Protein Alignment Cirl and LOC101884937

DIOPT Version :10

• Sequence 1: NP_001260807.1
• Gene: Cirl / 35846
• FlyBaseID: FBgn0033313
• Length: 1711
• Species: Drosophila melanogaster
• Sequence 2: XP_073764537.1
• Gene: LOC101884937 / 101884937
• -ID: -
• Length: 1497
• Species: Danio rerio
• Alignment Length: 1630
• Identity: 370/1630 - (22%)
• Similarity: 570/1630 - (34%)
• Gaps: 538/1630 - (33%)

  Fly     1 MLPTILS--------ISYEHISLDLSKYQTAYACEGKKLTIECDPGDVINLIRANYGRFSITICN 57
            |.|.:||        :|...:...|.:.:  .||||..:.:.|...|||.:..|||||....||:
Zfish    10 MCPVLLSNIAPSEQGLSRAAMPFGLMRRE--LACEGYPIELRCPGSDVIMIETANYGRTDDKICD 72

  Fly    58 -DHGNVEWSVNCMFPKSLSVLNSRCAHKQSCGVLAATSMFGDPCPGTHKYLEAHYQCI------- 114
             |...:| :|.|..|.:..:::.||.::..|.|:|...:|.||||||:||||..|:|:
Zfish    73 ADPFQME-NVQCYQPDAFKIMSHRCNNRTQCVVVAGADVFPDPCPGTYKYLEIQYECVPYKVDQK 136

  Fly   115 -----------------------SAA-------------------------------------QT 119
                                   |.|                                     :.
Zfish   137 VFVCPGTLVRVLEPSSVREAEHQSGAWCKDPLQAGDRLYVMPWTPYRTDMLYEYASWDDYIQNRV 201

  Fly   120 STTTNRPS-----------------------------------------------PPP------- 130
            :||...||                                               ..|
Zfish   202 TTTYKLPSRVDGTGFVVYDGAVFYNKERTRNIVKYDLRTRIKSGEAIIATANYHDTSPYRWGGKS 266

  Fly   131 -----------WVL-----SNGPPIF--------------------------------------- 140
                       ||:     :||..:.
Zfish   267 DIDLAVDEHGLWVIYATEANNGRLVVSQVNPYTLRFEGTWQTSFEKRMASDAFVACGILYAVRSV 331

  Fly   141 -------GNGSGLIHPPGVGAGAPPPPRLPTLPG----VVGISGNPG-----LFN---------- 179
                   ..|..:::..........|.|:| .|.    :..||.||.     ::|
Zfish   332 YQDDDSEAGGDLILYAYDTRRNREEPVRIP-FPNPYQHISSISYNPRDNQLYVWNNYIVLRYPLE 395

  Fly   180 -VPPQHTAVTHSTPSSSTTAVGGGRLKGGATSTTTTKHPAGRHDGLPPP--PQLHHHHNHHGEDT 241
             .|||.|....|||..|||       ...:.|:|.:.       |..|.  |.:..|
Zfish   396 FSPPQPTTDPLSTPLLSTT-------PPSSLSSTVSM-------GFNPTSVPSVTFH-------- 438

  Fly   242 ASPTKPSSKLPAGGNATSPSNTRILTGVGGSGTDDGTLLTTKSSPNRPPGTAASGSVVPGNGSVV 306
              |....::.|||...|:                  |:..|...|.||.|....
Zfish   439 --PVGAINRAPAGRPITA------------------TVPVTVRPPRRPQGPRTP----------- 472

  Fly   307 RTINNINLNAAGMSGGDDESKLFCGPTHARNLYWNMTRVGDVNVQPCPGGAAGIAKWRCVLMKRI 371
                                  .|.....|.:.|..|..|:...:|||.|:.|||.::|:
Zfish   473 ----------------------MCEGRVTRGVQWPPTHRGETVERPCPKGSLGIASYQCM----- 510

