DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cirl and Adgrl3

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	XP_008768190.1	Gene:	Adgrl3 / 170641	RGDID:	620836	Length:	1585	Species:	Rattus norvegicus

Alignment Length:	1694	Identity:	384/1694 - (22%)
Similarity:	622/1694 - (36%)	Gaps:	457/1694 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ILSISYEHISLDLSKYQTAYACEGKKLTIECDPGDVINLIRANYGRFSITIC-NDHGNVEWSVNC 68
            |.:.::....:.::..:...:||...:.:.|...|||.:..|||||....|| :|...:| ::.|
  Rat    83 IAAQAFSRAPIPMAVVRRELSCESYPIELRCPGTDVIMIESANYGRTDDKICDSDPAQME-NIRC 146

  Fly    69 MFPKSLSVLNSRCAHKQSCGVLAATSMFGDPCPGTHKYLEAHYQCI------------------- 114
            ..|.:..:::.||.::..|.|:|...:|.||||||:||||..|:|:
  Rat   147 YLPDAYKIMSQRCNNRTQCAVVAGPDVFPDPCPGTYKYLEVQYECVPYKVEQKVFLCPGLLKGVY 211

  Fly   115 -----------SAA--------------------QTSTTTNRPSPPPWV---------------- 132
                       |.|                    :|.|.|...|...::
  Rat   212 QSEHLFESDHQSGAWCKDPLQASDKIYYMPWTPYRTDTLTEYSSKDDFIAGRPTTTYKLPHRVDG 276

  Fly   133 ----------------------------LSNGPPIFG------------------------NGSG 145
                                        :.:|..|..                        ||..
  Rat   277 TGFVVYDGALFFNKERTRNIVKFDLRTRIKSGEAIIANANYHDTSPYRWGGKSDIDLAVDENGLW 341

  Fly   146 LIHPPGVGAG----APPPPRLPTLPG----------------VVGI---------------SGN- 174
            :|:......|    :...|....:.|                :.||               :||
  Rat   342 VIYATEQNNGKIVISQLNPYTLRIEGTWDTAYDKRSASNAFMICGILYVVKSVYEDDDNEATGNK 406

  Fly   175 -----------PGLFNVP-P---QHTAVTHSTPSSSTTAVGGG------RLKGGATSTTTTKHPA 218
                       ..|.:|| |   |:.|.....|..:...|...      .|..|...:.:.....
  Rat   407 IDYIYNTDQSKDSLVDVPFPNSYQYIAAVDYNPRDNLLYVWNNYHVVKYSLDFGPLDSRSGPVHH 471

  Fly   219 GRHDGLPPPPQLHHHHNHHGEDTASPTKPSSKLPAGGNATSPSNTRILTG-VG-GSGTDDGTLLT 281
            |:...:.||       .|...|...|       |..|.:|        || :| ||.|...||.|
  Rat   472 GQVSYISPP-------IHLDSDLERP-------PVRGIST--------TGPLGMGSTTTSTTLRT 514

  Fly   282 T-----KSSPNRPPGTAASGSVVPGNGSVVRTINNINLNAAGMSGGDDESKLFCGPTHARNLYWN 341
            |     :|:....||.....:..|.....|..:.....:||......:||   |....||.:.|.
  Rat   515 TTWNLGRSTTPSLPGRRNRSTSTPSPAIEVLDVTTHLPSAASQIPAMEES---CEAVEAREIMWF 576

  Fly   342 MTRVGDVNVQPCPGGAAGIAKWRCVLMKRIPDSGYDEYDDDISSTTPAPSGGDCLHNSSSCEPPV 406
            .||.|.|..||||.|..|::.:.|:                      ||.|
  Rat   577 KTRQGQVAKQPCPAGTIGVSTYLCL----------------------APDG-------------- 605

  Fly   407 SMAHKVNQRLRNFEPTWHPATPDLTQCRSLWLNNLEMRVNQRDSSLISIANDMSEVTSSKTLYGG 471
                           .|.|..|||:.|.|.|:|::..::...::: .:||.:::|.|.:. |..|
  Rat   606 ---------------IWDPQGPDLSNCSSPWVNHITQKLKSGETA-ANIARELAEQTRNH-LNAG 653

