Protein Alignment Cirl and Cirl

DIOPT Version :10

• Sequence 1: NP_001260807.1
• Gene: Cirl / 35846
• FlyBaseID: FBgn0033313
• Length: 1711
• Species: Drosophila melanogaster
• Sequence 2: XP_061501929.1
• Gene: Cirl / 1278792
• VectorBaseID: AGAMI1_008213
• Length: 1475
• Species: Anopheles gambiae
• Alignment Length: 1846
• Identity: 598/1846 - (32%)
• Similarity: 746/1846 - (40%)
• Gaps: 707/1846 - (38%)

  Fly     1 MLPTILSISYEHISLDLSKYQTAYACEGKKLTIECDPGDVINLIRANYGRFSITICNDHGNVEWS 65
            :||..::.|        .||:||||||||.|.|||:|||:||||||||||||||||||||||:||
Mosquito   160 LLPAAIAGS--------PKYETAYACEGKTLMIECEPGDLINLIRANYGRFSITICNDHGNVDWS 216

  Fly    66 VNCMFPKSLSVLNSRCAHKQSCGVLAATSMFGDPCPGTHKYLEAHYQCISAAQTSTTTNRPSPPP 130
            ||||.||||.||:|:||.||:|.|||:|||||||||||||||||||||:||||:|||||||| ||
Mosquito   217 VNCMSPKSLRVLHSKCAQKQNCSVLASTSMFGDPCPGTHKYLEAHYQCVSAAQSSTTTNRPS-PP 280

  Fly   131 WVLSNGPPIFGNGSGLIHPPGVGAGAPPPPRLPTLPGVVGISGNPGLFNVPPQHTAVTHSTPSSS 195
            |:.::.|.::...:            ...|.|..|.....:.|..|      :...|...||:.|
Mosquito   281 WLKTSQPIVWSTST------------VRSPVLSRLNLTTDLGGGGG------EVAVVAAVTPALS 327

  Fly   196 TTAV----GGGRLKGGATSTTTTKHPAG-RHDGLPPPPQLHHHHNHHGEDTASPTKPSSKLPAGG 255
            |:||    |.|   ||...|.|::.|.. |:.|.         .|....|..:..|..:....||
Mosquito   328 TSAVTLRPGAG---GGNVGTKTSQSPTTFRNKGF---------ENKSVNDDLAIIKTITDRKKGG 380

  Fly   256 NATSPSNTRILTG---VGGSGT------------DDG-----TLLTTKSSPNRPPGT-----AAS 295
            :...|...|...|   .|.:||            |||     |.....|....|||.     |.:
Mosquito   381 DPVEPLGPRTPYGGVEAGAAGTSGGGGLQKEEDDDDGADLFPTQTAVLSGAAAPPGVRKLDPAGT 445

  Fly   296 GSVVPGNGSVVRTINNINLNAAGMSGGDDESKLFCGPTHARNLYWNMTRVGDVNVQPCPGGAAGI 360
            .:.|.|.|||     .|:::.|            |||:.||||:||:||||:||||||||||.||
Mosquito   446 PTSVNGGGSV-----QIDISHA------------CGPSTARNLFWNVTRVGEVNVQPCPGGATGI 493

  Fly   361 AKWRCVLMKRIPDSGYDEYDDDISSTTP-------------------------------APSG-- 392
            ||||||.               ::|.||                               |||.
Mosquito   494 AKWRCVA---------------VASLTPEQRVHLQQEHQQMLQIQAAQQQSAGGAGGVNAPSADD 543

  Fly   393 ----GDCLHNSSSCEPPVSMAHKVNQRLRNFEPTWHPATPDLTQCRSLWLNNLEMRVNQRDSSLI 453
                ||...:|:|    |:::.|  |.:.. ..||:...|||||||||||||||:||.|.|||||
Mosquito   544 SGSHGDISFSSNS----VALSDK--QSMVG-AATWYAYRPDLTQCRSLWLNNLEVRVQQPDSSLI 601

  Fly   454 SIANDMSEVTSSKTLYGGDMLVTTKIIQTVSEKMMHDKETFPDQRQREAMIMELLHCVVKTGSNL 518
            |||||:::||||||||||||||.||||||:|:||.:|.||.||||||||::.|||:.||||||||
Mosquito   602 SIANDLAQVTSSKTLYGGDMLVATKIIQTMSQKMHYDIETIPDQRQREALVFELLNSVVKTGSNL 666

