DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cirl and Adgrb3

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	NP_001100368.1	Gene:	Adgrb3 / 301309	RGDID:	1309703	Length:	1522	Species:	Rattus norvegicus

Alignment Length:	1035	Identity:	217/1035 - (20%)
Similarity:	363/1035 - (35%)	Gaps:	305/1035 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   306 VRTINNINLNAAGMSGGDDESKL-----------FCGPTHARNLYWNMTRVGDVNVQPCPGGAAG 359
            |||...:.:......|..:|.:.           .|......::.|..|..||:....||..|.|
  Rat   479 VRTCQGVTVTGQQCEGTSEEIRRCSEQRCPAPYEICPEDVLISMVWKRTPAGDLAFNQCPLNATG 543

  Fly   360 IAKWRCVLMKRIPDSGYDEYDDDISSTTPAPSGGDCLHNSSSCEPPVSMAHKVNQRLRNFEPTWH 424
            ....||.|                           .||..:|.|.| |.|..::...|:.:   |
  Rat   544 TTSRRCSL---------------------------SLHGVASWEQP-SFARCISNEYRHLQ---H 577

  Fly   425 PATPDLTQCRSLWLNNLEMRVNQRDSSLISIANDMSEVTSSKTLYGGDMLVTTKIIQTVSEKMMH 489
            .....|.:.:.:...:          .:..:...:.::|..|..|.||:||:.:|::.|:
  Rat   578 SIKEHLAKGQRMLAGD----------GMSQVTKTLLDLTQRKNFYAGDLLVSVEILRNVT----- 627

  Fly   490 DKETFPDQRQREAMIMELLHCVVKTGSNLLDESQLSSWLDLNPEDQMRV---ATSLLTGLE---- 547
              :||  :|.......:.:....:..||||||.....|     ||..::   :..|:..:|
  Rat   628 --DTF--KRASYIPASDGVQNFFQIVSNLLDEENKEKW-----EDAQQIYPGSIELMQVIEDFIH 683

  Fly   548 ---------YNAFLLADTIIRERSVVQKVKNILLSVRVLETKTIQSSVVFPDSDQ-----WPLSS 598
                     .|::|:..             |::.|::.|...::.:.:.||...:     |..:|
  Rat   684 IVGMGMMDFQNSYLMTG-------------NVVASIQKLPAASVLTDINFPMKGRKGMVDWARNS 735

  Fly   599 -DRIELPRAAL-------IDNSEGGLVRIVFAAFDRLESILKPSYDHFD--LKSSRSYVRNTAIL 653
             ||:.:|::..       :|.|.      ||.    |.::|   |.:.|  |.:.|:|.
  Rat   736 EDRVVIPKSIFTPVSSKELDESS------VFV----LGAVL---YKNLDLILPTLRNYT------ 781

  Fly   654 SNDSDVNAGEIQQRLRILNSKVISASLGKGRHIQLSQP------ITLTLKHLKTENVTNPTCVFW 712
                            ::|||:|..::       ..:|      :.:.|.|| .....||.||.|
  Rat   782 ----------------VVNSKIIVVTI-------RPEPKRTDAFLEIELAHL-ANGTLNPYCVLW 822

  Fly   713 -----NYIDHAWSANGCSLESTNRTHSVCSCNHLTNFAILMDVVDEHQHSLFTMFDGNMRIFIYI 772
                 |.....||..||....|:.:|:.|.|:.|:.||||.    :....:.....|...:.:.:
  Rat   823 DDSKSNESLGTWSTQGCKTVLTDASHTKCLCDRLSTFAILA----QQPREIVMESSGTPSVTLIV 883

  Fly   773 SIGI-CVVFIVIALLTLKLFNGVFVKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITI 836
            ..|: |:..|.:|::...|:.  :::|.|:.|..:..|.:::..:|.|:|..||.....|...|.
  Rat   884 GSGLSCLALITLAVVYAALWR--YIRSERSIILINFCLSIISSNILILVGQTQTHNKSICTTTTA 946

  Fly   837 FLHCAILSGTAWFCYEAFHSYSTLTSDELLLEVDQTPKVNC------YYLLSYGLSLSVVAISLV 895
            |||...|:...|...||:.||..:|.           |:..      :..|.:||...|||.|:.
  Rat   947 FLHFFFLASFCWVLTEAWQSYMAVTG-----------KIRTRLIRKRFLCLGWGLPALVVATSVG 1000

  Fly   896 IDPST-YTQNDYCVLMEANALFYA-----------TFVIPVLVF--FVAAIGYTFLSWIIMCR-- 944
            ...:. |..:.||.|.....|.||           ..||.:|||  .|:..|       |:.:
  Rat  1001 FTRTKGYGTDHYCWLSLEGGLLYAFVGPAAAVVLVNMVIGILVFNKLVSRDG-------ILDKKL 1058

  Fly   945 KSRTGLKTKEHTRLASVRFDIRC-------------------------SFVFLLLLSAVWCSAYF 984
            |.|.|..::.|:.|.     ::|                         |.|.|.||:..|.||..
  Rat  1059 KHRAGQMSEPHSGLT-----LKCAKCGVVSTTALSAATASNAMASLWSSCVVLPLLALTWMSAVL 1118

  Fly   985 YLRGAKMDDDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYRKYVRQHAWLPKCLRCSKTS 1049
                 .|.|..:.::...|..|::|.|..|.:.|||...:::..:|..:|      .|.......
  Rat  1119 -----AMTDKRSILFQILFAVFDSLQGFVIVMVHCILRREVQDAFRCRLR------NCQDPINAD 1172

  Fly  1050 ISSGIVTGNGPTAGTLCSVSTSKKPKLPLGVSEEAHDDPQQQQQTPVPITEDAIMGATSDCELN- 1113
            .||....|:       ..:.|..:..:.:......|.|..       |.....|.|..|...||
  Rat  1173 SSSSFPNGH-------AQIMTDFEKDVDIACRSVLHKDIG-------PCRAATITGTLSRISLND 1223

  Fly  1114 EAQQRRTLKSGLMTGTL----------QAP-----PQTLG--GHVVLERGST-LRSTGHASPTSS 1160
            |.:::.|...||...||          |.|     |.::.  .:..|::.:| ||.|.:.....:
  Rat  1224 EEEEKGTNPEGLSYSTLPGNVISKVIIQQPTALHMPMSMNELSNPCLKKENTELRRTVYLCTDDN 1288

  Fly  1161 AGSTHLIFAHKQQQQQQQQGPLGESYY---------HQPDYYSWKQPSTGTGGLKT-PRE 1210
            .....:...|.|::..       ||.|         .||   |.|:.|....|::| |.|
  Rat  1289 LRGADMDIVHPQERMM-------ESDYIVMPRSSVSTQP---SMKEESKMNIGMETLPHE 1338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328
		GAIN	453..680	CDD:293098	50/257 (19%)
		GPS	705..752	CDD:197639	19/51 (37%)
		7tm_4	763..1014	CDD:304433	70/298 (23%)
Adgrb3	NP_001100368.1	TSP1	296..343	CDD:214559
		TSP1	348..398	CDD:214559
		TSP1	403..452	CDD:214559
		TSP1	458..508	CDD:214559	5/28 (18%)
		HormR	510..576	CDD:214468	20/93 (22%)
		GAIN	595..792	CDD:293098	50/258 (19%)
		GPS	816..867	CDD:197639	19/54 (35%)
		7tm_2	876..1143	CDD:278432	69/296 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010