DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cirl and Adgre1

DIOPT Version :10

Sequence 1:NP_001260807.1 Gene:Cirl / 35846 FlyBaseID:FBgn0033313 Length:1711 Species:Drosophila melanogaster
Sequence 2:NP_034260.1 Gene:Adgre1 / 13733 MGIID:106912 Length:931 Species:Mus musculus


Alignment Length:887 Identity:205/887 - (23%)
Similarity:337/887 - (37%) Gaps:223/887 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   290 PGTAASGS------------VVPGNGSVVRTIN------NINLNAAG---MSGGDDES------- 326
            ||...:||            |.|.:.:...|:.      |..|.::|   |..|.|||       
Mouse   162 PGFVLNGSICEDEDECVTRDVCPEHATCHNTLGSYYCTCNSGLESSGGGPMFQGLDESCEDVDEC 226

  Fly   327 ---KLFCGPTHARNLYWNMTRVGDVNVQPCPGG--------AAGIAKWRCVLMKRIPDSGYDEYD 380
               ...||||     :..:..:|..:.. ||.|        ....|...|        :..||.|
Mouse   227 SRNSTLCGPT-----FICINTLGSYSCS-CPAGFSLPTFQILGHPADGNC--------TDIDECD 277

  Fly   381 DDISSTTPAPSGGDCLHNSSS----CEPPVSMAH-KVNQRLRNFEPTWH---PATPDLTQCRSLW 437
            |      ..|....|.:...|    |.|..:.:: ::|  .::.|.|..   ..|.|..||   .
Mouse   278 D------TCPLNSSCTNTIGSYFCTCHPGFASSNGQLN--FKDLEVTCEDIDECTQDPLQC---G 331

  Fly   438 LNNLEMRVNQRDSSLISIANDMSEVTSSKTLYGG------------DMLVTTKIIQ--------- 481
            ||:  :..|...|.:.....|..........||.            |:::.::.||         
Mouse   332 LNS--VCTNVPGSYICGCLPDFQMDPEGSQGYGNFNCKRILFKCKEDLILQSEQIQQCQAVQGRD 394

  Fly   482 --------------TVSEKMMHDKETFPDQRQREAMIMELLHCVVKTGSNLLDESQLSSWLDLNP 532
                          |:.:....:|.. |...|..|           |..:|:.| |.::|.:|:.
Mouse   395 LGYASFCTLVNATFTILDNTCENKSA-PVSLQSAA-----------TSVSLVLE-QATTWFELSK 446

  Fly   533 EDQMRVATSLLTGLEYNAFLLADTIIRERSVVQKVKNILLSVRVLETKTIQSSVVFPDSDQWPLS 597
            |:...:.|.||..:|  :.:||..:|...:..|.::...|.:   |:|.|.......:|......
Mouse   447 EETSTLGTILLETVE--STMLAALLIPSGNASQMIQTEYLDI---ESKVINEECKENESINLAAR 506

  Fly   598 SDRIELPRAALIDNSEGGLVRIVFAAFDRLESILKPSYDHFDLKSSRSYVRNTAILSNDSDVNAG 662
            .|::.:....:.::...|...:.|.:|..:||:|                       |:.....|
Mouse   507 GDKMNVGCFIIKESVSTGAPGVAFVSFAHMESVL-----------------------NERFFEDG 548

  Fly   663 EIQQRLRILNSKVISASLGKGRHIQLSQPITLTLKHLKTENVT-NPTCVFWN--YIDHAWSANGC 724
            :..::|| :||:|:..::...:....|:||..||:|::.:..: .|.||.||  ..|..|:.:||
Mouse   549 QSFRKLR-MNSRVVGGTVTGEKKEDFSKPIIYTLQHIQPKQKSERPICVSWNTDVEDGRWTPSGC 612

  Fly   725 SLESTNRTHSVCSCNHLTNFAILMDVVDEHQHSLFTMFDGNMRIFIYISIGICVVFIVIALLTLK 789
            .:...:.||:|||||.:.|.||:|      .....|| :.::.|..::...|.:|.:.:|:.|..
Mouse   613 EIVEASETHTVCSCNRMANLAIIM------ASGELTM-EFSLYIISHVGTVISLVCLALAIATFL 670