  Fly   519 LDESQLSSWLDLNPEDQMRVATSLLTGLEYNAFLLADTIIRERSVVQKVKNILLSVRVLETKTI- 582
            ||:||.:|||||:.|||||||||||||||.|||||||||:||:.|||||||||||:|||||:..
Mosquito   667 LDQSQHASWLDLSVEDQMRVATSLLTGLEDNAFLLADTILREKHVVQKVKNILLSIRVLETRNFG 731

  Fly   583 QSSVVFPDS--DQWPLSSDRIELPRAALIDNSEGGLVRIVFAAFDRLESILKPSYD--------- 636
            :|:.:||||  ::|.:|||:||||:||||:|||||||||||.||||||.||:|.:.
Mosquito   732 KSTELFPDSSTERWQVSSDQIELPKAALIENSEGGLVRIVFVAFDRLEQILRPQFSNIQQQQHGS 796

  Fly   637 ----------------HFDLKSSRSYVRNTAIL-SND-------------------SDVNAG-EI 664
                            |.|.....|  .|.|.| :||                   |..:|| .:
Mosquito   797 GGAGPSSGRVEPSQHRHLDTDGIAS--ANVAGLGANDGTFGSSAGGGAGTRSTDAGSPSDAGVTV 859

  Fly   665 QQRLRILNSKVISASLGKGRHIQLSQPITLTLKHLKTENVTNPTCVFWNYIDHAWSANGCSLEST 729
            ..|||:||||||||||||||||||||||.:.|:||:|:||:|||||||||||||||.:||.:|.|
Mosquito   860 VPRLRLLNSKVISASLGKGRHIQLSQPIRMVLRHLRTKNVSNPTCVFWNYIDHAWSEDGCHVEYT 924

  Fly   730 NRTHSVCSCNHLTNFAILMDVVD-EHQHSLFTMFDGNMRIFIYISIGICVVFIVIALLTLKLFNG 793
            |.||:||.||||||||:|:|.|| |.|.||.:..|.:  :.:||.|.:.|..:||||...||
Mosquito   925 NSTHTVCMCNHLTNFALLVDAVDNETQLSLLSHLDDS--LLLYIGIAVLVAVVVIALFARKL--- 984

  Fly   794 VFVKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSGTAWFCYEAFHSYS 858
                                                                    ||.
Mosquito   985 --------------------------------------------------------CYS------ 987

  Fly   859 TLTSDELLLEVDQTPKVNCYYLLSYGLSLSVVAISLVIDPSTYTQNDYCVLMEANALFYATFVIP 923
                                         ||:|
Mosquito   988 -----------------------------SVLA-------------------------------- 991

  Fly   924 VLVFFVAAIGYTFLSWIIMCRKSRTGLKTKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLRG 988
                                 |.|.|   ......|.                         |||
Mosquito   992 ---------------------KLRNG---GPEAGAAG-------------------------LRG 1007

  Fly   989 AKMDDDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYRKYVRQHAWLPKCLRCSKTSISSG 1053
            ..:|.|.|              ||.|...|
Mosquito  1008 GPIDRDPA--------------GLSISAHH----------------------------------- 1023

  Fly  1054 IVTGNGPTAGTLCSVSTSKKPKLPLGVSEEAHDDPQQQQQTPVPITEDAIMGATSDCELNEAQQR 1118
                 |..||.|                ...|.                  |.:::..::
Mosquito  1024 -----GTVAGRL----------------HHHHH------------------GGSNNAGVD----- 1044

  Fly  1119 RTLKSGLMTGTLQAPPQTLGGHVVLERGSTLRSTGHASPTSSAGSTHLIFA---HKQQQQQQQQG 1180
                       |..|.....||      .......|..|....|. ||:.|   |.||||.||..
Mosquito  1045 -----------LHHPTVATAGH------HHHHMVHHHLPPPGTGH-HLLVADDFHHQQQQSQQPH 1091

