DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cirl and Adgrl2

DIOPT Version :9

Sequence 1:NP_001260807.1 Gene:Cirl / 35846 FlyBaseID:FBgn0033313 Length:1711 Species:Drosophila melanogaster
Sequence 2:NP_599235.3 Gene:Adgrl2 / 171447 RGDID:620835 Length:1487 Species:Rattus norvegicus


Alignment Length:1624 Identity:356/1624 - (21%)
Similarity:567/1624 - (34%) Gaps:496/1624 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 ILSIS-----YEHISLDLSKYQTAYACEGKKLTIECDPGDVINLIRANYGRFSITICN-DHGNVE 63
            |:|.|     :...:|.....:...:|||..:.:.|...|||.:..|||||....||: |...:|
  Rat    16 IISFSPNTEGFSRAALPFGLVRRELSCEGYSIDLRCPGSDVIMIESANYGRTDDKICDADPFQME 80

  Fly    64 WSVNCMFPKSLSVLNSRCAHKQSCGVLAATSMFGDPCPGTHKYLEAHYQCISAAQTSTTTNRPSP 128
             :.:|..|.:..::..||.::..|.|:..:.:|.||||||:||||..|:|:              
  Rat    81 -NTDCYLPDAFKIMTQRCNNRTQCVVVTGSDVFPDPCPGTYKYLEVQYECV-------------- 130

  Fly   129 PPWVLSNGPPIF---GNGSGLIHPPGV-------GAGAPPP----------PRLP---------- 163
             |::...   :|   |....::..|.:       ||....|          |..|          
  Rat   131 -PYMEQK---VFVCPGTLKAIVDSPSIYEAEQKAGAWCKDPLQAADKIYFMPWTPYRTDTLIEYA 191

  Fly   164 --------------TLPGVVG-----------------------------ISGNPGLFNVPPQHT 185
                          .||..|.                             |.....:.|....|.
  Rat   192 SLEDFQNSRQTTTYKLPNRVDGTGFVVYDGAVFFNKERTRNIVKFDLRTRIKSGEAIINYANYHD 256

  Fly   186 A---------------------VTHSTPSSS----TTAVGGGRLKGGATSTTT------------ 213
            .                     |.::|..::    .:.:....|:..||..||            
  Rat   257 TSPYRWGGKTDIDLAVDENGLWVIYATEQNNGMIVISQLNPYTLRFEATWETTYDKRAASNAFMI 321

  Fly   214 ----------------------------TKHPAGRHDGLPPPPQLHH--HHNHHGEDTA------ 242
                                        |:...|.|..:|.|.|..:  ..:::..|..      
  Rat   322 CGVLYVVRSVYQDNESEAGKNVIDYIYNTRLSRGEHVDVPFPNQYQYIAAVDYNPRDNQLYVWNN 386

  Fly   243 ----------SPTKPSSKLPAGGNATSPSNTRILTGVG--GSGTDDGTLLTTKSSP------NRP 289
                      .|..| :::|......:.|.....|.|.  .|.:..|.:.:|.:.|      .:|
  Rat   387 NFILRYSLEFGPPDP-AQVPTTAVTITSSAELFKTTVSTTSSTSQRGPVSSTVAGPQEGSRGTKP 450

  Fly   290 PGTAASGSVVPGNGSVVRTINNINLNAAGMSGGDDESKLFCGPTHARNLYWNMTRVGDVNVQPCP 354
            |...::..:.|        :.||          ....:.||.....:.:.|..|:.|.:..:|||
  Rat   451 PPAVSTTKIPP--------VTNI----------FPLPERFCEALEMKGIKWPQTQRGMMVERPCP 497

  Fly   355 GGAAGIAKWRCVLMKRIPDSGYDEYDDDISSTTPAPSGGDCLHNSSSCEPPVSMAHKVNQRLRNF 419
            .|..|.|.:.|:                      |.:|                           
  Rat   498 KGTRGTASYLCM----------------------ASTG--------------------------- 513

