Protein Alignment Cirl and CG15744

DIOPT Version :9

• Sequence 1: NP_001260807.1
• Gene: Cirl / 35846
• FlyBaseID: FBgn0033313
• Length: 1711
• Species: Drosophila melanogaster
• Sequence 2: NP_572870.2
• Gene: CG15744 / 2768909
• FlyBaseID: FBgn0030466
• Length: 1797
• Species: Drosophila melanogaster
• Alignment Length: 1746
• Identity: 337/1746 - (19%)
• Similarity: 555/1746 - (31%)
• Gaps: 605/1746 - (34%)

  Fly   218 AGRHDGLPPPPQLHHHHNHHGEDTASPTKPSSKLPAGGN-----------ATSPSNTRILTGVGG 271
            :.|...|.|||:.....|..|       .|..||..|.:           ...||..::
  Fly   182 SSREVRLQPPPKCESPGNFRG-------MPLKKLRVGKDFHCETLLQPLLELIPSQNQV------ 233

  Fly   272 SGTDDGTLLTTKSSPNRPPGTAASGSVVPGNGSVVRTINNINLNAAGMSGGDDESKLFCGPTHAR 336
              ..:|..|..|....|    .|.|        |.|...::...|....|..::.:       |:
  Fly   234 --AFEGDELQLKCHAPR----VAIG--------VPRESEDLPTKAYVFWGWSEKIR-------AK 277

  Fly   337 N-----LYWNMTRV-GDVNVQPCPGGAAGIAKWRCVLMKRIPDSGYDEYDDDISSTTPAPSG-GD 394
            |     :|.:.|:| ||||::                .:...|||..:....|:|.|...:| .|
  Fly   278 NSTEDIIYQDPTKVFGDVNLE----------------TRHSTDSGILQSILRIASLTQNHTGMWD 326

  Fly   395 CLHNSSS------------------CEPPVSMAHKVNQRLRNFEPTWH-PAT------------- 427
            |...|..                  ||..|...:|         .|:| |.|
  Fly   327 CTLRSQQANLSQAIVLHVVAKGTLYCEARVVHTNK---------GTYHWPRTMRGETVLQECVEE 382

  Fly   428 -PDLTQCRSL---------WLN----------------------NLEMRVNQRDSSLISIANDMS 460
             .|.||.|..         |||                      ||.:...|   :.:.||..:.
  Fly   383 PSDATQARRASHECGPSGEWLNLDTESCVYVSETTRILEQFAKVNLTLTKGQ---NALEIARRLH 444

  Fly   461 EVTSSKTLYG--GDMLVTTKIIQTVSEKMMHDKETFPDQRQREAMIMELLHCVVKTGSNLLDESQ 523
            ..|.::|...  .|.:....|.:|:.:.:  |:...|.|:|      |:.|.::...|.||:
  Fly   445 NFTQAQTQLNRIRDPMDLEYIARTLVKYL--DQLEQPQQQQ------EISHLLMDIVSQLLN--- 498

  Fly   524 LSSWLDLNPEDQMRVATSLLTGLEYNAFLLA-----------------DTIIRERSVVQKVKNIL 571
            |.:.|....:.:......||..:|.:|..||                 .::.::|::..:..||.
  Fly   499 LPAHLFRAAQSEQGTGQRLLHVVESSAMRLALASTQAEPLPAEMIPWRGSLAQQRNLFVEFFNIS 563

  Fly   572 LSVRV-LETKTIQSSVVFPDSDQWPLSSDRIELPRAALIDNSEGGLVRIVFAAFDRLESILKPSY 635
            |...| |....::.|   |...|...::|.|.:.....||    ..:::.::......:.|..:.
  Fly   564 LDAFVSLSCVWLEQS---PRGFQCNSANDTIPMYEHGDID----AAIQLPYSVIGNSSTTLPATT 621

  Fly   636 DHFDLKSSRSYVRNTAILSNDSDVNAGEIQQRLRILNSKVISASL-------GKGRHIQL----- 688
            ....|:...|..||..:|.|            ||..:::.:|:::       ..|..:|.
  Fly   622 TIRSLRLMISLHRNGKLLPN------------LRGSHNESLSSAIIGILAYSSDGEALQFRADNE 674

