_001007558.1	EGF_CA	33..63	CDD:238011	6/43 (14%)
		EGF_CA	81..>109	CDD:214542	5/27 (19%)
		EGF_CA	133..172	CDD:214542	8/39 (21%)
		EGF_CA	173..>203	CDD:214542	5/38 (13%)
		EGF_CA	222..255	CDD:214542	9/37 (24%)
		cEGF	245..275	CDD:289433	7/33 (21%)
		EGF_CA	272..>301	CDD:214542	6/42 (14%)
		EGF_CA	319..359	CDD:284955	13/64 (20%)
		Cell attachment site. /evidence=ECO:0000255	507..509		0/1 (0%)
		GPS	592..641	CDD:197639	20/54 (37%)
		7tm_2	646..886	CDD:278432	63/260 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45134
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12011
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.000