Protein Alignment Cirl and ADGRF3

DIOPT Version :10

• Sequence 1: NP_001260807.1
• Gene: Cirl / 35846
• FlyBaseID: FBgn0033313
• Length: 1711
• Species: Drosophila melanogaster
• Sequence 2: NP_001138640.1
• Gene: ADGRF3 / 165082
• HGNCID: 18989
• Length: 1079
• Species: Homo sapiens
• Alignment Length: 1186
• Identity: 249/1186 - (20%)
• Similarity: 395/1186 - (33%)
• Gaps: 367/1186 - (30%)

  Fly    10 YEHISL-------DLSKYQTAYACE----------GKKLTIECDPGDVINLIRANYGRFSITICN 57
            |.|:..       :||:..|..|..          |.:||.||:    :|    :.|.|   .|.
Human   127 YVHLDFPDKTWPPELSRTLTLPAASASSSPRPLLTGLRLTTECN----VN----HKGNF---YCA 180

  Fly    58 DHGNVEWSVN-CM-FPKSLSVLNSRCAHKQSCGVLAATSMFGDPCPGTHKYLEAHYQCISAAQTS 120
            .....:|:.: |: :|...|:.|     .|.||.|    :|..|.||..:.|
Human   181 CLSGYQWNTSICLHYPPCQSLHN-----HQPCGCL----VFSHPEPGYCQLL------------- 223

  Fly   121 TTTNRPSPPPWVLSNGPPIFGNGSGLIHPPGVGAGAPPPPRLPTLPGVVGISGNPGLFNVPPQHT 185
                                        |||     .|...||.:||::.::..   ..:|....
Human   224 ----------------------------PPG-----SPVTCLPAVPGILNLNSQ---LQMPGDTL 252

  Fly   186 AVT-HSTPSSSTTAVGGGRLKGGATSTTTTKHPAGRHDGLPPPPQLH-----HHHNHHGEDTASP 244
            ::| |              |...||:.:...    ||.|.|.|..|.     ...:.||:...|.
Human   253 SLTLH--------------LSQEATNLSWFL----RHPGSPSPILLQPGTQVSVTSSHGQAALSV 299

  Fly   245 TKPS--------SKLPAGGNATSPSNTRILTGVGGSGTDDGTL-----LTTKSSPNRP-----PG 291
            :..|        |...|.|   ...|...:..|....||...|     ::..:||...     |.
Human   300 SNMSHHWAGEYMSCFEAQG---FKWNLYEVVRVPLKATDVARLPYQLSISCATSPGFQLSCCIPS 361

  Fly   292 T--AASGSVVPGNGSVVRTINN---------------------INLNAAGMS------------G 321
            |  |.:.:..||.||...:.|.                     .:|.:.|::            .
Human   362 TNLAYTAAWSPGEGSKASSFNESGSQCFVLAVQRCPMADTTYACDLQSLGLAPLRVPISITIIQD 426

  Fly   322 GDDESKLFCGPTHARNLYWNMTRVGDVNVQPCPGGAAGIAKWRCVLMKRIPDSGYDEYDDDISST 386
            ||    :.| |..|..|.||:|:.|.|...|||....||.:..|
Human   427 GD----ITC-PEDASVLTWNVTKAGHVAQAPCPESKRGIVRRLC--------------------- 465

  Fly   387 TPAPSGGDCLHNSSSCEPPVSMAHKVNQRLRNFEPTWHPATPDLTQCR--SLWLNNLEMRVNQRD 449
                 |.|                          ..|.|.....|..|  :|:.....::..|..
Human   466 -----GAD--------------------------GVWGPVHSSCTDARLLALFTRTKLLQAGQGS 499

  Fly   450 SS------LISIANDMSEVTSSKTLYGGDMLVTTK-IIQTVSEKMMHDKETFPDQRQREAMIMEL 507
            .:      |..:....:|.:|...|.  .:|.|.| :.:.|:|..:        |..|.|    |
Human   500 PAEEVPQILAQLPGQAAEASSPSDLL--TLLSTMKYVAKVVAEARI--------QLDRRA----L 550

  Fly   508 LHCVVKTGSNLLDESQLSSWLDLNPEDQMRVATSLLTGLEYNAFLLADTIIRERSVVQKVKNILL 572
            .:.::.| ..:||....|.| .|....:....::||..:|..|..|..   ::......:.|:||
Human   551 KNLLIAT-DKVLDMDTRSLW-TLAQARKPWAGSTLLLAVETLACSLCP---QDHPFAFSLPNVLL 610

  Fly   573 SVRVL-ETKTIQSSVVFPDSDQWPLSSDRIELPR---AALIDNSEGGLVRIVFAAFDRLESILKP 633
            ..::. .|.....|:.||...  ||.:   ::||   |.|:.|  |..:.|......:|:.:|..
Human   611 QSQLFGPTFPADYSISFPTRP--PLQA---QIPRHSLAPLVRN--GTEISITSLVLRKLDHLLPS 668

