DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cirl and ADGRL1

DIOPT Version :10

Sequence 1:NP_001260807.1 Gene:Cirl / 35846 FlyBaseID:FBgn0033313 Length:1711 Species:Drosophila melanogaster
Sequence 2:XP_016881964.1 Gene:ADGRL1 / 22859 HGNCID:20973 Length:1506 Species:Homo sapiens


Alignment Length:1617 Identity:370/1617 - (22%)
Similarity:576/1617 - (35%) Gaps:492/1617 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 ACEGKKLTIECDPGDVINLIRANYGRFSITICN-DHGNVEWSVNCMFPKSLSVLNSRCAHKQSCG 88
            ||||..:.:.|...|||.:..|||||....||: |...:| :|.|..|.:..:::.||.::..|.
Human    40 ACEGYPIELRCPGSDVIMVENANYGRTDDKICDADPFQME-NVQCYLPDAFKIMSQRCNNRTQCV 103

  Fly    89 VLAATSMFGDPCPGTHKYLEAHYQCISAAQ------------------TSTTTNRPSPPPWVLSN 135
            |:|.:..|.||||||:||||..|.|:...:                  |||..:......|... 
Human   104 VVAGSDAFPDPCPGTYKYLEVQYDCVPYIEVEQKVFVCPGTLQKVLEPTSTHESEHQSGAWCKD- 167

  Fly   136 GPPIFGNGSGLIHPPGVGAGAPPPPRLPTLPGVVGISGNPGLFNVPPQHTAVTHSTPSSSTTAVG 200
              |:.. |..:...|.:      |.|..||.......          .:.|..|:|.......|.
Human   168 --PLQA-GDRIYVMPWI------PYRTDTLTEYASWE----------DYVAARHTTTYRLPNRVD 213

  Fly   201 G--------------------------GRLKGGATSTTTTKHPAGRHDGLP-------------- 225
            |                          .|:|.|.|...|    |..||..|              
Human   214 GTGFVVYDGAVFYNKERTRNIVKYDLRTRIKSGETVINT----ANYHDTSPYRWGGKTDIDLAVD 274

  Fly   226 ----------------------------------------------------------------- 225
                                                                             
Human   275 ENGLWVIYATEGNNGRLVVSQLNPYTLRFEGTWETGYDKRSASNAFMVCGVLYVLRSVYVDDDSE 339

  Fly   226 ------------------------PPP--------------QLHHHHNHH--------------- 237
                                    |.|              ||:..:|:.               
Human   340 AAGNRVDYAFNTNANREEPVSLTFPNPYQFISSVDYNPRDNQLYVWNNYFVVRYSLEFGPPDPSA 404

  Fly   238 GEDTASPTKPSSKLPAGGNATSP----SNTRILTGVGGSGTDDGTL------LTT-------KSS 285
            |||.:.|          |.||||    :.|...|.:..:.:...|.      |||       :..
Human   405 GEDDSLP----------GPATSPPLSTTTTARPTPLTSTASPAATTPLRRAPLTTHPVGAINQLG 459

  Fly   286 PNRPPGTAASGSVVPGNGSVVRTINNINLNAAGMSGGDDESKLFCGPTHARNLYWNMTRVGDVNV 350
            |:.||.||.    ||.    .|.....||:.:        .:|||.|...|.:.|..|:.|.:..
Human   460 PDLPPATAP----VPS----TRRPPAPNLHVS--------PELFCEPREVRRVQWPATQQGMLVE 508

  Fly   351 QPCPGGAAGIAKWRCVLMKRIPDSGYDEYDDDISSTTPAPSGGDCLHNSSSCEPPVSMAHKVNQR 415
            :|||.|..|||.::|:                       |:.|                      
Human   509 RPCPKGTRGIASFQCL-----------------------PALG---------------------- 528

  Fly   416 LRNFEPTWHPATPDLTQCRSLWLNNLEMRVNQRDSSLISIANDMSEVTSSKTLYGGDMLVTTKII 480
                  .|:|..|||:.|.|.|:|.:..::...::: .:||::::..|.. ::|.||:..:.|::
Human   529 ------LWNPRGPDLSNCTSPWVNQVAQKIKSGENA-ANIASELARHTRG-SIYAGDVSSSVKLM 585