  Fly   472 DMLVTTKII-QTVSEKMMHDKETFPDQR-----------QREAMIMELLHCVVKTGSNLLDESQL 524
            |:..:.:.: |.|....:..:...|..:           :||......:..:|:|.:|||....|
  Rat   654 DITYSVRAMDQLVGLLDVQLRNLTPGGKDSAARSLNKLQKRERSCRAYVQAMVETVNNLLQPQAL 718

  Fly   525 SSWLDLNPEDQMRVATSLLTGLEYNAFLLADTIIRERSVVQKVKNILLSVRVLETKTIQSSVVFP 589
            ::|.||...||:|.||.||..:|.:||:|||.:::...|.:...||.|.|..|.|:.....:.||
  Rat   719 NAWRDLTTSDQLRAATMLLDTVEESAFVLADNLLKTDIVRENTDNIQLEVARLSTEGNLEDLKFP 783

  Fly   590 DSDQWPLSSDRIELPRAALIDNSEGGLVRIVFAAFDRLESILKPSYDHFDLKSSRSYVRNTAILS 654
            ::..   ....|:|....|..|...|.:|:.|..::.|...|  |.::..:|      ..|..:|
  Rat   784 ENTG---HGSTIQLSANTLKQNGRNGEIRVAFVLYNNLGPYL--STENASMK------LGTEAMS 837

  Fly   655 NDSDVNAGEIQQRLRILNSKVISASLGK--GRHIQLSQPITLTLKHLK-TENVTNPTCVFWNYID 716
            .:..|          |:||.||:|::.|  ...:.|:.|:..|:||:| :|...||.|.||:|..
  Rat   838 TNHSV----------IVNSPVITAAINKEFSNKVYLADPVVFTVKHIKQSEENFNPNCSFWSYSK 892

  Fly   717 HA----WSANGCSLESTNRTHSVCSCNHLTNFAILMDVVDEHQHSLFTMFDGNMRIFIYISIGIC 777
            ..    ||..||.|.:||:||:.||||||||||:||..| |.:|| ..:.|..:.:..::.|.:.
  Rat   893 RTMTGYWSTQGCRLLTTNKTHTTCSCNHLTNFAVLMAHV-EVKHS-DAVHDLLLDVITWVGILLS 955

  Fly   778 VVFIVIALLTLKLFNGVFVKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAI 842
            :|.::|.:.|...|.|  ::|.|.:|:.::.:.|...|||||:||.:|:..|.|......||...
  Rat   956 LVCLLICIFTFCFFRG--LQSDRNTIHKNLCISLFVAELLFLIGINRTDQPIACAVFAALLHFFF 1018

  Fly   843 LSGTAWFCYEAFHSYSTLTSDELLLEV--DQTPKVNCYYLLSYGLSLSVVAISLVIDPSTYTQND 905
            |:...|...|....|.      :|:||  .:..:...:||:.||:...:||:|..:|..:|..:.
  Rat  1019 LAAFTWMFLEGVQLYI------MLVEVFESEHSRRKYFYLVGYGMPALIVAVSAAVDYRSYGTDK 1077

  Fly   906 YCVLMEANALFYATFVIPVLVFFVAAIGYTFLSWIIMCRKSRTGLKTKEHTRLASVRFDIRCSFV 970
            .|.| ..:..|..:|:.|..:  :..:...||...:......|.:...|...|.::.::....|:
  Rat  1078 VCWL-RLDTYFIWSFIGPATL--IIMLNVIFLGIALYKMFHHTAILKPESGCLDNINYEDNRPFI 1139

  Fly   971 ---------FLLLLSAVWCSAYFYLRGAKMDDDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIR 1026
                     .|.||...|.....|:      :::..:..|.|..||:|.|::||:|||:..:|:|
  Rat  1140 KSWVIGAIALLCLLGLTWAFGLMYI------NESTVIMAYLFTIFNSLQGMFIFIFHCVLQKKVR 1198

  Fly  1027 REYRKYVRQHAWLPKCLRCSKTSISSGIVTGNGPTAG--TLCSVSTSKKPKLPLGVSEEAHDDPQ 1089
            :||.|.:|.|.       ||..|..|.|  |:|.|:|  |....||..:.::     ....:|..
  Rat  1199 KEYGKCLRTHC-------CSGKSTESSI--GSGKTSGSRTPGRYSTGSQSRI-----RRMWNDTV 1249

