DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cirl and adgrf1

DIOPT Version :9

Sequence 1:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	NP_001107298.1	Gene:	adgrf1 / 100135087	XenbaseID:	XB-GENE-6468452	Length:	1304	Species:	Xenopus tropicalis

Alignment Length:	1195	Identity:	229/1195 - (19%)
Similarity:	392/1195 - (32%)	Gaps:	392/1195 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SISYEHISLDLSKYQTAYAC--EGKKLTIECDPGDVINLIRANYGRFSITI-CNDHGNVEWSVNC 68
            |:|...|:...|.|...|.|  |........|....|..|..: |..|:|: |::..|:  .|.|
Frog   323 SVSNLLIASVTSDYAGNYRCMFENSSTLYSVDTNITIASITMS-GPDSVTVTCDNSDNI--LVTC 384

  Fly    69 MFPKSLSVLNSRCAHKQSCGV-----LAATS--------MFGDPC-PGTHKYLEAHYQC------ 113
            .....::.|:..|:...:.||     |.:||        ...|.| .|:    .|.|.|
Frog   385 STDGDINSLSLTCSSDPNKGVFNRSQLCSTSTCWTYIVQASPDQCTDGS----TATYSCTCFTSY 445

  Fly   114 ---ISAAQTSTTTNRPSPPPWVLSNGPPIFGNGSGLIHPPGVG---------------AGAPPPP 160
               :|.| .|.|.::|                  ||...|..|               :....|.
Frog   446 GAKVSKA-VSVTYSKP------------------GLTLIPAAGTLSISEGQSIWLECKSSKDVPD 491

  Fly   161 RLPTLPGVVGISGNPGLFNVPPQHTAVTHSTPSSSTTAVGGG-------RLKGGATSTTTTKHPA 218
            .:....|.:..:....|||....::......||:.|:..|..       :|:....|....|..|
Frog   492 IIWNFSGTINTTVQTTLFNYYASNSTSVLYIPSAVTSWQGNFYCSSESLKLQSTQKSVVVVKLIA 556

  Fly   219 GRHDGLPPPPQLHHHHNHHGEDTASPTKPSSKLPAGGNATSPSNTRILTGV-------------- 269
            .....:.|            .||...:..::|....|:..|.....:..||
Frog   557 SSQIDINP------------VDTVYQSGTATKFSCCGSDMSGYTATLQIGVITTAMTLYGNCFNV 609

  Fly   270 ------GGSGTDDGTLL-----TTKSSPNR-------------PPGTAASGSVVPGNGSVVRTIN 310
                  .|:.|...|:.     |.||:|.:             |||..|.|.::    :|..:..
Frog   610 TYNCANCGNYTASCTITNSLGGTVKSAPMKLTLRQQVEIKCGAPPGVGALGDII----TVPCSSE 670

  Fly   311 NINLNAAGMSGGDDESKLFCGPTHARNLYWNMTRVGDVNVQPCPGGAAGIAKWRCVLMKRIPDSG 375
            ||||..                    |..:..|..|                |:.|    :||:.
Frog   671 NINLTG--------------------NKSYTCTSTG----------------WQAV----VPDNC 695

  Fly   376 YDEYDDDISSTTPA---PSGGDCLHNSSSCEPPVSMAHKVNQRLRNFEPTWHPATPDLTQCRSLW 437
            ..:..:.:.|..|:   |.|.:.|        ||.:|        |...|......::|
Frog   696 VLQVLNRLVSDVPSLTGPGGAEIL--------PVYVA--------NLSATVTAEKENIT------ 738

  Fly   438 LNNLEMRVNQRDSSLISIANDMSEVTSSKTLYGGDMLVTTKIIQTVSEKMMHDKETFPDQRQREA 502
                     ...|:::::.|.:.:||:           ||:.:|             ||..|.
Frog   739 ---------SSPSNIVTVVNILQQVTT-----------TTQTVQ-------------PDVMQN-- 768

  Fly   503 MIMELLHCVVKTGSNLLDESQLSSWLDLNPEDQMRVATSLLTGLEYNAFLLADTIIRERSVVQKV 567
                    .:.|.:.::|::..::|.::|  ::....|.||..:|
Frog   769 --------FLTTVNVVVDDTSKNAWNNMN--NRTDRGTQLLNSVE-------------------- 803