  Fly  1181 PLGESYY-HQPDYYS--WKQPSTGTGGLKTPREYYNN--------AGAAASSPQQAHEVFYWTQK 1234
            |...:.: |.|:..:  .......:..|.|..  :||        .|..:.||
Mosquito  1092 PANNNLHNHHPNNLAGGGNHHHVNSNNLVTTT--FNNLNGGGGIGGGNCSPSP------------ 1142

  Fly  1235 PNSGH-------------NGKKKRGAGGVPASPSGSLHSRTAAASQVLFYPSYKKTKPGQPTGYP 1286
            |.||:             |.........:.:|.:.|.::..|||:.:|...:.|.........:|
Mosquito  1143 PGSGYDHHHPGHHLARLNNNVNVNFPSNISSSSNNSTNNSAAAAAALLLTGAGKGGDDALAKPFP 1207

  Fly  1287 QYAEALDPPLATGN-------AAAYYQQQQQLRRQQLHQQQQQQQQQQLSSDEEQAEQHAHLLHL 1344
            .|        .|.|       ||.::.||||   ||.||||||||.||
Mosquito  1208 SY--------RTNNNQINLLRAANHHAQQQQ---QQQHQQQQQQQHQQ----------------- 1244

  Fly  1345 QRRAGSQQQLP---APPPHMAQYQQEFMQRQYRNKHSNCDLGMGDAYYNQGSVGGADGGPVYEEI 1406
                 .||..|   ||...:...||:...|.:.:...............||.  |.||||.....
Mosquito  1245 -----HQQPAPSANAPSAAVLLQQQQHHHRHHLHHQPQAAAATAGTILLQGF--GGDGGPSSPSA 1302

  Fly  1407 LSNRNSDVQHYEVGDFDVDEVYNNSVGTGVFNNMRAAVAAGGSRYGGGSLSGGSVSSRSQQQQLK 1471
            .|                 .:.:.|:.|.:........:..|...|||   |||:
Mosquito  1303 SS-----------------LIASTSLITTIAQPTSQQTSPAGRGRGGG---GGSM---------- 1337

  Fly  1472 KQQQQQSLAQQRSARRCTADDDDDEDEEEDEEATAAEQLHDSVCDEDEEEDESDLEDDAHGLPPQ 1536
                                |....|.......||||.:                   |:.|
Mosquito  1338 --------------------DSSGSDRSSSGSTTAAEMV-------------------AYNL--- 1360

  Fly  1537 SDERMRRLMAMQDEDFKRRFQRQLRKHGAPLDYGALPPGAGPQPEHNGAVFGVSGGVGEGSLRGA 1601
                                ..::...||.:..||..||......|:      .|.:|..:..|.
Mosquito  1361 --------------------SGEIGDGGAGMANGAGSPGNQLHLHHH------QGSIGSSASSGL 1399

  Fly  1602 FRQQQQQALNAKSPGGRLAVNELFGHGNSGPPLPPANQTPAQKRQQLQKLSPQSTTSSSSHTSHS 1666
            .    ..|....:.||.::|      |.:|                      ..|:|:||..|.|
Mosquito  1400 L----VVAAGGANAGGSVSV------GTAG----------------------TITSSASSSASAS 1432

  Fly  1667 NPNPHPHQLTHPHPHQHPPHHQQRHL 1692
            .|      |.|.|.|.|..||..:||
Mosquito  1433 VP------LLHHHHHHHLHHHLHQHL 1452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Rha_Lectin_dCirl	22..113	CDD:438687	77/90 (86%)
		GAIN	451..682	CDD:465137	165/279 (59%)
		GPS	705..752	CDD:197639	34/46 (74%)
		7tmB2_CELSR_Adhesion_IV	763..1035	CDD:320557	30/271 (11%)
		TM helix 1	765..790	CDD:320557	8/24 (33%)
		TM helix 2	801..823	CDD:320557	0/21 (0%)
		TM helix 3	832..859	CDD:320557	2/26 (8%)
		TM helix 4	875..895	CDD:320557	3/19 (16%)
		TM helix 5	913..942	CDD:320557	0/28 (0%)
		TM helix 6	960..987	CDD:320557	0/26 (0%)
		TM helix 7	997..1022	CDD:320557	4/24 (17%)
		Herpes_TAF50	<1219..1365	CDD:308764	40/168 (24%)
Cirl	XP_061501929.1	None