DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cirl and Adgrg4

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	NP_001349814.1	Gene:	Adgrg4 / 236798	MGIID:	2685213	Length:	3025	Species:	Mus musculus

Alignment Length:	1332	Identity:	277/1332 - (20%)
Similarity:	447/1332 - (33%)	Gaps:	431/1332 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 WSVNCMFPKSLSVLNSRCAHKQSCGVLA--ATSMFG--------DPCPGTHKYL------EAHYQ 112
            ::...|.|..:.|   ...|..| |.||  .||..|        .|...|.:.|      |:...
Mouse  1808 FTTKVMTPNRMEV---ETLHSPS-GTLATSTTSQIGLVSRDVTVMPLISTSESLPSLGISESTSL 1868

  Fly   113 CISAAQTSTT----------TNRPSPPPWVLSNGPPIFGNGSGLIHPPGVGAGAP--------PP 159
            .||:....||          |..|..|...||:.|.:   .|....|....:..|        .|
Mouse  1869 SISSTFPPTTLAAILPTFEKTAMPVTPGITLSSNPSV---NSRATSPTWSSSSLPSDSRASIFTP 1930

  Fly   160 PRLPTLPGVVGISGNPGLFNVPPQHTAVTHSTPSSSTTAVGGGRLKGGATSTTTTKHPAGRHDGL 224
            .||.|     ..||.......|......|:|..:.:..:.|...:...||||||...........
Mouse  1931 SRLLT-----SSSGEMSESTFPASDIIATYSNFTVAPLSDGSATIATQATSTTTLDIITANSLTS 1990

  Fly   225 PPPPQLHHHHNHH------------GEDTASPTKPSSKLPAGGNATSPSNTRILTGVGGSGTDDG 277
            ||.|......:.|            |.|  |.|..|.::..|..:.|||.||....:|.
Mouse  1991 PPIPSKDKDGSLHTSTFLESSLRTTGAD--SSTDMSERMSFGRTSISPSLTRHDLSIGS------ 2047

  Fly   278 TLLT----TKSSP-NRPPGTAASGSVVPGNGSVVRTINNINLNAAGMSGGDDESKLFCGPTHARN 337
              ||    |.:|| ::.|.|:.|.::.|...    |::::...|...|
Mouse  2048 --LTVSSPTNTSPWSKVPVTSESHTLFPSKS----TLDSVMSTATTTS----------------- 2089

  Fly   338 LYWNMTRVGD----VNVQPC-PGGAAGIAKWRCVLMKRIPDSGYDE--YDDDISSTTPAPSGGDC 395
                 |.:|.    ::.:.. |..|.|.:         :..|.::.  .|...||....||....
Mouse  2090 -----TAIGTSFPLMSTEMAHPSTATGFS---------LVSSSFETTWMDSIFSSLFTQPSTSPT 2140

  Fly   396 LHNSSSCEPPVSMAHKVNQRLRNFEP------TWHPATPDLTQCRSLWLNNLEMRVNQRDSSLIS 454
            ...|:.....:.|:..|...    ||      ..|..|.|       |||.:      ..:|..|
Mouse  2141 AKESTVSFYNIKMSFSVFDE----EPRVLVTTVIHDLTKD-------WLNFM------FQNSEFS 2188

  Fly   455 IANDMSEVTSSKT------LY----------GGD-------------------MLVTTKIIQTVS 484
            :||...::.|.||      :|          |.|                   .|.:.::|.::.
Mouse  2189 LANLAIQIKSRKTSKEETAMYRYILEQKKGQGMDAIFHVPYSCACWVIIKAKSSLESVELISSIR 2253

  Fly   485 EKMMHDKETFPDQRQRE-AMIMELLHCVV---KTGSNLLDESQLS-----SWLDLNP-------- 532
            .| :|...|..:..|.: .::::..|.||   :.|....||:...     .|...:|
Mouse  2254 TK-IHGNLTHGNFTQDQLTLLVKSDHVVVEKLEPGKCEADETPSKYKGTYKWPLTDPTETAQERC 2317

  Fly   533 -EDQMRVAT----------------------SLLTGLEYNAFLLADTIIRERS---VVQKVKNIL 571
             :::.|.||                      .||.||......||:..|.:.:   |.:.:.|::
Mouse  2318 IKNENRNATRICSISIQTGKCQWEKPRLKQCKLLQGLPDKIVDLANITISDENADDVAEHILNLV 2382

  Fly   572 LSVRVL---ETKTIQSSVV-FPDSDQWPLSSDRIEL-----------PRAALIDNSEGGLVRIVF 621
            .....|   |||.|.|.|. ..:.|:..::..:|.|           ..|:.:......::||:.
Mouse  2383 NESPPLDEEETKIIVSKVADISNCDEISINLTQIILQILNTVTEKQSDSASNLPPVSNEILRIIE 2447