  Fly   568 KNILLSVRVLETKTIQSSVVFPDSDQWPLSSDRIELPRAALIDNSEGGLVRIVFAAFDRLESILK 632
                                              :..|...|||   |.:.|:..:..:|..|:
Frog   804 ----------------------------------QFARKLQIDN---GSISIINNSNVQLAGII- 830

  Fly   633 PSYDHFDLKSSRSY-----------VRNTAILSNDSDVNAGE----------------IQQRLRI 670
                   ..|||||           :..:.::|.||..|...                :....::
Frog   831 -------ANSSRSYNESFNFSQGNNLTGSVLISKDSVSNMENNTNIITIAYATLKDILLNTSTKV 888

  Fly   671 LNSKVISASLGKGRHIQLSQPITLTLKHLKTENVTN-PTCVFWNYIDHAWSANGCSLESTNRTHS 734
            :|..|::..|.    .|:.....:::...|:....| |.|||||...:.|.:.||  :..|...:
Frog   889 VNGLVMTTVLS----TQVPSNFKISMNFKKSNQTLNVPGCVFWNLETNNWDSTGC--QGVNNAEN 947

  Fly   735 V-CSCNHLTNFAILMDVVDEHQHSLFTMFDGNMRIFI-YISIGICVVFIVIALLTLKLFNGVFVK 797
            | |.|:|||:|:|||.         :...|..:..:| ||.:.|.::.::|.:    ...|:..|
Frog   948 VSCDCDHLTSFSILMS---------YKAVDSIVLDYITYIGLAISIISLLICI----TIEGLIWK 999

  Fly   798 SA---RTSIYTSIYLCLLAIELL-----FLLGIE----------QTETSIFCGFITIFLHCAILS 844
            |.   :||....:.|..:|:.||     |::|..          .|..|..|...|.|.|...||
Frog  1000 SVTKNKTSYMRHVCLVNIAVSLLIADIWFIIGSAISTLLKSDPLNTANSNACVSATFFTHFFYLS 1064

  Fly   845 GTAWFCYEAFHSYSTLTSDELLLEVDQTPKVNCYYLLSYG--LSLSVVAISLVIDPSTYTQNDYC 907
            ...|........:..|.  .:|.::.::..:...:.:.||  |.:|::.:::.....||...:.|
Frog  1065 LFFWMLTMGLILFYRLV--YVLHDMSKSRMMAIAFTMGYGCPLLISIITVAVTQPGRTYLNGNAC 1127

  Fly   908 VLMEANALFYATFVIPVLVFFVAAIGYTFLSWII--MCRKSRTGLKTKEHTRLASVRFDIRCSFV 970
            .|..:::..:..||:|.|.  :..:.:..|:.:|  :.|.| .|.|.|:..:  |....|..|..
Frog  1128 WLNFSDSKAFIAFVLPALT--IILVNFIILAVVIIKLLRPS-VGDKPKKEDK--STLIHIGKSIA 1187

  Fly   971 FLL-LLSAVWCSAYFYLRGAKMDDDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYRKYVR 1034
            .|. ||...|......:    :..|...|.| .|...|:|.||:|.:|.|:.::|:|........
Frog  1188 ILTPLLGLTWGFGIATI----IAPDALWVLG-IFAALNSLQGLFILLFGCLLDKKVRDSLLSRFS 1247

  Fly  1035 QHAWLPKCLR-----CSKTSISSGI 1054
            ...|..:..:     .|:..||.|:
Frog  1248 LSRWSSQQTKSSHVTSSEIQISRGV 1272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328	22/94 (23%)
		GAIN	453..680	CDD:293098	36/253 (14%)
		GPS	705..752	CDD:197639	21/48 (44%)
		7tm_4	763..1014	CDD:304433	62/274 (23%)
adgrf1	NP_001107298.1	SEA	169..>232	CDD:279699
		IG_like	277..359	CDD:214653	9/35 (26%)
		ig	277..357	CDD:278476	9/33 (27%)
		GAIN	723..>806	CDD:293098	22/195 (11%)
		GPS	924..961	CDD:280071	16/38 (42%)
		7tm_4	1010..1227	CDD:304433	51/228 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000