  Fly   481 QTVSEKMMHDKETF-PDQRQ-----------REAMIMELLHCVVKTGSNLLDESQLSSWLDLNPE 533
            :.:.:.:....:.. |.:|:           ||....:.:..||:|..|||....|.||.|:|..
Human   586 EQLLDILDAQLQALRPIERESAGKNYNKMHKRERTCKDYIKAVVETVDNLLRPEALESWKDMNAT 650

  Fly   534 DQMRVATSLLTGLEYNAFLLADTIIRERSVVQKVKNILLSVRVLETKTIQSSVVFPDSDQWPLSS 598
            :|:..||.||..||..||||||.:......:...:|::|.|.||.|:.....:||| .:::| ..
Human   651 EQVHTATMLLDVLEEGAFLLADNVREPARFLAAKENVVLEVTVLNTEGQVQELVFP-QEEYP-RK 713

  Fly   599 DRIELPRAALIDNSEGGLVRIVFAAFDRLESILKPSYDHFDLKSSRSYVRNTAILSNDSDVNAGE 663
            :.|:|....:..||..|:|::||..::.|...|.               ...|.:....:...|.
Human   714 NSIQLSAKTIKQNSRNGVVKVVFILYNNLGLFLS---------------TENATVKLAGEAGPGG 763

  Fly   664 IQQRLRILNSKVISASLGK-GRHIQLSQPITLTLKHLKTENVTNPTCVFWNYIDHA----WSANG 723
            ......::||:||:||:.| ...:.|..|:..|:.||:.:|..|..|.||||.:.:    ||..|
Human   764 PGGASLVVNSQVIAASINKESSRVFLMDPVIFTVAHLEDKNHFNANCSFWNYSERSMLGYWSTQG 828

  Fly   724 CSLESTNRTHSVCSCNHLTNFAILMDVVDEHQHSLFTMFDGNMRIFIYISIGICVVFIVIALLTL 788
            |.|..:|:||:.|:|:||||||:||...:.:|..:..:.   :.:..::.|.|.:|.:.|.:.|.
Human   829 CRLVESNKTHTTCACSHLTNFAVLMAHREIYQGRINELL---LSVITWVGIVISLVCLAICISTF 890

  Fly   789 KLFNGVFVKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSGTAWFCYEA 853
            ....|  :::.|.:|:.::.:.|...|||||:||::|:..|.|......||...|:..:|.|.|.
Human   891 CFLRG--LQTDRNTIHKNLCINLFLAELLFLVGIDKTQYEIACPIFAGLLHYFFLAAFSWLCLEG 953

  Fly   854 FHSYSTLTSDELLLEV--DQTPKVNCYYLLSYGLSLSVVAISLVIDPSTYTQNDYCVLMEANALF 916
            .|.|.      ||:||  .:..:...|||..|.....||.|:..||..:|.....|.|...| .|
Human   954 VHLYL------LLVEVFESEYSRTKYYYLGGYCFPALVVGIAAAIDYRSYGTEKACWLRVDN-YF 1011

  Fly   917 YATFVIPVLVFFVAAIGYTFLSWII--MCRKSRTGLKTKEHTRLASVRFDIRCSFVFLLLLSAVW 979
            ..:|:.|  |.||..:...||...:  |.|.|.. || .:.:||.:::.....:...|.||...|
Human  1012 IWSFIGP--VSFVIVVNLVFLMVTLHKMIRSSSV-LK-PDSSRLDNIKSWALGAIALLFLLGLTW 1072

  Fly   980 CSAYFYLRGAKMDDDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYRKYVRQHAWLPKCLR 1044
            .....::....:      |..|.|..||...|::||||||...:|:.:||          .||||
Human  1073 AFGLLFINKESV------VMAYLFTTFNAFQGVFIFVFHCALQKKVHKEY----------SKCLR 1121

  Fly  1045 CSKTSISSGIVTGNGPTAGTLCSVSTS---KKPKLPLGVSEEAHDDPQQQQQTPVPITEDAIMGA 1106
            .|...|.|       |..||..|:.||   ...:...|                   |:..|...
Human  1122 HSYCCIRS-------PPGGTHGSLKTSAMRSNTRYYTG-------------------TQSRIRRM 1160

