DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cirl and adgrf11

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	XP_005160858.1	Gene:	adgrf11 / 100537132	ZFINID:	ZDB-GENE-121214-165	Length:	691	Species:	Danio rerio

Alignment Length:	749	Identity:	151/749 - (20%)
Similarity:	267/749 - (35%)	Gaps:	211/749 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   341 NMTRVGDVNVQPCPGGAAGIAKWRCVLMKRIPDSGYDEYDDDISSTTPAPSGGD----CLHNSSS 401
            |..|.....||.|||...|            |...::.|.|  .:......||.    |..::..
Zfish    33 NHIRERSTGVQECPGLING------------PRDHFNCYKD--GTLENGQKGGQLNRTCGKHNEG 83

  Fly   402 CEPPVSMAHKVNQRLRNFEPTWHPATPDLTQ-----CRSLWLNNLEMRVNQRDSSLISIANDMSE 461
            |:          ..|.:.:|......|.:.:     .::|::.::...|.|..:   :.|....|
Zfish    84 CQ----------YGLGSSKPILDDRVPQVIEDLQRKAQALFVWDMPEFVAQLST---ATAQHHEE 135

  Fly   462 VTSSKTLYGGDMLVTTKIIQTVSEKMMHDKE-----TFPDQRQREAMIMELLHCVVKTGSNLLDE 521
            :|.|           ...:||:.:.::|..|     ||   |:.|      :..:::|...|:.:
Zfish   136 ITES-----------AATVQTMVKILVHIAEISQNITF---RKPE------MENILQTVDILVSK 180

  Fly   522 SQLSSWLDLNPEDQMRVATSLLTGLEYNAFLLADTIIRERSVVQKVKNILLSVRVLETKTIQSSV 586
            ....:|..|| ..:|.|.||:                   |::..|::|...:
Zfish   181 KSRRTWEKLN-NSKMTVNTSI-------------------SLLGAVEDICSRL------------ 213

  Fly   587 VFPDSDQWPLSSDRIELPRAALIDNSEGGLVRIVFAAFDRL-ESILKP-SYDHFDLKSSRSYV-- 647
               ..|.:.::...|||.. .:|:||..|...:..:..:.| :.:||| |.....|.:..|.:
Zfish   214 ---THDSFVINKTSIELIN-TVIENSYSGKSHLPNSTTEILIQQVLKPTSLTIIILTTLHSILPA 274

  Fly   648 RNTAILSNDSDVNAGEIQQRLRILNSKVISASLGKGRHIQLSQPITLTLKHLK------TENVTN 706
            |.||......||.          :|..|:...:.:            ||:::.      .:::.|
Zfish   275 RYTANGKGKPDVR----------INGDVVVVKVNQ------------TLQNISFVFDTTEQSLGN 317

  Fly   707 PTCVFWNYIDHAWSANGCSL-----ESTNRTHSVCSCNHLTNFAILMDVVDEHQHSLFTMFDGNM 766
            |.|||||:....|.:.||.:     |........|.|||.|:|::||        |.|.:.|..:
Zfish   318 PQCVFWNFHLSTWDSTGCEVKPNLSEEEKIDKITCECNHTTSFSLLM--------SPFFIDDKAL 374

  Fly   767 RIFIYISIGICVVFIVIALL-------TLKLFNGVFVKSARTSIYTSIYLCLLAIELLFLLGIEQ 824
            ....|..:||.|:.:||:|:       |:...|..:::.. ..:.|::  .||..::.|::|...
Zfish   375 DYITYTGLGISVLSLVISLIIGAIVWTTVTKSNSAYLRHV-CLVNTNV--SLLVADVCFIIGASI 436

  Fly   825 TETSIF-----CGFITIFLHCAILSGTAWFCYEAFHSYSTLTSDELLL--------EVDQTPKVN 876
            .:....     |..:...:|...|:...|.          |.|..|||        ::.:...:.
Zfish   437 VQPGQLAPVGPCTAVAFSMHLFFLAFFFWM----------LISAMLLLYMTTMVYSQMSRAKMMA 491

  Fly   877 CYYLLSYGLSLSVVAISLVIDPSTY--TQNDYCVLMEANALFYATFVIPVLVFFVA-AIGYTFLS 938
            ..:.|.||..|.:|.|       ||  |..:...::||:..:........|..||: |..:|.::
Zfish   492 IAFFLGYGAPLLIVVI-------TYGLTAREGKYILEADVCWLNFDETKALQIFVSLASSFTAVN 549

  Fly   939 WII---------MCRKSRTGLKTKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLRGAKMDDD 994
            .:|         :.||.    :.||...|.:|   .|...:...|....|....    |..:..|
Zfish   550 VLIIIVVLYKMLIVRKQ----QNKETNILPTV---TRVVLIVSPLFGVTWGLGI----GTMLSPD 603

  Fly   995 TADVYG--YCFICFNTLLGLYIFVFHCIQNEKIR 1026
                ||  ..|...|:|.|::..|...:.|.::|
Zfish   604 ----YGIHLVFTILNSLQGIFNLVSGLLVNSQVR 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328
		GAIN	453..680	CDD:293098	46/235 (20%)
		GPS	705..752	CDD:197639	19/51 (37%)
		7tm_4	763..1014	CDD:304433	58/284 (20%)
adgrf11	XP_005160858.1	GAIN	143..>227	CDD:293098	22/127 (17%)
		GPS	318..363	CDD:280071	16/44 (36%)
		7tm_4	374..620	CDD:304433	57/280 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810