DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cirl and lat-1

DIOPT Version :9

Sequence 1:NP_001260807.1 Gene:Cirl / 35846 FlyBaseID:FBgn0033313 Length:1711 Species:Drosophila melanogaster
Sequence 2:NP_001366731.1 Gene:lat-1 / 174419 WormBaseID:WBGene00002251 Length:1014 Species:Caenorhabditis elegans


Alignment Length:1336 Identity:275/1336 - (20%)
Similarity:451/1336 - (33%) Gaps:493/1336 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 CEGKKLTIECDPGDVINLIRANYGRFSITIC-NDHGNVEWSVNCMFPKSLSVLNSRCAHKQSCGV 89
            |:|:...:.|..|.||:::..||||||:.:| .|:..|..::||...|:.|:|..:|.....|..
 Worm    44 CDGEAAELSCPAGKVISIVLGNYGRFSVAVCLPDNDIVPSNINCQNHKTKSILEKKCNGDSMCYF 108

  Fly    90 LAATSMF-GDPCPGTHKYLEAHYQCISAAQTSTTTNRPSPPPWVLSNGPPIFGNGSGLIHPPGVG 153
            ......| .||||.|.||||..|.|:..|.|:|||                              
 Worm   109 TVDKKTFTEDPCPNTPKYLEVKYNCVVPATTTTTT------------------------------ 143

  Fly   154 AGAPPPPRLPTLPGVVGISGNPGLFNVPPQHTAVTHSTPSSSTTAVGGGRLKGGATSTTTTKHPA 218
                                                      ||           ||||||    
 Worm   144 ------------------------------------------TT-----------TSTTTT---- 151

  Fly   219 GRHDGLPPPPQLHHHHNHHGEDTASPTKPSSKLPAGGNATSPSNTRILTGVGGSGTDDGTLLTTK 283
                                                                     |.:|:..:
 Worm   152 ---------------------------------------------------------DSSLIVDE 159

  Fly   284 SSPNRPPGTAASGSVVPGNGSVVRTINNINLNAAGMSGGDDESKLFCGPTHARNLYWNMTRVGDV 348
            ....:....         |..|::.:..             :..:||..|:.|.:.|..|:.|..
 Worm   160 EEEAQKDAL---------NSDVIKPVKK-------------KEDVFCSATNRRGVNWQNTKSGTT 202

  Fly   349 NVQPCPGGAAGIAKWRCVLMKRIPDSGYDEYDDDISSTTPAPSGGDCLHNSSSCEPPVSMAHKVN 413
            :..|||.|::|...|.|                                                
 Worm   203 SSAPCPEGSSGKQLWAC------------------------------------------------ 219

  Fly   414 QRLRNFEPTWHPATPDLTQCRSLWLNNLEMRVNQRDSSLISI--ANDMSEV---------TSSKT 467
                ..|..|....|:...|.|.|       ::.|:|.|..:  :.|:|.:         .:.:.
 Worm   220 ----TEEGQWLTEFPNSAGCESNW-------ISSRNSVLSGVISSEDVSGLPEFLRNLGSETRRP 273

  Fly   468 LYGGDMLVTTKIIQTVSEKMMHDKETFPDQRQREAMIMELLHCVVKTGSNLLDESQLSSWLDLNP 532
            :.|||                               :.::||.:.||.:.:.:||.....|.|:.
 Worm   274 MVGGD-------------------------------LPKVLHLLEKTVNVIAEESWAYQHLPLSN 307

  Fly   533 EDQMRVATSLLTGLEY-------------NAFLLADTIIRERSVVQKVKNILLS----VRVLETK 580
            :..:.|...:|...|.             :.|:||    .|:::|...|.::.|    |.|....
 Worm   308 KGAVEVMNYMLRNQEIWGSWDVTKRKEFASRFILA----AEKAMVASAKGMMTSAESNVIVQPAI 368

  Fly   581 TIQSS------------VVFPDSDQW-PLSSDRIELPRAAL--IDNSEGGLVRIVFAAFDRLESI 630
            |::.|            ::||.:..| ..:.|.:.:||.|:  |:..|   .::.|::||.|.:.
 Worm   369 TVEISHKIKMSSQPTDYILFPSAALWNGQNVDNVNIPRDAILKINKDE---TQVFFSSFDNLGAQ 430

  Fly   631 LKPSYDHFDLKSSRSYVRNTAILSNDSDVNAGEIQQRLRILNSKVISASL---GKGRHIQ-LSQP 691
            :.||    |:        ..||...|      :.:.|.|.:.|:::.|||   ||.|.:: |:||
 Worm   431 MTPS----DV--------TVAIAGTD------QTEVRKRRVVSRIVGASLIENGKERRVENLTQP 477

  Fly   692 ITLTLKHLKT--ENVTNPTCVFWNYIDHAWSANGCSLESTNRTHSVCSCNHLTNFAILMDV---- 750
            :.:|..|.::  .:::|||||:||:.:..|..:||.|...|:|.:.|.|.|||:||:||||    
 Worm   478 VRITFYHKESSVRHLSNPTCVWWNHHELKWKPSGCKLSYHNKTMTSCDCTHLTHFAVLMDVRGHD 542

