DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cirl and adgrf8

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	XP_021324214.1	Gene:	adgrf8 / 100537224	ZFINID:	ZDB-GENE-130531-41	Length:	1719	Species:	Danio rerio

Alignment Length:	1209	Identity:	239/1209 - (19%)
Similarity:	399/1209 - (33%)	Gaps:	375/1209 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 VINLIRANYGRFSITICNDHG---NVEWSVNCMFPKSLSVLNSRCAHKQ--------SCGVLAAT 93
            :|||:..|.    .|:|:.:|   :.:...|.::|      :|.|...|        :||.:...
Zfish   609 IINLLSVNI----TTVCDLNGTGFDCKCEANHVWP------SSTCTTYQVCDSIVGGTCGCIQTL 663

  Fly    94 SMFGDPCP-------------GTHKYLE---AHYQC--------------ISA---AQTSTTTNR 125
            ...|..|.             |.:....   ..|.|              :|:   ....|||.:
Zfish   664 PSNGSLCQQDINECQPSPSVCGPNSICNNEIGSYSCSCLNGFTPANSNLLVSSNNKCTAPTTTPQ 728

  Fly   126 PSPPPWVLSNGPPIFGNGSGLIHPPGVGAGAPPPPRLPTLPGVVGISGNPGLFNVPPQHTAVTHS 190
            |||.|....:..|.         |........||...||                .||.|..| :
Zfish   729 PSPQPSPQPSTQPT---------PQTTPQTTTPPQPTPT----------------TPQPTTTT-T 767

  Fly   191 TPSSSTTAVGGGRLKGGATSTTTTKHPAGRHDGLPPPPQLHHHHNHHGEDTASPTKPSSKLPAGG 255
            ||..:||.         .|:||||...|.:...:..........|.....|.:....|.||.:..
Zfish   768 TPEPTTTT---------TTTTTTTTTVATKVITMSLKMDQTFDTNLADSTTQTFKDLSGKLESSI 823

  Fly   256 NATSPSN--------TRILTGVGGSGTDDGTLLTTKSSPNRPPGTAA------------------ 294
            :::..||        .::.....||...|.|:..|.|:.:.....||
Zfish   824 DSSYSSNLKGYVSKSVKVNAYRPGSVFADYTISATSSNLDFSSANAALSSSLQAQGIILAADAFA 888

  Fly   295 --------SGSVVP-------------GNGSVVRTINNINLNAAGMSGGDDESKLFCGPTHARN- 337
                    :|.|.|             ..|.:...:||.:.:....|...|...|........|
Zfish   889 QSDQKDFITGQVYPQQKLELICTQPDFAQGQITWKVNNKDPDKNQYSLSSDNRTLTANSVTESNS 953

  Fly   338 --------------LYW---------NMTRVGDVNVQPCPGGAAGIAKWRCVLMKRIPDSGYD-E 378
                          :.|         |:....:..|..|||.:         ::|...|:||. |
Zfish   954 GQYSCITQRTTIPYIQWQNIAVKQLPNINVGNNYRVVQCPGSS---------VLKCSVDAGYSIE 1009

  Fly   379 Y--DDDISSTTPAPSG---------GDCL-------------------HNSSS-----------C 402
            :  .:.:..:..|..|         |:|.                   ::.||           |
Zfish  1010 WVQGETVQVSESAADGITLNYASQIGNCTQEQTFTCRLKGLPALLIYGYSQSSVIVKNTDQQYDC 1074

  Fly   403 EPPVSMAHKVNQRLRNFEPT--------------WHPATPD---------LTQCRSLWLNNLEMR 444
            :.........|::.....||              |.|...:         |||...|       :
Zfish  1075 QNEELGLGNQNEQRNGICPTGTKGIITYECDSKAWRPIKENCILGVISDLLTQIPVL-------Q 1132

  Fly   445 VNQRDSSL--ISIANDMSEVTSSKTLYGGDMLVTTKIIQTVSEKMMHDKETFPDQRQREAMI-ME 506
            |.|..|.|  :|.|.:.:.:..:::      ..|.|.|..:..::.:..:|        |:| ..
Zfish  1133 VGQIPSFLSNLSFATEQNNINITQS------AATVKAIVDILSQIANLAQT--------ALIGPP 1183

  Fly   507 LLHCVVKTGSNLLDESQLSSWLDLNPEDQMRVATSLLTGLEYNAFLLADTIIRERSVVQKVKNIL 571
            :::..:||...::..:...:|..||.::     |:..|.::   .|.|...|.:|.:.|...| |
Zfish  1184 VMNSFLKTLDIIVSTNSTETWNTLNNDN-----TTENTNIK---LLKATETISDRLIDQFTVN-L 1239

