DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cirl and Adgrb2

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	NP_001101384.1	Gene:	Adgrb2 / 313058	RGDID:	1309431	Length:	1560	Species:	Rattus norvegicus

Alignment Length:	1551	Identity:	320/1551 - (20%)
Similarity:	522/1551 - (33%)	Gaps:	398/1551 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 KLTIECDPGDVINLI--RANYGRF-SITICNDHGNVEWSVNCMFPKSLSVLNSRCAHKQSCGVLA 91
            :|.:..:|.:...|:  .|...|| .:.:.|::.:.:::...:           |...:.||..|
  Rat   149 QLCLSAEPSEAPRLLAPAALAFRFVEVLLINNNNSSQFTCGVL-----------CRWSEECGRAA 202

  Fly    92 ATSM-FGDP---CPGTHKYLEAHYQCISAAQTSTTTNRPSPP-PWVLSN-------GPP----IF 140
            ..:. |..|   |||            .|..:..||..|.|| ...|||       .||    :.
  Rat   203 GRACGFAQPGCSCPG------------EAGASPATTTPPGPPAAHTLSNALVPGGPAPPAEADLH 255

  Fly   141 GNGSGLIHPPGVGAGAPPP---------PRLPTLPGV-VGISGNPGLFNVPP------------- 182
            ...|..:....:..|..|.         ||....||: :..:|:|......|
  Rat   256 SGSSNDLFTTEMRYGEEPEEEPKVKTQWPRSADEPGLYMAQTGDPAAEEWSPWSVCSLTCGQGLQ 320

  Fly   183 QHTAVTHSTP----------------SSSTTAVGGGRLKGGATSTTTTKHPAGRHDGLPP--PPQ 229
            ..|....|:|                :|:|..|.|...:.|:.|..:.....|....:..  |||
  Rat   321 VRTRSCVSSPYGTLCSGPLRETRPCNNSATCPVHGVWEEWGSWSLCSRSCGRGSRSRMRTCVPPQ 385

  Fly   230 LHHHHNHHGEDTASP---TKPSSKLPAGGNATSPSNTRILT----GVGGSGTDDGT-LLTTKSSP 286
                  |.|:....|   ||..|.      |..|...:.|.    |...|...:|| ..:.|.|.
  Rat   386 ------HGGKACEGPELQTKLCSM------AACPVEGQWLEWGPWGPCSSSCANGTQQRSRKCSV 438

  Fly   287 NRPPGTAASGSVVPGNGSVVRTINNINLNAAGMSGGDDESKLFCGPTHARNLYW----NMTRVGD 347
            ..|.....:|::..     .|..:|.:..|.....|...:...|..|  .:..|    .|.:...
  Rat   439 AGPAWATCAGALTD-----TRECSNFDCPATDGKWGPWNAWSLCSKT--CDTGWQRRFRMCQASG 496

  Fly   348 VNVQPCPGGAAGIAKWRCVLMKRIP---DSGYDEYDDDISSTTPAPSGGDCLHNSSSCEPPVSMA 409
            ....||.|....:   :....||.|   :...|||  .:..|....:.|:.::|  .| ||.:..
  Rat   497 TQGYPCEGTGEEV---KPCSEKRCPAFHEMCRDEY--VMLMTWKRAAAGEIIYN--KC-PPNASG 553

  Fly   410 HKVNQRLRNFEPTWHPATPDLTQC-----RSLWLNNLE-MRVNQR---DSSLISIANDMSEVTSS 465
            ....:.|.:.:...:...|...:|     |.|:|:..| :...||   ...:..:...:.|:.:.
  Rat   554 SASRRCLLSAQGVAYWGLPSFARCISHEYRYLYLSLREHLAKGQRMLAGEGMSQVVRSLQELLAR 618

  Fly   466 KTLYGGDMLVTTKIIQTVSEKMMHDKETF---PDQRQREAMIMELLHCVVKTGSNLLDESQLSSW 527
            :|.|.||:|.:..|::.|::..  .:.|:   .|..||...::          |.::|......|
  Rat   619 RTYYSGDLLFSVDILRNVTDTF--KRATYVPSADDVQRFFQVV----------SFMVDSENKDKW 671

  Fly   528 LDLNPEDQMRV---ATSLLTGLEYNAFLLADTIIRERSVVQKVKNILLSVRVLETKTIQSSVVFP 589
                 :|..:|   :..||..:|....|:.|.:...:|.:....|:::|::......:.|.:.||
  Rat   672 -----DDAQQVSPGSVHLLRVVEDFIHLVGDALKAFQSSLIVTDNLVISIQREPISAVSSDITFP 731

  Fly   590 -----DSDQWPL-SSDRIELPRAALIDNSEG-----GLVRIVFAAFDRLESILK----PSYDHF- 638
                 ....|.. |.||:.||:..|..:|.|     |..........|....:.    |::...
  Rat   732 MRGRRGMKDWVRHSEDRLFLPKEVLSLSSPGKPATPGAATAGSPGRGRGPGTVPPGPGPAHQRLL 796

  Fly   639 --DLKSSRSYVRNTAILSNDSDVNAGEIQQRLRILNSKVISASLGKGRHIQLSQPITLTLKHLKT 701
              |.:.|.||....|:|.....:.....:..|.: .|:|::.::...........||:.|.:: .
  Rat   797 PADPEESSSYFVIGAVLYRTLGLILPPPRPPLAV-TSRVMTVTVRPPTQPPAEPLITVELSYI-I 859

