DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cirl and Adgrg7

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	NP_001100568.1	Gene:	Adgrg7 / 304014	RGDID:	1307217	Length:	785	Species:	Rattus norvegicus

Alignment Length:	674	Identity:	138/674 - (20%)
Similarity:	256/674 - (37%)	Gaps:	161/674 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   438 LNNLEMRVNQRDSSLISIANDMSEVTS-SKTLYGGDMLVTTKIIQTVSEKMMHDKETFPDQRQRE 501
            |..||.::|...::..:|::|...:|: :..|...::...|.::..:..|..:...
  Rat   143 LEILEKQINDISNNSQNISSDAQVLTTDASKLTAENITSATTVVGQIFNKTRNANS--------- 198

  Fly   502 AMIMELLHCVVKTGSNLLDESQLSSWLDLNPEDQMRVATSLLTGLEYNAFLLADTIIRERSV-VQ 565
                |.....|.|.|.:||.|: ..:......|.....::|:..:|..:|.|.|..:.|.:| :|
  Rat   199 ----EAKKVAVTTVSQILDASE-DVFQKAAENDNSNSFSNLIEQMENYSFSLGDEAVVEPNVAIQ 258

  Fly   566 KVK-------NILLSVRVLETKTIQSSVVFPDSDQWPLSSD-RIELPRAALIDNSEGGLVRIVFA 622
            .|.       ::|.||:...:.::.||....:.....|..| :.||   .::.|:.|......|.
  Rat   259 SVSRNSDSGPSVLFSVQKGSSDSLVSSETSINKTADELKPDGQTEL---QILLNTGGNKNSCGFV 320

  Fly   623 AFDRLESILKPSYDHFDLKSSRSYVRNT----AILSNDSDVNAGEIQQRLRILNSKVISASLGKG 683
            .           |.:..|..|:::...:    .|:|  |.|||.|.:|
  Rat   321 V-----------YQNHKLFQSKTFTATSDFSQKIIS--SKVNASEQEQ----------------- 355

  Fly   684 RHIQLSQPITLTLKHLKTENVTNPT------------CVFWNYIDHAWSANGCSLESTNRTHSV- 735
                         .::..:.|.|||            ||:||.:...|...||. :|.|.:..:
  Rat   356 -------------NNVSVKMVFNPTYDKREFQLYSYACVYWNILKKDWDTAGCQ-KSVNASGFLG 406

  Fly   736 CSCNHLTNFAILMDVVDEHQHSLFTMFDGNMRIFIYISIGICVVFIVIALLTLKLFNGVFVKSAR 800
            |.|||.||||:||....::::.  ...|....|...:||....:.|:..:||.|:     .|::.
  Rat   407 CQCNHTTNFAVLMSFKKDYKYP--KSLDVLSNIGCALSIAGLAITILFQILTRKI-----RKTSV 464

  Fly   801 TSIYTSIYLCLLAIELLFLLGIEQTETSI---------------------------FCGFITIFL 838
            |.:..|:.:.:|...|||:.|||.:..::                           .|..|...|
  Rat   465 TWVLVSLCISMLIFNLLFVFGIENSNKNLKTSDSNINANPNENKIPETDTIETPNPSCTAIAALL 529

  Fly   839 HCAILSGTAWFCYEAFHSYSTLTSDELLLEVDQTPK------VNCYYLLSYGLSLSVVAISLVID 897
            |..:|....|         :.|::.:|...:.:|.|      :....|:.:|:...:|.:::.|.
  Rat   530 HYFLLGTFTW---------NGLSATQLYFLLIRTMKPLPRHFIVIISLVGWGVPAIIVGVTIGII 585

  Fly   898 PS----------TYTQNDYCVLME------ANALFYATFVIPVLVFFVAAIG-YTFLSWIIMCRK 945
            .:          .|.|.:.|.|..      |.:....:|::||.:..:..|. :..::..::.:.
  Rat   586 YALSGNKSYWELDYRQEEICWLAVPKNNDFARSPLLWSFIMPVTIILITNIAIFVIITVKVLWKN 650

  Fly   946 SRTGLKTKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLRGAKMDDDTADVYGYCFICFNTLL 1010
            ::....||:.:.|..|...:..:.||    ...|..||..|..   :||...|:.|.|..|||..
  Rat   651 NQNLTSTKKVSSLKKVLSTLSIAVVF----GVTWIFAYAMLIN---NDDIRIVFSYIFCLFNTTQ 708

  Fly  1011 GLYIFVFHCIQNEKIRREYRKYVR 1034
            ||.||:.:.::.:..:.|..|.::
  Rat   709 GLQIFILYTVRTKVFQNEASKILK 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328
		GAIN	453..680	CDD:293098	46/240 (19%)
		GPS	705..752	CDD:197639	22/59 (37%)
		7tm_4	763..1014	CDD:304433	61/300 (20%)
Adgrg7	NP_001100568.1	GPS	378..418	CDD:396408	17/40 (43%)
		7tmB2_GPR128	428..727	CDD:320385	63/321 (20%)
		TM helix 1	431..455	CDD:320385	5/23 (22%)
		TM helix 2	465..486	CDD:320385	6/20 (30%)
		TM helix 3	523..545	CDD:320385	6/30 (20%)
		TM helix 4	565..581	CDD:320385	3/15 (20%)
		TM helix 5	617..640	CDD:320385	4/22 (18%)
		TM helix 6	666..688	CDD:320385	6/25 (24%)
		TM helix 7	695..720	CDD:320385	10/24 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810