DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cirl and ADGRF1

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	NP_722582.2	Gene:	ADGRF1 / 266977	HGNCID:	18990	Length:	910	Species:	Homo sapiens

Alignment Length:	726	Identity:	154/726 - (21%)
Similarity:	264/726 - (36%)	Gaps:	214/726 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   375 GYDEYDDDISSTTPAPSG--GDCLHNSSSCEPP----------VSMAHKVNQRLRNFEPTWHPAT 427
            |:...||:.  |.|..||  |:.   ::.||..          :|:..::|   :||......||
Human   263 GFGSKDDEY--TLPCSSGYRGNI---TAKCESSGWQVIRETCVLSLLEELN---KNFSMIVGNAT 319

  Fly   428 PDLTQCRSLWLNNLEMRVNQRDS-------SLISIANDMSEVTSSKTLYGGDMLVTTKIIQTVSE 485
            ....   |.::.||.:.:.|..|       |::||.:::|.::.:...             .||.
Human   320 EAAV---SSFVQNLSVIIRQNPSTTVGNLASVVSILSNISSLSLASHF-------------RVSN 368

  Fly   486 KMMHDKETFPDQRQREAMIMELLHCVVKTGSNLLDESQLSSWLDLNPEDQMRVATSLLTGLEYNA 550
            ..|.|                    |:....|:|:.:.:::|            |.||...:|
Human   369 STMED--------------------VISIADNILNSASVTNW------------TVLLREEKY-- 399

  Fly   551 FLLADTIIRERSVVQKVKNILLSVRVLETKTIQSSVVFPDSDQWPLSSDRIELPRAALIDNSEGG 615
                                 .|.|:|||....|::|.|.:  .||:..|..:....:..|
Human   400 ---------------------ASSRLLETLENISTLVPPTA--LPLNFSRKFIDWKGIPVN---- 437

  Fly   616 LVRIVFAAFDRLESILKPSYDHFDLK----SSRSYVRNTAILSNDSDVNAGEIQQRLRILNSKVI 676
                        :|.||..|. :.:|    ::...:|...::.:|         |..|.|...:|
Human   438 ------------KSQLKRGYS-YQIKMCPQNTSIPIRGRVLIGSD---------QFQRSLPETII 480

  Fly   677 S-ASL--------GKGRHIQLSQPITLT-----------LKHLKTE-NVTNPTCVFWNYIDHAWS 720
            | |||        .|..:.|::.|:..|           |...|.| |::.|.||||::....|:
Human   481 SMASLTLGNILPVSKNGNAQVNGPVISTVIQNYSINEVFLFFSKIESNLSQPHCVFWDFSHLQWN 545

  Fly   721 ANGCSLESTNRTHSVCSCNHLTNFAILMDVVDEHQHSLF---TMFDGNMRIFIYISIGICVVFIV 782
            ..||.|.:..:....|.|.|||:|:|||        |.|   |:|. .::...|:.:||.:..::
Human   546 DAGCHLVNETQDIVTCQCTHLTSFSILM--------SPFVPSTIFP-VVKWITYVGLGISIGSLI 601

  Fly   783 IALLTLKLFNGVFVKSARTS-----IYTSIYLCLLAIELLFLLGIEQTET---SIFCGFITIFLH 839
            :.|:...|| ...:|.::||     ...:|.|.||..::.|::|.....|   |..|.....|.|
Human   602 LCLIIEALF-WKQIKKSQTSHTRRICMVNIALSLLIADVWFIVGATVDTTVNPSGVCTAAVFFTH 665

  Fly   840 CAILSGTAW-------FCYE---AFHSYSTLTSDELLLEVDQTPKVNCYYLLSYG--LSLSVVAI 892
            ...||...|       ..|.   .||.    .:..|::.|.        :.|.||  |.:||:.|
Human   666 FFYLSLFFWMLMLGILLAYRIILVFHH----MAQHLMMAVG--------FCLGYGCPLIISVITI 718

  Fly   893 SLVIDPSTYTQNDYCVLMEANALFYATFVIPVLVFFVAAIGYTFLSWIIMCR------KSRTGLK 951
            ::....:||.:.|.|.|..:|.      ..|:|.|.|.|:....::::::..      :...|.:
Human   719 AVTQPSNTYKRKDVCWLNWSNG------SKPLLAFVVPALAIVAVNFVVVLLVLTKLWRPTVGER 777

  Fly   952 TKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLRGAKMDDDTADVYGYCFICFNTLLGLYIFV 1016
            .....:...:|.. :...:...||...|....    |..:|.... .:...|...|...|.:|..
Human   778 LSRDDKATIIRVG-KSLLILTPLLGLTWGFGI----GTIVDSQNL-AWHVIFALLNAFQGFFILC 836

  Fly  1017 FHCIQNEKIRR 1027
            |..:.:.|:|:
Human   837 FGILLDSKLRQ 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328
		GAIN	453..680	CDD:293098	40/231 (17%)
		GPS	705..752	CDD:197639	18/46 (39%)
		7tm_4	763..1014	CDD:304433	56/276 (20%)
ADGRF1	NP_722582.2	SEA	154..>215	CDD:279699
		GPS	532..572	CDD:280071	15/39 (38%)
		7tm_4	582..834	CDD:304433	57/277 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810