  Fly   420 EPTWHPATPDLTQCRSLWLNNLEMRVNQRDSSLISIANDMSEVTSSKTLYGGDMLVTTKIIQTV- 483
              ||:|..|||:.|.|.|:|.|..::...::: .|:||::::.|.. |::.||:..:.::::.: 
  Rat   514 --TWNPKGPDLSNCTSHWVNQLAQKIRSGENA-ASLANELAKHTKG-TVFAGDVSSSVRLMEQLV 574

  Fly   484 ------------SEKMMHDKETFPDQRQREAMIMELLHCVVKTGSNLLDESQLSSWLDLNPEDQM 536
                        |||....: ::...::||......|..:|.|..|||....|..|..:|..:|.
  Rat   575 DILDAQLQELKPSEKDSAGR-SYNKLQKREKTCRAYLKAIVDTVDNLLRAETLDCWKHMNSSEQA 638

  Fly   537 RVATSLLTGLEYNAFLLADTIIRERSVVQKVKNILLSVRVLETKTIQSSVVFPDSDQWPLSSDRI 601
            ..||.||..||..||:|||.::....|.....||:|.|.||.|:.......|....:...||  |
  Rat   639 HTATMLLDTLEEGAFVLADNLLEPTRVSMPTDNIVLEVAVLSTEGQVQDFTFHLGFKGAFSS--I 701

  Fly   602 ELPRAALIDNSEGGLVRIVFAAFDRLESILKPSYDHFDLKSSRSYV-RNTAILSNDSDVNAGEIQ 665
            :|....:..||..||.::||..:..|...|  |.::..:|.....: ||:.|             
  Rat   702 QLSANTVKQNSRNGLAKVVFIIYRSLGPFL--STENATVKLGADLLGRNSTI------------- 751

  Fly   666 QRLRILNSKVISASLGK-GRHIQLSQPITLTLKHLKTENVTNPTCVFWNYIDHA----WSANGCS 725
                .:||.|:|.|:.| ...:.|:.|:..::.|:.::|..|..|.||||.:..    ||..||.
  Rat   752 ----AVNSHVLSVSINKESSRVYLTDPVLFSMPHIDSDNYFNANCSFWNYSERTMMGYWSTQGCK 812

  Fly   726 LESTNRTHSVCSCNHLTNFAILMD----VVDEHQHSLFTMFDGNMRIFIYISIGICVVFIVIALL 786
            |..||:|.:.|:|:|||||||||.    |..:..|.|.      :.:..::.|.:.:|.:.|.:.
  Rat   813 LVDTNKTRTTCACSHLTNFAILMAHREIVYKDGVHKLL------LTVITWVGIVVSLVCLAICIF 871

  Fly   787 TLKLFNGVFVKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSGTAWFCY 851
            |...|.|  ::|.|.:|:.::.:.|...|.:||:||::|:.:|.|......||...|:..:|.|.
  Rat   872 TFCFFRG--LQSDRNTIHKNLCINLFIAEFIFLIGIDKTQYTIACPVFAGLLHFFFLAAFSWMCL 934

  Fly   852 EAFHSYSTLTSDELLLEV--DQTPKVNCYYLLSYGLSLSVVAISLVIDPSTYTQNDYCVLMEANA 914
            |....|.      :|:||  .:..:...||:..|....:||.:|..||..:|...:.|.|...| 
  Rat   935 EGVQLYL------MLVEVFESEYSRKKYYYVAGYLFPATVVGVSAAIDYKSYGTLEACWLHVDN- 992

  Fly   915 LFYATFVIPVLVFFVAAIGYTFLSWIIMCR--KSRTGLKTKEHTRLASVRFDIRC---------- 967
            .|..:|:.||.  |:..:...||. |.:|:  |....|| .:.:||.::.....|          
  Rat   993 YFIWSFIGPVT--FIILLNIIFLV-ITLCKMVKHSNTLK-PDSSRLENINNYRVCDGYYNTDLPG 1053

  Fly   968 --------------SFVFLLLLSAVWCSAYFYLRGAKMDDDTADVYGYCFICFNTLLGLYIFVFH 1018
                          :|..|.||...|.....:     ::::|. |..|.|..||...||:||:||
  Rat  1054 YEDNKPFIKSWVLGAFALLCLLGLTWSFGLLF-----VNEETV-VMAYLFTAFNAFQGLFIFIFH 1112