  Fly   372 PDSGYDEYDDDISSTTPAPSGGDCLHNSSSCEPPVSMAHKVNQRLRNFEPTWHPATPDLTQCRSL 436
                    .||:                                      .|:|..|||:.|.|.
Zfish   511 --------SDDV--------------------------------------VWNPRGPDLSNCTSP 529

  Fly   437 WLNNLEMRVNQRDSSLISIANDMSEVTSSKT---LYGGDMLVTTKIIQTVSEKM--------MHD 490
            |:|.:..::...::     |..::.|..:.|   :|.||:..:.::::.:.:.:        ..:
Zfish   530 WVNQVAQKIKSGEN-----AAHIAAVLVNHTRGRVYAGDVTSSVRLMEQLLDILDSQLQALRPGN 589

  Fly   491 KET----FPDQRQREAMIMELLHCVVKTGSNLLDESQLSSWLDLNPEDQMRVATSLLTGLEYNAF 551
            ||:    :...::||......:..||:|..|||....|.||.|:|..:|...||.||..:|..||
Zfish   590 KESATRNYNKLQKRERTCRAFIQAVVQTVDNLLRLEALESWQDMNSTEQSHTATMLLDVMEKGAF 654

  Fly   552 LLADTIIRERSVVQKVKNILLSVRVLETKTIQSSVVFPDSDQWPLSSDRIELPRAALIDNSEGGL 616
            |||:.:.... ...:..|:.|.|.||.|:.....:.||:|..   |...|.:..:.:...|..|.
Zfish   655 LLANNLYGGH-FSDRAPNVDLEVYVLNTEMELKDLSFPNSYD---SDSTIHVSSSTIKQYSRNGQ 715

  Fly   617 VRIVFAAFDRLESILKPSYDHFDLKSSRSYVRNTAILSNDSDVNAGEIQQRLRILNSKVISASLG 681
            |::||..:..|.:.|...               .|.|..|:::::       ..:|:.:||||:.
Zfish   716 VKVVFTLYKNLGAFLSTL---------------NATLKPDAELHS-------LAVNTHIISASMN 758

  Fly   682 K-GRHIQLSQPITLTLKHLKTENVTNPTCVFWNYIDHA----WSANGCSLESTNRTHSVCSCNHL 741
            | ...:.|::|:..||:||:.|:..:|.|.||||.:.:    ||:.||....:|.||:.|:|:||
Zfish   759 KESSRVFLTEPVLFTLRHLQLEDHFSPNCSFWNYSERSMTGQWSSQGCRRLHSNNTHTTCACSHL 823

  Fly   742 TNFAILMDVVDEHQHSLFTMFDGNMRIFIYISIGICVVFIVIALLTLKLFNGVF-----VKSART 801
            ||||:||:    ||...:......:.:|:...:|     :||:|:.|.|....|     ::|.||
Zfish   824 TNFAVLMN----HQQPTYPGGVQGLILFVITWVG-----MVISLVCLALCISTFCCLRGLQSDRT 879

  Fly   802 SIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSGTAWFCYEAFHSYSTLTSDELL 866
            :|:.::.|.|...:||||:|:::|..::.|..:...||..:||...|.|.|....|      .|:
Zfish   880 TIHKNLCLTLFISQLLFLIGMDKTHYTVVCPVLAGLLHFFLLSVFCWLCMETVQLY------VLM 938

  Fly   867 LEV--DQTPKVNCYYLLSYGLSLSVVAISLVIDPSTYTQNDYCVLMEANALFYATFVIPVLVFFV 929
            :||  .:|.:...|||.:||....|||||..||..:|.....|.|...| .|..||:.|..:..:
Zfish   939 VEVFESETSRRKYYYLSAYGFPTLVVAISTAIDYRSYGGAKACWLRVDN-YFIWTFIGPASLVIL 1002

