Protein Alignment Cirl and mth-2

DIOPT Version :9

• Sequence 1: NP_001260807.1
• Gene: Cirl / 35846
• FlyBaseID: FBgn0033313
• Length: 1711
• Species: Drosophila melanogaster
• Sequence 2: NP_001364698.1
• Gene: mth-2 / 173752
• WormBaseID: WBGene00017947
• Length: 971
• Species: Caenorhabditis elegans
• Alignment Length: 1157
• Identity: 203/1157 - (17%)
• Similarity: 368/1157 - (31%)
• Gaps: 374/1157 - (32%)

  Fly    62 VEWSVNCMFPK------SLSVLNSRCAHKQ------SCGVLAATSMF------------------ 96
            :|:.||..|..      :.:|||....|.|      :||:|.....|
 Worm    41 MEFQVNVGFSNDGYAVFTTAVLNMTPYHFQMYVNGRNCGLLTLQCKFQLQPNESLNIVLDKIDMQ 105

  Fly    97 ----------GDPCPGTHKYLEAHYQ----CISAAQTSTTTNRPSPPPWVLSNGPPIFGNGSGLI 147
                      |...|..  |:...|:    |...:|.||.|.                    |.:
 Worm   106 SNLMTFTYRGGKKDPDV--YINGCYESMSSCAYGSQQSTDTR--------------------GTL 148

  Fly   148 HPPGVGAGAPPPPRLPTLPGVVGISGNPGLFNVPPQHTAVTH-----STPSSSTTAVGGGRLKGG 207
            :...:.|.....|..........||..| .:|..|...:.|.     |:.|.||:..........
 Worm   149 YQDSICACVGSFPTCLFSENDTCISNRP-FWNYDPPTASTTEEIDTSSSTSRSTSTPSSTEASST 212

  Fly   208 ATSTTTTKHPAGRHDGLPPPPQLHHHHNHHGEDTASPTKPSSKLPAGGNATSPSNTRILTGVGGS 272
            .|||||.:...                      |..||.|::        |:.::|..:|.:..|
 Worm   213 VTSTTTARTTT----------------------TMIPTTPTT--------TTIASTSTVTSIVTS 247

  Fly   273 GTDDGTLLTTKSSPNRPPGTAASGSVVPGNGSVVRTINNINLNAAGMSGGDDESKLFCGPTHARN 337
            .|...|.:.|.:.....|.|.|: |......|...|..:.:.:...::...:.:.....||.:
 Worm   248 TTVTSTTVPTTTVVTTVPTTTAT-STSTSTASTTTTTPSTSTHTTTVTYSTNATSSTTSPTTS-- 309

  Fly   338 LYWNMTRVGDVNVQPCPGGAAGIAKWRCVLMKRIPDS--GYDEYDDDISSTTPAPSGGDCLHNSS 400
                      ...:|.|...|.:.   ...:|.:.||  |.:.....::.|......|..|:.:.
 Worm   310 ----------PTPEPEPTTTATVL---APTLKNLSDSGVGINNVSTVLNETLTYSEMGANLNATQ 361

  Fly   401 SCEPPVSMAHKVNQRLRNFEPTWHPATPDLTQCRSL-WLNNLEMRVNQRDSSLISIANDMSEVTS 464
            ..|....:.:..|             .|.||...|: .|:||:..:....:.:....|....|.:
 Worm   362 VAEISTILINSAN-------------VPGLTAENSMAILHNLDNMLYVSPTIMYQSGNSAQGVLN 413

  Fly   465 SKTLYGGDMLVTTKIIQTVSEKMMHDKETFPDQRQREAMIMELLHCVVKTGSNL------LDESQ 523
            |         :.|.:..||            |||      :|.|:     |.||      ||.|.
 Worm   414 S---------LGTMVDNTV------------DQR------IEYLN-----GQNLGFSSKRLDCSN 446

  Fly   524 LSS---WLDLNPEDQMRVATSLLTGLEYNAFLLADTIIRERSVVQKVKNILLSVRVLETKTIQSS 585
            |.:   .|||..:.::..:|..|.  ::::.|:.   :.:....|.:.::..::       .:.:
 Worm   447 LGADDGLLDLGSKFELINSTDSLG--KWHSILVP---LSDLCSTQDLSHVFFTI-------YRDT 499

