Protein Alignment Cirl and Adgrg6

DIOPT Version :9

• Sequence 1: NP_001260807.1
• Gene: Cirl / 35846
• FlyBaseID: FBgn0033313
• Length: 1711
• Species: Drosophila melanogaster
• Sequence 2: XP_218313.7
• Gene: Adgrg6 / 308376
• RGDID: 1308551
• Length: 1248
• Species: Rattus norvegicus
• Alignment Length: 1217
• Identity: 254/1217 - (20%)
• Similarity: 408/1217 - (33%)
• Gaps: 399/1217 - (32%)

  Fly    32 TIECD-------PGDVINLIRANYGRFSITICNDHGNVE----WSVNCMFPKSLSVLNSRCAHKQ 85
            ||.||       |||...|:    |.....|.:..|:|.    |:.. |.|||||.|
  Rat   274 TIPCDLTIGTVVPGDGTLLL----GSDRDEIASLKGSVYNFRLWNFT-MDPKSLSNL-------- 325

  Fly    86 SCGVLAATSMFGDPCPGTHKYLEAHYQCISAAQTSTTTNRPSP-PPWVLSNGPPIFGNGSGLIHP 149
            ||      ||.|:.....:.:.....|.:.|....:..:...| |...|:|...:.......:.|
  Rat   326 SC------SMSGNVIDWHNDFWSISTQALKAENNLSCGSYLIPLPAAELTNCSDLGTLCQATVSP 384

  Fly   150 PGVGAGAPPPPRLPTLPGVVGISGNPGLFNVPPQHTAVTHSTPSSSTTAVGGGRLKGGATSTTTT 214
            |     .||.|.:.|              |:|                              .|.
  Rat   385 P-----TPPSPIVTT--------------NIP------------------------------VTN 400

  Fly   215 KHPAGRHDGL--PPPPQLHHHHNHHGEDTASPTKPSSKLPAGGNATSPS--------NTRILTGV 269
            :....::||:  .....:|:..||      ...:..||:....|||..:        |......:
  Rat   401 RIRKQKNDGIMYRISVVIHNDLNH------PEVRVQSKVAEWLNATFQNWNYTVYVVNISFHQDL 459

  Fly   270 GGSG-------TDDG------TLLTTKSSPNRPPGTAASGSVVPGNGSVVRTINNINLNAAGMSG 321
            |...       .||.      .||...::.|           |..||.::.  ..::.|.|.:..
  Rat   460 GEDRMKVKRDVMDDDKRLVLWALLVYNATNN-----------VSLNGEMIE--QKLSANNASLED 511

  Fly   322 GDDESKLFCGPTHARNLYWNMTRVGDVNVQPCPGGAAGIAKWRCVLMKRIPDSGYDEYDDDISST 386
            |....|:            ::.::|..|....|.|    .||..     |..|.|.:
  Rat   512 GIRLCKV------------DVKQLGMCNTLGDPEG----FKWTA-----ISPSVYKQ-------- 547

  Fly   387 TPAPSG------GDCLHNSSSCEPPVSMAHKVNQRLRNFEPTWHPATPDLTQCRSLWLNNLEMRV 445
             |.|:.      ..||.|.:|                   ..|.|.  |.:.|
  Rat   548 -PCPNKPGFFMMRTCLCNETS-------------------TFWGPI--DASNC------------ 578

  Fly   446 NQRDSSLISIANDMSEVTSSKTLYGGDMLVTTKIIQTVSE-KMMHDKETFPDQRQREAMIMELLH 509
             .|.|:  .:||::.::|..     |..|.:..|...|.: |.:.:||...|:.....::....:
  Rat   579 -SRQSN--EVANEILDLTGD-----GQNLTSANINSIVEQVKRIVNKEENIDRTLGSTLMNIFSN 635

  Fly   510 CVVKTGSNLLDES--------QLSSWLDLNPEDQMRVATSLLTGLEYNAFLLADTIIRERSVVQK 566
            .:..:.||||:.|        :|:..:|||....:.:.|
  Rat   636 ILSSSDSNLLESSTEALKTIDELAFKIDLNSTPHVNIET-------------------------- 674

  Fly   567 VKNILLSVRVLETKT---IQSSVVFPDSDQWPLSSDRIELPRAALIDNSEGGLVRIVFAAFDRLE 628
             :|:.|.|..|...|   ...|:..|.::......|         .:|.:...:..|....:.||
  Rat   675 -QNLALGVSSLMPGTNAPSNFSIGLPSNNDSYFQMD---------FENGQADPLASVILPPNLLE 729

