DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cirl and ADGRE1

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	XP_011526096.1	Gene:	ADGRE1 / 2015	HGNCID:	3336	Length:	978	Species:	Homo sapiens

Alignment Length:	1141	Identity:	242/1141 - (21%)
Similarity:	409/1141 - (35%)	Gaps:	330/1141 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 NDHGNVEWSVNC----MFPKSLSVLNS----RCAHKQS----------------CGVLAATSMFG 97
            |..||     ||    :.|...:..|:    .||.||.                |..:...|...
Human    29 NTKGN-----NCRDSTLCPAYATCTNTVDSYYCACKQGFLSSNGQNHFKDPGVRCKDIDECSQSP 88

  Fly    98 DPC-PGTH-KYLEAHYQCISAAQTSTTTNRPSPPPWVLSNGPPIFGNGSGLIHPPGVGAGAPPPP 160
            .|| |.:. |.|...|:|......|:    |:...||
Human    89 QPCGPNSSCKNLSGRYKCSCLDGFSS----PTGNDWV---------------------------- 121

  Fly   161 RLPTLPGVVGISGNPGLF-----------NVPPQHTAVTHSTPSSSTTAVGGGRLKGGATS---- 210
                       .|.||.|           :|.|:|:...:|..|.|.:...|...:.....
Human   122 -----------PGKPGNFSCTDINECLTSSVCPEHSDCVNSMGSYSCSCQVGFISRNSTCEDIDE 175

  Fly   211 ----------TTTTKHPAGRH-----DGLPPPPQLHHHHNHHGEDTASPTKPSSKLPAGGNATSP 260
                      .::.|:.:||:     ||...|.         |.|.. |.||       ||.
Human   176 CSQSPQPCGPNSSCKNMSGRYKCSCLDGFSSPT---------GNDWI-PGKP-------GNF--- 220

  Fly   261 SNTRILTGVGGSGTDDGTLLTTKSSPNRPPGTAASGSVVPGNGSVVRTINNIN-------LNAAG 318
                       |.||....||:              ||.|.:...|.::.:.|       ::...
Human   221 -----------SCTDISESLTS--------------SVCPEHSDCVNSMGSYNCSCQVGFISRNS 260

  Fly   319 MSGGDDESKLFCG-----PTHARNLYWNMTRVGDVNVQPCPG--GAAGIAKWRCVLMKRIPDSGY 376
            :|...||    |.     |.||.   .|.| ||:.:....||  .::|...::.:      .:..
Human   261 ISSDVDE----CADPRACPEHAT---CNNT-VGNYSCFCNPGFESSSGHLSFQGL------KASC 311

  Fly   377 DEYDD-----DISST---TP-----------APSGG---------------DCLHNSSSCEPPVS 407
            ::.|:     .|:||   ||           |||.|               :|..:.|:|.|...
Human   312 EDIDECTEMCPINSTCTNTPGSYFCTCHPGFAPSNGQLNFTDQGVECRDIDECRQDPSTCGPNSI 376

  Fly   408 MAHKVNQRLRNFEPTWHPATPDLTQ------CRSLWLNNLEMRVNQRDSSLISIANDMSEVTSSK 466
            ..:.:..........:|| .|:.:|      |:.:.....|..:  .|:..|   ....|.|:.|
Human   377 CTNALGSYSCGCIAGFHP-NPEGSQKDGNFSCQRVLFKCKEDVI--PDNKQI---QQCQEGTAVK 435

  Fly   467 TLYGGDMLVTTKIIQTVSEKMMHDKETFPDQRQREAMIMELLHCVVKTGSNLLDESQLSSWLDLN 531
            ..|.........|. :|.:|:..:|.|....:......:.:|             .|:|:|....
Human   436 PAYVSFCAQINNIF-SVLDKVCENKTTVVSLKNTTESFVPVL-------------KQISTWTKFT 486

  Fly   532 PEDQMRVATSLLTGLEYNAFLLADTIIRERSVVQKVKNILLSVRVLETKTIQSSVVFPDSDQWPL 596
            .|:...:||..|..:|  :..||       |..:...||..:||. |...|:|.|:..:..:..:
Human   487 KEETSSLATVFLESVE--SMTLA-------SFWKPSANITPAVRT-EYLDIESKVINKECSEENV 541