  Fly   622 AAFDRLE---------------SILKPSYDH------FDLKSSRSYVRNTAILSNDSDVNAGEIQ 665
            ....::|               ::|:  .||      |.::||...:.....|        |:|.
Mouse  2448 RVGHKMEFAGRTANLTVAKLALAVLR--VDHKFEGMAFSIQSSEEVIAPQIFL--------GDIP 2502

  Fly   666 QRLRI----------------------------------------LNSKVISASLGKGRHIQLSQ 690
            .|..:                                        |.:.|:|||:.......|:.
Mouse  2503 LRKALASIYLPKSLREKVPLDGLQTILFNFFGQTSLFKAKTITSELMTYVVSASISNTSIQNLAD 2567

  Fly   691 PITLTLKHLKTE-NVTNPTCVFWNYIDH----AWSANGCSLESTNRTHSVCSCNHLTNFAILMDV 750
            |:.:.|||::.: |.....|.||::..:    .|:.:||.|:.:|..:::|.|||||:|.:|||:
Mouse  2568 PVIIILKHIQGDWNYDQVYCAFWDFDTNNGLGGWNPSGCKLKESNINYTICQCNHLTHFGVLMDL 2632

  Fly   751 VDEHQHSLFTMFDGNMRIFI---YISIGICVVFIVIALLTLKLFNGVFVKSARTSIYTSIYLCLL 812
                  |..|:...|.||.:   |...||..:|:.||::|...|:.: .|...:.|..::...||
Mouse  2633 ------SRSTVDAVNERILVIITYTGCGISSIFLGIAMVTYIAFHKL-RKDYPSKILINLCTALL 2690

  Fly   813 AIELLFLLGIEQTETSI----FCGFITIFLHCAILSGTAWFCYEAFHSYSTLTSDELLLEVDQTP 873
            .:.|.||  :....||.    .|....:.||..:|....|...||.|.|..|.
Mouse  2691 MLNLAFL--VNSWLTSFQKVGLCITAAVALHYFLLVSLTWMGLEAVHMYFALV------------ 2741

  Fly   874 KV-NCY---YLLSY-----GLSLSVVAISL--------VIDPST---YTQNDYCVLMEANALFYA 918
            || |.|   |:|.:     |:....|||.|        .:.|:|   :.::|:...:...|.|..
Mouse  2742 KVFNTYIPNYILKFCLAGWGIPAITVAIILSVRKDLYGTLSPTTPFCWIKDDHIFYISVVAYFCL 2806

  Fly   919 TFVIPVLVFFVAAIGYTFLSWIIMCRKSRTGLKTKEHTRLASVRFDIRCSFVFLLLLSAVWCSAY 983
            .|::.:.:|....:..|.:       ||::     :.||...:..|::.:.....||...|..|:
Mouse  2807 IFLMNLSMFCTVLVQLTSV-------KSQS-----QKTRKKMILNDLKGTISLTFLLGLTWGFAF 2859

  Fly   984 FYLRGAKMDDDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYR-----KYVRQH---AWL- 1039
            |.....::      .:.|.|...|||.|..||||:|:..|.:|.::.     :::|..   .|:
Mouse  2860 FAWGPVRI------FFLYLFAICNTLQGFLIFVFYCVMKESVREQWHMPLHCRWLRLENFAGWIN 2918

  Fly  1040 ------------------PKCLRC-------SKTSISSGIVTGNG-----------------PT- 1061
                              |..:..       |..||.|.|...||                 ||
Mouse  2919 VRHKQKRLKKNNESKLLTPSLMSTTTFKSIGSVPSIPSEINFSNGDFDDSPDTFSFLSCKAAPTF 2983

  Fly  1062 -----AGTLCSVSTSKKPKLPLGVSEEAHDDP 1088
                 ...:.:.||.|:...|:.||.:.|..|
Mouse  2984 IRRALPAEIQTNSTQKQRSFPINVSRDTHLTP 3015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328	15/64 (23%)
		GAIN	453..680	CDD:293098	63/380 (17%)
		GPS	705..752	CDD:197639	18/50 (36%)
		7tm_4	763..1014	CDD:304433	65/277 (23%)
Adgrg4	NP_001349814.1	LamG	<54..162	CDD:328935
		DnaJ	<276..746	CDD:333066
		GPS	2587..2629	CDD:307782	15/41 (37%)
		7tmB2_GPR112	2642..2903	CDD:320663	71/293 (24%)
		TM helix 1	2644..2669	CDD:320663	8/24 (33%)
		TM helix 2	2679..2701	CDD:320663	6/23 (26%)
		TM helix 3	2712..2739	CDD:320663	8/26 (31%)
		TM helix 4	2754..2770	CDD:320663	3/15 (20%)
		TM helix 5	2793..2816	CDD:320663	4/22 (18%)
		TM helix 6	2838..2863	CDD:320663	6/24 (25%)
		TM helix 7	2867..2892	CDD:320663	11/30 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910