  Fly   790 LFNGVFVKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSGTAWFCYEAF 854
            |...  |::..|.::..:.:||...::|||.||::|:....|..|..|||...|:...|...||.
Mouse   671 LCRA--VQNHNTYMHLHLCVCLFLAKILFLTGIDKTDNQTACAIIAGFLHYLFLACFFWMLVEAV 733

  Fly   855 HSYSTLTSDELLLEVDQTPKVNCYY-----------LLSYGLSLSVVAISLVIDPSTYTQNDYCV 908
                     .|.|.|.....|| |:           ...|||.:.||.||..:.|..|..::.|.
Mouse   734 ---------MLFLMVRNLKVVN-YFSSRNIKMLHLCAFGYGLPVLVVIISASVQPRGYGMHNRCW 788

  Fly   909 LMEANALFYATFVIPVLVFFVAAIGYTFLSWII------MCRKSRTGLKTKEHTRLASVRFDIRC 967
            | .....|..:|:.||.:  :..|....|:|.:      :|..|....|.|: |||.:.:     
Mouse   789 L-NTETGFIWSFLGPVCM--IITINSVLLAWTLWVLRQKLCSVSSEVSKLKD-TRLLTFK----- 844

  Fly   968 SFVFLLLLSAVWCSAYFYLRGAKMDDDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYRKY 1032
            :...:.:|...|....|.:      ...|.:..|.|...|:|.|.:||:.||:.|.::|.||:| 
Mouse   845 AIAQIFILGCSWVLGIFQI------GPLASIMAYLFTIINSLQGAFIFLIHCLLNRQVRDEYKK- 902

  Fly  1033 VRQHAWLPKCLRCSKTSISSGIVTGNGPTAGTLCS--VSTSK 1072
                      |...||.:||     :..|:|.|.|  .||||
Mouse   903 ----------LLTRKTDLSS-----HSQTSGILLSSMPSTSK 929

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CirlNP_001260807.1 Gal_Rha_Lectin_dCirl 22..113 CDD:438687
GAIN 451..682 CDD:465137 45/265 (17%)
GPS 705..752 CDD:197639 20/49 (41%)
7tmB2_CELSR_Adhesion_IV 763..1035 CDD:320557 74/288 (26%)
TM helix 1 765..790 CDD:320557 5/24 (21%)
TM helix 2 801..823 CDD:320557 7/21 (33%)
TM helix 3 832..859 CDD:320557 8/26 (31%)
TM helix 4 875..895 CDD:320557 10/30 (33%)
TM helix 5 913..942 CDD:320557 7/34 (21%)
TM helix 6 960..987 CDD:320557 3/26 (12%)
TM helix 7 997..1022 CDD:320557 9/24 (38%)
Herpes_TAF50 <1219..1365 CDD:308764
Adgre1NP_034260.1 EGF_CA 33..63 CDD:238011
EGF_CA 81..115 CDD:214542
EGF_CA 133..172 CDD:214542 4/9 (44%)
EGF_CA 173..>203 CDD:214542 4/29 (14%)
EGF_CA 222..258 CDD:238011 8/41 (20%)
EGF_CA 272..>301 CDD:214542 9/34 (26%)
EGF_CA 319..352 CDD:214542 9/37 (24%)
Cell attachment site. /evidence=ECO:0000255 506..508 0/1 (0%)
GPS 591..640 CDD:197639 20/54 (37%)
GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098 595..642 19/52 (37%)
7tmB2_EMR 644..906 CDD:320555 75/299 (25%)
TM helix 1 646..671 CDD:320555 5/24 (21%)
TM helix 2 680..702 CDD:320555 7/21 (33%)
TM helix 3 711..738 CDD:320555 9/35 (26%)
TM helix 4 755..775 CDD:320555 7/19 (37%)
TM helix 5 792..815 CDD:320555 5/24 (21%)
TM helix 6 839..864 CDD:320555 5/35 (14%)
TM helix 7 868..893 CDD:320555 9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

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