  Fly   689 --------SQPITLTLK-HLKTENVTNPTCVFWNYIDHAWSANGCSLESTNRTHSVCSCNHLTNF 744
                    .|.:|:.|: |.....::.|...:|:..:..|..:.|.....:||..:.||:....:
  Fly   675 LDPEEDVYQQRVTVMLRAHPYHNPLSAPQPAWWDADEQRWETSVCQQHYQHRTLVMFSCSRTGYY 739

  Fly   745 AILM------DVVDEHQHSLFTMFDGNMRIFIYISIGICVVFIVIALLTLKLF-NGVFVKSARTS 802
            .:|.      |...|...:.|.    :....:|...|:.........:|..:| ..|.:...:..
  Fly   740 GLLQRSQYLNDFRSEESGARFR----HPPAAVYAGCGLLFACCAFNAVTFAVFGRAVRINRVQRH 800

  Fly   803 IYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLH----CAILSGTAWFCYEAFHSYSTLTSD 863
            ...:.:|.|.|:.|.|.|||.||.:...|..:.:.:|    |.:|    |.|......|..||..
  Fly   801 ALVNTWLALGALALAFSLGIYQTASQPQCRLLGLLMHYLGLCVLL----WVCVSLSSMYKRLTKT 861

  Fly   864 -------------ELLLEVDQTPKVNCYYLLSYGLSLSVVAISLVIDPSTYTQNDYCVLMEA--- 912
                         |...|.::.|.:. .||:.:|::|.:..||..::.:.|...|||.|..:
  Fly   862 TTSGQGQCPGQDMEPQRERERKPILG-IYLVGWGIALLICGISSAVNLAEYATYDYCFLHSSTTL 925

  Fly   913 NALFYATFVIPVLVFFVAAIGYTFLS---------------------------------WIIMCR 944
            |||.....::.:....:|...|..||                                 |:....
  Fly   926 NALLVPAVILVIFCGILALCIYYQLSQQAVNVLQLQMQHQQNRQYSDNNTQATEHIDLDWLDANG 990

  Fly   945 KSRT-----------GLKTKEHTR---------LASVRFD--------IRCSFVFLLLLSAVWCS 981
            .:.|           |.|.::|.:         |:|:..|        :|..|:||:|.:..|.|
  Fly   991 SATTAAIGGGSGNHGGRKEQDHMQEQYSTLSNPLSSIVDDFERSNLSHLRGHFIFLVLYAGAWLS 1055

  Fly   982 AYFYLRGAKMDDDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYRKYVRQHAWLPKCLRCS 1046
            |..|:.|.:      ::|...|....::||:::.:|:.:.....|:         ||       |
  Fly  1056 AAAYVNGGQ------ELYVLSFAGCCSVLGIFLLIFYNLSRNDARQ---------AW-------S 1098

  Fly  1047 K----TSISSGIVTGNGPTAGTLCSVSTSKKPKLPLGVSEEAHDDPQQQQQTPVPITEDAIMGAT 1107
            :    .||.:.:||.|
  Fly  1099 QGRDGRSIPAKLVTYN------------------------------------------------- 1114

  Fly  1108 SDCELNEAQQRRTLKSGLMTGTLQAPPQT--LGGHVVLER-----GSTLRSTGHASPTSSAGSTH 1165
                 |.:|.|....|.:|.|     |.|  :...:|..:     ||...:...|...|::..:.
  Fly  1115 -----NGSQARGAHPSSMMPG-----PGTAMISNSIVAYKANPGPGSLYEANNSAGSRSNSQCSR 1169

  Fly  1166 LIFAHKQQQQQQQQGPLGESYYHQPDYYSWKQPSTGTGGLKTPREYYNNAGAAASSPQQAHEVFY 1230
            .:.:..:.|.:.||..|.:              :.|.||:    ...||...
  Fly  1170 SMRSQTRSQTRSQQEQLLQ--------------ANGAGGV----TIINNTSG------------- 1203

