Protein Alignment CG8642 and ANGPTL1

DIOPT Version :9

• Sequence 1: NP_610396.2
• Gene: CG8642 / 35845
• FlyBaseID: FBgn0033312
• Length: 429
• Species: Drosophila melanogaster
• Sequence 2: NP_001363692.1
• Gene: ANGPTL1 / 9068
• HGNCID: 489
• Length: 491
• Species: Homo sapiens
• Alignment Length: 497
• Identity: 139/497 - (27%)
• Similarity: 222/497 - (44%)
• Gaps: 108/497 - (21%)

  Fly     7 ILILIMLPSAWCLQVPSKIKSTTKAPVKEIP-PTNGTQIGNVTAVA-PVPEKLAEVHI------D 63
            :|..:::.:..|.....|||   |...:..| .|:|.:.....|.. .|||:.....|      .
Human    10 VLFFLLVDTGHCRGGQFKIK---KINQRRYPRATDGKEEAKKCAYTFLVPEQRITGPICVNTKGQ 71

  Fly    64 QHKTIR--ISKGDLDDLLDVYM----------------GKIAESAATIKDKENEINKLQTK--DQ 108
            ...||:  |::.||::|.||..                |.|......::.:...:|...|:  .|
Human    72 DASTIKDMITRMDLENLKDVLSRQKREIDVLQLVVDVDGNIVNEVKLLRKESRNMNSRVTQLYMQ 136

  Fly   109 TGDELLRKFENLTQVCSAQQS--SFTTAIKEKDEQIKELEQKVKVYETRLKRKQHVLAEL----- 166
            ...|::||.:|..::...:..  :.||.:.:...:.:|||.|.... |.|...|.|:..|
Human   137 LLHEIIRKRDNSLELSQLENKILNVTTEMLKMATRYRELEVKYASL-TDLVNNQSVMITLLEEQC 200

  Fly   167 -----RKLNGSSALLI----EHLKGKVVY---------------FERKFREKKDDLLADWEAATT 207
                 |:....|..|:    :|:.....|               :.|       ||:...:.||:
Human   201 LRIFSRQDTHVSPPLVQVVPQHIPNSQQYTPGLLGGNEIQRDPGYPR-------DLMPPPDLATS 258

  Fly   208 -SCVPFGRSP-----------------------GIHLI---HLPGFLPFLVPCEGQTAAGPGWTC 245
             :..||...|                       ||::|   :..|  |..:.||.....| |||.
Human   259 PTKSPFKIPPVTFINEGPFKDCQQAKEAGHSVSGIYMIKPENSNG--PMQLWCENSLDPG-GWTV 320

  Fly   246 IQRRLDGSVNFYRNWDAYSKGFGKLNGEFFIGLEKLHRLTSSQPHELYISIRRFGGETSYAHYDD 310
            ||:|.||||||:|||:.|.||||.::||:::|||.::.|::...::|.|.:..:..:..||.|..
Human   321 IQKRTDGSVNFFRNWENYKKGFGNIDGEYWLGLENIYMLSNQDNYKLLIELEDWSDKKVYAEYSS 385

  Fly   311 FLIGSEEEGYELKLLGHYQGNASDALRTHDKMKFSTYDRDNDAFTHMNCAEHHQGAWWYDFCSRS 375
            |.:..|.|.|.|: ||.|||||.|::..|:..:|:|.|||.|.:.. |||..|:|.|||:.|:.|
Human   386 FRLEPESEFYRLR-LGTYQGNAGDSMMWHNGKQFTTLDRDKDMYAG-NCAHFHKGGWWYNACAHS 448

  Fly   376 NLNGRYFKG---EVDNPQSIYWEPWY--SFRSLKSVQMLIRP 412
            ||||.:::|   ...:...|:|..:.  |: ||::|||:|:|
Human   449 NLNGVWYRGGHYRSKHQDGIFWAEYRGGSY-SLRAVQMMIKP 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8642	NP_610396.2	GluZincin	72..>163	CDD:301352	23/110 (21%)
		FReD	213..413	CDD:238040	85/231 (37%)
ANGPTL1	NP_001363692.1	PB1	74..138	CDD:383100	13/63 (21%)
		FReD	275..490	CDD:238040	84/221 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40314
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X25
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810