DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cirl and adgre15

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	XP_021333205.1	Gene:	adgre15 / 100536619	ZFINID:	ZDB-GENE-121214-33	Length:	543	Species:	Danio rerio

Alignment Length:	630	Identity:	145/630 - (23%)
Similarity:	260/630 - (41%)	Gaps:	142/630 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   446 NQRDSSLISIANDMSEVTSSKTLYGGDMLVTTKIIQTV---SEKM-MHDKETFPDQRQREAMIME 506
            ||....|.::...:..:|:.:.    .:...|.|:..|   |||: :......|.|
Zfish    27 NQSSGCLKNLLEQIENITAQEL----PLNTVTDILTVVFNASEKISVSSSSASPAQ--------- 78

  Fly   507 LLHCVVKTGSNLLDESQ-LSSWLDLNPEDQMRVATSLLTGLEYNAFLLADTIIRERSVVQKVKNI 570
                :...|:.:|..|: |.|.| :.|.:.....:..|..:|...|::...:..:
Zfish    79 ----LASYGTKVLKSSEKLISTL-VKPTETSANVSFTLAAVEGKVFMVGPQVTLD---------- 128

  Fly   571 LLSVRVLETKTIQSSVVFPDSDQWPLSSDRIELPRAALIDNSEGGLVRIVFAAFDRLESILKPSY 635
                ::.:..|..|||             .|:|...|..:|....   :.|.::..:|::||.
Zfish   129 ----KIPQLDTTNSSV-------------DIDLIGIAKNNNDRSA---VAFMSYTTMENLLKA-- 171

  Fly   636 DHFDLKSSRSYVRNTAILSNDSDVNAGEIQQRLRILNSKVISASLGKGRHIQLSQPITLTLKHLK 700
            |.|          ||   :||:          ::.:.|.||||:|.|..:..|::.:..|.:|::
Zfish   172 DFF----------NT---TNDT----------IKTMMSTVISATLPKTSNTALTKAVNFTFRHIR 213

  Fly   701 T-ENVTNPTCVFWNYIDHAWSANGCSLESTNRTHSVCSCNHLTNFAILMDVVDEHQHSLFTMFDG 764
            . |...:.:||:||..:  |..:|||:.::|.:|:||||.||:.||::|........|......|
Zfish   214 EFEPSGSLSCVYWNISE--WIVDGCSVLNSNSSHTVCSCVHLSTFALIMQTSSSPPPSDLLELLG 276

  Fly   765 NMRIFIYISIGICVVFIVIALLTLKL------FNGVFVKSARTSIYTSIYLCLLAIELLFLLGIE 823
                .:.:.:|:  ||..:|||:..|      .|.|    ||.:|..|    ||:..||||| .:
Zfish   277 ----LVCVIVGL--VFFSLALLSFALCQWSPGVNNV----ARINICIS----LLSAHLLFLL-TQ 326

  Fly   824 Q-----TETSIFCGFITIFLHCAILSGTAWFCYEA------FHSYSTLTSD--ELLLEVDQTPKV 875
            |     ....:.|..|...||...||...|...||      ..:.|.::|.  |:|     :...
Zfish   327 QFLSLIRPQQVLCVAIAGLLHFLFLSAFVWMFIEAVLLFICVKNLSQISSKKREVL-----SSGF 386

  Fly   876 NCYYLLSYGLSLSVVAISLVIDPSTYTQNDYCVLMEANALFYATFVIPVLVFFVAAIGYTFLSWI 940
            .|  ::.|.|::.||.:|:.:.|..| .:::| .::.:..|..:|:.||.|  :.|:.......|
Zfish   387 LC--VIGYVLAMVVVCVSIGLVPEGY-GSEHC-WIKTDEGFIWSFLGPVCV--ILALNLILFFKI 445

  Fly   941 IMCRKSRTGLKTKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLRGAKMDDDTADVYGYCFIC 1005
            ::...|.......|.:::...:..:..:....::|...|...:|        .:.::|....|:.
Zfish   446 VITLNSTLKNLNAEVSQMKQTKVMVFKTLGQFVVLGCPWILGFF--------TNGSEVLEIVFLI 502

  Fly  1006 FNTLLGLYIFVFHCIQNEKIRREYRKYVRQHAWLPKCLRCSKTSI 1050
            ||:..|.:||:.:|:.|.:||::|:...       .|| ||..||
Zfish   503 FNSQQGTFIFLIYCLLNNEIRQQYKNCF-------TCL-CSGHSI 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328
		GAIN	453..680	CDD:293098	42/231 (18%)
		GPS	705..752	CDD:197639	19/46 (41%)
		7tm_4	763..1014	CDD:304433	61/269 (23%)
adgre15	XP_021333205.1	GPS	219..265	CDD:197639	19/47 (40%)
		7tm_GPCRs	272..531	CDD:333717	68/299 (23%)
		TM helix 1	272..296	CDD:320095	7/29 (24%)
		TM helix 2	305..326	CDD:320095	12/29 (41%)
		TM helix 3	340..362	CDD:320095	7/21 (33%)
		TM helix 4	386..402	CDD:320095	5/17 (29%)
		TM helix 5	420..443	CDD:320095	6/24 (25%)
		TM helix 6	467..492	CDD:320095	3/32 (9%)
		TM helix 7	494..519	CDD:320095	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12011
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.000