  Fly  1019 CIQNEKIRREYRKYVRQHAWLPKCLRCSKTSISSGIVTGNGPTAGTLCSVSTSKKPKLPLGVSEE 1083
            |...:|:|:||.|..|.  |.  |  |......|...:....|:.|....|:..:.::     ..
  Rat  1113 CALQKKVRKEYAKCFRH--WY--C--CGGLPTESPHSSVKASTSRTSARYSSGTQSRI-----RR 1166

  Fly  1084 AHDDPQQQQQTPVPITEDAIMGATSDCELNEAQQRRTLKSG-----LMTGTLQAPPQT------- 1136
            ..:|..::|.....|:.|  :.:||           ||..|     |:|..|..|..|       
  Rat  1167 MWNDTVRKQSESSFISGD--INSTS-----------TLNQGMTGNYLLTNPLLRPHGTNNPYNTL 1218

  Fly  1137 LGGHVVLERGS--TLRSTGHA----SPTSSAGSTHLIFAHKQQQQQQQQGPLGESY-YHQPDYYS 1194
            |...||....|  ...|.||:    ..||:..:..|            .|....|| ..:.||:.
  Rat  1219 LAETVVCNAPSAPVFNSPGHSLNNTRDTSAMDTLPL------------NGNFNNSYSLRKADYHD 1271

  Fly  1195 WKQ-----------------------------PSTGTGGLKTP---------------------- 1208
            ..|                             ..|....||.|                      
  Rat  1272 GVQVVDCGLSLNDTAFEKMIISELVHNNLRGSNKTHNLELKLPVKPVIGGSSSEDDAIVADASSL 1336

  Fly  1209 -------REYYNNAGAAASSPQQAHEVFYWTQKPNSGHNGKKKRGAGGVPASPSGSLHSRTAAAS 1266
                   .|:.:....|...||:.|.:.|..||       |.|      |.:....:...||.|.
  Rat  1337 MHGDNPGLEFRHKELEAPLIPQRTHSLLYQPQK-------KVK------PEATDSYVSQLTAEAD 1388

  Fly  1267 QVLFYP---SYKKTKPG-----QPTGYPQYAEALDPPLATGNAAAYYQQQQQL---RRQQLHQQ 1319
            :.|..|   |...:.|.     .|...|..||.|.|...:.|...||:....|   |:.|:..|
  Rat  1389 EHLQSPNRDSLYTSMPNLRDSPYPESSPDMAEDLSPSRRSENEDIYYKSMPNLGAGRQLQMCYQ 1452

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CirlNP_001260807.1 Gal_Lectin 33..113 CDD:280328 31/80 (39%)
GAIN 453..680 CDD:293098 63/240 (26%)
GPS 705..752 CDD:197639 26/54 (48%)
7tm_4 763..1014 CDD:304433 68/278 (24%)
Adgrl2NP_599235.3 Gal_Lectin 49..129 CDD:396628 31/80 (39%)
OLF 142..398 CDD:413369 27/255 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 422..462 8/47 (17%)
HormR 469..533 CDD:214468 24/114 (21%)
GAIN 542..764 CDD:406802 64/245 (26%)
GPS 788..840 CDD:197639 25/51 (49%)
7tm_GPCRs 848..1129 CDD:421689 79/305 (26%)
TM helix 1 850..875 CDD:410628 4/30 (13%)
TM helix 2 884..906 CDD:410628 6/21 (29%)
TM helix 3 915..942 CDD:410628 7/32 (22%)
TM helix 4 954..974 CDD:410628 6/19 (32%)
TM helix 5 991..1020 CDD:410628 10/32 (31%)
TM helix 6 1036..1087 CDD:410628 6/55 (11%)
TM helix 7 1091..1116 CDD:410628 12/25 (48%)
Latrophilin 1128..1487 CDD:396778 73/374 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1139..1160 4/20 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1386..1428 11/41 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 78 1.000 Domainoid score I8556
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 357 1.000 Inparanoid score I2154
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000766
OrthoInspector 1 1.000 - - otm45134
orthoMCL 1 0.900 - - OOG6_102405
Panther 1 1.100 - - O PTHR12011
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X858
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1211.820

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