DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cirl and adgre5b.2

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	XP_005160278.1	Gene:	adgre5b.2 / 101882660	ZFINID:	ZDB-GENE-121214-277	Length:	693	Species:	Danio rerio

Alignment Length:	704	Identity:	168/704 - (23%)
Similarity:	285/704 - (40%)	Gaps:	122/704 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   380 DDDISSTTPAPSGGDCLHN---SSSCEPPVSMAHKVNQRLRNFEPTWHPATPDLTQC--RSLWLN 439
            |..:||..||...|...:|   ::|.:|.:.::...:..:.........:.|.||..  .||.:.
Zfish    28 DKGLSSVIPAVCHGVQCNNGPTTASADPDLEISGDTDSEISGDSDLEISSQPYLTMSTQASLDIT 92

  Fly   440 NLEMRVNQRDSSLISIANDMSEVTSSKTLYGGDMLVTTKIIQTVSEKMMHDKETFPDQRQREAMI 504
            ......:::|   :..|...||.||...............|:....|...|::..|::..:...:
Zfish    93 ASSFPAHRQD---VIRATQTSETTSQNAFVSPKGAAEQTEIECDQFKSKPDEDHTPEKLNQMMSL 154

  Fly   505 M------------------ELLHCVVKTGSNLL------DESQLSSWLDLNPEDQMRVATSLLTG 545
            :                  |||..:..:..:||      |...||.:||: .|:.||     |.|
Zfish   155 LKDSCESLNDPVEKHFNAEELLENLCNSTDDLLLEGKVADGENLSVFLDM-VENSMR-----LIG 213

  Fly   546 LEYNAFLLADTIIRERSVVQKVKNILLSVRVLETKTIQSSVVFPDSDQWPLSSDRIELPRAALID 610
            .:     |.|.:.:     .:.:|....|.:...:|       |.|....||:|      :||..
Zfish   214 PQ-----LKDPVTK-----METQNTYAEVALTRNQT-------PPSGSVTLSTD------SALFS 255

  Fly   611 NSEGGLVRIVFAAFDRLESILKPSYDHFDLKSSRSYVRNTA-ILSNDSDVNAGEIQQRLRI---- 670
            .|...:|...::.|     .....:.:.|:.||......|: .|..||       ::||.:
Zfish   256 TSWETVVGKAYSGF-----AFVALFSYKDMNSSSDLSHKTSRTLQEDS-------RKRLHVDEKK 308

  Fly   671 ----LNSKVISASLGKGRHIQLSQPITLTLKHLKTENVTNP----TCVFWNYIDHAWSANGCSLE 727
                |||||::|.:......:||..:.||..| :.|...:.    |||:||..:..||..||..|
Zfish   309 ITYQLNSKVVTAVVSNPDTKKLSDLMMLTFTH-EEERAESGGVAYTCVYWNESEKVWSGRGCVKE 372

  Fly   728 STNRTHSVCSCNHLTNFAILMDVVDEHQHSLFTMFDGNMRIFIYISIGICVVFIVIALLTLKLFN 792
            .:|.||:||..:||::||:||        :|:.:.|      .:.|:.|..|.:|::||.|.|..
Zfish   373 WSNSTHTVCHWSHLSSFAVLM--------ALYPVQD------TFASVLITRVGLVLSLLCLFLCI 423

  Fly   793 GVF-----VKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSGTAWFCYE 852
            ..|     ::..|.||:..:.:||...:|:||.||..|...:.|..:...||...||...|...|
Zfish   424 LTFRFCRSIQGTRNSIHLHLSVCLFIADLVFLCGISSTHNQVACAIVAGLLHFFFLSAFCWMLLE 488

  Fly   853 AFHSYSTLTSDELLLEVDQTPKVNCY-YLLSYGLSLSVVAISLVIDPSTYTQNDYCVLMEANALF 916
            ....|      .:::.|..|...:.| |.:.||:.|.:|:||.:..|..|..|.:|.|.....|.
Zfish   489 GVQLY------RMVVLVFHTTLKHLYLYAVGYGVPLVIVSISAITFPKGYGTNKHCWLSLEGYLI 547

  Fly   917 YATFVIPVLVFFVAAIGYTFLSWIIMCRKSRTGLKTKEHTRLASVRFDIRCSFVFLLLLSAVWCS 981
            .:.|....::..:..|.:....|.:..:.|..   ..:.::|..:|..:..:...|.:|...|..
Zfish   548 LSFFAPVCIIVILNIIVFIITVWKLALKFSSL---NPDLSKLHKIRSFLATAVAQLCVLGGSWVF 609

  Fly   982 AYFYLRGAKMDDDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYRK-YVR 1034
            .:|..:     .:..:|..|.||..|:|.|..||:.||:.::::|.||.. :||
Zfish   610 GFFLFQ-----KNGTEVMLYLFIILNSLQGALIFIMHCLLSKQVRVEYHSLFVR 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328
		GAIN	453..680	CDD:293098	54/259 (21%)
		GPS	705..752	CDD:197639	21/50 (42%)
		7tm_4	763..1014	CDD:304433	62/256 (24%)
adgre5b.2	XP_005160278.1	GPS	353..398	CDD:197639	22/52 (42%)
adgre5b.2	XP_005160278.1	7tm_4	406..637	CDD:304433	60/244 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010