  Fly   634 SYDH---FDLKSSRSYVRNTAILSNDSDVNAGEIQQRLRILNSKVISASLGKGRHIQLSQPITLT 695
            :|..   ..|.::...|...:|::.|...:.||:                              .
Human   669 NYGQGLGDSLYATPGLVLVISIMAGDRAFSQGEV------------------------------I 703

  Fly   696 LKHLKTENVTNPTCVFWNYIDHA-------WSANGCSLESTNRTHSV-CSCNHLTNFAILMD--- 749
            :....|:.  :|.||||   ||:       ||..||..:..:.:.:. |.|.|||.|::||.
Human   704 MDFGNTDG--SPHCVFW---DHSLFQGRGGWSKEGCQAQVASASPTAQCLCQHLTAFSVLMSPHT 763

  Fly   750 VVDEHQHSLFTMFDGNMRIFIYISIGICVVFIVIALLTLKLFNGVFVKSA----RTSIYTSIYLC 810
            |.:|...:|.|.          :.:|..::.:::.|....|...|.|::.    |.:...::..|
Human   764 VPEEPALALLTQ----------VGLGASILALLVCLGVYWLVWRVVVRNKISYFRHAALLNMVFC 818

  Fly   811 LLAIELLFLLG--IEQTETSIFCGFITIFLHCAILSGTAWFCYEAFHSYSTLTSDELLLEVDQTP 873
            |||.:..||..  :.....|..|.......|...|:...|...:|.     :.:.:||....|..
Human   819 LLAADTCFLGAPFLSPGPRSPLCLAAAFLCHFLYLATFFWMLAQAL-----VLAHQLLFVFHQLA 878

  Fly   874 K---VNCYYLLSY--GLSLSVVAISLVIDPSTYTQNDYCVLMEANALFYATFVIPVLVFFVAAIG 933
            |   :....||.|  .|.|:.|.:.|.:....|.:...|.|.......| |||.|||    |.||
Human   879 KHRVLPLMVLLGYLCPLGLAGVTLGLYLPQGQYLREGECWLDGKGGALY-TFVGPVL----AIIG 938

  Fly   934 YTFL----SWIIMCRKSRT-GLKTKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLRGAKMDD 993
            ...|    :.:.:.|.|.: |...::...|..|   |:...:...:....|     .|..|.:.:
Human   939 VNGLVLAMAMLKLLRPSLSEGPPAEKRQALLGV---IKALLILTPIFGLTW-----GLGLATLLE 995

  Fly   994 DTADVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYRK-YVRQHA-----WLPKC----LRCSKT 1048
            :.:.|..|.|...|||.|::|.:|.|:.:.||:...|| :.|..|     .|..|    |.|:..
Human   996 EVSTVPHYIFTILNTLQGVFILLFGCLMDRKIQEALRKRFCRAQAPSSTISLVSCCLQILSCASK 1060

  Fly  1049 SISSGIVTGNGPTAGT 1064
            |:|.||...:....||
Human  1061 SMSEGIPWPSSEDMGT 1076

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Rha_Lectin_dCirl	22..113	CDD:438687	25/102 (25%)
		GAIN	451..682	CDD:465137	49/244 (20%)
		GPS	705..752	CDD:197639	20/57 (35%)
		7tmB2_CELSR_Adhesion_IV	763..1035	CDD:320557	66/288 (23%)
		TM helix 1	765..790	CDD:320557	2/24 (8%)
		TM helix 2	801..823	CDD:320557	6/23 (26%)
		TM helix 3	832..859	CDD:320557	4/26 (15%)
		TM helix 4	875..895	CDD:320557	6/21 (29%)
		TM helix 5	913..942	CDD:320557	11/32 (34%)
		TM helix 6	960..987	CDD:320557	3/26 (12%)
		TM helix 7	997..1022	CDD:320557	10/24 (42%)
		Herpes_TAF50	<1219..1365	CDD:308764
ADGRF3	NP_001138640.1	HRM	431..477	CDD:397086	19/98 (19%)
		GPS	713..758	CDD:460350	17/47 (36%)
		GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098	715..765		18/52 (35%)
		7tmB2_GPR113	767..1037	CDD:320381	69/297 (23%)
		TM helix 1	769..794	CDD:320381	4/34 (12%)
		TM helix 2	809..831	CDD:320381	6/21 (29%)
		TM helix 3	842..869	CDD:320381	4/31 (13%)
		TM helix 4	883..903	CDD:320381	6/19 (32%)
		TM helix 5	922..951	CDD:320381	11/33 (33%)
		TM helix 6	967..994	CDD:320381	6/34 (18%)
		TM helix 7	999..1024	CDD:320381	10/24 (42%)