DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cirl and ADGRL2

DIOPT Version :9

Sequence 1:NP_001260807.1 Gene:Cirl / 35846 FlyBaseID:FBgn0033313 Length:1711 Species:Drosophila melanogaster
Sequence 2:NP_001352934.1 Gene:ADGRL2 / 23266 HGNCID:18582 Length:1469 Species:Homo sapiens


Alignment Length:1602 Identity:362/1602 - (22%)
Similarity:575/1602 - (35%) Gaps:466/1602 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 YEHISLDLSKYQTAYACEGKKLTIECDPGDVINLIRANYGRFSITICN-DHGNVEWSVNCMFPKS 73
            :...:|.....:...:|||..:.:.|...|||.:..|||||....||: |...:| :.:|..|.:
Human    26 FSRAALPFGLVRRELSCEGYSIDLRCPGSDVIMIESANYGRTDDKICDADPFQME-NTDCYLPDA 89

  Fly    74 LSVLNSRCAHKQSCGVLAATSMFGDPCPGTHKYLEAHYQCISAAQTSTTTNRPSPPPWVLSNGPP 138
            ..::..||.::..|.|:..:.:|.||||||:||||..|:|:               |::...   
Human    90 FKIMTQRCNNRTQCIVVTGSDVFPDPCPGTYKYLEVQYECV---------------PYMEQK--- 136

  Fly   139 IF---GNGSGLIHPPGV-------GAGAPPPPRLPTLPGVVGISGNPGLFNVPPQHTAVTHSTPS 193
            :|   |....::..|.:       ||....|           :.....::.:|        .||.
Human   137 VFVCPGTLKAIVDSPCIYEAEQKAGAWCKDP-----------LQAADKIYFMP--------WTPY 182

  Fly   194 SSTTAVGGGRLKG--GATSTTTTKHPAGRHDG----------------------------LPPPP 228
            .:.|.:....|:.  .:..|||.|.| .|.||                            :....
Human   183 RTDTLIEYASLEDFQNSRQTTTYKLP-NRVDGTGFVVYDGAVFFNKERTRNIVKFDLRTRIKSGE 246

  Fly   229 QLHHHHNHHGEDTASPTKPSSK----LPAGGN------ATSPSNTRILTG--------------- 268
            .:.::.|:|  || ||.:...|    |....|      ||..:|..|:..               
Human   247 AIINYANYH--DT-SPYRWGGKTDIDLAVDENGLWVIYATEQNNGMIVISQLNPYTLRFEATWET 308

  Fly   269 ------------------VGGSGTDDGTLLTTKSS-------------------PNR-------- 288
                              |..|...|....|.|:|                   ||:        
Human   309 VYDKRAASNAFMICGVLYVVRSVYQDNESETGKNSIDYIYNTRLNRGEYVDVPFPNQYQYIAAVD 373

  Fly   289 ------------------------PPGTA---ASGSVVPGNGSVVRTI----------NNINLNA 316
                                    ||..|   .:...:..:..:.:||          ..::...
Human   374 YNPRDNQLYVWNNNFILRYSLEFGPPDPAQVPTTAVTITSSAELFKTIISTTSTTSQKGPMSTTV 438

  Fly   317 AGMSGGDDESK---------------------LFCGPTHARNLYWNMTRVGDVNVQPCPGGAAGI 360
            ||...|...:|                     .||....::.:.|..|:.|.:..:|||.|..|.
Human   439 AGSQEGSKGTKPPPAVSTTKIPPITNIFPLPERFCEALDSKGIKWPQTQRGMMVERPCPKGTRGT 503

  Fly   361 AKWRCVLMKRIPDSGYDEYDDDISSTTPAPSGGDCLHNSSSCEPPVSMAHKVNQRLRNFEPTWHP 425
            |.:.|::                       |.|                            ||:|
Human   504 ASYLCMI-----------------------STG----------------------------TWNP 517