  Fly   702 ENVTNPTCVFWNY--IDHA---WSANGCSLESTNRTHSVCSCNHLTNFAILMDVVDEHQHSLFTM 761
            ...|:|.|..|:|  .|.:   |:...|....|...|:.|.|.||:.||:|.    :....|...
  Rat   860 NGTTDPHCASWDYSRADASLGDWNTESCQTLETQAAHTRCQCQHLSTFAVLA----QPPKDLTLE 920

  Fly   762 FDGNMRIFIYISIGICVVFIVIALLTLKLFNGV---FVKSARTSIYTSIYLCLLAIELLFLLGIE 823
            ..|...:.:.|.   |.| ..:|||||......   |:||.|:.|..:..|.:||..:|.|:|..
  Rat   921 LAGAPSVPLVIG---CAV-SCMALLTLLAIYAAFWRFIKSERSIILLNFCLSILASNILILVGQS 981

  Fly   824 QTETSIFCGFITIFLHCAILSGTAWFCYEAFHSYSTLTSDELLLEVDQTPKVNCYYL-LSYGLSL 887
            :..:...|.....|||...||...|...||:.||..:....      :|..|...:| |.:||..
  Rat   982 RVLSKGVCTMTAAFLHFFFLSSFCWVLTEAWQSYLAVIGRM------RTRLVRKRFLCLGWGLPA 1040

  Fly   888 SVVAISLVIDPST-YTQNDYCVLMEANALFYATFVIPVLVFFVAAIGYTFLSWIIMCRK--SRTG 949
            .|||:|:....:. |..:.||.|.....|.|| ||.|..|..:.    ..|..||:..|  :|.|
  Rat  1041 LVVAVSVGFTRTKGYGTSSYCWLSLEGGLLYA-FVGPAAVIVLV----NMLIGIIVFNKLMARDG 1100

  Fly   950 LKTKEHTRLASVRFDIRC----------------------------------SFVFLLLLSAVWC 980
            :..|...:.|...   ||                                  |.|.|.||:..|.
  Rat  1101 VSDKSKKQRAGSE---RCPWASLLLPCSACGAVPSPLLSSASARNAMASLWSSCVVLPLLALTWM 1162

  Fly   981 SAYFYLRGAKMDDDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYRKYVRQHAWLPKCLRC 1045
            ||..     .|.|..:.::...|..||:..|..|...||.    :|||.:..|       ||
  Rat  1163 SAVL-----AMTDRRSVLFQALFAVFNSAQGFVITAVHCF----LRREVQDVV-------KC--- 1208

  Fly  1046 SKTSISSGIVTGNGPTAGTLCSVSTSKKPKLPLGV--SEEAHDDPQQQQQTPVPITED------- 1101
                                           .:||  ::|:.|.|...:...:.|..|
  Rat  1209 -------------------------------QMGVCRTDESEDSPDSCKNGQLQILSDFEKDVDL 1242

  Fly  1102 ----------------AIMGATSDCELNEAQQRRTLKSGLMTGTLQAPPQTLGGHVVLERGSTLR 1150
                            .|.|..|...|:|.::.::...|...|...:|   |.|::::...:
  Rat  1243 ACQTVLFKEVNTCNPSTITGTLSRLSLDEDEEPKSCLVGPEGGLSFSP---LPGNILVPMAA--- 1301

  Fly  1151 STGHASPTSSAGSTHLIFAHKQQQQQQQQGPL---GESYYHQPDYYSWKQPST------------ 1200
            |.|...|                ...|:..|:   ||....|.| .:|.:||.
  Rat  1302 SPGLGEP----------------PPPQETNPVYMCGEGGLRQLD-LTWLRPSEPGSEGDYMVLPR 1349

  Fly  1201 ----------GTGGLKTPREYYNNAGAAASSPQQAHEVFYWTQKPNS----GHNGKKKRGAGGVP 1251
                      ||||.:.||      .....:|::|.:....|:...|    .|:|.....|.|..
  Rat  1350 RTLSLQPGGGGTGGEEAPR------ARPEGTPRRAAKTVAHTEGYPSFLSVEHSGLGLGPAYGSL 1408

  Fly  1252 ASPSGSLHS---RTAAASQVLFYPSYKKTKPGQPTGYPQYAEALDPPLATGNAAAYYQQQQQLRR 1313
            .:|.|....   .|.:|.||.......:|.|....|......:|              ::::||.
  Rat  1409 QNPYGMTFQPPPPTPSARQVPEPGERSRTMPRTVPGSTMKLGSL--------------ERKKLRY 1459

  Fly  1314 QQLHQQQQQQQQQQLSSDEEQAEQHAHLLHLQRRAGSQQQLPAPP---PHMAQYQQ 1366
            ..|..::....:::.|....:..|..|.....|...|.::.|:||   |.::|:::
  Rat  1460 SDLDFEKVMHTRKRHSELYHELNQKFHTFDRYRSQSSAKEKPSPPGGRPGLSQHRR 1515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328	15/86 (17%)
		GAIN	453..680	CDD:293098	49/250 (20%)
		GPS	705..752	CDD:197639	17/51 (33%)
		7tm_4	763..1014	CDD:304433	76/291 (26%)
Adgrb2	NP_001101384.1	TSP1	304..352	CDD:214559	6/47 (13%)
		TSP1	357..407	CDD:214559	13/61 (21%)
		TSP1	412..462	CDD:214559	11/54 (20%)
		TSP1	468..518	CDD:214559	10/54 (19%)
		HormR	521..585	CDD:214468	13/68 (19%)
		GAIN	605..>762	CDD:293098	36/173 (21%)
		GPS	863..916	CDD:197639	17/56 (30%)
		7tm_2	922..1191	CDD:278432	76/291 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010