DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cirl and Adgrf3

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	XP_006239862.1	Gene:	Adgrf3 / 298857	RGDID:	1305868	Length:	992	Species:	Rattus norvegicus

Alignment Length:	783	Identity:	163/783 - (20%)
Similarity:	285/783 - (36%)	Gaps:	230/783 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   340 WNMTRVGDVNVQPCPGGAAGIAKWRCVLMKRIPDSGYDEYDDDISSTTPAPSGGDCLHNSSSCEP 404
            ||:|:.|.:...|||....|:.|..|                        .|.|
  Rat   362 WNVTKAGFMAQAPCPMNKTGVVKRLC------------------------GSNG----------- 391

  Fly   405 PVSMAHKVNQRLRNFEPTWHPATPDLTQCRSLWLNN-----LE------------MRVNQRDSSL 452
                             .|.|.....|:.:.|.|.:     ||            :|..||...:
  Rat   392 -----------------IWGPVQDSCTEAKILDLYSKAKLLLEGQGKPNEQVPRILRELQRQVGV 439

  Fly   453 ISIANDMSEVTSSKTLYGGDMLVTTKIIQTVSEKMMHDKETFPDQRQREAMIMELLHCVVKTGSN 517
            :|..:|:.|:..:.||       ..|::...|.::            .:..:.:||    .|...
  Rat   440 VSTPSDLREMLHTVTL-------LAKVVAETSTEL------------TDRALKDLL----TTTDK 481

  Fly   518 LLDESQLSSWLDLNPEDQMRVATSLLTGLEYNAFLLADTIIRERSVVQ-----KVKNILLSVRVL 577
            :||.:..|.| .|....:..:.:..|..:|        |::...|..|     ...|:||..::|
  Rat   482 ILDVNISSLW-TLARAQEPSMGSDFLKAVE--------TLVHSVSPQQHPFSFSSSNVLLQSQLL 537

  Fly   578 ETKTIQSSVVFPDSDQWPLSSDRIE--LP---RAALIDNSEGGLVRIVFAAFDRLESILKPSYDH 637
            ...:       |...|.|.:...::  :|   .|.|:.|  |..|||...|..:|:|.|..:|
  Rat   538 RHSS-------PLGYQMPSAPPLLQARIPWHSLAPLVLN--GTNVRITSLALQKLDSRLPSNY-- 591

  Fly   638 FDLKSSRSYVRNT-----------AILSNDSDVNAGEIQQRLRILNSKVISASLGKGRHIQLSQP 691
                  |..:|:|           :|.::..|....|:     |::.:.::.:|
  Rat   592 ------RQGLRDTSYATPGMILVISITADGQDFTQAEV-----IMDFEDMNGTL----------- 634

  Fly   692 ITLTLKHLKTENVTNPTCVFWNYIDH-------AWSANGCSLESTNRTHSVCSCNHLTNFAILMD 749
                  |          ||||   ||       .||..||.|::.|.:...|.|.|||.|:|||.
  Rat   635 ------H----------CVFW---DHNAFQGRGGWSDEGCELQAANASAVQCVCRHLTAFSILMS 680

  Fly   750 VVDEHQHSLFTMFDGNMRIFIYISIGICVVFIVIALLTLKLFNGVFVKS-----ARTSIYTSIYL 809
                 ||::  ..|..:.:...:.:|..::.:::.|:..:|...|.|::     ..|:::..: :
  Rat   681 -----QHAV--PEDPLLDLLSQVGVGASILALLVCLVIYRLVWRVVVRNKVAFFRHTALFNMV-I 737

  Fly   810 CLLAIELLFLLG--IEQTETSIFCGFITIFL-HCAILSGTAWFCYEAFHSYSTLTSDELLLEVDQ 871
            |||..:..||..  :.....|:.| ..|.|| |...|:...|...:|.     :.:.:||....|
  Rat   738 CLLVADTCFLGNPWLPSGYHSLVC-LATAFLCHFFYLATFFWMLAQAL-----VLAHQLLFVFHQ 796

  Fly   872 TPK---VNCYYLLSY--GLSLSVVAISLVIDPSTYTQNDYCVLMEANALFYATFVIPVLVFFVAA 931
            ..|   ::...:|.|  .|..:.|.:.|.:....|.:...|:|.......:| |..|||. .|:.
  Rat   797 LSKPLVLSMMSILGYLCPLGFAGVTLGLYLPQRKYLREGKCLLSGDGVSLHA-FSEPVLA-IVSV 859

  Fly   932 IGYTFLSWII-MCRKSRT-GLKTKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLRGAKMDDD 994
            .|...:..:: :.|.|.: |...::...|..|   ::...:...:....|......|....:
  Rat   860 NGLVLVIAVLKLLRPSLSEGPAVEKRQALVGV---LKALLILTPIFGLTWGLGVTTLFEGSL--- 918

  Fly   995 TADVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYRKYVRQHAWLPKCLRCSKTSISSGIVTGNG 1059
               |:.|.|:..|:|.|::||||.|:.::|:....||::|..       |.|.::||  :||...
  Rat   919 ---VFHYIFVILNSLQGVFIFVFGCLTDKKVLEALRKWLRGS-------RSSNSAIS--MVTNES 971

  Fly  1060 PTA 1062
            .|:
  Rat   972 CTS 974

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328
		GAIN	453..680	CDD:293098	47/247 (19%)
		GPS	705..752	CDD:197639	21/53 (40%)
		7tm_4	763..1014	CDD:304433	53/265 (20%)
Adgrf3	XP_006239862.1	HRM	353..>395	CDD:295297	13/84 (15%)
		GPS	632..679	CDD:197639	21/76 (28%)
		7tm_4	687..935	CDD:304433	53/265 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810