  Fly   426 ATPDLTQCRSLWLNNLEMRVNQRDSSLISIANDMSEVTSSKTLYGGDMLVTTKIIQTV------- 483
            ..|||:.|.|.|:|.|..::...::: .|:||::::.|.. .::.||:..:.::::.:       
Human   518 KGPDLSNCTSHWVNQLAQKIRSGENA-ASLANELAKHTKG-PVFAGDVSSSVRLMEQLVDILDAQ 580

  Fly   484 ------SEKMMHDKETFPDQRQREAMIMELLHCVVKTGSNLLDESQLSSWLDLNPEDQMRVATSL 542
                  |||....: ::...::||......|..:|.|..|||....|.||..:|..:|...||.|
Human   581 LQELKPSEKDSAGR-SYNKLQKREKTCRAYLKAIVDTVDNLLRPEALESWKHMNSSEQAHTATML 644

  Fly   543 LTGLEYNAFLLADTIIRERSVVQKVKNILLSVRVLETKTIQSSVVFPDSDQWPLSSDRIELPRAA 607
            |..||..||:|||.::....|....:||:|.|.||.|:.......||...:...||  |:|....
Human   645 LDTLEEGAFVLADNLLEPTRVSMPTENIVLEVAVLSTEGQIQDFKFPLGIKGAGSS--IQLSANT 707

  Fly   608 LIDNSEGGLVRIVFAAFDRLESILKPSYDHFDLKSSRSYV-RNTAILSNDSDVNAGEIQQRLRIL 671
            :..||..||.::||..:..|...|  |.::..:|....:: ||:.|                 .:
Human   708 VKQNSRNGLAKLVFIIYRSLGQFL--STENATIKLGADFIGRNSTI-----------------AV 753

  Fly   672 NSKVISASLGK-GRHIQLSQPITLTLKHLKTENVTNPTCVFWNYIDHA----WSANGCSLESTNR 731
            ||.|||.|:.| ...:.|:.|:..||.|:..:|..|..|.||||.:..    ||..||.|..||:
Human   754 NSHVISVSINKESSRVYLTDPVLFTLPHIDPDNYFNANCSFWNYSERTMMGYWSTQGCKLVDTNK 818

  Fly   732 THSVCSCNHLTNFAILMDVVDEHQHSLFTMFDG----NMRIFIYISIGICVVFIVIALLTLKLFN 792
            |.:.|:|:|||||||||      .|......||    .:.:..::.|.|.:|.:.|.:.|...|.
Human   819 TRTTCACSHLTNFAILM------AHREIAYKDGVHELLLTVITWVGIVISLVCLAICIFTFCFFR 877

  Fly   793 GVFVKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSGTAWFCYEAFHSY 857
            |  ::|.|.:|:.::.:.|...|.:||:||::|:.:|.|......||...|:..||.|.|....|
Human   878 G--LQSDRNTIHKNLCINLFIAEFIFLIGIDKTKYAIACPIFAGLLHFFFLAAFAWMCLEGVQLY 940

  Fly   858 STLTSDELLLEV--DQTPKVNCYYLLSYGLSLSVVAISLVIDPSTYTQNDYCVLMEANALFYATF 920
            .      :|:||  .:..:...||:..|....:||.:|..||..:|.....|.|...| .|..:|
Human   941 L------MLVEVFESEYSRKKYYYVAGYLFPATVVGVSAAIDYKSYGTEKACWLHVDN-YFIWSF 998

  Fly   921 VIPVLVFFVAAIGYTFLSWIIMCR--KSRTGLKTKEHTRLASVRFDIRCSFVFLLLLSAVWCSAY 983
            :.||.  |:..:...||. |.:|:  |....|| .:.:||.:::..:..:|..|.||...|....
Human   999 IGPVT--FIILLNIIFLV-ITLCKMVKHSNTLK-PDSSRLENIKSWVLGAFALLCLLGLTWSFGL 1059

  Fly   984 FYLRGAKMDDDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYRKYVRQHAWLPKCLRCSKT 1048
            .::     :::|. |..|.|..||...|::||:|||...:|:|:||.|..| |::   |  |...
Human  1060 LFI-----NEETI-VMAYLFTIFNAFQGVFIFIFHCALQKKVRKEYGKCFR-HSY---C--CGGL 1112

