DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cirl and Adgrb2

DIOPT Version :10

Sequence 1:NP_001260807.1 Gene:Cirl / 35846 FlyBaseID:FBgn0033313 Length:1711 Species:Drosophila melanogaster
Sequence 2:NP_001101384.1 Gene:Adgrb2 / 313058 RGDID:1309431 Length:1560 Species:Rattus norvegicus


Alignment Length:1551 Identity:320/1551 - (20%)
Similarity:522/1551 - (33%) Gaps:398/1551 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 KLTIECDPGDVINLI--RANYGRF-SITICNDHGNVEWSVNCMFPKSLSVLNSRCAHKQSCGVLA 91
            :|.:..:|.:...|:  .|...|| .:.:.|::.:.:::...:           |...:.||..|
  Rat   149 QLCLSAEPSEAPRLLAPAALAFRFVEVLLINNNNSSQFTCGVL-----------CRWSEECGRAA 202

  Fly    92 ATSM-FGDP---CPGTHKYLEAHYQCISAAQTSTTTNRPSPP-PWVLSN-------GPP----IF 140
            ..:. |..|   |||            .|..:..||..|.|| ...|||       .||    :.
  Rat   203 GRACGFAQPGCSCPG------------EAGASPATTTPPGPPAAHTLSNALVPGGPAPPAEADLH 255

  Fly   141 GNGSGLIHPPGVGAGAPPP---------PRLPTLPGV-VGISGNPGLFNVPP------------- 182
            ...|..:....:..|..|.         ||....||: :..:|:|......|             
  Rat   256 SGSSNDLFTTEMRYGEEPEEEPKVKTQWPRSADEPGLYMAQTGDPAAEEWSPWSVCSLTCGQGLQ 320

  Fly   183 QHTAVTHSTP----------------SSSTTAVGGGRLKGGATSTTTTKHPAGRHDGLPP--PPQ 229
            ..|....|:|                :|:|..|.|...:.|:.|..:.....|....:..  |||
  Rat   321 VRTRSCVSSPYGTLCSGPLRETRPCNNSATCPVHGVWEEWGSWSLCSRSCGRGSRSRMRTCVPPQ 385

  Fly   230 LHHHHNHHGEDTASP---TKPSSKLPAGGNATSPSNTRILT----GVGGSGTDDGT-LLTTKSSP 286
                  |.|:....|   ||..|.      |..|...:.|.    |...|...:|| ..:.|.|.
  Rat   386 ------HGGKACEGPELQTKLCSM------AACPVEGQWLEWGPWGPCSSSCANGTQQRSRKCSV 438

  Fly   287 NRPPGTAASGSVVPGNGSVVRTINNINLNAAGMSGGDDESKLFCGPTHARNLYW----NMTRVGD 347
            ..|.....:|::..     .|..:|.:..|.....|...:...|..|  .:..|    .|.:...
  Rat   439 AGPAWATCAGALTD-----TRECSNFDCPATDGKWGPWNAWSLCSKT--CDTGWQRRFRMCQASG 496

  Fly   348 VNVQPCPGGAAGIAKWRCVLMKRIP---DSGYDEYDDDISSTTPAPSGGDCLHNSSSCEPPVSMA 409
            ....||.|....:   :....||.|   :...|||  .:..|....:.|:.::|  .| ||.:..
  Rat   497 TQGYPCEGTGEEV---KPCSEKRCPAFHEMCRDEY--VMLMTWKRAAAGEIIYN--KC-PPNASG 553

  Fly   410 HKVNQRLRNFEPTWHPATPDLTQC-----RSLWLNNLE-MRVNQR---DSSLISIANDMSEVTSS 465
            ....:.|.:.:...:...|...:|     |.|:|:..| :...||   ...:..:...:.|:.:.
  Rat   554 SASRRCLLSAQGVAYWGLPSFARCISHEYRYLYLSLREHLAKGQRMLAGEGMSQVVRSLQELLAR 618

  Fly   466 KTLYGGDMLVTTKIIQTVSEKMMHDKETF---PDQRQREAMIMELLHCVVKTGSNLLDESQLSSW 527
            :|.|.||:|.:..|::.|::..  .:.|:   .|..||...::          |.::|......|
  Rat   619 RTYYSGDLLFSVDILRNVTDTF--KRATYVPSADDVQRFFQVV----------SFMVDSENKDKW 671