  Fly   586 VVFPDSDQW--------PLSSDRIE-------LPRAALIDNSEGGLVRIVFAAFDRLESILKPSY 635
            .:|....|:        |:||...|       :||:|....:|
 Worm   500 SLFVGPQQYRTYTGTNKPISSGEAETYTPPPRVPRSAGFYEAE---------------------- 542

  Fly   636 DHFDLKSSRSYVRNTAILSNDSDVNAGEIQQRLRILNSKVISASL---GKGRHIQLSQPITLTLK 697
                     .|..|    :....|......::..:..:.|:||::   |....:..:...|:.|.
 Worm   543 ---------PYQMN----ATSQTVPLSPCARQTSLPPTPVMSATVMNNGVAVSVSATSEATMALL 594

  Fly   698 HLKTENVTNP-----TCVFWNYIDHAWSAN-GCSLESTNRTHSVCSCNHLTNFAILMDVVDEHQH 756
            ......:..|     ...:|:...:||:.: .|.:.|.:.......|.|||:|||::|.
 Worm   595 RFNISTLMKPLHGNLKVTWWDIGRNAWAEDRQCEIVSESDGILEARCTHLTDFAIIVDA------ 653

  Fly   757 SLFTMFDGNMRIFIYISIGICVVFI-VIALLTLKLFN-GVFVKS-ARTSIYTSI----------- 807
               .:.|.|:.....|::|..|..: :::|..|..|: ..::.| |.:.:|:.:
 Worm   654 ---ALNDPNVCDNALITLGYVVNGLSIVSLAFLTFFSISAYINSLANSRLYSYVRGHNLARRDFL 715

  Fly   808 ----YLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSGTAWFCYEAFHSYSTLTSDELLLE 868
                :..||...:.|.:...|..:...|..:...::..:|.......::|..:         :|.
 Worm   716 ALIYHFDLLLFYVFFTVFSNQDVSGDMCTAMAAVMYALLLCSLFLTIFQALRN---------ILV 771

  Fly   869 VDQTPKVNCYYLLS--YG---LSLSVVAISLVI--------------DPSTYTQNDYCVLMEANA 914
            ...||   .|.||:  :|   :.::.||:..::              |...:.:.||.|
 Worm   772 FLPTP---AYRLLNICFGTVPVLITSVALPFILSIFLLVFTKFFDRQDCFCWVRPDYIV------ 827

  Fly   915 LFYATFVIPVLVFFVAAIGYT-FLSWIIMCRKSRTGLKTKEH------TRLASVRFDIRCSFVFL 972
               |..:|||.|..::.:..| |:.:.:.|...|...:...|      |::.|:       .|..
 Worm   828 ---AAIIIPVTVLLLSTVVCTSFMIYKVFCGMKRKFSQGGHHYDPNVITKIVSI-------VVMQ 882

  Fly   973 LLLSAVWCSAYFYLRGAKMDDDTADVYGYCFICFNTLLG------LYIFVFHCIQNEKIRREYRK 1031
            :.|...|...:    |......|.    :....|..:||      |.||:
 Worm   883 ISLGLPWILQF----GTLYSPYTT----FWHYTFTIVLGSQGTILLLIFL--------------- 924

  Fly  1032 YVRQHAWLPKCLRCSKTSISSGIVTGNGPTAGTLCSVSTSKKPKLPLGVSEE 1083
            |.|..||.      :.:::.|         .|...|.:::|:.||   |.||
 Worm   925 YKRYRAWQ------ADSTLKS---------RGQSYSKNSTKRTKL---VEEE 958

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328	17/94 (18%)
		GAIN	453..680	CDD:293098	41/250 (16%)
		GPS	705..752	CDD:197639	14/52 (27%)
		7tm_4	763..1014	CDD:304433	52/300 (17%)
mth-2	NP_001364698.1	GPS	607..656	CDD:197639	13/57 (23%)
		7tm_GPCRs	662..933	CDD:421689	56/327 (17%)
		TM helix 1	664..690	CDD:410628	6/25 (24%)
		TM helix 2	706..735	CDD:410628	3/28 (11%)
		TM helix 4	779..803	CDD:410628	5/23 (22%)
		TM helix 5	824..852	CDD:410628	10/36 (28%)
		TM helix 6	868..897	CDD:410628	6/39 (15%)
		TM helix 7	902..927	CDD:410628	7/43 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158951
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940