Protein Alignment Cirl and Adgrg3

DIOPT Version :9

• Sequence 1: NP_001260807.1
• Gene: Cirl / 35846
• FlyBaseID: FBgn0033313
• Length: 1711
• Species: Drosophila melanogaster
• Sequence 2: XP_038954076.1
• Gene: Adgrg3 / 291854
• RGDID: 1305674
• Length: 574
• Species: Rattus norvegicus
• Alignment Length: 538
• Identity: 126/538 - (23%)
• Similarity: 199/538 - (36%)
• Gaps: 92/538 - (17%)

  Fly   531 NPEDQMRVATSLLTGLEYNAFLLADTIIRERSVVQKVKNILLSVRVLETKTIQSSVVFPDSDQWP 595
            |||:...|. .|....|||.|.|:|.........|...|      ..|...:|...:..:|....
  Rat    54 NPEEPRNVC-RLKEDYEYNTFDLSDIAQCFTKCGQSDTN------SCEVGNLQRYWLNYESHLLE 111

  Fly   596 LSSDRIELPRA-ALIDN-----SEGGLVRIVFAAFDR---------LESILKPSYDHFDLKSSRS 645
            .|.:.:::|.. |||.|     ||..|..:|.:...|         .:.:..|......|..:||
  Rat   112 NSMETVDMPFVKALIQNISTDVSEDLLYSLVPSQIPRQVMRGEDQPADRVRLPKSLFGALPGNRS 176

  Fly   646 YVRNTAILSNDSDVNAGEIQQRLR--------ILNSKVISASLGKGRHIQLSQPITLTLKHLKTE 702
            .||....:.|   :..|.:.:..|        :||::::..|:|:.....||:|:.:|..|....
  Rat   177 AVRLAITILN---IGPGNVFKGPRLLEDKGSSVLNNRMVGLSVGQMHATGLSEPVEITFSHQHQS 238

  Fly   703 NVTNPTCVFWNYIDHAWSANGCSLE-STNRTHSVCSCNHLTNFAILM-DVVDEHQHSLFTMFDGN 765
            .....|||||:.....|.::|||.| ...||  ||.|:|||.||:|: ..:|:......|.....
  Rat   239 PNVILTCVFWDMAKGDWDSHGCSTEPGDGRT--VCRCDHLTFFALLLRPTLDQATARTLTRISQA 301

  Fly   766 MRIFIYISIGICVVFIVIALLTLKLFNGVFVKSARTSIYTSIYLCLLAIELLFLLGIEQTETS-- 828
            ......|.:...:|..|....:|:.|..........::.||::|    :.|.||:.:......
  Rat   302 GSAVSMIFLAFTMVLYVAFRFSLQRFKSEDAPKIHMALSTSLFL----LNLTFLINVGSGSQGPP 362

  Fly   829 IFCGFITIFLHCAILSGTAWFCYEAFHSYSTLTSDELLLEVDQTPKVNCYY--------LLSYGL 885
            ..|.......|..:|....|...||||.|.      |:::|     .|.|:        ||.:||
  Rat   363 ASCWVRAAIFHYFLLCVFTWMGLEAFHLYL------LVIKV-----FNTYFGHYFLKLSLLGWGL 416

  Fly   886 SLSVV---------AISLVIDPSTYTQNDYCVLMEANALFYATFVIPVLVFFVAAIGYTFLSWII 941
            .:.:|         .:..:.|....|..:.|...:..||:.......::.|...|:....::|.|
  Rat   417 PVLIVIGVGSSNSYGVYTIRDQENRTSLELCWFQKEPALYATVHGYFLVTFLFGAVVLAMVAWKI 481

  Fly   942 MCRKSRTGLKTKEHTRLASVRFDIRCSFVFLLLLSAV----WCSAYFYLRGAKMDDDTADVYGYC 1002
            ....|.|..|.:..|..         |.:.:|.||::    |..|.....|...        .|.
  Rat   482 FTLPSVTAGKGQGQTWK---------SVLTVLGLSSLVGMTWGLAVLTPLGLST--------VYI 529

  Fly  1003 FICFNTLLGLYIFVFHCI 1020
            |...|:|.||:||.:..|
  Rat   530 FTLLNSLQGLFIFCWFII 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328
		GAIN	453..680	CDD:293098	38/171 (22%)
		GPS	705..752	CDD:197639	21/48 (44%)
		7tm_4	763..1014	CDD:304433	55/273 (20%)
Adgrg3	XP_038954076.1	GPS	244..282	CDD:396408	20/39 (51%)
		7tm_GPCRs	292..551	CDD:421689	59/288 (20%)
		TM helix 1	294..319	CDD:410628	3/24 (13%)
		TM helix 2	333..355	CDD:410628	6/25 (24%)
		TM helix 3	366..393	CDD:410628	8/32 (25%)
		TM helix 4	406..426	CDD:410628	5/19 (26%)
		TM helix 5	454..481	CDD:410628	5/26 (19%)
		TM helix 6	495..522	CDD:410628	7/35 (20%)
		TM helix 7	524..549	CDD:410628	9/32 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810