  Fly   528 LDLNPEDQMRV---ATSLLTGLEYNAFLLADTIIRERSVVQKVKNILLSVRVLETKTIQSSVVFP 589
                 :|..:|   :..||..:|....|:.|.:...:|.:....|:::|::......:.|.:.||
  Rat   672 -----DDAQQVSPGSVHLLRVVEDFIHLVGDALKAFQSSLIVTDNLVISIQREPISAVSSDITFP 731

  Fly   590 -----DSDQWPL-SSDRIELPRAALIDNSEG-----GLVRIVFAAFDRLESILK----PSYDHF- 638
                 ....|.. |.||:.||:..|..:|.|     |..........|....:.    |::... 
  Rat   732 MRGRRGMKDWVRHSEDRLFLPKEVLSLSSPGKPATPGAATAGSPGRGRGPGTVPPGPGPAHQRLL 796

  Fly   639 --DLKSSRSYVRNTAILSNDSDVNAGEIQQRLRILNSKVISASLGKGRHIQLSQPITLTLKHLKT 701
              |.:.|.||....|:|.....:.....:..|.: .|:|::.::...........||:.|.:: .
  Rat   797 PADPEESSSYFVIGAVLYRTLGLILPPPRPPLAV-TSRVMTVTVRPPTQPPAEPLITVELSYI-I 859

  Fly   702 ENVTNPTCVFWNY--IDHA---WSANGCSLESTNRTHSVCSCNHLTNFAILMDVVDEHQHSLFTM 761
            ...|:|.|..|:|  .|.:   |:...|....|...|:.|.|.||:.||:|.    :....|...
  Rat   860 NGTTDPHCASWDYSRADASLGDWNTESCQTLETQAAHTRCQCQHLSTFAVLA----QPPKDLTLE 920

  Fly   762 FDGNMRIFIYISIGICVVFIVIALLTLKLFNGV---FVKSARTSIYTSIYLCLLAIELLFLLGIE 823
            ..|...:.:.|.   |.| ..:|||||......   |:||.|:.|..:..|.:||..:|.|:|..
  Rat   921 LAGAPSVPLVIG---CAV-SCMALLTLLAIYAAFWRFIKSERSIILLNFCLSILASNILILVGQS 981

  Fly   824 QTETSIFCGFITIFLHCAILSGTAWFCYEAFHSYSTLTSDELLLEVDQTPKVNCYYL-LSYGLSL 887
            :..:...|.....|||...||...|...||:.||..:....      :|..|...:| |.:||..
  Rat   982 RVLSKGVCTMTAAFLHFFFLSSFCWVLTEAWQSYLAVIGRM------RTRLVRKRFLCLGWGLPA 1040

  Fly   888 SVVAISLVIDPST-YTQNDYCVLMEANALFYATFVIPVLVFFVAAIGYTFLSWIIMCRK--SRTG 949
            .|||:|:....:. |..:.||.|.....|.|| ||.|..|..:.    ..|..||:..|  :|.|
  Rat  1041 LVVAVSVGFTRTKGYGTSSYCWLSLEGGLLYA-FVGPAAVIVLV----NMLIGIIVFNKLMARDG 1100

  Fly   950 LKTKEHTRLASVRFDIRC----------------------------------SFVFLLLLSAVWC 980
            :..|...:.|...   ||                                  |.|.|.||:..|.
  Rat  1101 VSDKSKKQRAGSE---RCPWASLLLPCSACGAVPSPLLSSASARNAMASLWSSCVVLPLLALTWM 1162

  Fly   981 SAYFYLRGAKMDDDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYRKYVRQHAWLPKCLRC 1045
            ||..     .|.|..:.::...|..||:..|..|...||.    :|||.:..|       ||   
  Rat  1163 SAVL-----AMTDRRSVLFQALFAVFNSAQGFVITAVHCF----LRREVQDVV-------KC--- 1208

  Fly  1046 SKTSISSGIVTGNGPTAGTLCSVSTSKKPKLPLGV--SEEAHDDPQQQQQTPVPITED------- 1101
                                           .:||  ::|:.|.|...:...:.|..|       
  Rat  1209 -------------------------------QMGVCRTDESEDSPDSCKNGQLQILSDFEKDVDL 1242

