DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cirl and Adgrf5

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	XP_038938942.1	Gene:	Adgrf5 / 245977	RGDID:	621679	Length:	1426	Species:	Rattus norvegicus

Alignment Length:	1148	Identity:	241/1148 - (20%)
Similarity:	396/1148 - (34%)	Gaps:	267/1148 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LSKYQTAYACEGKKLTIECDPGDVINLIRANY---GRFSI--------TICNDHGNVEWSVNCMF 70
            |:|.:....|:...:::.|...::.|..|..:   |:.:|        ......|..:.|||...
  Rat   386 LAKEERKVVCDNNPISLNCCSENIANWSRIEWKQEGKINIEGQTSKDEVHSTGRGRGDTSVNTGT 450

  Fly    71 PKSLSVLNSRCAHKQSCGVLAATSMFGDPCPGTHKYLEAHYQC-------------ISAAQTSTT 122
            |:  :.|.|.|    |...|.|.   |..||.........|.|             |:...||..
  Rat   451 PE--TDLESSC----STYTLKAD---GTQCPSGSSGTTVIYTCEFVSVYGAKGSKNIAVTFTSVG 506

  Fly   123 TNR------PSPPPWVLSNGPPIFGNGSGLIHPPGVGAGAPPPPRLPTLPGVVGISGNPGLFNVP 181
            .|.      |..|..|:.........|:.|    ...........|...|..:.:|..
  Rat   507 DNSSYKGEVPEAPRHVMEVSTVQSTTGNRL----ETSKSQEQQANLTITPDPISVSEG------- 560

  Fly   182 PQHTAVTHSTPSSS------TTAVG---------GGRLKGGATSTTTTKHPAGRHDGLPPPPQLH 231
             |..::|..:..||      .|:.|         ..|.:.||.|..|.|......:|      .:
  Rat   561 -QSFSITCLSDVSSFDEVYWNTSAGIKIHPRFYTMRRYRDGAESVLTVKTSTREWNG------TY 618

  Fly   232 H----HHNHHG----EDTASPTKPSS-----KLPAGGNATSPSNTRILTGVGGSGTDDGT--LLT 281
            |    :.|.:.    :.|..|....|     .|.|.|..||....:...     ..:||.  ::|
  Rat   619 HCIFRYKNSYSIATKDVTVHPLPLESDIMMDPLEASGLCTSSHQFKCCI-----EENDGEEYIVT 678

  Fly   282 TKSSPNRPPGTAASGSVVPGNGSVV--RTINNINLNAAGMSGGDDESKLFCGPTHA-----RNLY 339
            ..          ...|..|....|:  :.....:|.....|....:..:||..|:|     |:..
  Rat   679 FH----------VDSSSFPAEREVIGKQACYTYSLPGKLPSRCPKDIDVFCHFTNAANSSVRSPS 733

  Fly   340 WNMTRVGDVNVQPCPGGAAGIAKWRCVLMKRIPDSGYDEYDDDISSTTPAPSGG----DCLHNSS 400
            ..:|.|...|: .|.....||.:...|:.|....:|       :|.:.....||    .|:.:..
  Rat   734 MKLTLVPGKNI-TCQDPIIGIGEPGKVIQKLCQFAG-------VSRSPGQTIGGTVTYKCVGSQW 790

  Fly   401 SCEPPVSMAHKVNQRLRNFEPTWHPATPDLTQCRSLWLNNLEMRVNQRDSSLISIANDMSEVTSS 465
            ..|....::..:|..|:..:..  ..:|...|....:|.:|.:...:.:..:.|....:..:.|.
  Rat   791 KEETRACISAPINGLLQLAKAL--IKSPSQDQKLPKYLRDLSVSTGKEEQDIRSSPGSLGAIISI 853

  Fly   466 KTLYGGDMLVTTKIIQTVSEKMMHDKETFPDQRQREAMIMELLHCVVKTGSNLLDESQLSSWLDL 530
            .     |:|.|  :...|:.:||.|                    ::.|.:.:||:|.|:||..|
  Rat   854 L-----DLLST--VPTQVNSEMMRD--------------------ILATINVILDKSTLNSWEKL 891

  Fly   531 -----NPEDQM-----RVATSLLTGLEYNAFLLADTIIRERSVVQKVKNILLSVRVLETKTIQSS 585
                 |...|.     |.:.:|..|.....||....:..:..|:::.          ..:..|..
  Rat   892 LQQQSNQSSQFLQSVERFSKALELGDSTPPFLFHPNVQMKSMVIKRG----------HAQMYQQK 946

  Fly   586 VVFPDSDQW-PLSSDRIELPRAALIDNSEGGLVRIVFAAFDRLESILKPSYDHFDLKSSRSYVRN 649
            .||.|||.| .::.|..:|  .:|..:|.     ||..||..|:
  Rat   947 FVFTDSDLWGDVAIDECQL--GSLQPDSS-----IVTVAFPTLK--------------------- 983