  Fly   572 LSVRVLETKTIQSSVVFPDSDQWPLSSDRIEL-------PRAALIDNSEGGLVRIVFAAFDRLES 629
            .|:::..| |:.||:....:    ||:...|:       |..|.|         |:|...|
Zfish  1240 TSIQLSRT-TVNSSLSVTST----LSNSTTEIVIPQVFGPTTATI---------IIFTTLD---- 1286

  Fly   630 ILKPSYDHFDLKSSRSYVRNTAILSNDSDVNAGEIQQRLRILNSKVISASLGKG-RHIQLSQPIT 693
                     ::..:|:...|     |.||::    .||   :|..|:...:.|. .:|..:..||
Zfish  1287 ---------NILPTRNISNN-----NSSDIS----DQR---INGDVVVVKVDKTVNNISFAFDIT 1330

  Fly   694 LTLKHLKTENVTNPTCVFWNYIDHAWSANGCSLESTNRTHSV--CSCNHLTNFAILMD--VVDEH 754
                   .:::.||.|||||:...||.:.||.::.......:  |.|||.|:|:|||.  ::|
Zfish  1331 -------NQSLGNPQCVFWNFNLSAWDSTGCEVKQVGNDSGIITCECNHTTSFSILMSPFILD-- 1386

  Fly   755 QHSLFTMFDGNMRIFI-YISIGICVVFIVIALLTLKLFNGVFVKSA--RTSIYTSIYLCLLAIEL 816
              ||...:...:.:.| .||:.:|::...|...::....||.|.|:  |.....:|.|.||...:
Zfish  1387 --SLILAYITYIGVTISMISLVLCLIIEAIVWRSVTSARGVTVVSSYMRHISLVNIALSLLIANV 1449

  Fly   817 LFLLG-----IEQTETSIFCGFITIFLHCAILSGTAWFCYEAFHSYSTLTSDELLL--------E 868
            .|::|     :|:......|..:..|:|...|:...|.          |.|..|||        :
Zfish  1450 CFIIGAAISDLEKPTPVGRCSPVVFFIHFFYLAVFFWM----------LISGMLLLYMTVMVFGQ 1504

  Fly   869 VDQTPKVNCYYLLSYGLSLSVVAISL--VIDPSTYTQNDYCVL--MEANALFYATFVIPVLVFFV 929
            :.:...:...:.:.||..|.:.:|::  ...|..|.....|.|  .|:.||.  .||||.|.  :
Zfish  1505 MSRIKMIAISFPVGYGAPLLIASITVASTAGPQNYVSKQACWLNWNESRALL--AFVIPALT--I 1565

  Fly   930 AAIGYTFLSWIIMCRKSRTGLKTKEHTRLASVRF-DIRCSFVFLLLLSAVWCSAYFYLRGAKMDD 993
            .||....|. :::.:...||:.........:..| .:||......|....|        |..:..
Zfish  1566 VAINLVVLV-VVLYKMLGTGVGAATQPSEKNTFFVVVRCVAFLTPLFGLTW--------GFGIGT 1621

  Fly   994 DTADVYG--YCFICFNTLLGLYIFVFHCIQNEKIRREYR 1030
            ..:...|  ..|...|...|.:|.:|..|.:.|:|...|
Zfish  1622 MLSSALGVHVLFTLLNAFQGFFILLFGTILDAKVREALR 1660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328	18/99 (18%)
		GAIN	453..680	CDD:293098	45/234 (19%)
		GPS	705..752	CDD:197639	20/50 (40%)
		7tm_4	763..1014	CDD:304433	58/273 (21%)
adgrf8	XP_021324214.1	EGF_CA	156..189	CDD:214542
		EGF_CA	324..357	CDD:214542
		EGF_CA	508..>540	CDD:214542
		EGF_CA	673..706	CDD:214542	3/32 (9%)
		Ig	899..968	CDD:325142	9/68 (13%)
		GPS	1337..1379	CDD:307782	16/41 (39%)
		7tm_GPCRs	1387..1660	CDD:333717	65/295 (22%)
		TM helix 1	1390..1414	CDD:320095	4/23 (17%)
		TM helix 2	1434..1455	CDD:320095	5/20 (25%)
		TM helix 3	1470..1492	CDD:320095	6/31 (19%)
		TM helix 4	1513..1529	CDD:320095	3/15 (20%)
		TM helix 5	1551..1574	CDD:320095	10/26 (38%)
		TM helix 6	1598..1623	CDD:320095	6/32 (19%)
		TM helix 7	1627..1652	CDD:320095	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900