DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cirl and ADGRG4

DIOPT Version :9

Sequence 1:NP_001260807.1 Gene:Cirl / 35846 FlyBaseID:FBgn0033313 Length:1711 Species:Drosophila melanogaster
Sequence 2:NP_722576.3 Gene:ADGRG4 / 139378 HGNCID:18992 Length:3080 Species:Homo sapiens


Alignment Length:1293 Identity:255/1293 - (19%)
Similarity:427/1293 - (33%) Gaps:450/1293 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 ICNDHGNVEWSVNCMFPKSLSVLNSRCAHKQSCGVLAATSMFGDPCPGTHKYLEAHYQCISAAQT 119
            |..:||   .|.|.....||..:.|..|..:.......||:    .|||     .....:|.|.:
Human  1945 ILPNHG---LSENPSLSTSLRAITSTLADVKHTFEKMTTSV----TPGT-----TLPSILSGATS 1997

  Fly   120 STTTNRPSPPPWVLSNGPPIFGNGSGLIHPPGVGAGAP------------------------PPP 160
            .:..::.....|:||:.|    :||    ||...:.||                        |..
Human  1998 GSVISKSPILTWLLSSLP----SGS----PPATVSNAPHVMTSSTVEVSKSTFLTSDMISAHPFT 2054

  Fly   161 RLPTLPGVVGISGNPGLFNVPPQHTAVTHSTPSSSTTAVGGGRLKGGATSTTTTKHPAGRHDGLP 225
            .|.|||...             ..|.:|.:.|   |..:||          .||..|.    .||
Human  2055 NLTTLPSAT-------------MSTILTRTIP---TPTLGG----------ITTGFPT----SLP 2089

  Fly   226 PPPQL---------HHHHNHHGEDTASPTKPSSKLPAGGNATSPSNTRILTGVGGSGTDDGTLLT 281
            ....:         |...:.....||:|...|..........|||.|.....||.......|:  
Human  2090 MSINVTDDIVYISTHPEASSRTTITANPRTVSHPSSFSRKTMSPSTTDHTLSVGAMPLPSSTI-- 2152

  Fly   282 TKSSPNRPPGTAASGS--VVPGNGSVVRTINNINLNAAGMSGGDDESKLFCGPTHARNLYWNMTR 344
             .||.||.| ||:|.|  ::|     ..|:::: ||.                         ||.
Human  2153 -TSSWNRIP-TASSPSTLIIP-----KPTLDSL-LNI-------------------------MTT 2184

  Fly   345 VGDVNVQPCPGGAAGIAKWRCVLMKRIPDSGYDEYDDDISSTTPAPSGGDCLHNSSSCEPPVSMA 409
            ...|     ||                             ::.|..|.|.....:::...|:|..
Human  2185 TSTV-----PG-----------------------------ASFPLISTGVTYPFTATVSSPISSF 2215

  Fly   410 HKVNQRLRNFEPTWHPATPDL---------TQCRS-LWLNNLEMR----VNQRDSSLISIANDMS 460
                     ||.||..:||..         |..:| :...|:||.    |.:....:.|:.|:.:
Human  2216 ---------FETTWLDSTPSFLSTEASTSPTATKSTVSFYNVEMSFSVFVEEPRIPITSVINEFT 2271

  Fly   461 EVTSSKTLYGGDMLVTTKIIQTVS-----EKMMHDKETFPDQRQREAMIMELL-----HCV---- 511
            |.:.:......:..:.|...|..|     |:|:.|:...   .|||...|..:     .||    
Human  2272 ENSLNSIFQNSEFSLATLETQIKSRDISEEEMVMDRAIL---EQREGQEMATISYVPYSCVCQVI 2333

  Fly   512 VKTGSNL---------------------LDESQLS------------------------------ 525
            :|..|:|                     ..:.||:                              
Human  2334 IKASSSLASSELMRKIKSKIHGNFTHGNFTQDQLTLLVNCEHVAVKKLEPGNCKADETASKYKGT 2398

  Fly   526 -SWLDLNPEDQMRV---------AT----------------------SLLTGLEYNAFLLADTII 558
             .||..||.:..:.         ||                      .||..|......||:..|
Human  2399 YKWLLTNPTETAQTRCIKNEDGNATRFCSISINTGKSQWEKPKFKQCKLLQELPDKIVDLANITI 2463

  Fly   559 RERS---VVQKVKNILLSVRVL---ETKTIQSSVV-FPDSDQWPLSSDRIELPRAALI----DNS 612
            .:.:   |.:.:.|::.....|   |||.|.|.:. ....|:..::...:.|....::    :||
Human  2464 SDENAEDVAEHILNLINESPALGKEETKIIVSKISDISQCDEISMNLTHVMLQIINVVLEKQNNS 2528