  Fly  1102 ----------------AIMGATSDCELNEAQQRRTLKSGLMTGTLQAPPQTLGGHVVLERGSTLR 1150
                            .|.|..|...|:|.::.::...|...|...:|   |.|::::...:   
  Rat  1243 ACQTVLFKEVNTCNPSTITGTLSRLSLDEDEEPKSCLVGPEGGLSFSP---LPGNILVPMAA--- 1301

  Fly  1151 STGHASPTSSAGSTHLIFAHKQQQQQQQQGPL---GESYYHQPDYYSWKQPST------------ 1200
            |.|...|                ...|:..|:   ||....|.| .:|.:||.            
  Rat  1302 SPGLGEP----------------PPPQETNPVYMCGEGGLRQLD-LTWLRPSEPGSEGDYMVLPR 1349

  Fly  1201 ----------GTGGLKTPREYYNNAGAAASSPQQAHEVFYWTQKPNS----GHNGKKKRGAGGVP 1251
                      ||||.:.||      .....:|::|.:....|:...|    .|:|.....|.|..
  Rat  1350 RTLSLQPGGGGTGGEEAPR------ARPEGTPRRAAKTVAHTEGYPSFLSVEHSGLGLGPAYGSL 1408

  Fly  1252 ASPSGSLHS---RTAAASQVLFYPSYKKTKPGQPTGYPQYAEALDPPLATGNAAAYYQQQQQLRR 1313
            .:|.|....   .|.:|.||.......:|.|....|......:|              ::::||.
  Rat  1409 QNPYGMTFQPPPPTPSARQVPEPGERSRTMPRTVPGSTMKLGSL--------------ERKKLRY 1459

  Fly  1314 QQLHQQQQQQQQQQLSSDEEQAEQHAHLLHLQRRAGSQQQLPAPP---PHMAQYQQ 1366
            ..|..::....:::.|....:..|..|.....|...|.::.|:||   |.::|:::
  Rat  1460 SDLDFEKVMHTRKRHSELYHELNQKFHTFDRYRSQSSAKEKPSPPGGRPGLSQHRR 1515

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CirlNP_001260807.1 Gal_Rha_Lectin_dCirl 22..113 CDD:438687 16/89 (18%)
GAIN 451..682 CDD:465137 49/254 (19%)
GPS 705..752 CDD:197639 17/51 (33%)
7tmB2_CELSR_Adhesion_IV 763..1035 CDD:320557 83/312 (27%)
TM helix 1 765..790 CDD:320557 8/24 (33%)
TM helix 2 801..823 CDD:320557 7/21 (33%)
TM helix 3 832..859 CDD:320557 10/26 (38%)
TM helix 4 875..895 CDD:320557 9/20 (45%)
TM helix 5 913..942 CDD:320557 9/28 (32%)
TM helix 6 960..987 CDD:320557 10/60 (17%)
TM helix 7 997..1022 CDD:320557 7/24 (29%)
Herpes_TAF50 <1219..1365 CDD:308764 31/155 (20%)
Adgrb2NP_001101384.1 AGRB_N 26..220 CDD:465991 16/93 (17%)
TSP1 304..352 CDD:214559 6/47 (13%)
TSP1 357..407 CDD:214559 13/61 (21%)
TSP1 412..462 CDD:214559 11/54 (20%)
TSP1 468..518 CDD:214559 10/54 (19%)
HormR 521..585 CDD:214468 13/68 (19%)
GAIN 604..>759 CDD:465137 35/171 (20%)
GPS 863..916 CDD:197639 17/56 (30%)
7tmB2_BAI2 922..1212 CDD:320654 85/357 (24%)
TM helix 1 924..949 CDD:320654 8/28 (29%)
TM helix 2 959..981 CDD:320654 7/21 (33%)
TM helix 3 990..1018 CDD:320654 10/27 (37%)
TM helix 4 1028..1048 CDD:320654 8/19 (42%)
TM helix 5 1066..1095 CDD:320654 10/33 (30%)
TM helix 6 1142..1169 CDD:320654 8/31 (26%)
TM helix 7 1174..1199 CDD:320654 7/28 (25%)

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