  Fly   597 S------SDRIELPRAALIDNSEGGLVRIVFAAFDRLESILKPSY--DHFDLKSSRSYVRNTAIL 653
            :      .|::::..:.:.::.......:.|.:|..:||:|...:  ||
Human   542 TLDLVAKGDKMKIGCSTIEESESTETTGVAFVSFVGMESVLNERFFKDH---------------- 590

  Fly   654 SNDSDVNAGEIQQRLRILNSKVISASLGKGRHIQLSQPITLTLKHLK-TENVTNPTCVFW--NYI 715
              .:.:...||:.:   :||:|:...:...:....|.||..||:::: .:....|.||.|  :..
Human   591 --QAPLTTSEIKLK---MNSRVVGGIMTGEKKDGFSDPIIYTLENIQPKQKFERPICVSWSTDVK 650

  Fly   716 DHAWSANGCSLESTNRTHSVCSCNHLTNFAILMDVVDEHQHSLFTMFDGNMRIFIYISIGICVVF 780
            ...|::.||.:...:.|:::||||.:.|.|::|      .....|| |.::.|..::.|.|.:|.
Human   651 GGRWTSFGCVILEASETYTICSCNQMANLAVIM------ASGELTM-DFSLYIISHVGIIISLVC 708

  Fly   781 IVIALLTLKLFNGVFVKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSG 845
            :|:|:.|..|...  :::..|.::..:.:|||..:.|||.||.:|:..:.|..|..|||...|:.
Human   709 LVLAIATFLLCRS--IRNHNTYLHLHLCVCLLLAKTLFLAGIHKTDNKMGCAIIAGFLHYLFLAC 771

  Fly   846 TAWFCYEAFHSYSTLTSDELLLEVDQTPKVNCYY-----------LLSYGLSLSVVAISLVIDPS 899
            ..|...||.          :|..:.:..||..|:           ...|||.:.||.||..:.|.
Human   772 FFWMLVEAV----------ILFLMVRNLKVVNYFSSRNIKMLHICAFGYGLPMLVVVISASVQPQ 826

  Fly   900 TYTQNDYCVLMEANALFYATFVIPV-LVFFVAAIGYTFLSWIIMCRKSRTG--LKTKEHTRLASV 961
            .|..::.|.| .....|..:|:.|| .|..:.::..|:..||:..|.|...  :.|.:.|||.:.
Human   827 GYGMHNRCWL-NTETGFIWSFLGPVCTVIVINSLLLTWTLWILRQRLSSVNAEVSTLKDTRLLTF 890

  Fly   962 RFDIRCSFVFLLLLSAVWCSAYFYLRGAKMDDDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIR 1026
            :     :|..|.:|...|....|.:      ...|.|..|.|...|:|.|.:||:.||:.|.::|
Human   891 K-----AFAQLFILGCSWVLGIFQI------GPVAGVMAYLFTIINSLQGAFIFLIHCLLNGQVR 944

  Fly  1027 REYRKYVRQHAWLPKCLRCSKTSISSGIVTGNGPTA 1062
            .||::      |:....:.|..|.:|.|:..:.|:|
Human   945 EEYKR------WITGKTKPSSQSQTSRILLSSMPSA 974

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328	19/81 (23%)
		GAIN	453..680	CDD:293098	43/234 (18%)
		GPS	705..752	CDD:197639	15/48 (31%)
		7tm_4	763..1014	CDD:304433	69/264 (26%)
ADGRE1	XP_011526096.1	EGF_CA	33..62	CDD:238011	9/33 (27%)
		EGF_CA	80..114	CDD:214542	8/33 (24%)
		EGF_CA	132..171	CDD:214542	7/38 (18%)
		EGF_CA	172..206	CDD:214542	5/33 (15%)
		EGF_CA	224..260	CDD:214542	8/49 (16%)
		EGF_CA	264..297	CDD:214542	12/40 (30%)
		EGF_CA	313..>342	CDD:214542	6/28 (21%)
		EGF_CA	360..400	CDD:284955	7/40 (18%)
		GPS	638..687	CDD:197639	15/54 (28%)
		7tm_2	691..932	CDD:278432	69/264 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910