  Fly   930 AAIGYTFLSWIIMCRKSRTGLKTKEHTRLASVRFD-IRC----SFVFLLLLSAVWCSAYFYLRGA 989
            ..:....::...|.|.| |.||..      |.||| |:|    |...|||:|..|.....::
Zfish  1003 LNLAVLVITVHRMLRHS-TVLKPD------SSRFDNIKCWTVSSVTLLLLVSLTWIFGLLFI--- 1057

  Fly   990 KMDDDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYRKYVRQHAWLPKCLRCSKTSISSGI 1054
               :|.:.|..|.|..||.|.|::||:.||...:|:::||.|.:||.   |.|...|.|.
Zfish  1058 ---NDNSVVMAYLFTSFNALHGMFIFLLHCALQKKVQKEYSKCLRQS---PCCGHASSTG----- 1111

  Fly  1055 VTGNGPTAGTLCSVSTSKKPKLPLGVSEEAHDDPQQQQQ-------TPVPITEDAIMGATSDCEL 1112
                  |.|:|.| |..:......|.|:..|...|:|.:       |....||.:.|.|    |:
Zfish  1112 ------THGSLKS-SAHRGNNRYYGGSQSRHAPAQRQSRIRRMWNDTVRRQTESSFMAA----EI 1165

  Fly  1113 NEAQQRRTLKSGLMTGTLQAPP--QTLGGHVVLERGSTLRSTGHASPTSSAGSTHLIFAHKQQQQ 1175
            |...   ||..|.|...|.|.|  ||..|.   ...:||.:.....|:.:..:....|
Zfish  1166 NNTP---TLTRGTMGNHLLANPMLQTRSGS---SPYNTLLAETFNPPSPAVFNATGTF------- 1217

  Fly  1176 QQQQGPLGESYYHQPDYYSWKQPSTGTGGLKTPREYYNNAGAAASSPQQAHEVFYWTQKPNSGHN 1240
            :..:|.|..|           :.|.|..|::....|.|:                     .|.|.
Zfish  1218 RNSKGTLSRS-----------RESCGLEGVRLNGNYNNS---------------------YSLHG 1250

  Fly  1241 GKKKRGAGGVPASPSGSLHSRTAAASQVLFYPSYKKTKPGQPTGYPQYAEALD----PPLATGNA 1301
            |.... .||||....|.    :...|..|..|....|..|....... |.||:    ..|...|.
Zfish  1251 GSSDL-LGGVPVGSGGV----SGEVSPALLTPRGADTSSGLRRNLSD-AAALEKMIISELVQSNL 1309

  Fly  1302 AAYYQQQQQLRRQQLHQQQQQQQQQQLSSDEEQAEQHAHLLHLQRRAGSQQQLPAPPPHMAQYQQ 1366
            .....:........:|:|             :.|...:|      |...|:.||.|||...|.::
Zfish  1310 RPSTDRYGNGTNSTMHRQ-------------DYATSTSH------REPPQRPLPRPPPPPPQDEE 1355

  Fly  1367 EFMQR 1371
            |.:.:
Zfish  1356 ELLYK 1360

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Rha_Lectin_dCirl	22..113	CDD:438687	37/91 (41%)
		GAIN	451..682	CDD:465137	58/245 (24%)
		GPS	705..752	CDD:197639	23/50 (46%)
		7tmB2_CELSR_Adhesion_IV	763..1035	CDD:320557	87/283 (31%)
		TM helix 1	765..790	CDD:320557	6/24 (25%)
		TM helix 2	801..823	CDD:320557	9/21 (43%)
		TM helix 3	832..859	CDD:320557	8/26 (31%)
		TM helix 4	875..895	CDD:320557	10/19 (53%)
		TM helix 5	913..942	CDD:320557	5/28 (18%)
		TM helix 6	960..987	CDD:320557	12/31 (39%)
		TM helix 7	997..1022	CDD:320557	11/24 (46%)
		Herpes_TAF50	<1219..1365	CDD:308764	30/149 (20%)
LOC101884937	XP_073764537.1	None