DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cirl and adgre9

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	XP_021333151.1	Gene:	adgre9 / 101883848	ZFINID:	ZDB-GENE-121214-61	Length:	660	Species:	Danio rerio

Alignment Length:	697	Identity:	172/697 - (24%)
Similarity:	288/697 - (41%)	Gaps:	160/697 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   395 CLHNSSSCEPPVSMAHKVNQRLRNFEPTWHPATPDLTQCRSLWLNNLEMRVNQRDSSLISIANDM 459
            ||..:::|     ||:..|.:...            ..|: |...|..:..|      ..|.:|:
Zfish    79 CLGQNTAC-----MAYSCNSKSSG------------CSCK-LGSYNCSINCN------YDIYSDL 119

  Fly   460 SEV---TSSKTLYGGDMLVTTKIIQTVSEKMMHDKETFPDQRQREAMIMELLHCVVKTGSNLLDE 521
            .:.   |.|.|.. |||  ||.:               ....|..|....||: ::...|..|..
Zfish   120 CDCRADTHSCTCL-GDM--TTSV---------------GSPNQTVASTTNLLN-LISNMSGQLSP 165

  Fly   522 SQLSSWLDLNPEDQMRVATS---------LLTGLEY-NAF--LLADTIIRERSVVQKVKNILLS- 573
            :...::|.:....||:|:||         :..|..| |||  |::..::...::.  ||||.|:
Zfish   166 TDAGNFLSVVDAAQMKVSTSDSPVEKSTLVSFGNAYLNAFENLVSALVVATDNMT--VKNIALNN 228

  Fly   574 --VRVLETKTIQSSVVFPDSDQWPL--SSDRIELPRAALIDNSEGGLVRIVFAAFDRLESILKPS 634
              |.||......|:...|     |:  .:.::|:....:...|......:.|.::..::|||||
Zfish   229 TEVTVLAIGVNASAADIP-----PIYTKTAQLEIDLIGIAKQSISKSASVAFVSYSAMDSILKP- 287

  Fly   635 YDHFDLKSSRSYVRNTAILSNDSDVNAGEIQQRLRILNSKVISASLGKGRHIQLSQPITLTLKHL 699
             |.|          ||:             :..::.:.|.||||:|.:..:..|::|:..||||:
Zfish   288 -DFF----------NTS-------------ENTVKTMMSTVISATLSQTNNTALTKPVNFTLKHI 328

  Fly   700 KTEN-VTNPTCVFWNYIDHAWSANGCSLESTNRTHSVCSCNHLTNFAILMDVVDEHQHSLFTMFD 763
            :..| .::.:||:||  |..|..:|||:.::|.:|:||||.||:.||::|........|     .
Zfish   329 QGFNPKSSLSCVYWN--DSEWIVDGCSVLNSNSSHTVCSCVHLSTFALIMQTSSTPPES-----S 386

  Fly   764 GNMRIFIYISIGICVVFIVIALLTLKL------FNGVFVKSARTSIYTSIYLCLLAIELLFLLGI 822
            ..:.:...:.:.:.:||..:|||:..|      .|.|    ||.:|..|    ||:..||||| .
Zfish   387 DLLELLNLVCVIVGLVFFSLALLSFALCQWSPGVNNV----ARINICIS----LLSAHLLFLL-T 442

  Fly   823 EQ-----TETSIFCGFITIFLHCAILSGTAWFCYEA------FHSYSTLTSDELLLEVDQTPKVN 876
            :|     ....:||..|...||...||...|...||      ..:.|.::|.:     .:.....
Zfish   443 QQFLSLIRPQQVFCVAIAGLLHFLFLSAFVWMFIEAVLLFICVQNLSRISSKK-----KEVLSSG 502

  Fly   877 CYYLLSYGLSLSVVAISLVIDPSTYTQNDYCVLMEANALFYATFVIPVLVFFVAAIGYTFLSWII 941
            ...::.|.|:|.||.:|:.:.|..| .::.|.:..|.. |..:|:.||.|  :.|:...|...|:
Zfish   503 FLCVIGYVLALVVVGVSIGLVPEGY-GSEQCWIKTAEG-FIWSFLGPVCV--ILALNTIFFIKIV 563

  Fly   942 MCRKSRTGLKTKEHTRLASVR---FDIRCSFVFLLLLSAVWCSAYFYLRGAKMDDDTADVYGYCF 1003
            :...|.......|.:::...:   |.....||   :|...|... |::.|       ::|....|
Zfish   564 LTLNSTLKNLNAEVSQMKQTKILAFKTLSQFV---VLGCPWILG-FFING-------SEVLEILF 617

  Fly  1004 ICFNTLLGLYIFVFHCIQNEKIRREYRKYVRQHAWLPKCLRCSKTSI 1050
            :..|:..|.:|||.:|:.|.:||::|:...       .|| ||..||
Zfish   618 LVLNSQQGTFIFVIYCVLNNEIRQQYKNCF-------TCL-CSGHSI 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328
		GAIN	453..680	CDD:293098	56/246 (23%)
		GPS	705..752	CDD:197639	20/46 (43%)
		7tm_4	763..1014	CDD:304433	63/270 (23%)
adgre9	XP_021333151.1	GPS	335..380	CDD:197639	20/46 (43%)
		7tm_GPCRs	389..648	CDD:333717	71/294 (24%)
		TM helix 1	389..413	CDD:320095	5/23 (22%)
		TM helix 2	422..443	CDD:320095	12/29 (41%)
		TM helix 3	457..479	CDD:320095	7/21 (33%)
		TM helix 4	503..519	CDD:320095	5/15 (33%)
		TM helix 5	537..560	CDD:320095	8/25 (32%)
		TM helix 6	584..609	CDD:320095	6/28 (21%)
		TM helix 7	611..636	CDD:320095	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12011
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.000