  Fly  1090 QQQQTPVPITEDAIMGATSDCELNEAQQRRTLKSGLMTGTLQAPPQTLGGHVVLERGSTLRSTGH 1154
            ::|.....||.|    ..|...||    |.|:.:.||:..|                  ||..|.
  Rat  1250 RKQSESSFITGD----INSSASLN----RGTMANHLMSNAL------------------LRPHGT 1288

  Fly  1155 ASPTSSAGSTHLIFAHKQQQQQQQQGPLGE-SYYHQP--DYYSWKQPSTGTGGLKTPREYYNNAG 1216
            .:|.::.                    ||| :..:.|  ..|:.::|...|.||      .||
  Rat  1289 NNPYNTL--------------------LGEPAVCNNPSISMYNAQEPYRETKGL------LNN-- 1325

  Fly  1217 AAASSPQQAHEVFYWTQKPNSGHNGKKKRGAGG------VPASPSGSLHSRTAAASQVL------ 1269
                    |.:.......|.:|::|.....|||      |.....|..|:.||...::|
  Rat  1326 --------ARDTSVMDTLPLNGNHGNSYSIAGGEYLSNCVQIIDRGYNHNETALEKKILKELTSN 1382

  Fly  1270 FYPSYKKTKPGQPTGYPQYAEALDPPLATGNA--------AAYYQQQQQLRRQQLHQQQQQQ--Q 1324
            :.|||.................|...|.:|:.        ||.:..::.|..:.:|::....  .
  Rat  1383 YIPSYLNNHERSSEQNRNMMNKLVDNLGSGSEDDAIVLDDAASFNHEESLGLELIHEESDAPLLP 1447

  Fly  1325 QQQLSSDEEQAEQHAHLLHLQRRAGSQQQLPAPPPHMAQYQQEFMQRQYRNKHSNCDLGMGDAYY 1389
            .:..|:|..|..      |..||...|....:..|.:.....|..|..:|           |:.|
  Rat  1448 PRVYSTDNHQPH------HYSRRRLPQDHSESFFPLLTDEHTEDPQSPHR-----------DSLY 1495

  Fly  1390 NQGSVGGADGGPVYEEILSNRNSDVQHYEVGDFDVDEVYNNSVGTGVFNNMRAAVAAGGSRYGGG 1454
            .  |:....|.|..:.:.::..::....:.||.: |..|.:....|..|::....|.  .:.|.|
  Rat  1496 T--SMPALAGVPAADSVTTSTQTEAAAAKGGDAE-DVYYKSMPNLGSRNHVHPLHAY--YQLGRG 1555

  Fly  1455 SLSG 1458
            |..|
  Rat  1556 SSDG 1559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328	32/80 (40%)
		GAIN	453..680	CDD:293098	63/238 (26%)
		GPS	705..752	CDD:197639	27/50 (54%)
		7tm_4	763..1014	CDD:304433	61/261 (23%)
Adgrl3	XP_008768190.1	Gal_Lectin	111..191	CDD:396628	32/80 (40%)
		OLF	205..461	CDD:128580	27/255 (11%)
		HormR	562..626	CDD:214468	29/117 (25%)
		GAIN	634..855	CDD:406802	63/243 (26%)
		GPS	881..933	CDD:197639	28/52 (54%)
		7tmB2_Latrophilin-3	941..1207	CDD:320671	71/282 (25%)
		TM helix 1	944..968	CDD:320671	4/23 (17%)
		TM helix 2	977..998	CDD:320671	7/20 (35%)
		TM helix 3	1008..1030	CDD:320671	5/21 (24%)
		TM helix 4	1049..1065	CDD:320671	6/15 (40%)
		TM helix 5	1084..1107	CDD:320671	4/24 (17%)
		TM helix 6	1143..1165	CDD:320671	5/27 (19%)
		TM helix 7	1169..1194	CDD:320671	11/24 (46%)
		Latrophilin	1207..1585	CDD:396778	91/451 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	78	1.000	Domainoid score	I8556
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	357	1.000	Inparanoid score	I2154
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000766
OrthoInspector	1	1.000	-	-		otm45134
orthoMCL	1	0.900	-	-		OOG6_102405
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X858
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.960