  Fly   613 EGGL-------VRIVFAAFDRLE---------------SILKPSYDH-FD--LKSSRSYVRNTAI 652
            ...|       :||:.....::|               ::|:.  || ||  ..|..||...|  
Human  2529 ASDLHEISNEILRIIERTGHKMEFSGQIANLTVAGLALAVLRG--DHTFDGMAFSIHSYEEGT-- 2589

  Fly   653 LSNDSDVNAGEI---------------QQRL-------------------------RILNSKVIS 677
               |.::..|.:               .:|:                         :.|.:.|:|
Human  2590 ---DPEIFLGNVPVGGILASIYLPKSLTERIPLSNLQTILFNFFGQTSLFKTKNVTKALTTYVVS 2651

  Fly   678 ASLGKGRHIQ-LSQPITLTLKHL-KTENVTNPTCVFWNYIDH----AWSANGCSLESTNRTHSVC 736
            ||:.....|| |:.|:.:||:|: ..:|.....|.||::.::    .|:::||.::.||..:::|
Human  2652 ASISDDMFIQNLADPVVITLQHIGGNQNYGQVHCAFWDFENNNGLGGWNSSGCKVKETNVNYTIC 2716

  Fly   737 SCNHLTNFAILMDV----VDEHQHSLFTMFDGNMRIFIYISIGICVVFIVIALLTLKLFNGVFVK 797
            .|:|||:|.:|||:    ||.....:       :.:..|...||..:|:.:|::|...|:.: .|
Human  2717 QCDHLTHFGVLMDLSRSTVDSVNEQI-------LALITYTGCGISSIFLGVAVVTYIAFHKL-RK 2773

  Fly   798 SARTSIYTSIYLCLLAIELLFLLG--IEQTETSIFCGFITIFLHCAILSGTAWFCYEAFHSYSTL 860
            .....|..::...||.:.|:||:.  :...:....|....:.||..:|....|...||.|.|..|
Human  2774 DYPAKILINLCTALLMLNLVFLINSWLSSFQKVGVCITAAVALHYFLLVSFTWMGLEAVHMYLAL 2838

  Fly   861 TSDELLLEVDQTPKV-NCY---YLLSY-----GLSLSVVAISLVIDPSTY----TQNDYCVLMEA 912
            .            || |.|   |:|.:     |:...:|||::.:....|    ....:|.:.: 
Human  2839 V------------KVFNIYIPNYILKFCLVGWGIPAIMVAITVSVKKDLYGTLSPTTPFCWIKD- 2890

  Fly   913 NALFYATFVIPVLVFFVAAIGYTFLSWIIMCRKSRTGLKTKEHTRLASVRFDIRCSFVFLLLLSA 977
            :::||.:.|....:.|:..:. .|.:.::.....::.:   :.||...:..|::.:.....||..
Human  2891 DSIFYISVVAYFCLIFLMNLS-MFCTVLVQLNSVKSQI---QKTRRKMILHDLKGTMSLTFLLGL 2951

  Fly   978 VWCSAYFYLRGAKMDDDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYR------------ 1030
            .|..|:|.....:      :.:.|.|..||||.|.:||||||:..|.:|.:::            
Human  2952 TWGFAFFAWGPMR------NFFLYLFAIFNTLQGFFIFVFHCVMKESVREQWQIHLCCGWLRLDN 3010

  Fly  1031 -------------------KYVRQHAWLPKCLRCSKTSISSGIVTGNGPTAGTLCSVS 1069
                               |.:.:|..|...|   |::.:|......|...||...:|
Human  3011 SSDGSSRCQIKVGYKQEGLKKIFEHKLLTPSL---KSTATSSTFKSLGSAQGTPSEIS 3065

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CirlNP_001260807.1 Gal_Lectin 33..113 CDD:280328 14/57 (25%)
GAIN 453..680 CDD:293098 64/399 (16%)
GPS 705..752 CDD:197639 17/54 (31%)
7tm_4 763..1014 CDD:304433 56/265 (21%)
ADGRG4NP_722576.3 LamG 28..210 CDD:304605
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 946..965
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1274..1348
CytochromB561_N <1668..>1909 CDD:286826
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2109..2141 8/31 (26%)
GPS 2684..2727 CDD:280071 14/42 (33%)
7tm_2 2743..2982 CDD:278432 56/262 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3051..3080 4/15 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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