  Fly  1049 SISSGIVTGNGPTAGTLCSVSTSKKPKLPLGVSEEAHDDPQQQQQTPVPITEDAIMGATSDCELN 1113
            ...|...:....|..|....|:..:.::     ....:|..::|.....|:.|  :.:||     
Human  1113 PTESPHSSVKASTTRTSARYSSGTQSRI-----RRMWNDTVRKQSESSFISGD--INSTS----- 1165

  Fly  1114 EAQQRRTLKSG-----LMTGTLQAPPQT-------LGGHVVLERGS--------TLRSTGH---- 1154
                  ||..|     |:|..|..|..|       |...||....|        |.|.|.|    
Human  1166 ------TLNQGMTGNYLLTNPLLRPHGTNNPYNTLLAETVVCNAPSAPVFNSPATYRETRHSLNN 1224

  Fly  1155 ASPTSSAGSTHLIFAHKQQQQQQQQGPLGESY-YHQPDY-------------------------- 1192
            |..||:..:..|            .|....|| .|:.||                          
Human  1225 ARDTSAMDTLPL------------NGNFNNSYSLHKGDYNDSVQVVDCGLSLNDTAFEKMIISEL 1277

  Fly  1193 -YSWKQPSTGT-------------GGLKTPRE----------YYNNAG--------AAASSPQQA 1225
             ::..:.|:.|             ||..:..:          :.:|.|        .|...||:.
Human  1278 VHNNLRGSSKTHNLELTLPVKPVIGGSSSEDDAIVADASSLMHSDNPGLELHHKELEAPLIPQRT 1342

  Fly  1226 HEVFYWTQKPNSGHNGKKKRGAGGVPASPSGSLHSRTAAASQVLFYPSYKKTKPG-QPTGYPQYA 1289
            |.:.|..||.      .|..|.....:..:........:.::...|.|....:.. .|...|...
Human  1343 HSLLYQPQKK------VKSEGTDSYVSQLTAEAEDHLQSPNRDSLYTSMPNLRDSPYPESSPDME 1401

  Fly  1290 EALDPPLATGNAAAYYQQQQQLRRQQLHQQQQQQQQQQLSSD 1331
            |.|.|...:.|...||:....|...  ||.|...|..:.:||
Human  1402 EDLSPSRRSENEDIYYKSMPNLGAG--HQLQMCYQISRGNSD 1441

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CirlNP_001260807.1 Gal_Lectin 33..113 CDD:280328 31/80 (39%)
GAIN 453..680 CDD:293098 65/240 (27%)
GPS 705..752 CDD:197639 25/50 (50%)
7tm_4 763..1014 CDD:304433 70/258 (27%)
ADGRL2NP_001352934.1 Gal_Lectin 49..129 CDD:307994 31/80 (39%)
OLF 142..398 CDD:321983 39/278 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 426..460 4/33 (12%)
HormR 469..533 CDD:214468 24/114 (21%)
GAIN 542..764 CDD:318649 66/245 (27%)
GPS 788..840 CDD:197639 26/57 (46%)
7tmB2_Latrophilin-2 848..1105 CDD:320672 79/276 (29%)
TM helix 1 850..875 CDD:320672 5/24 (21%)
TM helix 2 884..906 CDD:320672 6/21 (29%)
TM helix 3 915..942 CDD:320672 8/32 (25%)
TM helix 4 954..974 CDD:320672 6/19 (32%)
TM helix 5 991..1020 CDD:320672 10/32 (31%)
TM helix 6 1036..1063 CDD:320672 5/31 (16%)
TM helix 7 1067..1092 CDD:320672 11/25 (44%)
Latrophilin 1104..1469 CDD:308136 72/382 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1368..1410 7/41 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 79 1.000 Domainoid score I8672
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 366 1.000 Inparanoid score I2163
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000766
OrthoInspector 1 1.000 - - otm40998
orthoMCL 1 0.900 - - OOG6_102405
Panther 1 1.100 - - O PTHR12011
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X858
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1110.820

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