  Fly   650 TAILSNDSDVNAGEIQQRLRILNSKVISASLGKGRHIQLSQP--ITLTLKHLKTENVTNPTCVFW 712
             |||:.|.        ||....||.|::.::..    .:.:|  |::|.|: ...:...|.||||
  Rat   984 -AILAQDG--------QRKTPSNSLVMTTTVSH----NIVKPFRISMTFKN-NHRSGGKPQCVFW 1034

  Fly   713 NYI----DHAWSANGCSLES---TNRTHSVCSCNHLTNFAILMDVVDEHQHSLFTMFDGNMRIFI 770
            |:.    ...|.::||::|.   .||....|.|||||:|:|||........||..:.   :.|..
  Rat  1035 NFSLANNTGGWDSSGCTVEDDGRDNRDRVFCKCNHLTSFSILMSPDSPDPGSLLKIL---LDIIS 1096

  Fly   771 YISIGICVVFIVIALLTLKLFNGVFVKSARTS-----IYTSIYLCLLAIELLFLLG-------IE 823
            ||.:|..:|.:. |.|.::......|...|||     ...:|.||||..::.|::.       ..
  Rat  1097 YIGLGFSIVSLA-ACLVVEAMVWKSVTKNRTSYMRHICIVNIALCLLIADIWFIVAGAIHDGHYP 1160

  Fly   824 QTETSIFCGFITIFLHCAILSGTAWFCYEAFHSYSTLTSDELLLEVDQTPKVNCYYLLSYGLSLS 888
            ..||:  |...|.|:|...||...|........:..|..  :|.:..::.:....:.|.||..|.
  Rat  1161 LNETA--CVAATFFIHFFYLSVFFWMLTLGLMLFYRLIF--ILHDASKSTQKAIAFSLGYGCPLI 1221

  Fly   889 VVAISL-VIDP-STYTQNDYCVLMEANALFYATFVIPVLVFFVAAIGYTFLSWIIMCRKSRTGLK 951
            :.:|:: |..| ..|.:.:.|.|...:......|.||.|:..|..:..|.   :::.:..|..:.
  Rat  1222 ISSITVGVTQPQEVYMRKNACWLNWEDTRALLAFAIPALIIVVVNVSITV---VVITKILRPSVG 1283

  Fly   952 TKEHTRLASVRFDIRCSF-VFLLLLSAVWCSAYFYLRGAKMDDDTADVYGYCFICFNTLLGLYIF 1015
            .|...:..|..|.|..|. |...||...|   .|.|  |.:...:..|:...|...|...||:|.
  Rat  1284 DKPGKQEKSSLFQISKSIGVLTPLLGLTW---GFGL--ATVIQGSNAVFHIIFTLLNAFQGLFIL 1343

  Fly  1016 VFHCIQNEKIRR------EYRKYVRQHAWLPKCLRCSKTSISS 1052
            :|.|:.::|::.      ...::..||:        ..||:.|
  Rat  1344 LFGCLWDQKVQEALLHKFSLSRWSSQHS--------KSTSLGS 1378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328	20/90 (22%)
		GAIN	453..680	CDD:293098	50/237 (21%)
		GPS	705..752	CDD:197639	22/53 (42%)
		7tm_4	763..1014	CDD:304433	62/265 (23%)
Adgrf5	XP_038938942.1	FR3	592..622	CDD:409353	8/35 (23%)
		Ig strand E	602..608	CDD:409353	2/5 (40%)
		Ig strand F	616..623	CDD:409353	2/12 (17%)
		CDR3	623..632	CDD:409353	1/8 (13%)
		GPS	1029..1076	CDD:396408	19/46 (41%)
		7tm_GPCRs	1090..1363	CDD:421689	66/288 (23%)
		TM helix 1	1091..1116	CDD:410628	7/28 (25%)
		TM helix 2	1131..1153	CDD:410628	6/21 (29%)
		TM helix 3	1167..1190	CDD:410628	6/22 (27%)
		TM helix 4	1210..1226	CDD:410628	4/15 (27%)
		TM helix 5	1248..1271	CDD:410628	5/22 (23%)
		TM helix 6	1295..1320	CDD:410628	10/29 (34%)
		TM helix 7	1325..1350	CDD:410628	8/24 (33%)
		SEA	181..273	CDD:396113
		IG	298..372	CDD:214652
		Ig_3	548..621	CDD:404760	17/86 (20%)
		FR1	548..567	CDD:409353	4/26 (15%)
		Ig strand A	548..551	CDD:409353	1/2 (50%)
		Ig strand A'	555..557	CDD:409353	0/1 (0%)
		Ig strand B	561..568	CDD:409353	2/6 (33%)
		CDR1	568..575	CDD:409353	2/6 (33%)
		Ig strand D	591..598	CDD:409353	1/6 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810