  Fly  1231 WTQKPNSGHN---GKKKRGAGGVPASPSGSLHSRTAAASQVLFYPSYKKTKPGQPTGYPQYAEAL 1292
               :|.:|..   |......||.|..|    ||..|     |.:.|.....|.        ||..
  Fly  1204 ---QPGAGGGPAAGGVSGSTGGAPVPP----HSLNA-----LLHGSSHDLIPS--------AEIF 1248

  Fly  1293 DPPLATGNAAAYYQQQQQL-RRQQLHQQQQQQQQQQLSSDEEQAEQHAHLLHLQRRAGSQQQLPA 1356
            ..|.....|..::::|::| :|.....|:|...|.||   :.|.:...|..|....|.|:|.
  Fly  1249 YNPNQINVARKFFKKQKRLAKRNNFELQRQTMPQMQL---QMQMQMQLHSQHSLSDASSEQL--- 1307

  Fly  1357 PPPHMAQYQQEFMQRQYRNKHSNCDLGMGDAYYNQGS-VGGADGGPVYEEILSNRNSDVQHYEVG 1420
                .:::..........:|.:|.:|    .|.|||| :.||               ..:|..:|
  Fly  1308 ----YSRHHNAMTMLAGGSKINNTNL----HYKNQGSPMAGA---------------PKEHGNMG 1349

  Fly  1421 DFDVDEVYNNSVGTGVFNNMRAAVAAGGSRYGGGSLSGGSVSSRSQQQQLKKQQQ-QQSLAQQRS 1484
                                  |:::||...........|.||.|:..|...... .::|..|..
  Fly  1350 ----------------------AMSSGGDSMQFKRFVPASASSASKIMQANIYTNIPETLTPQHE 1392

  Fly  1485 ARRCTAD----------------DDDDEDEEEDEE----ATAAEQLHDSVCDEDEEEDESDLEDD 1529
            ..:..|:                |||:|||||:|.    ||..|..|     |.||||.|.|::.
  Fly  1393 VIKLRANGRTRTPSLLDETLHELDDDEEDEEEEEHGQTPATMEEPEH-----ELEEEDASSLDEH 1452

  Fly  1530 ----AHGLPPQSDERMRRLMAMQDEDFKRRFQRQLRKHGAPLDYGA--------LPPGAGPQP-- 1580
                |:.|||.|.  |..|       |:.|..........|:...:        ||..:..:|
  Fly  1453 APLYANTLPPASG--MSSL-------FRNRGSSHQPMSSTPVKQPSLEAMNSLGLPEVSLEEPLL 1508

  Fly  1581 -EH-----NGAVFGVSGGVGEGSLRGAF--------RQQQQQALNAKSP----GGRLAVNELFGH 1627
             :|     |......|..:   .|...|        :|||.::||..|.    ||        |.
  Fly  1509 QKHEIYVSNSLQVTTSNSI---QLDDDFPSVLIRFSQQQQSKSLNNISEMLAGGG--------GG 1562

  Fly  1628 GNSGPPLP-----------PANQTPAQKRQQLQKLSPQSTTSSSSHTSHSNPNPHP 1672
            |.:.|.|.           ..|:....:.|||:::...|:::.|....|     ||
  Fly  1563 GGNAPGLDSLGDQQESSQLSVNEGSTLEEQQLRQIYSCSSSNLSQLKGH-----HP 1613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328
		GAIN	453..680	CDD:293098	47/246 (19%)
		GPS	705..752	CDD:197639	10/52 (19%)
		7tm_4	763..1014	CDD:304433	67/332 (20%)
CG15744	NP_572870.2	LRR_8	107..168	CDD:290566
		LRR_4	107..147	CDD:289563
		leucine-rich repeat	109..133	CDD:275378
		leucine-rich repeat	134..157	CDD:275378
		LRRCT	166..216	CDD:214507	11/40 (28%)
		IG_like	229..344	CDD:214653	30/157 (19%)
		HRM	<366..412	CDD:295297	9/45 (20%)
		7tm_4	768..>975	CDD:304433	45/211 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462143
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840