DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cirl and Adgrb1

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	XP_006520332.1	Gene:	Adgrb1 / 107831	MGIID:	1933736	Length:	1620	Species:	Mus musculus

Alignment Length:	1256	Identity:	250/1256 - (19%)
Similarity:	411/1256 - (32%)	Gaps:	363/1256 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   295 SGSVVPGNGSV--VRTINNINLNAAGMSGGDDESKL-----------FCGPTHARNLYWNMTRVG 346
            |.||..|.||.  .|..:......|...|..||.:.           .|...:...:.|..|..|
Mouse   533 SCSVTCGGGSQRRERVCSGPFFGGAACQGPQDEYRQCGAQRCPEPHEICDEDNFGAVVWKETPAG 597

  Fly   347 DVNVQPCPGGAAGIAKWRCVLMKRIPDSGYDEYDDDISSTTPAPSGGDCLHNSSSCEPPVSMAHK 411
            :|....||..|.|:...||            |.|::                        .:|.
Mouse   598 EVAAVRCPRNATGLILRRC------------ELDEE------------------------GIAF- 625

  Fly   412 VNQRLRNFEPTWHPATPDLTQCRSLWLNNLEMRVNQR---------DSSLISIANDMSEVTSSKT 467
                       |.|  |...:|.|:...|::|...:.         ...:..:...:.|::...|
Mouse   626 -----------WEP--PTYIRCVSIDYRNIQMMTREHLAKAQRGLPGEGVSEVIQTLLEISQDGT 677

  Fly   468 LYGGDMLVTTKIIQTVSE--KMMHDKETFPDQRQREAMIMELLHCVVKTGSNLLDESQLSSW--- 527
            .|.||:|.|..:::.::|  :..:...| |...|....|:          ||||.|.....|
Mouse   678 SYSGDLLSTIDVLRNMTEIFRRAYYSPT-PGDVQNFVQII----------SNLLAEENRDKWEEA 731

  Fly   528 --LDLNPEDQMRVATSLLTGLEYNAFLLADTIIRERSVVQKVKNILLSVRVLETKTIQSSVVFPD 590
              :..|.::..|:....   ::...|.:.|.    |...|...|::||:..|.... .:.:.||
Mouse   732 QLMGPNAKELFRLVEDF---VDVIGFRMKDL----RDAYQVTDNLVLSIHKLPASG-ATDISFP- 787

  Fly   591 SDQWPLSSDRIELPRAALIDNSEGGLVRIVFAAFDRL---ESILKPSYDHFDLKSSRSYVRNTAI 652
            ...|..:.|..::|.                   ||:   :|:........|  .|..:|..|.:
Mouse   788 MKGWRATGDWAKVPE-------------------DRVTVSKSVFSTGLAEAD--DSSVFVVGTVL 831

  Fly   653 LSNDSDVNAGEIQQRLRILNSKVISASLGKGRHIQLSQPITLTLKHLKTENVTNPTCVFWNYID- 716
            ..|.....|  :|:...:|||||||.:: |.....|..|:.:...|: ....||.||:.|:..|
Mouse   832 YRNLGSFLA--LQRNTTVLNSKVISVTV-KPPPRSLLTPLEIEFAHM-YNGTTNQTCILWDETDG 892

  Fly   717 ---------HAWSANGCSLESTNRTHSVCSCNHLTNFAILMDVVDEHQHSLFTMFDGNMRIFIYI 772
                     ..||..||.....:...:.|.|:.|:.||||..:..:......|:    ..:.:.:
Mouse   893 PSSSAPPQLGPWSWRGCRTVPLDALRTRCLCDRLSTFAILAQLSADATMDKVTV----PSVTLIV 953

  Fly   773 SIGI-CVVFIVIALLTLKLFNGVFVKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITI 836
            ..|: .:..:::.::.:.::.  :::|.|:.|..:..|.:::...|.|:|..||...:.|..:..
Mouse   954 GCGVSSLTLLMLVIIYVSVWR--YIRSERSVILINFCLSIISSNALILIGQTQTRNKVVCTLVAA 1016

  Fly   837 FLHCAILSGTAWFCYEAFHSYSTLTS---DELLLEVDQTPKVNCYYLLSYGLSLSVVAISLVIDP 898
            |||...||...|...||:.||..:|.   ..|:.:        .:..|.:||...|||||:....
Mouse  1017 FLHFFFLSSFCWVLTEAWQSYMAVTGRLRSRLVRK--------RFLCLGWGLPALVVAISVGFTK 1073

  Fly   899 ST-YTQNDYCVLMEANALFYATFVIP----VLVFFVAAIGYTFLSWIIMCRKSRTGL---KTKEH 955
            :. |:..:||.|.....|.|| ||.|    |||..|  ||....:.::    |:.|:   |.||.
Mouse  1074 AKGYSTMNYCWLSLEGGLLYA-FVGPAAAVVLVNMV--IGILVFNKLV----SKDGITDKKLKER 1131