  Fly  1107 TSDCELNEAQQRRTLKSGLMTGTLQAPPQ----TLGGHVVLERGSTLRSTGHASP-----TSSAG 1162
            .:|      ..|:..:|..|.|.:.:.|.    |:|.|::  ....|:..|..||     ..|.|
Human  1161 WND------TVRKQTESSFMAGDINSTPTLNRGTMGNHLL--TNPVLQPRGGTSPYNTLIAESVG 1217

  Fly  1163 ---STHLIFAHKQQQQQQQQGPLGESYYHQPDYYS---WKQPSTGTGGLKTPREYYNNAGAAASS 1221
               |:..:|...:.:.       |.::...|..:|   |..|:   |..:.|:.           
Human  1218 FNPSSPPVFNSPELEP-------GLAFRAHPCLFSSLFWLPPA---GSYREPKH----------- 1261

  Fly  1222 PQQAHEVFYWTQKPNSGH--------NGKKKRGAGGVPASPSGSLHSRTAAASQVLF-------- 1270
            |....|.......|.:|:        :|....|.|| |..|.|...:..||..:::.        
Human  1262 PLGGREACGMDTLPLNGNFNNSYSLRSGDFPPGDGG-PEPPRGRNLADAAAFEKMIISELVHNNL 1325

  Fly  1271 ---YPSYKKTKPGQP-------------TGYPQYAE---------ALDPPLATGNAAAYYQQQQQ 1310
               ..:.|...|.:|             .|.|..|:         ||:.||....|.:.. .|..
Human  1326 RGSSSAAKGPPPPEPPVPPVPGGGGEEEAGGPGGADRAEIELLYKALEEPLLLPRAQSVL-YQSD 1389

  Fly  1311 LRRQQLHQQQQQQQQQQLSSDEEQAEQHAHLLHLQ--------RRAGSQQQLPAPPP 1359
            |...:....:.....:.|||...:...:|...:|:        ...|..:.||.|||
Human  1390 LDESESCTAEDGATSRPLSSPPGRDSLYASGANLRDSPSYPDSSPEGPSEALPPPPP 1446

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CirlNP_001260807.1 Gal_Rha_Lectin_dCirl 22..113 CDD:438687 37/88 (42%)
GAIN 451..682 CDD:465137 63/242 (26%)
GPS 705..752 CDD:197639 24/50 (48%)
7tmB2_CELSR_Adhesion_IV 763..1035 CDD:320557 78/275 (28%)
TM helix 1 765..790 CDD:320557 5/24 (21%)
TM helix 2 801..823 CDD:320557 8/21 (38%)
TM helix 3 832..859 CDD:320557 8/26 (31%)
TM helix 4 875..895 CDD:320557 7/19 (37%)
TM helix 5 913..942 CDD:320557 9/30 (30%)
TM helix 6 960..987 CDD:320557 4/26 (15%)
TM helix 7 997..1022 CDD:320557 12/24 (50%)
Herpes_TAF50 <1219..1365 CDD:308764 37/190 (19%)
ADGRL1XP_016881964.1 Gal_Rha_Lectin_LPHN1 35..131 CDD:438701 38/91 (42%)
OLF 143..399 CDD:470611 30/279 (11%)
PHA03247 <399..503 CDD:223021 32/129 (25%)
HormR 484..547 CDD:214468 26/113 (23%)
GAIN 557..782 CDD:465137 63/243 (26%)
GPS 806..858 CDD:197639 24/51 (47%)
7tmB2_Latrophilin-1 865..1122 CDD:320673 81/288 (28%)
TM helix 1 867..892 CDD:320673 5/27 (19%)
TM helix 2 901..923 CDD:320673 8/21 (38%)
TM helix 3 932..959 CDD:320673 8/32 (25%)
TM helix 4 971..991 CDD:320673 7/19 (37%)
TM helix 5 1008..1037 CDD:320673 9/31 (29%)
TM helix 6 1053..1080 CDD:320673 4/26 (15%)
TM helix 7 1084..1109 CDD:320673 12/30 (40%)
Latrophilin 1121..1506 CDD:460538 74/383 (19%)

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