  Fly   751 VDEHQHSLFTMFDGNMRIFIYISIGICVVFIVIALLTLKLFNGVFVKSARTSIYTSIYLCL-LAI 814
            ::|...:|.|       :..|:.   |::.|:..|||...:. :|.::....::....||| |||
 Worm   543 LNEIDQTLLT-------LLTYVG---CIISIICLLLTFFAYL-IFSRNGGDRVFIHENLCLSLAI 596

  Fly   815 -ELLFLLGIEQTETSIFCGFITIFLHCAILSGTAWFCYEAFHSYSTLTSDELLLEV-DQTPKVNC 877
             |:.||.||.:||.|:.||.|.:.|....||...|...|.:|.:..||      || ...|:...
 Worm   597 AEITFLAGITRTEDSLQCGIIAVALMYMFLSALTWMLLEGYHIHRMLT------EVFPSDPRRFT 655

  Fly   878 YYLLSYGLSLSVVAISLVIDPSTYTQNDYCVLMEANALFYATFVIPVLVFFVAAIGYTFLSWIIM 942
            |.|:.|.....:..::.:.:...:...|:|.|...|...:         ||.....:.|      
 Worm   656 YLLVGYIPPAIITLVAYLYNSDGFGTPDHCWLSTQNNFIW---------FFAGPACFIF------ 705

  Fly   943 CRKSRTGLKT----KEHTRLA------------SVRFDIRCSFVFLLLLSAVWCSAYFYLRGAKM 991
            |..|...:||    .:||...            |:|..::.|.....||...|....|:     :
 Worm   706 CANSLVLVKTLCTVYQHTSGGYLPCRHDVDSGRSIRNWVKGSLALASLLGVTWIFGLFW-----V 765

  Fly   992 DDDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYRKYVRQHAWLPKCLRCSKTSISSGIVT 1056
            :|..:.|..|.|...|:|.||:||:||.:..||:|::...::.:..                   
 Worm   766 EDSRSIVMAYVFTISNSLQGLFIFLFHVVFAEKMRKDVGHWMYRRG------------------- 811

  Fly  1057 GNGPTAGTLCSVSTSKKPKLPLGVSEEAHDDPQQQQQTPVPITEDAIMGATSDCELNEAQQRRTL 1121
                     |..|::..|      :.:.|:                             .||..:
 Worm   812 ---------CGGSSNSSP------NHKRHN-----------------------------VQRDLM 832

  Fly  1122 KSGLMTGTLQAPPQTLGGHVVLERGST-LRSTGHASPTSSAGSTHLIF----AHKQQQQQQQQGP 1181
            ..|:.:.|                ||. |.:|.....|:|..:..|::    .|..|....||.|
 Worm   833 SPGVNSST----------------GSDFLYNTNDKYLTNSDTTNRLVYNGIMNHPNQMSVYQQHP 881

  Fly  1182 LGESYYHQPDYYSWKQPSTGT----GGLKTPREYYNNAGAAASSPQQAHEVFY-WTQKP------ 1235
            ..:.|..||..|.:...:.|.    ..:..|..|...|.|......| |:::. |..:|      
 Worm   882 HHQIYEQQPGTYDYATIAYGDMMPGHRVAAPPAYQRLAVAEGRYGSQ-HQLYQGWHHRPPPEFSP 945

  Fly  1236 -----NSGHNGKKKRGAGGVPASPSGSLHSRTAAAS 1266
                 ::|....:..|.|.....|..|..|..:|.|
 Worm   946 PPPPLSTGPPNSRHYGTGSSGRRPPSSKMSDDSAYS 981

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CirlNP_001260807.1 Gal_Lectin 33..113 CDD:280328 31/81 (38%)
GAIN 453..680 CDD:293098 50/269 (19%)
GPS 705..752 CDD:197639 24/50 (48%)
7tm_4 763..1014 CDD:304433 66/269 (25%)
lat-1NP_001366731.1 Gal_Lectin 51..133 CDD:396628 31/81 (38%)
HormR 180..244 CDD:214468 20/122 (16%)
GAIN 258..462 CDD:406802 48/259 (19%)
GPS 493..541 CDD:197639 24/47 (51%)
7tmB2_latrophilin-like_invertebrate 548..808 CDD:320556 75/296 (25%)
TM helix 1 551..575 CDD:320556 7/34 (21%)
TM helix 2 584..605 CDD:320556 9/20 (45%)
TM helix 3 615..637 CDD:320556 7/21 (33%)
TM helix 4 655..671 CDD:320556 3/15 (20%)
TM helix 5 690..713 CDD:320556 6/37 (16%)
TM helix 6 744..766 CDD:320556 5/26 (19%)
TM helix 7 771..796 CDD:320556 11/24 (46%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 66 1.000 Domainoid score I6575
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 280 1.000 Inparanoid score I1756
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000766
OrthoInspector 1 1.000 - - otm14722
orthoMCL 1 0.900 - - OOG6_102405
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3208
SonicParanoid 1 1.000 - - X858
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
109.890

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