  Fly   956 T----------------------------RLASVRFDIRCSFVFLLLLSAVWCSAYFYLRGAKMD 992
            .                            ..::....:..|.|.|.||:..|.||..     .:.
Mouse  1132 AGQLPVPPLGRALTCAECGVLSAAEANSDATSNAMASLWSSCVVLPLLALTWMSAVL-----AVT 1191

  Fly   993 DDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYRKYVRQHAWLPKCLRCSKTSISSGIVTG 1057
            |..:.::...|..|::|.|..|.:.|||    :|||.:..|       ||....:..      .|
Mouse  1192 DRRSALFQILFAVFDSLEGFVIVMVHCI----LRREVQDAV-------KCRVVDRQE------EG 1239

  Fly  1058 NGPTAG--------------------------------------TLCSVSTSKKPKLPLGVSEEA 1084
            ||.:.|                                      |.....|.|:|.||
Mouse  1240 NGDSGGSFQNGHAQLMTDFEKDVDLACRSGERLTVLNKDIAACRTATITGTFKRPSLP------- 1297

  Fly  1085 HDDPQQQQQTPVPITEDAIMGATSDCELNEAQQRRTLKSGLMTGTLQAPPQTLGGHVVLERGSTL 1149
            .::..:..:.|.| |.:::....|...|:                  ..|:..||.:......:|
Mouse  1298 EEEKMKLAKGPPP-TFNSLPANVSKLHLH------------------GSPRYPGGPLPDFPNHSL 1343

  Fly  1150 RSTGHASPTSS-AGSTHLIFAHKQQQQQQQQGPLGESYYHQPDYYSWKQPSTGTGGLK-TPREYY 1212
            ......:|.|| .|...:......:..:.|:..|..||...|         |.|..|: .|:|..
Mouse  1344 TLKKDKAPKSSFIGDGDIFKKLDSELSRAQEKALDTSYVILP---------TATATLRPKPKEEP 1399

  Fly  1213 NNAGAAASSPQ-------QAHEVFYWTQKPNSGHNGKKKRGAGGV-----PASPSGSLHSRTAAA 1265
            ..:......||       .|.:..:.|:.|.:      :...||.     |..|...
Mouse  1400 KYSINIDQMPQTRLIHLSMAPDASFPTRSPPA------REPPGGAPPEVPPVQPPPP-------- 1450

  Fly  1266 SQVLFYPSYKKTKPGQPTGYPQYAEALDPPLA-TGNAAAYYQQQQQLRRQQLHQQQQQQQQQQLS 1329
                  |......|.||...|...|...|.|. ||..||:....     .....:.:......:|
Mouse  1451 ------PPPPPPPPQQPIPPPPTLEPAPPSLGDTGEPAAHPGPS-----SGAGAKNENVATLSVS 1504

  Fly  1330 SDEEQAEQHAHL-----LHLQRRAGSQQQLPAPPPHMAQYQQEFMQRQYRNKHSNCDLGMGDAYY 1389
            |.|.:..::|.|     :|.::|                :|..|.....:.:|         |..
Mouse  1505 SLERRKSRYAELDFEKIMHTRKR----------------HQDMFQDLNRKLQH---------AAE 1544

  Fly  1390 NQGSVGGADGGPVYEEILSNR 1410
            .:..|.|||..|..::..:.|
Mouse  1545 KEKEVPGADSKPEKQQTPNKR 1565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328
		GAIN	453..680	CDD:293098	50/236 (21%)
		GPS	705..752	CDD:197639	17/56 (30%)
		7tm_4	763..1014	CDD:304433	65/290 (22%)
Adgrb1	XP_006520332.1	TSP1	264..314	CDD:214559
		TSP1	359..407	CDD:214559
		TSP1	412..462	CDD:214559
		TSP1	470..520	CDD:214559
		TSP1	525..575	CDD:214559	11/41 (27%)
		HormR	577..643	CDD:214468	20/115 (17%)
		GAIN	661..859	CDD:374574	50/241 (21%)
		GPS	880..938	CDD:197639	17/57 (30%)
		7tmB2_BAI_Adhesion_VII	945..1234	CDD:320379	76/325 (23%)
		TM helix 1	947..971	CDD:320379	1/23 (4%)
		TM helix 2	981..1002	CDD:320379	4/20 (20%)
		TM helix 3	1012..1034	CDD:320379	7/21 (33%)
		TM helix 4	1052..1068	CDD:320379	6/15 (40%)
		TM helix 5	1088..1111	CDD:320379	11/25 (44%)
		TM helix 6	1166..1191	CDD:320379	8/29 (28%)
		TM helix 7	1196..1221	CDD:320379	8/28 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010