  Fly   629 SILKPSYDHFDLKSSRSYVRNTAILSNDSDVNAGEIQQRLRILNSKVISASLGKGRHIQLSQPIT 693
            : |.|.......::..::...|.:..        ::..:.:||.|.|::.|:|......|..|:.
  Rat   730 N-LSPEDSILVRRAQFTFFNKTGLFQ--------DVGSQRKILVSYVMACSIGNITIQNLKDPVQ 785

  Fly   694 LTLKHLKTENVTNPTCVFWNYIDH----AWSANGCSLES-TNRTHSVCSCNHLTNFAILMDV--- 750
            :.:||.:|:.|..|.|.||:...:    .|:.:||...| ::...::|.|||.|:|.:|||:
  Rat   786 IKIKHTRTQEVHQPICAFWDLNQNKSFGGWNTSGCVAHSDSDAGETICLCNHFTHFGVLMDLPRS 850

  Fly   751 ---VDEHQHSLFTMFDGNMRIFI-YISIGICVVFIVIALLTLKLFNGVFVKSAR---TSIYTSIY 808
               :|.....:.|        || ||..||..:|....|||...|.    |..|   :.|..::.
  Rat   851 ASQIDGRNTKVLT--------FITYIGCGISAIFSAATLLTYVAFE----KLRRDYPSKILMNLS 903

  Fly   809 LCLLAIELLFLLG--IEQTETSIFCGFITIFLHCAILSGTAWFCYEAFHSYSTLTSDELLLEVDQ 871
            ..||.:.|:|||.  |.....:..|..:...||..:|:...|...||.|.|..|.
  Rat   904 SALLFLNLIFLLDGWITSFGVAGLCTAVAALLHFFLLATFTWMGLEAIHMYIALV---------- 958

  Fly   872 TPKV-NCY---YLLSY-----GLSLSVVAISL-------VIDPSTY---TQNDYCVLMEANALFY 917
              || |.|   |:|.:     ||...||:|.|       |....:|   ..:::|.:.:
  Rat   959 --KVFNTYIHRYILKFCIIGWGLPALVVSIILVSRKQNEVYGKESYGKDQDDEFCWIQD------ 1015

  Fly   918 ATFVIPVLVFFVAAIGYTFLSWII-----------MC-RKSRTGLKTKEHTRLASVRFDIRCSFV 970
                 || ||:|:..||..:.:.:           :| |..:...:|.....|.::|..:..:|
  Rat  1016 -----PV-VFYVSCAGYFGIMFFLNVAMFIVVMVQICGRNGKRSNRTLREEVLRNLRSVVSLTF- 1073

  Fly   971 FLLLLSAVWCSAYFYLRGAKMDDDTADVYG-------YCFICFNTLLGLYIFVFHCIQNEKIRRE 1028
               ||...|..|:|             .:|       |.|..||:|.||:||:|||...|.::::
  Rat  1074 ---LLGMTWGFAFF-------------AWGPLNIPFMYLFSIFNSLQGLFIFIFHCAMKENVQKQ 1122

  Fly  1029 YRKYV--------RQHAW--------------LPKCLRCSKTSISSGIVTGNGPTAGTLC----- 1066
            :|:::        ....|              |.|.|..|....:|..:|....::.|..
  Rat  1123 WRRHLCCGRFRLADNSDWSKTATNIIKKSSDNLGKSLSSSSIGSNSTYLTSKSKSSSTTYFKRNS 1187

  Fly  1067 -SVSTSKKPKLPLGVSEEAHDDPQQQQQTPVPITEDAIMG---ATSD 1109
             |.|||....|    |:..|...:|....||....|.:.|   |.||
  Rat  1188 HSDSTSMDKSL----SKLTHAGGEQTSIIPVHQVIDKVKGYCNAHSD 1230

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328	24/90 (27%)
		GAIN	453..680	CDD:293098	40/238 (17%)
		GPS	705..752	CDD:197639	17/57 (30%)
		7tm_4	763..1014	CDD:304433	72/294 (24%)
Adgrg6	XP_218313.7	CUB	38..146	CDD:238001
		LamG	178..337	CDD:304605	25/81 (31%)
		GPS	799..844	CDD:280071	14/44 (32%)
		7tm_4	861..1108	CDD:304433	73/299 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810