DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cirl and ADGRF2

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	NP_001355044.1	Gene:	ADGRF2 / 222611	HGNCID:	18991	Length:	708	Species:	Homo sapiens

Alignment Length:	660	Identity:	131/660 - (19%)
Similarity:	240/660 - (36%)	Gaps:	166/660 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   388 PAPSGGDC---LHNSSSCEPPVSMAHKVNQRLRNFEPTWHPATPDLTQCRSLWLNNLEMRVNQRD 449
            ||...|.|   ..:.|.|..|.....:.|......:.|||..|   ..|::  ||.|  .:.:.|
Human   102 PARPHGVCDGVCTDYSQCTQPCPPDTQGNMGFSCRQKTWHKIT---DTCQT--LNAL--NIFEED 159

  Fly   450 SSLISIANDMSEVT----SSKTLYGGDMLV------TTKIIQTVSEKMMHDKETFPDQRQREAMI 504
            |.|:....|..:::    .|:|:  .|||:      .:.:|:.:.:.        |......|:|
Human   160 SRLVQPFEDNIKISVYTGKSETI--TDMLLQKCPTDLSCVIRNIQQS--------PWIPGNIAVI 214

  Fly   505 MELLHCV---VKTG-------------SNLLDESQLSSWLDLNPEDQMRVATSLLTGLEYNAFL- 552
            ::|||.:   :.||             :::|:...:|:|..:...:...:....:.......|:
Human   215 VQLLHNISTAIWTGVDEAKMQSYSTIANHILNSKSISNWTFIPDRNSSYILLHSVNSFARRLFID 279

  Fly   553 -----LADTIIRERSVV----QKVKNILLSVRVLETKTIQSSVVFPDSDQWPLSSDRI-ELPRAA 607
                 ::|..|......    ...||...|:|:.:|....:..|.       :|.|.: ::|..:
Human   280 KHPVDISDVFIHTMGTTISGDNIGKNFTFSMRINDTSNEVTGRVL-------ISRDELRKVPSPS 337

  Fly   608 LIDNSEGGLVRIVFAAFDRLESILKPSYDHFDLKSSRSYVRNTAILSNDSDVNAGEIQQRLRILN 672
                      :::..||..:.:||:.|                 :|.|.:             :|
Human   338 ----------QVISIAFPTIGAILEAS-----------------LLENVT-------------VN 362

  Fly   673 SKVISASLGKGRHIQLSQPITLTLKHLKTENVTNPTCVFWNYIDHAWSANGCSLESTNRTHSVCS 737
            ..|:||.|.|    :|.: |:|..:.:.........||.|:.:::.|....|.:...|...:||.
Human   363 GLVLSAILPK----ELKR-ISLIFEKISKSEERRTQCVGWHSVENRWDQQACKMIQENSQQAVCK 422

  Fly   738 CNH---LTNFAILMDVVDEHQHSLFTMFDGNMRIFIYISIGICVVFIVIALLTLKLFNGVFVKSA 799
            |..   .|:|:|||.     .|.|.::.   :....|:.:||.:..:::.|....|   |:.:..
Human   423 CRPSKLFTSFSILMS-----PHILESLI---LTYITYVGLGISICSLILCLSIEVL---VWSQVT 476

  Fly   800 RTSIYTSIYLCLLAIELLFLLGIEQTETSIF----------CGFITIFLHCAILSGTAWFCYEA- 853
            :|.|....::|::.|....|:.......:.|          |...|.|:|...||...|...:|
Human   477 KTEITYLRHVCIVNIAATLLMADVWFIVASFLSGPITHHKGCVAATFFVHFFYLSVFFWMLAKAL 541

  Fly   854 ---------FHSYSTLTSDELLLEVDQTPKVNCYYLLSYGLSLSVVAISL-VIDPST-YTQNDYC 907
                     ||   ||....|:..:         :.:.||..|::.||:: ..:|.. |.:.:.|
Human   542 LILYGIMIVFH---TLPKSVLVASL---------FSVGYGCPLAIAAITVAATEPGKGYLRPEIC 594

  Fly   908 VLMEANALFYATFVIPVLVFFVAAIGYTFLSWIIMCRKSRTGLKTKEHTRLASVRFDIRCS---F 969
            .|..........||||.|...|..: .|....|:..:::..|     ::....||..:|.|   .
Human   595 WLNWDMTKALLAFVIPALAIVVVNL-ITVTLVIVKTQRAAIG-----NSMFQEVRAIVRISKNIA 653

  Fly   970 VFLLLLSAVW 979
            :...||...|
Human   654 ILTPLLGLTW 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328
		GAIN	453..680	CDD:293098	41/263 (16%)
		GPS	705..752	CDD:197639	14/49 (29%)
		7tm_4	763..1014	CDD:304433	50/242 (21%)
ADGRF2	NP_001355044.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810